mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PDCD6IP

Gene summary

Basic gene Info.	Gene symbol	PDCD6IP
	Gene name	programmed cell death 6 interacting protein
	Synonyms	AIP1\|ALIX\|DRIP4\|HP95
	Cytomap	UCSC genome browser: 3p22.3
	Type of gene	protein-coding
	RefGenes	NM_001162429.2, NM_001256192.1,NM_013374.5,NR_027867.1,
	Description	ALG-2 interacting protein 1ALG-2-interacting protein XPDCD6-interacting proteinapoptosis-linked gene 2-interacting protein Xdopamine receptor interacting protein 4programmed cell death 6-interacting protein
	Modification date	20141222
dbXrefs	MIM : 608074
	HGNC : HGNC
	Ensembl : ENSG00000170248
	HPRD : 06425
	Vega : OTTHUMG00000130751
Protein	UniProt: Q8WUM4 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PDCD6IP
	BioGPS: 10015
Pathway	NCI Pathway Interaction Database: PDCD6IP
	KEGG: PDCD6IP
	REACTOME: PDCD6IP
	Pathway Commons: PDCD6IP
Context	iHOP: PDCD6IP
	ligand binding site mutation search in PubMed: PDCD6IP
	UCL Cancer Institute: PDCD6IP
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for PDCD6IP

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
I212	A211S	LUAD	1
A150	A149V	LUAD	1
K202	L201F	STAD	1
L440	E442G	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for PDCD6IP

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
K202	L201F	-1.6259653
I212	A211S	-0.87880712
L440	E442G	-0.73003863
A150	A149V	-0.53883367

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PDCD6IP from PDB

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Differential gene expression and gene-gene network for PDCD6IP

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PDCD6IP and the right PPI network was created from samples without mutations in the LBS of PDCD6IP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for PDCD6IP

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0017661	Glomerulonephritis, IGA	1	Biomarker
umls:C0029408	Osteoarthritis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for PDCD6IP

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PDCD6IP go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
III		Peptide ligand (ASP,GLU,GLU,ALA,LEU,LYS,GLN,LEU,ALA,GLU,TRP,VAL,SER)	3c3o	A	A150 K202 I212
III		Peptide ligand (LYS,GLU,GLU,GLU,ASP,ASP,ASP,MET,LYS,GLU,LEU,GLU,ASN,TRP,ALA,GLY,SER,MET)	3c3q	A	A150 K202 I212
III		Peptide ligand (GLU,ASP,ASP,ASP,ILE,LYS,GLN,LEU,ALA,ALA,TRP,ALA,THR)	3c3r	A	K202 I212
III		Peptide ligand (GLU,LEU,TYR,PRO,LEU,THR,SER,LEU,ARG,SER,LEU)	2r02	A	L440
III		Peptide ligand (GLU,LEU,TYR,PRO,LEU,ALA,SER,LEU,ARG,SER,LEU)	2r05	A	L440
III		Peptide ligand (GLU,LYS,PRO,TYR,LYS,GLU,VAL,THR,GLU,ASP,LEU,LEU,HIS,LEU,ASN)	2xs1	A	L440
III		Peptide ligand (ALA,TYR,ASP,PRO,ALA,ARG,LYS,LEU,LEU)	2xs8	A	L440

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Conservation information for LBS of PDCD6IP

Multiple alignments for Q8WUM4 in multiple species

LBS	AA sequence	# species	Species
A150	GLKIAAKHYQF	1	Homo sapiens
A150	AIKTAANYFSH	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
A150	EIKVSAKLFQQ	1	Caenorhabditis elegans
A150	GLKTAAKQYQF	1	Mus musculus
A150	GLKESCRLFKL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A150	SLKTSCLYFQN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A150	ELKEACRYLQE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A335	DPIGKATLVKS	1	Homo sapiens
A335	KILDRANLAVA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
A335	PTLPKAVLAKP	1	Caenorhabditis elegans
A335	DPIGKATLVKP	1	Mus musculus
A335	SKVKPVMMVQA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A335	PSIKPALMVKP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A335	PVINPVSMVKP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A502	TVLDKAVQADG	1	Homo sapiens
A502	GYFASSTSSDG	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
A502	GILHTASNADK	1	Caenorhabditis elegans
A502	AVLDKAVQADG	1	Mus musculus
A502	NYIENGMKVDT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A502	GYLDEGSAIDK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A502	GYLRQGEEITR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A505	DKAVQADGQVK	2	Homo sapiens, Mus musculus
A505	ASSTSSDGIVR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
A505	HTASNADKMVK	1	Caenorhabditis elegans
A505	ENGMKVDTETA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A505	DEGSAIDKQTN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A505	RQGEEITRETT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D143	QNLDND-EGLK	2	Homo sapiens, Mus musculus
D143	TNSNGDSNAIK	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D143	QQFHTD-DEIK	1	Caenorhabditis elegans
D143	QRLEST-EGLK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D143	SNNDAA-ESLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D143	MGND----ELK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D506	KAVQADGQVKE	2	Homo sapiens, Mus musculus
D506	SSTSSDGIVRE	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
D506	TASNADKMVKE	1	Caenorhabditis elegans
D506	NGMKVDTETAS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D506	EGSAIDKQTNE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D506	QGEEITRETTQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E672	VANLKEGTKFY	2	Homo sapiens, Mus musculus
E672	VSNVEVGRKFY	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
E672	KANLEEGTKFY	1	Caenorhabditis elegans
E672	KENIISGKQFY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E672	KENLSAGTAFY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E672	KENIEEGQVFY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E679	TKFYNELTEIL	2	Homo sapiens, Mus musculus
E679	RKFYNDLSKIV	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
E679	TKFYNDLTPIL	1	Caenorhabditis elegans
E679	KQFYQDLITAL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E679	TAFYENLITST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E679	QVFYEDLKESI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F199	QAQEVFFLKAT	2	Homo sapiens, Mus musculus
F199	QCQECYWQKAV	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F199	QAQEAIYIKGH	1	Caenorhabditis elegans
F199	QAQQMVWKKAC	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F199	QAQECFWFKAV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F199	QAQECCWARAL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F676	KEGTKFYNELT	2	Homo sapiens, Mus musculus
F676	EVGRKFYNDLS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
F676	EEGTKFYNDLT	1	Caenorhabditis elegans
F676	ISGKQFYQDLI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F676	SAGTAFYENLI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F676	EEGQVFYEDLK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G673	ANLKEGTKFYN	2	Homo sapiens, Mus musculus
G673	SNVEVGRKFYN	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
G673	ANLEEGTKFYN	1	Caenorhabditis elegans
G673	ENIISGKQFYQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G673	ENLSAGTAFYE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G673	ENIEEGQVFYE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I212	M-KDAIIAKLA	2	Homo sapiens, Mus musculus
I212	Y-KDATIAKLA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I212	M-KATSMVKIS	1	Caenorhabditis elegans
I212	IERHSILSRLA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I212	H-KDSLIAKLS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I212	M-KHSPIARLA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I683	NELTEILVRFQ	2	Homo sapiens, Mus musculus
I683	NDLSKIVGTFR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
I683	NDLTPILVRLQ	1	Caenorhabditis elegans
I683	QDLITALESKL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I683	ENLITSTSNLY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I683	EDLKESIGVLH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K147	D-EGLKIAAKH	1	Homo sapiens
K147	DSNAIKTAANY	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K147	D-DEIKVSAKL	1	Caenorhabditis elegans
K147	D-EGLKTAAKQ	1	Mus musculus
K147	T-EGLKESCRL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K147	A-ESLKTSCLY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K147	---ELKEACRY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K151	LKIAAKHYQFA	1	Homo sapiens
K151	IKTAANYFSHA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K151	IKVSAKLFQQS	1	Caenorhabditis elegans
K151	LKTAAKQYQFA	1	Mus musculus
K151	LKESCRLFKLS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K151	LKTSCLYFQNA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K151	LKEACRYLQES	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K202	EVFFLKATRDK	2	Homo sapiens, Mus musculus
K202	ECYWQKAVAEG	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K202	EAIYIKGHKDK	1	Caenorhabditis elegans
K202	QMVWKKACFDD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K202	ECFWFKAVQDK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K202	ECCWARALRDA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K209	RDKM-KDAIIA	2	Homo sapiens, Mus musculus
K209	AEGY-KDATIA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K209	KDKM-KATSMV	1	Caenorhabditis elegans
K209	FDDIERHSILS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K209	QDKH-KDSLIA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K209	RDAM-KHSPIA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K215	DAIIAKLANQA	2	Homo sapiens, Mus musculus
K215	DATIAKLAARA	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K215	ATSMVKISAQV	1	Caenorhabditis elegans
K215	HSILSRLALQV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K215	DSLIAKLSQQI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K215	HSPIARLALQV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K501	RTVLDKAVQAD	1	Homo sapiens
K501	EGYFASSTSSD	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
K501	RGILHTASNAD	1	Caenorhabditis elegans
K501	RAVLDKAVQAD	1	Mus musculus
K501	RNYIENGMKVD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K501	RGYLDEGSAID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K501	QGYLRQGEEIT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L146	ND-EGLKIAAK	1	Homo sapiens
L146	GDSNAIKTAAN	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L146	TD-DEIKVSAK	1	Caenorhabditis elegans
L146	ND-EGLKTAAK	1	Mus musculus
L146	ST-EGLKESCR	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L146	AA-ESLKTSCL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L146	----ELKEACR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L216	AIIAKLANQAA	2	Homo sapiens, Mus musculus
L216	ATIAKLAARAS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L216	TSMVKISAQVA	1	Caenorhabditis elegans
L216	SILSRLALQVA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L216	SLIAKLSQQIV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L216	SPIARLALQVS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L337	IGKATLVKS--	1	Homo sapiens
L337	LDRANLAVARI	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L337	LPKAVLAKP--	1	Caenorhabditis elegans
L337	IGKATLVKP--	1	Mus musculus
L337	VKPVMMVQA--	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L337	IKPALMVKPSS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L337	INPVSMVKP-I	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L440	QLIKELPELLQ	2	Homo sapiens, Mus musculus
L440	RSFADIDKLRS	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L440	RLFSELPTLYQ	1	Caenorhabditis elegans
L440	DSLQDLEQLRA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L440	ASLNNLLINNK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L440	KTLAGLNEFSS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L680	KFYNELTEILV	2	Homo sapiens, Mus musculus
L680	KFYNDLSKIVG	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
L680	KFYNDLTPILV	1	Caenorhabditis elegans
L680	QFYQDLITALE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L680	AFYENLITSTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L680	VFYEDLKESIG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M208	ATRDKM-KDAI	2	Homo sapiens, Mus musculus
M208	AVAEGY-KDAT	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
M208	GHKDKM-KATS	1	Caenorhabditis elegans
M208	ACFDDIERHSI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M208	AVQDKH-KDSL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M208	ALRDAM-KHSP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N494	RAEGTNFRTVL	1	Homo sapiens
N494	WAQVGEIEGYF	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N494	VTEIGKYRGIL	1	Caenorhabditis elegans
N494	RAEGAKFRAVL	1	Mus musculus
N494	LADLTNIRNYI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N494	YEKLKKLRGYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N494	NKRIVTLQGYL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N669	VELVANLKEGT	2	Homo sapiens, Mus musculus
N669	KEIVSNVEVGR	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
N669	VELKANLEEGT	1	Caenorhabditis elegans
N669	SELKENIISGK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N669	DEVKENLSAGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N669	EQVKENIEEGQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R686	TEILVRFQNKC	2	Homo sapiens, Mus musculus
R686	SKIVGTFRDTC	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
R686	TPILVRLQQKV	1	Caenorhabditis elegans
R686	ITALESKLKEI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R686	ITSTSNLYNEV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R686	KESIGVLHEDV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V498	TNFRTVLDKAV	1	Homo sapiens
V498	GEIEGYFASST	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
V498	GKYRGILHTAS	1	Caenorhabditis elegans
V498	AKFRAVLDKAV	1	Mus musculus
V498	TNIRNYIENGM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V498	KKLRGYLDEGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V498	VTLQGYLRQGE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
V509	QADGQVKECYQ	1	Homo sapiens
V509	SSDGIVREKYL	1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
V509	NADKMVKEKFE	1	Caenorhabditis elegans
V509	QADGQVKERYQ	1	Mus musculus
V509	KVDTETASLFK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
V509	AIDKQTNELFQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V509	EITRETTQIFE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)