mutLBSgeneDB |
Gene summary for 100616459 |
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Basic gene Info. | Gene symbol | 100616459 |
Gene name | ||
Synonyms | ||
Cytomap | UCSC genome browser: | |
Type of gene | ||
RefGenes | ||
Description | ||
Modification date | ||
dbXrefs | ||
Protein | UniProt: P26599 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_100616459 | |
BioGPS: 100616459 | ||
Pathway | NCI Pathway Interaction Database: 100616459 | |
KEGG: 100616459 | ||
REACTOME: 100616459 | ||
Pathway Commons: 100616459 | ||
Context | iHOP: 100616459 | |
ligand binding site mutation search in PubMed: 100616459 | ||
UCL Cancer Institute: 100616459 | ||
Assigned class in mutLBSgeneDB |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for 100616459 |
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LBS | AAchange of nsSNV | Cancer type | # samples |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for 100616459 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L253 | R254H | -1.3416917 | R52 | R52G | -1.2016857 | R185 | V183M | -1.1953637 | L263 | S262N | -1.12968 | R523 | R523P | -0.9649879 | R418 | R418C | -0.89647237 | K368 | R366L | -0.83858439 | N376 | A377T | -0.70295778 | L378 | A377T | -0.70295778 | H457 | T455M | -0.60240656 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for 100616459 |
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Phenotype information for 100616459 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for 100616459 |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2adc | A | H457 R523 | NUC | Nucleic Acids | 2adc | A | K368 N376 L378 R418 | III | Peptide ligand (SER,GLU,GLY,LEU,LEU,GLY,LEU) | 3zzz | B | L253 | NUC | Nucleic Acids | 2adb | A | R185 L263 | NUC | Nucleic Acids | 2ad9 | A | R52 |
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Conservation information for LBS of 100616459 |
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LBS | AA sequence | # species | Species |
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