mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NAALAD2
Gene summary
Basic gene Info.Gene symbolNAALAD2
Gene nameN-acetylated alpha-linked acidic dipeptidase 2
SynonymsGCPIII|GPCIII|NAADALASE2|NAALADASE2
CytomapUCSC genome browser: 11q14.3-q21
Type of geneprotein-coding
RefGenesNM_001300930.1,
NM_005467.3,
DescriptionN-acetylated alpha-linked acidic dipeptidase IIN-acetylated-alpha-linked acidic dipeptidase 2N-acetylated-alpha-linked acidic dipeptidase IINAALADase IIglutamate carboxypeptidase III
Modification date20141207
dbXrefs MIM : 611636
HGNC : HGNC
Ensembl : ENSG00000077616
HPRD : 07494
Vega : OTTHUMG00000166368
ProteinUniProt: Q9Y3Q0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NAALAD2
BioGPS: 10003
PathwayNCI Pathway Interaction Database: NAALAD2
KEGG: NAALAD2
REACTOME: NAALAD2
Pathway Commons: NAALAD2
ContextiHOP: NAALAD2
ligand binding site mutation search in PubMed: NAALAD2
UCL Cancer Institute: NAALAD2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for NAALAD2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y262G261SBLCA1
H367R368WCOAD1
N247L249FCOAD1
D443N441KCOAD1
D443D443GCOAD1
D443S445CGBM1
E426E427DHNSC1
Y262G261CLUAD1
D443S442LLUAD1
D377D377ELUSC1
H367H367NLUSC1
Y542P540QLUSC1
N247G246RSKCM1
N247G246ESKCM1
D377A375DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for NAALAD2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N247G246R0.092315337
N247G246E0.081605288
Y262G261S-1.0755498
Y542P540Q-1.0176551
D377A375D-0.88322876
N247L249F-0.77090375
Y262G261C-0.75643248
D443D443G-0.75403741
H367H367N-0.67661609
E426E427D-0.67108616
D443N441K-0.64856667
D443S445C-0.42379916
H367R368W-0.38692618
D377D377E-0.31336714
D443S442L-0.23041537
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NAALAD2 from PDB

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Differential gene expression and gene-gene network for NAALAD2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NAALAD2 and the right PPI network was created from samples without mutations in the LBS of NAALAD2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for NAALAD2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for NAALAD2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NAALAD2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)3fecAD377
ZNZINC(2+)3fedAD377
ZNZINC(2+)3feeAD377
ZNZINC(2+)3ff3AD377
ZNZINC(2+)3fecAH367 D377 D443
ZNZINC(2+)3fedAH367 D377 D443
ZNZINC(2+)3feeAH367 D377 D443
ZNZINC(2+)3ff3AH367 D377 D443
BIX(2S)-2-{[(S)-[(3S)-3-AMINO-3-CARBOXYPROPYL](HYDROXY)PHOSPHORYL]METHYL}PENTANEDIOIC ACID3fedAN247 H367 D377 D443 Y542
GLUL-GLUTAMIC ACID3fecAN247 Y542
QUSQUISQUALATE3feeAN247 Y542
GLUL-GLUTAMIC ACID3ff3AN247 Y542
CACALCIUM(2+)3fecAY262 E426
CACALCIUM(2+)3fedAY262 E426
CACALCIUM(2+)3feeAY262 E426
CACALCIUM(2+)3ff3AY262 E426


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Conservation information for LBS of NAALAD2
Multiple alignments for Q9Y3Q0 in multiple species
LBSAA sequence# speciesSpecies
D256LNGAGDPLTPG2Homo sapiens, Mus musculus
D256YYYVGDPLTPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D256MHGDGDALSPY1Caenorhabditis elegans
D377VFGAIDPTSGV1Homo sapiens
D377CTGASDSSVGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D377VYGSIDPNSGT1Caenorhabditis elegans
D377VFGGIDPTTGT1Mus musculus
D443AYINSDSSIEG1Homo sapiens
D443AYINVDVAVSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D443VYINMD-CIQG1Caenorhabditis elegans
D443AYINSDSAIEG1Mus musculus
E414ASWDAEEFGLL2Homo sapiens, Mus musculus
E414ASWDARQFNAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E414NAWDAEEFGLI1Caenorhabditis elegans
E415SWDAEEFGLLG2Homo sapiens, Mus musculus
E415SWDARQFNAIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E415AWDAEEFGLIG1Caenorhabditis elegans
E423LLGSTEWAEEN2Homo sapiens, Mus musculus
E423AIGSTEFLEYW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E423LIGSTEFVEEF1Caenorhabditis elegans
E426STEWAEENVKI1Homo sapiens
E426STEFLEYWKES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E426STEFVEEFVNI1Caenorhabditis elegans
E426STEWAEENAKL1Mus musculus
F199RYGKIFRGNKV2Homo sapiens, Mus musculus
F199RANQSDFALAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F199RYGHGFRGDKI1Caenorhabditis elegans
G417DAEEFGLLGST2Homo sapiens, Mus musculus
G417DARQFNAIGST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G417DAEEFGLIGST1Caenorhabditis elegans
G508NKLGSGSDFEA2Homo sapiens, Mus musculus
G508----YTSDLTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G508RVPGGGSDHAP1Caenorhabditis elegans
H367VILGGHRDSWV2Homo sapiens, Mus musculus
H367LVVGAPRDSWC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H367IMLGNHFDAWV1Caenorhabditis elegans
H543SYPVYHTIYET2Homo sapiens, Mus musculus
H543PMPFLGSCEDT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H543TYPLYHTMYET1Caenorhabditis elegans
K689PSSHNKYAGES2Homo sapiens, Mus musculus
K689PNLRNSHS-QL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K689VSDSDSYSSSL1Caenorhabditis elegans
L418AEEFGLLGSTE2Homo sapiens, Mus musculus
L418ARQFNAIGSTE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L418AEEFGLIGSTE1Caenorhabditis elegans
N247AAQRGNVLN-L2Homo sapiens, Mus musculus
N247SLYRGSVANHY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N247GVQRGSL---M1Caenorhabditis elegans
P263LTPGYPAKEYT2Homo sapiens, Mus musculus
P263LTPGWSAHEET1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P263LSPYYPSKKEL1Caenorhabditis elegans
R200YGKIFRGNKVK2Homo sapiens, Mus musculus
R200ANQSDFALATA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R200YGHGFRGDKIH1Caenorhabditis elegans
R524GIASGRARYTK2Homo sapiens, Mus musculus
R524GIPVVNLAFER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R524GVPVINFTF-K1Caenorhabditis elegans
R526ASGRARYTKNK2Homo sapiens, Mus musculus
R526PVVNLAFERNE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R526PVINFTF-KNY1Caenorhabditis elegans
S507INKLGSGSDFE2Homo sapiens, Mus musculus
S507-----YTSDLT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S507IRVPGGGSDHA1Caenorhabditis elegans
T259AGDPLTPGYPA2Homo sapiens, Mus musculus
T259VGDPLTPGWSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T259DGDALSPYYPS1Caenorhabditis elegans
Y262PLTPGYPAKEY2Homo sapiens, Mus musculus
Y262PLTPGWSAHEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y262ALSPYYPSKKE1Caenorhabditis elegans
Y542SSYPVYHTIYE2Homo sapiens, Mus musculus
Y542TPMPFLGSCED1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y542DTYPLYHTMYE1Caenorhabditis elegans
Y690SSHNKYAGESF2Homo sapiens, Mus musculus
Y690NLRNSHS-QLF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y690SDSDSYSSSLM1Caenorhabditis elegans


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