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mutLBSgeneDB |
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| Gene summary for ZBTB33 |
 Gene summary |
| Basic gene Info. | Gene symbol | ZBTB33 |
| Gene name | zinc finger and BTB domain containing 33 | |
| Synonyms | ZNF-kaiso|ZNF348 | |
| Cytomap | UCSC genome browser: Xq23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001184742.1, NM_006777.3, | |
| Description | WUGSC:H_DJ525N14.1kaiso transcription factortranscriptional regulator Kaisozinc finger and BTB domain-containing protein 33 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300329 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000177485 | ||
| HPRD : 02269 | ||
| Vega : OTTHUMG00000171159 | ||
| Protein | UniProt: Q86T24 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZBTB33 | |
| BioGPS: 10009 | ||
| Pathway | NCI Pathway Interaction Database: ZBTB33 | |
| KEGG: ZBTB33 | ||
| REACTOME: ZBTB33 | ||
| Pathway Commons: ZBTB33 | ||
| Context | iHOP: ZBTB33 | |
| ligand binding site mutation search in PubMed: ZBTB33 | ||
| UCL Cancer Institute: ZBTB33 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 16354688 |
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| Ligand binding site mutations for ZBTB33 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y14 | G16D | COAD | 1 | R501 | R501G | COAD | 1 | S566 | S567L | SKCM | 1 | L586,Y584 | R585C | SKCM | 1 | R510 | R510Q | STAD | 1 | L586,Y584 | R585G | STAD | 1 | L6 | K5Q | UCEC | 1 | Y536,T538 | R537C | UCEC | 1 | L533 | P532L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ZBTB33 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y584 | R585G | -1.3830473 | L586 | R585G | -1.3830473 | R510 | R510Q | -1.2880316 | R501 | R501G | -1.1426582 | Y584 | R585C | -1.0711965 | L586 | R585C | -1.0711965 | L6 | K5Q | -0.86282845 | Y536 | R537C | -0.58399794 | T538 | R537C | -0.58399794 | L533 | P532L | -0.54553407 | Y14 | G16D | -0.19740231 | S566 | S567L | -0.011248292 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ZBTB33 from PDB |
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| Differential gene expression and gene-gene network for ZBTB33 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ZBTB33 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ZBTB33 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ZBTB33 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 4f6m | A | L533 Y536 | NUC | Nucleic Acids | 2lt7 | A | R501 Y536 | NUC | Nucleic Acids | 4f6n | A | R501 Y536 | NUC | Nucleic Acids | 2lt7 | A | R510 T538 S566 Y584 L586 | NUC | Nucleic Acids | 4f6m | A | T538 Y584 L586 | NUC | Nucleic Acids | 4f6n | A | T538 Y584 L586 |
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| Conservation information for LBS of ZBTB33 |
| Multiple alignments for Q86T24 in multiple species |
| LBS | AA sequence | # species | Species |
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