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mutLBSgeneDB |
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| Gene summary for USP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | USP2 |
| Gene name | ubiquitin specific peptidase 2 | |
| Synonyms | UBP41|USP9 | |
| Cytomap | UCSC genome browser: 11q23.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001243759.1, NM_004205.4,NM_171997.2, | |
| Description | 41 kDa ubiquitin-specific proteasedeubiquitinating enzyme 2ubiquitin carboxyl-terminal hydrolase 2ubiquitin specific protease 12ubiquitin specific protease 9ubiquitin thioesterase 2ubiquitin-specific-processing protease 2 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 604725 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000036672 | ||
| HPRD : 05287 | ||
| Vega : OTTHUMG00000166200 | ||
| Protein | UniProt: O75604 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_USP2 | |
| BioGPS: 9099 | ||
| Pathway | NCI Pathway Interaction Database: USP2 | |
| KEGG: USP2 | ||
| REACTOME: USP2 | ||
| Pathway Commons: USP2 | ||
| Context | iHOP: USP2 | |
| ligand binding site mutation search in PubMed: USP2 | ||
| UCL Cancer Institute: USP2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0016579 | protein deubiquitination | 17290220 | GO:0050821 | protein stabilization | 17290220 |
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| Ligand binding site mutations for USP2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q355 | Q355H | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for USP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Q355 | Q355H | -0.23298071 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for USP2 from PDB |
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| Differential gene expression and gene-gene network for USP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for USP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2239176 | Carcinoma, Hepatocellular | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for USP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of USP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NEH | ETHYLAMINE | 2ibi | A | Q355 |
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| Conservation information for LBS of USP2 |
| Multiple alignments for O75604 in multiple species |
| LBS | AA sequence | # species | Species | C276 | NLGNTCFMNSI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C425 | KSSLTCTDCGY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C428 | LTCTDCGYCST | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | C476 | DEKPTCCRCRA | 3 | Bos taurus, Mus musculus, Rattus norvegicus | C476 | DEKPTCCRCRG | 1 | Homo sapiens | C479 | PTCCRCRARKR | 3 | Bos taurus, Mus musculus, Rattus norvegicus | C479 | PTCCRCRGRKR | 1 | Homo sapiens | G556 | GTTMGGHYTAY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H557 | TTMGGHYTAYC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N274 | LRNLGNTCFMN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q355 | FVGYNQQDAQE | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | Q355 | FMGYNQQDAQE | 1 | Mus musculus |
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