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mutLBSgeneDB |
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| Gene summary for DPP3 |
 Gene summary |
| Basic gene Info. | Gene symbol | DPP3 |
| Gene name | dipeptidyl-peptidase 3 | |
| Synonyms | DPPIII | |
| Cytomap | UCSC genome browser: 11q12-q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256670.1, NM_005700.4,NM_130443.3, | |
| Description | DPP IIIdipeptidyl aminopeptidase IIIdipeptidyl arylamidase IIIdipeptidyl peptidase 3dipeptidyl peptidase IIIenkephalinase B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606818 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000254986 | ||
| HPRD : 06012 | ||
| Vega : OTTHUMG00000167143 | ||
| Protein | UniProt: Q9NY33 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DPP3 | |
| BioGPS: 10072 | ||
| Pathway | NCI Pathway Interaction Database: DPP3 | |
| KEGG: DPP3 | ||
| REACTOME: DPP3 | ||
| Pathway Commons: DPP3 | ||
| Context | iHOP: DPP3 | |
| ligand binding site mutation search in PubMed: DPP3 | ||
| UCL Cancer Institute: DPP3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 10387075 |
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| Ligand binding site mutations for DPP3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E512,E508 | R510W | COAD | 2 | V412 | A414V | COAD | 1 | I392,N394 | P393L | SKCM | 1 | P387 | P387S | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DPP3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P387 | P387S | -0.93903774 | N394 | P393L | -0.82136391 | I392 | P393L | -0.82136391 | V412 | A414V | -0.52162455 | E508 | R510W | -0.48694998 | E512 | R510W | -0.48694998 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DPP3 from PDB |
| PDB ID | PDB title | PDB structure | 5EGY | Structure of ligand free human DPP3 in closed form. |  |
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| Differential gene expression and gene-gene network for DPP3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DPP3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DPP3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DPP3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 3fvy | A | E508 | III | Peptide ligand (VAL,VAL,TYR,PRO,TRP) | 3t6j | A | P387 I392 N394 E508 E512 | III | Peptide ligand (VAL,VAL,TYR,PRO,TRP) | 3t6b | A | P387 N394 V412 E508 | III | Peptide ligand (VAL,VAL,TYR,PRO,TRP) | 3t6b | B | P387 N394 V412 E508 E512 |
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| Conservation information for LBS of DPP3 |
| Multiple alignments for Q9NY33 in multiple species |
| LBS | AA sequence | # species | Species | A388 | GSGIPAGINIP | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | A388 | GSGVPAGINIP | 1 | Drosophila melanogaster | E316 | YIGFIESYRDP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E316 | NIGFIETYREP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E316 | YIGFIETYRDP | 1 | Drosophila melanogaster | E508 | ASSYEECRAES | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E508 | AGPFEECRAEV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E508 | GSSYEECRAEA | 1 | Drosophila melanogaster | E512 | EECRAESVGLY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E512 | EECRAEVIAMF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E512 | EECRAEAVGLY | 1 | Drosophila melanogaster | F109 | GNYKSFGDTKF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F109 | GNFKSFGDTKF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F109 | GNYKGMGDSKI | 1 | Drosophila melanogaster | F443 | WKGPSFDVQVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F443 | YQSDSFEVQVG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F443 | YKVKAFEVQVG | 1 | Drosophila melanogaster | G164 | RHLGLGKEGVT | 2 | Mus musculus, Rattus norvegicus | G164 | RHLGLGKEGIT | 1 | Homo sapiens | G164 | ALLGFPSQGYT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G164 | EILGFAPDGIT | 1 | Drosophila melanogaster | G167 | GLGKEGVTT-- | 2 | Mus musculus, Rattus norvegicus | G167 | GLGKEGITT-- | 1 | Homo sapiens | G167 | GFPSQGYTSAY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G167 | GFAPDGITT-- | 1 | Drosophila melanogaster | G389 | SGIPAGINIPN | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | G389 | SGVPAGINIPN | 1 | Drosophila melanogaster | H450 | VQVGLHELLGH | 4 | Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus | H450 | VQVGIHELLGH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H455 | HELLGHGSGKL | 5 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Drosophila melanogaster, Mus musculus, Rattus norvegicus | H568 | NWRQAHMQARF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H568 | KWGQPHMQARF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H568 | LWLQAHSRARF | 1 | Drosophila melanogaster | I386 | FAGSGIPAGIN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I386 | FTGSGIPAGIN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I386 | FAGSGVPAGIN | 1 | Drosophila melanogaster | I390 | GIPAGINIPNY | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | I390 | GVPAGINIPNY | 1 | Drosophila melanogaster | I392 | PAGINIPNYDD | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | I392 | PAGINIPNYDE | 1 | Drosophila melanogaster | I672 | ESRKLIVQPNT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I672 | LPRRQFIQSNS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I672 | KPRMILVQANT | 1 | Drosophila melanogaster | K670 | RKESRKLIVQP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K670 | KRLPRRQFIQS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K670 | HKKPRMILVQA | 1 | Drosophila melanogaster | L163 | LRHLGLGKEGV | 2 | Mus musculus, Rattus norvegicus | L163 | LRHLGLGKEGI | 1 | Homo sapiens | L163 | AALLGFPSQGY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L163 | NEILGFAPDGI | 1 | Drosophila melanogaster | N391 | IPAGINIPNYD | 4 | Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Mus musculus, Rattus norvegicus | N391 | VPAGINIPNYD | 1 | Drosophila melanogaster | N394 | GINIPNYDDLR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N394 | GINIPNYDDVR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N394 | GINIPNYDEIR | 1 | Drosophila melanogaster | P387 | AGSGIPAGINI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P387 | TGSGIPAGINI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P387 | AGSGVPAGINI | 1 | Drosophila melanogaster | Q446 | PSFDVQVGLHE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q446 | DSFEVQVGIHE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q446 | KAFEVQVGLHE | 1 | Drosophila melanogaster | R572 | AHMQARFVILR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R572 | PHMQARFSIMK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R572 | AHSRARFVIMK | 1 | Drosophila melanogaster | R669 | LRKESRKLIVQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R669 | SKRLPRRQFIQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R669 | AHKKPRMILVQ | 1 | Drosophila melanogaster | V412 | VSLGNVL-AVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V412 | VSLGNILSAAA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V412 | VSLGNVL---A | 1 | Drosophila melanogaster | Y318 | GFIESYRDPFG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y318 | GFIETYREPSG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y318 | GFIETYRDPAG | 1 | Drosophila melanogaster |
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