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mutLBSgeneDB |
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| Gene summary for PARP2 |
 Gene summary |
| Basic gene Info. | Gene symbol | PARP2 |
| Gene name | poly (ADP-ribose) polymerase 2 | |
| Synonyms | ADPRT2|ADPRTL2|ADPRTL3|ARTD2|PARP-2|pADPRT-2 | |
| Cytomap | UCSC genome browser: 14q11.2-q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001042618.1, NM_005484.3, | |
| Description | ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2ADP-ribosyltransferase diphtheria toxin-like 2ADPRT-2NAD(+) ADP-ribosyltransferase 2hPARP-2poly (ADP-ribose) polymerase family, member 2poly (ADP-ribosyl) transferase-like 2poly [ADP- | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607725 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000129484 | ||
| Vega : OTTHUMG00000166106 | ||
| Protein | UniProt: Q9UGN5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PARP2 | |
| BioGPS: 10038 | ||
| Pathway | NCI Pathway Interaction Database: PARP2 | |
| KEGG: PARP2 | ||
| REACTOME: PARP2 | ||
| Pathway Commons: PARP2 | ||
| Context | iHOP: PARP2 | |
| ligand binding site mutation search in PubMed: PARP2 | ||
| UCL Cancer Institute: PARP2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for PARP2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E335 | A336V | COAD | 1 | H428 | L426I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PARP2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E335 | A336V | -1.3589953 | H428 | L426I | -1.09391 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PARP2 from PDB |
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| Differential gene expression and gene-gene network for PARP2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PARP2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023787 | Lipodystrophy | 1 | Biomarker |
| umls:C0031117 | Peripheral Nervous System Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PARP2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Investigational | DB07232 | Veliparib | Small molecule |  |
| Approved | DB09074 | Olaparib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PARP2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 2YQ | (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE | 4pjv | A | E335 H428 | 09L | OLAPARIB | 4tvj | A | E335 H428 | 09L | OLAPARIB | 4tvj | B | E335 H428 | 3AB | 3-AMINOBENZAMIDE | 3kcz | A | H428 | 3AB | 3-AMINOBENZAMIDE | 3kcz | B | H428 | 78P | (2R)-2-(7-CARBAMOYL-1H-BENZIMIDAZOL-2-YL)-2-METHYLPYRROLIDINIUM | 3kjd | A | H428 | 78P | (2R)-2-(7-CARBAMOYL-1H-BENZIMIDAZOL-2-YL)-2-METHYLPYRROLIDINIUM | 3kjd | B | H428 | 2YQ | (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2, 4-TRIAZOL-5-YL)-2,7,8,9-TETRAHYDRO-3H-PYRIDO[4,3,2- DE]PHTHALAZIN-3-ONE | 4pjv | B | H428 | FSU | 2-(3-METHOXYPROPYL)-3-OXO-2,3-DIHYDRO-1H- ISOINDOLE-4-CARBOXAMIDE | 4zzx | A | H428 | FSU | 2-(3-METHOXYPROPYL)-3-OXO-2,3-DIHYDRO-1H- ISOINDOLE-4-CARBOXAMIDE | 4zzx | B | H428 | D7N | 2-[1-(4,4-DIFLUOROCYCLOHEXYL)-PIPERIDIN-4-YL] -6-FLUORO-3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4- CARBOXAMIDE | 4zzy | A | H428 |
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| Conservation information for LBS of PARP2 |
| Multiple alignments for Q9UGN5 in multiple species |
| LBS | AA sequence | # species | Species | A464 | KGIYFADMSSK | 2 | Homo sapiens, Mus musculus | A464 | KGVYFADMFSK | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | E335 | KIQLLEALGDI | 1 | Homo sapiens | E335 | KVKLLEALGDI | 1 | Mus musculus | E335 | KIEMVEALGEI | 1 | Arabidopsis thaliana | E335 | KLEMVEALSEI | 1 | Oryza sativa subsp. japonica | E558 | TLNYNEYIVYN | 1 | Homo sapiens | E558 | TLNYNEFIVYS | 1 | Mus musculus | E558 | MLLYNEYIVYN | 1 | Arabidopsis thaliana | E558 | SLMYNEYIVYN | 1 | Oryza sativa subsp. japonica | F463 | GKGIYFADMSS | 2 | Homo sapiens, Mus musculus | F463 | GKGVYFADMFS | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | G429 | MLLWHGSRLTN | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | G429 | MLLWHGSRMSN | 1 | Homo sapiens | G429 | MLLWHGSRLSN | 1 | Mus musculus | G454 | EAPITGYMFGK | 2 | Homo sapiens, Mus musculus | G454 | EAPVTGYMFGK | 1 | Arabidopsis thaliana | G454 | EAPISGFMFGK | 1 | Oryza sativa subsp. japonica | G460 | YMFGKGIYFAD | 2 | Homo sapiens, Mus musculus | G460 | YMFGKGVYFAD | 1 | Arabidopsis thaliana | G460 | FMFGKGVYFAD | 1 | Oryza sativa subsp. japonica | H428 | RMLLWHGSRLT | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | H428 | RMLLWHGSRMS | 1 | Homo sapiens | H428 | RMLLWHGSRLS | 1 | Mus musculus | I134 | NKYYLIQLLED | 2 | Homo sapiens, Mus musculus | I134 | NKFFVLQVLES | 1 | Arabidopsis thaliana | I134 | NKFYIIQALES | 1 | Oryza sativa subsp. japonica | I461 | MFGKGIYFADM | 2 | Homo sapiens, Mus musculus | I461 | MFGKGVYFADM | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | K469 | ADMSSKSANYC | 2 | Homo sapiens, Mus musculus | K469 | ADMFSKSANYC | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | Q332 | LSEKIQLLEAL | 1 | Homo sapiens | Q332 | LSDKVKLLEAL | 1 | Mus musculus | Q332 | LKQKIEMVEAL | 1 | Arabidopsis thaliana | Q332 | LKAKLEMVEAL | 1 | Oryza sativa subsp. japonica | S328 | TQKELSEKIQL | 1 | Homo sapiens | S328 | TEKELSDKVKL | 1 | Mus musculus | S328 | TPQKLKQKIEM | 1 | Arabidopsis thaliana | S328 | TPQKLKAKLEM | 1 | Oryza sativa subsp. japonica | S470 | DMSSKSANYCF | 2 | Homo sapiens, Mus musculus | S470 | DMFSKSANYCY | 1 | Arabidopsis thaliana | S470 | DMFSKSANYCC | 1 | Oryza sativa subsp. japonica | Y455 | APITGYMFGKG | 2 | Homo sapiens, Mus musculus | Y455 | APVTGYMFGKG | 1 | Arabidopsis thaliana | Y455 | APISGFMFGKG | 1 | Oryza sativa subsp. japonica | Y462 | FGKGIYFADMS | 2 | Homo sapiens, Mus musculus | Y462 | FGKGVYFADMF | 2 | Arabidopsis thaliana, Oryza sativa subsp. japonica | Y473 | SKSANYCFASR | 2 | Homo sapiens, Mus musculus | Y473 | SKSANYCYANT | 1 | Arabidopsis thaliana | Y473 | SKSANYCCASE | 1 | Oryza sativa subsp. japonica |
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