mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 101060747
Gene summary
Basic gene Info.Gene symbol101060747
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt: O15530
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_101060747
BioGPS: 101060747
PathwayNCI Pathway Interaction Database: 101060747
KEGG: 101060747
REACTOME: 101060747
Pathway Commons: 101060747
ContextiHOP: 101060747
ligand binding site mutation search in PubMed: 101060747
UCL Cancer Institute: 101060747
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for 101060747

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for 101060747
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K77R78Q-1.377672
K495V493L-1.1616827
L88L88F-1.0186398
Q247Y248H-0.95452228
K257S258A-0.74668191
S94S94P-0.74350913
R521T522M-0.72418366
K467G468R-0.55206677
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 101060747 from PDB

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Differential gene expression and gene-gene network for 101060747
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 101060747 and the right PPI network was created from samples without mutations in the LBS of 101060747. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for 101060747
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for 101060747
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00482CelecoxibSmall molecule
ExperimentalDB01863Inositol 1,3,4,5-TetrakisphosphateSmall molecule
ExperimentalDB019337-HydroxystaurosporineSmall molecule
ExperimentalDB019463-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-DioneSmall molecule
ExperimentalDB02010StaurosporineSmall molecule
ExperimentalDB03777Rbt205 InhibitorSmall molecule
ExperimentalDB04522PhosphonoserineSmall molecule
ExperimentalDB0693210,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamineSmall molecule
ExperimentalDB070335-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONESmall molecule
ExperimentalDB071321-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREASmall molecule
ExperimentalDB073002-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amineSmall molecule
ExperimentalDB074563-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONESmall molecule
ExperimentalDB074573-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 101060747 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
PSEO-PHOSPHOETHANOLAMINE2r7bAK257
4IPINOSITOL 1,3,4,5-TETRAKISPHOSPHATE1w1dAK467 K495 R521
4PTDIC4-PHOSPHATIDYLINOSITOL(3,4,5)TRISPHOSPHATE1w1gAK467 K495 R521
IIIPeptide ligand (MET,PHE,ARG,ASP,PHE,ASP,TYR,ILE,ALA)4rrvAK77
STUSTAUROSPORINE1okyAL88
UCN7-HYDROXYSTAUROSPORINE1okzAL88
LY4LY3335311uu3AL88
BI23-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,DIONE1uu7AL88
BI1RBT205 INHIBITOR1uu8AL88
BI3BISINDOLYLMALEIMIDE III1uu9AL88
BI83-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE1uvrAL88
39Z5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE2pe0AL88
5171-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA2pe1AL88
4643-[5-({5-[(AMINOCARBONYL)AMINO]-2-OXO-2H-INDOL-3-YL}METHYL)-1H-PYRROL-3-YL]-N-(2-PIPERIDIN-1-YLETHYL)BENZAMIDE2pe2AL88
25310,11-DIMETHOXY-4-METHYLDIBENZO[C,F]-2,7-NAPHTHYRIDINE-3,6-DIAMINE2r7bAL88
CKG8-(CYCLOHEXA-2,5-DIEN-1-YLIDENEAMINO)-1-(PIPERIDIN-4-YLMETHYL)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE2xchAL88
9BD2-(1H-IMIDAZOL-1-YL)-9-METHOXY-8-(2-METHOXYETHOXY)BENZO[C][2,7]NAPHTHYRIDIN-4-AMINE3h9oAL88
MP64-(2-CYCLOPROPYLETHYLIDENE)-9-(1H-PYRAZOL-4-YL)-6-{[(1R)-1,2,2-TRIMETHYLPROPYL]AMINO}BENZO[C][1,6]NAPHTHYRIDIN-1(4H)-ONE3nayAL88
MP64-(2-CYCLOPROPYLETHYLIDENE)-9-(1H-PYRAZOL-4-YL)-6-{[(1R)-1,2,2-TRIMETHYLPROPYL]AMINO}BENZO[C][1,6]NAPHTHYRIDIN-1(4H)-ONE3nayBL88
JOZ3,4-DIHYDROISOQUINOLIN-1(2H)-ONE3nuuAL88
BI43-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE3orzAL88
BI43-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE3orzBL88
BI43-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE3orzCL88
BI43-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE3orzDL88
BI43-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE3otuAL88
SYPN-[2-({6-[(2-SULFANYLETHYL)AMINO]PYRIMIDIN-4-YL}AMINO)ETHYL]PROPANAMIDE3pwyAL88
3S16-[2-(HYDROXYMETHYL)PHENYL]ISOQUINOLIN-1(2H)-ONE3sc1AL88
LI8N-(3-(4-(3-(3-AMINO-2,2-DIMETHYL-3-OXOPROPANAMIDO)PROPYLAMINO)-5-BROMOPYRIMIDIN-2-YLAMINO)PHENYL)PYRROLIDINE-1-CARBOXAMIDE1z5mAL88 S94
MH41-METHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-N-[(2-METHYLPYRIDIN-4-YL)METHYL]-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE2xckAL88 S94
8H12-(5-{[(2S)-2-AMINO-3-PHENYLPROPYL]OXY}PYRIDIN-3-YL)-8,9-DIMETHOXYBENZO[C][2,7]NAPHTHYRIDIN-4-AMINE3ionAL88 S94
8I12-(5-{[(2R)-2-AMINO-3-PHENYLPROPYL]OXY}PYRIDIN-3-YL)-8,9-DIMETHOXYBENZO[C][2,7]NAPHTHYRIDIN-4-AMINE3iopAL88 S94
3RC(3S)-3-(1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)-3H-PYRROLO[2,3-B]PYRIDINE3rcjAL88 S94
ABQ[4-AMINO-7-(PROPAN-2-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL](6-{[(3S,4R)-4-(4-FLUOROPHENYL)TETRAHYDROFURAN-3-YL]AMINO}PYRAZIN-2-YL)METHANONE3rwpAL88 S94
3RW[4-AMINO-7-(PROPAN-2-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL](6-{[2-(PYRIDIN-3-YL)ETHYL]AMINO}PYRAZIN-2-YL)METHANONE3rwqAL88 S94
ATPATP4ct2AL88 S94
AZ7(3S)-3-(4-CHLOROPHENYL)-4-(5,7-DICHLORO-1H-BENZIMIDAZOL-2-YL)BUTANOIC ACID4a07AQ247
ATPATP1h1wAS94
ATPATP2biyAS94
ATPATP3hrcAS94
ATPATP3hrfAS94
MP71-(3,4-DIFLUOROBENZYL)-2-OXO-N-{(1R)-2-[(2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL)OXY]-1-PHENYLETHYL}-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE3naxAS94
MP71-(3,4-DIFLUOROBENZYL)-2-OXO-N-{(1R)-2-[(2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL)OXY]-1-PHENYLETHYL}-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE3qc4AS94
MP71-(3,4-DIFLUOROBENZYL)-2-OXO-N-{(1R)-2-[(2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOL-5-YL)OXY]-1-PHENYLETHYL}-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE3qc4BS94
3Q06-(3-AMINO-2H-INDAZOL-6-YL)-N~4~-ETHYLPYRIMIDINE-2,4-DIAMINE3qcqAS94
3Q5TERT-BUTYL {(3R,6S)-1-[2-AMINO-6-(3-AMINO-2H-INDAZOL-6-YL)PYRIMIDIN-4-YL]-6-METHYLPIPERIDIN-3-YL}CARBAMATE3qd3AS94
3Q6TERT-BUTYL {(3R,5R)-1-[2-AMINO-6-(3-AMINO-2H-INDAZOL-6-YL)PYRIMIDIN-4-YL]-5-METHYLPIPERIDIN-3-YL}CARBAMATE3qd4AS94
ATPATP4a06AS94
ATPATP4a07AS94
ATPATP4aw0AS94
ATPATP4aw1AS94
ATPATP4ct1AS94
ATPATP4rqkAS94
ATPATP4rqvAS94
ATPATP4rrvAS94
ATPATP4xx9AS94
ATPATP5ackAS94


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Conservation information for LBS of 101060747
Multiple alignments for O15530 in multiple species
LBSAA sequence# speciesSpecies
A109TSREYAIKILE3Homo sapiens, Mus musculus, Rattus norvegicus
A109TDAMFAVKVLQ1Caenorhabditis elegans
A109TGTVYALKIMD1Arabidopsis thaliana
A109NGTVYALKIMD1Arabidopsis thaliana
A109SRREYAIKVCE1Drosophila melanogaster
A162FGLSYAKNGEL3Homo sapiens, Mus musculus, Rattus norvegicus
A162MALESCEGGEL2Arabidopsis thaliana, Arabidopsis thaliana
A162FVIGLVENGDL1Caenorhabditis elegans
A162FVMTYARKGDM1Drosophila melanogaster
A227TDFGTAKVL--3Homo sapiens, Mus musculus, Rattus norvegicus
A227ADFGSVKPMQD2Arabidopsis thaliana, Arabidopsis thaliana
A227TDFGSAQAFGG1Caenorhabditis elegans
A227ADFGSAKVMTA1Drosophila melanogaster
D223HIQITDFGTAK3Homo sapiens, Mus musculus, Rattus norvegicus
D223HIKIADFGSVK2Arabidopsis thaliana, Arabidopsis thaliana
D223HILITDFGSAQ1Caenorhabditis elegans
D223HTLIADFGSAK1Drosophila melanogaster
E130PYVTRERDVMS3Homo sapiens, Mus musculus, Rattus norvegicus
E130AYVKLERIVLD2Arabidopsis thaliana, Arabidopsis thaliana
E130DAIIREKNILT1Caenorhabditis elegans
E130DYIKREREVMH1Drosophila melanogaster
E166YAKNGELLKYI3Homo sapiens, Mus musculus, Rattus norvegicus
E166SCEGGELFDQI2Arabidopsis thaliana, Arabidopsis thaliana
E166LVENGDLGESL1Caenorhabditis elegans
E166YARKGDMLPYI1Drosophila melanogaster
E209RDLKPENILLN3Homo sapiens, Mus musculus, Rattus norvegicus
E209RDIKPENLLLT2Arabidopsis thaliana, Arabidopsis thaliana
E209RDMKPDNVLIQ1Caenorhabditis elegans
E209RDLKPENILLD1Drosophila melanogaster
E90GKILGEGSFST3Homo sapiens, Mus musculus, Rattus norvegicus
E90GKIYGVGSYSK2Arabidopsis thaliana, Arabidopsis thaliana
E90LQSMGEGAYSQ1Caenorhabditis elegans
E90GRYIGEGSYSI1Drosophila melanogaster
F142-H-PFFVKLYF3Homo sapiens, Mus musculus, Rattus norvegicus
F142GH-PFVTQLYT1Caenorhabditis elegans
F142-H-PGIIKLYF1Arabidopsis thaliana
F142-H-PGIVKLFF1Arabidopsis thaliana
F142-NVPGFVNLSC1Drosophila melanogaster
F147FVKLYFTFQDD3Homo sapiens, Mus musculus, Rattus norvegicus
F147VTQLYTHFHDQ1Caenorhabditis elegans
F147IIKLYFTFQDT1Arabidopsis thaliana
F147IVKLFFTFQDT1Arabidopsis thaliana
F147FVNLSCTFQDQ1Drosophila melanogaster
F149KLYFTFQDDEK3Homo sapiens, Mus musculus, Rattus norvegicus
F149QLYTHFHDQAR1Caenorhabditis elegans
F149KLYFTFQDTSS1Arabidopsis thaliana
F149KLFFTFQDTQS1Arabidopsis thaliana
F149NLSCTFQDQRS1Drosophila melanogaster
F157DEKLYFGLSYA3Homo sapiens, Mus musculus, Rattus norvegicus
F157QARIYFVIGLV1Caenorhabditis elegans
F157TSSLYMALESC1Arabidopsis thaliana
F157TQSLYMALESC1Arabidopsis thaliana
F157QRSLYFVMTYA1Drosophila melanogaster
F224IQITDFGTAKV3Homo sapiens, Mus musculus, Rattus norvegicus
F224IKIADFGSVKP2Arabidopsis thaliana, Arabidopsis thaliana
F224ILITDFGSAQA1Caenorhabditis elegans
F224TLIADFGSAKV1Drosophila melanogaster
F242----SFVGTAQ3Homo sapiens, Mus musculus, Rattus norvegicus
F242----TFVGTAA2Arabidopsis thaliana, Arabidopsis thaliana
F242----TFVGTAL1Caenorhabditis elegans
F242HRKASFVGTAQ1Drosophila melanogaster
F282AGLPPFRAGNE3Homo sapiens, Mus musculus, Rattus norvegicus
F282SGTSPFKDASE2Arabidopsis thaliana, Arabidopsis thaliana
F282AGQPPFRAVNQ1Caenorhabditis elegans
F282AGLPPFRGSND1Drosophila melanogaster
F93LGEGSFSTVVL3Homo sapiens, Mus musculus, Rattus norvegicus
F93YGVGSYSKVVR2Arabidopsis thaliana, Arabidopsis thaliana
F93MGEGAYSQVFR1Caenorhabditis elegans
F93IGEGSYSIVYL1Drosophila melanogaster
G165SYAKNGELLKY3Homo sapiens, Mus musculus, Rattus norvegicus
G165ESCEGGELFDQ2Arabidopsis thaliana, Arabidopsis thaliana
G165GLVENGDLGES1Caenorhabditis elegans
G165TYARKGDMLPY1Drosophila melanogaster
G225QITDFGTAKVL3Homo sapiens, Mus musculus, Rattus norvegicus
G225KIADFGSVKPM2Arabidopsis thaliana, Arabidopsis thaliana
G225LITDFGSAQAF1Caenorhabditis elegans
G225LIADFGSAKVM1Drosophila melanogaster
G278YQLVAGLPPFR3Homo sapiens, Mus musculus, Rattus norvegicus
G278YQMLSGTSPFK2Arabidopsis thaliana, Arabidopsis thaliana
G278FQCLAGQPPFR1Caenorhabditis elegans
G278YQMIAGLPPFR1Drosophila melanogaster
G89FGKILGEGSFS3Homo sapiens, Mus musculus, Rattus norvegicus
G89FLQSMGEGAYS1Caenorhabditis elegans
G89FGKIYGVGSYS1Arabidopsis thaliana
G89LGKIYGVGSYS1Arabidopsis thaliana
G89FGRYIGEGSYS1Drosophila melanogaster
G91KILGEGSFSTV3Homo sapiens, Mus musculus, Rattus norvegicus
G91KIYGVGSYSKV2Arabidopsis thaliana, Arabidopsis thaliana
G91QSMGEGAYSQV1Caenorhabditis elegans
G91RYIGEGSYSIV1Drosophila melanogaster
H203GKGIIHRDLKP3Homo sapiens, Mus musculus, Rattus norvegicus
H203DNKIVHRDMKP1Caenorhabditis elegans
H203SMGLIHRDIKP1Arabidopsis thaliana
H203NMGLIHRDIKP1Arabidopsis thaliana
H203RRNVVHRDLKP1Drosophila melanogaster
I118LEKRHIIKENK3Homo sapiens, Mus musculus, Rattus norvegicus
I118MDKKFITKENK2Arabidopsis thaliana, Arabidopsis thaliana
I118LQKSYLNRHQK1Caenorhabditis elegans
I118CEKRLILRERK1Drosophila melanogaster
I119EKRHIIKENKV3Homo sapiens, Mus musculus, Rattus norvegicus
I119DKKFITKENKT2Arabidopsis thaliana, Arabidopsis thaliana
I119QKSYLNRHQKM1Caenorhabditis elegans
I119EKRLILRERKQ1Drosophila melanogaster
I201LHGKGIIHRDL3Homo sapiens, Mus musculus, Rattus norvegicus
I201LHDNKIVHRDM1Caenorhabditis elegans
I201IHSMGLIHRDI1Arabidopsis thaliana
I201IHNMGLIHRDI1Arabidopsis thaliana
I201MHRRNVVHRDL1Drosophila melanogaster
I221DMHIQITDFGT3Homo sapiens, Mus musculus, Rattus norvegicus
I221DGHIKIADFGS2Arabidopsis thaliana, Arabidopsis thaliana
I221DGHILITDFGS1Caenorhabditis elegans
I221DMHTLIADFGS1Drosophila melanogaster
K111REYAIKILEKR3Homo sapiens, Mus musculus, Rattus norvegicus
K111TVYALKIMDKK2Arabidopsis thaliana, Arabidopsis thaliana
K111AMFAVKVLQKS1Caenorhabditis elegans
K111REYAIKVCEKR1Drosophila melanogaster
K115IKILEKRHIIK3Homo sapiens, Mus musculus, Rattus norvegicus
K115LKIMDKKFITK2Arabidopsis thaliana, Arabidopsis thaliana
K115VKVLQKSYLNR1Caenorhabditis elegans
K115IKVCEKRLILR1Drosophila melanogaster
K163GLSYAKNGELL3Homo sapiens, Mus musculus, Rattus norvegicus
K163ALESCEGGELF2Arabidopsis thaliana, Arabidopsis thaliana
K163VIGLVENGDLG1Caenorhabditis elegans
K163VMTYARKGDML1Drosophila melanogaster
K169NGELLKYIRKI3Homo sapiens, Mus musculus, Rattus norvegicus
K169GGELFDQITRK2Arabidopsis thaliana, Arabidopsis thaliana
K169NGDLGESLCHF1Caenorhabditis elegans
K169KGDMLPYINRV1Drosophila melanogaster
K173LKYIRKIGSFD3Homo sapiens, Mus musculus, Rattus norvegicus
K173FDQITRKGRLS2Arabidopsis thaliana, Arabidopsis thaliana
K173GESLCHFGSFD1Caenorhabditis elegans
K173LPYINRVGSFD1Drosophila melanogaster
K257ELLTEKSACKS3Homo sapiens, Mus musculus, Rattus norvegicus
K257EVLNSSPATFG2Arabidopsis thaliana, Arabidopsis thaliana
K257EMLADGDVGPQ1Caenorhabditis elegans
K257EVLQNGPITPA1Drosophila melanogaster
K465MGPVDKRKGLF3Homo sapiens, Mus musculus, Rattus norvegicus
K465ISAVKKLQKIT2Arabidopsis thaliana, Arabidopsis thaliana
K465QGYLEKKRGLF1Caenorhabditis elegans
K465KGFVNKRKGLF1Drosophila melanogaster
K467PVDKRKGLFAR3Homo sapiens, Mus musculus, Rattus norvegicus
K467AVKKLQKITSK2Arabidopsis thaliana, Arabidopsis thaliana
K467YLEKKRGLFAR1Caenorhabditis elegans
K467FVNKRKGLFAR1Drosophila melanogaster
K495VNKVLKGEIPW3Homo sapiens, Mus musculus, Rattus norvegicus
K495SKLVVKGNIIW2Arabidopsis thaliana, Arabidopsis thaliana
K495PNLVLKGEVPW1Caenorhabditis elegans
K495VQMIKKGEIPW1Drosophila melanogaster
K76---PRKKRPED3Homo sapiens, Mus musculus, Rattus norvegicus
K76--GCPKRTSND1Caenorhabditis elegans
K76-----NFTSHD1Arabidopsis thaliana
K76-----NFTYHD1Arabidopsis thaliana
K76QNPAPRRSPND1Drosophila melanogaster
K77--PRKKRPEDF3Homo sapiens, Mus musculus, Rattus norvegicus
K77-GCPKRTSNDF1Caenorhabditis elegans
K77----NFTSHDF1Arabidopsis thaliana
K77----NFTYHDF1Arabidopsis thaliana
K77NPAPRRSPNDF1Drosophila melanogaster
L113YAIKILEKRHI3Homo sapiens, Mus musculus, Rattus norvegicus
L113YALKIMDKKFI2Arabidopsis thaliana, Arabidopsis thaliana
L113FAVKVLQKSYL1Caenorhabditis elegans
L113YAIKVCEKRLI1Drosophila melanogaster
L137DVMSRLD----3Homo sapiens, Mus musculus, Rattus norvegicus
L137IVLDQLE----2Arabidopsis thaliana, Arabidopsis thaliana
L137NILTYLSQECG1Caenorhabditis elegans
L137EVMHQMT----1Drosophila melanogaster
L145PFFVKLYFTFQ3Homo sapiens, Mus musculus, Rattus norvegicus
L145PFVTQLYTHFH1Caenorhabditis elegans
L145PGIIKLYFTFQ1Arabidopsis thaliana
L145PGIVKLFFTFQ1Arabidopsis thaliana
L145PGFVNLSCTFQ1Drosophila melanogaster
L155QDDEKLYFGLS3Homo sapiens, Mus musculus, Rattus norvegicus
L155HDQARIYFVIG1Caenorhabditis elegans
L155QDTSSLYMALE1Arabidopsis thaliana
L155QDTQSLYMALE1Arabidopsis thaliana
L155QDQRSLYFVMT1Drosophila melanogaster
L159KLYFGLSYAKN3Homo sapiens, Mus musculus, Rattus norvegicus
L159SLYMALESCEG2Arabidopsis thaliana, Arabidopsis thaliana
L159RIYFVIGLVEN1Caenorhabditis elegans
L159SLYFVMTYARK1Drosophila melanogaster
L168KNGELLKYIRK3Homo sapiens, Mus musculus, Rattus norvegicus
L168EGGELFDQITR2Arabidopsis thaliana, Arabidopsis thaliana
L168ENGDLGESLCH1Caenorhabditis elegans
L168RKGDMLPYINR1Drosophila melanogaster
L196SALEYLHGKGI3Homo sapiens, Mus musculus, Rattus norvegicus
L196TGLQFLHDNKI1Caenorhabditis elegans
L196DALEYIHSMGL1Arabidopsis thaliana
L196DALEYIHNMGL1Arabidopsis thaliana
L196LACEHMHRRNV1Drosophila melanogaster
L212KPENILLNEDM3Homo sapiens, Mus musculus, Rattus norvegicus
L212KPDNVLIQKDG1Caenorhabditis elegans
L212KPENLLLTSDG1Arabidopsis thaliana
L212KPENLLLTLDG1Arabidopsis thaliana
L212KPENILLDEDM1Drosophila melanogaster
L279QLVAGLPPFRA3Homo sapiens, Mus musculus, Rattus norvegicus
L279QMLSGTSPFKD2Arabidopsis thaliana, Arabidopsis thaliana
L279QCLAGQPPFRA1Caenorhabditis elegans
L279QMIAGLPPFRG1Drosophila melanogaster
L88KFGKILGEGSF3Homo sapiens, Mus musculus, Rattus norvegicus
L88MFLQSMGEGAY1Caenorhabditis elegans
L88EFGKIYGVGSY1Arabidopsis thaliana
L88ELGKIYGVGSY1Arabidopsis thaliana
L88IFGRYIGEGSY1Drosophila melanogaster
M134RERDVMSRLD-3Homo sapiens, Mus musculus, Rattus norvegicus
M134LERIVLDQLE-2Arabidopsis thaliana, Arabidopsis thaliana
M134REKNILTYLSQ1Caenorhabditis elegans
M134REREVMHQMT-1Drosophila melanogaster
N164LSYAKNGELLK3Homo sapiens, Mus musculus, Rattus norvegicus
N164LESCEGGELFD2Arabidopsis thaliana, Arabidopsis thaliana
N164IGLVENGDLGE1Caenorhabditis elegans
N164MTYARKGDMLP1Drosophila melanogaster
N210DLKPENILLNE3Homo sapiens, Mus musculus, Rattus norvegicus
N210DMKPDNVLIQK1Caenorhabditis elegans
N210DIKPENLLLTS1Arabidopsis thaliana
N210DIKPENLLLTL1Arabidopsis thaliana
N210DLKPENILLDE1Drosophila melanogaster
P125KENKVPYVTRE3Homo sapiens, Mus musculus, Rattus norvegicus
P125KENKTAYVKLE2Arabidopsis thaliana, Arabidopsis thaliana
P125RHQKMDAIIRE1Caenorhabditis elegans
P125RERKQDYIKRE1Drosophila melanogaster
P280LVAGLPPFRAG3Homo sapiens, Mus musculus, Rattus norvegicus
P280MLSGTSPFKDA2Arabidopsis thaliana, Arabidopsis thaliana
P280CLAGQPPFRAV1Caenorhabditis elegans
P280MIAGLPPFRGS1Drosophila melanogaster
Q150LYFTFQDDEKL3Homo sapiens, Mus musculus, Rattus norvegicus
Q150LYTHFHDQARI1Caenorhabditis elegans
Q150LYFTFQDTSSL1Arabidopsis thaliana
Q150LFFTFQDTQSL1Arabidopsis thaliana
Q150LSCTFQDQRSL1Drosophila melanogaster
Q220EDMHIQITDFG3Homo sapiens, Mus musculus, Rattus norvegicus
Q220KDGHILITDFG1Caenorhabditis elegans
Q220SDGHIKIADFG1Arabidopsis thaliana
Q220LDGHIKIADFG1Arabidopsis thaliana
Q220EDMHTLIADFG1Drosophila melanogaster
Q247FVGTAQYVSPE4Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus
Q247FVGTAAYVPPE2Arabidopsis thaliana, Arabidopsis thaliana
Q247FVGTALYVSPE1Caenorhabditis elegans
Q274GCIIYQLVAGL3Homo sapiens, Mus musculus, Rattus norvegicus
Q274GCTLYQMLSGT2Arabidopsis thaliana, Arabidopsis thaliana
Q274GCILFQCLAGQ1Caenorhabditis elegans
Q274GCIVYQMIAGL1Drosophila melanogaster
R129VPYVTRERDVM3Homo sapiens, Mus musculus, Rattus norvegicus
R129TAYVKLERIVL2Arabidopsis thaliana, Arabidopsis thaliana
R129MDAIIREKNIL1Caenorhabditis elegans
R129QDYIKREREVM1Drosophila melanogaster
R131YVTRERDVMSR3Homo sapiens, Mus musculus, Rattus norvegicus
R131YVKLERIVLDQ2Arabidopsis thaliana, Arabidopsis thaliana
R131AIIREKNILTY1Caenorhabditis elegans
R131YIKREREVMHQ1Drosophila melanogaster
R172LLKYIRKIGSF3Homo sapiens, Mus musculus, Rattus norvegicus
R172LFDQITRKGRL2Arabidopsis thaliana, Arabidopsis thaliana
R172LGESLCHFGSF1Caenorhabditis elegans
R172MLPYINRVGSF1Drosophila melanogaster
R204KGIIHRDLKPE3Homo sapiens, Mus musculus, Rattus norvegicus
R204MGLIHRDIKPE2Arabidopsis thaliana, Arabidopsis thaliana
R204NKIVHRDMKPD1Caenorhabditis elegans
R204RNVVHRDLKPE1Drosophila melanogaster
R283GLPPFRAGNEY3Homo sapiens, Mus musculus, Rattus norvegicus
R283GTSPFKDASEW2Arabidopsis thaliana, Arabidopsis thaliana
R283GQPPFRAVNQY1Caenorhabditis elegans
R283GLPPFRGSNDY1Drosophila melanogaster
R472KGLFARRRQLL3Homo sapiens, Mus musculus, Rattus norvegicus
R472QKITSKKVQLI2Arabidopsis thaliana, Arabidopsis thaliana
R472RGLFARRRMFL1Caenorhabditis elegans
R472KGLFARKRMLL1Drosophila melanogaster
R474LFARRRQLLLT3Homo sapiens, Mus musculus, Rattus norvegicus
R474ITSKKVQLILT2Arabidopsis thaliana, Arabidopsis thaliana
R474LFARRRMFLLT1Caenorhabditis elegans
R474LFARKRMLLLT1Drosophila melanogaster
R521VHTPNRTYYLM3Homo sapiens, Mus musculus, Rattus norvegicus
R521ICTPKKVLSFE2Arabidopsis thaliana, Arabidopsis thaliana
R521IHTPNRVYYLF1Caenorhabditis elegans
R521VHTPNRTYYLD1Drosophila melanogaster
S135ERDVMSRLD--3Homo sapiens, Mus musculus, Rattus norvegicus
S135ERIVLDQLE--2Arabidopsis thaliana, Arabidopsis thaliana
S135EKNILTYLSQE1Caenorhabditis elegans
S135EREVMHQMT--1Drosophila melanogaster
S160LYFGLSYAKNG3Homo sapiens, Mus musculus, Rattus norvegicus
S160LYMALESCEGG2Arabidopsis thaliana, Arabidopsis thaliana
S160IYFVIGLVENG1Caenorhabditis elegans
S160LYFVMTYARKG1Drosophila melanogaster
S92ILGEGSFSTVV3Homo sapiens, Mus musculus, Rattus norvegicus
S92IYGVGSYSKVV2Arabidopsis thaliana, Arabidopsis thaliana
S92SMGEGAYSQVF1Caenorhabditis elegans
S92YIGEGSYSIVY1Drosophila melanogaster
S94GEGSFSTVVLA3Homo sapiens, Mus musculus, Rattus norvegicus
S94GVGSYSKVVRA2Arabidopsis thaliana, Arabidopsis thaliana
S94GEGAYSQVFRC1Caenorhabditis elegans
S94GEGSYSIVYLA1Drosophila melanogaster
T128KVPYVTRERDV3Homo sapiens, Mus musculus, Rattus norvegicus
T128KTAYVKLERIV2Arabidopsis thaliana, Arabidopsis thaliana
T128KMDAIIREKNI1Caenorhabditis elegans
T128KQDYIKREREV1Drosophila melanogaster
T148VKLYFTFQDDE3Homo sapiens, Mus musculus, Rattus norvegicus
T148TQLYTHFHDQA1Caenorhabditis elegans
T148IKLYFTFQDTS1Arabidopsis thaliana
T148VKLFFTFQDTQ1Arabidopsis thaliana
T148VNLSCTFQDQR1Drosophila melanogaster
T222MHIQITDFGTA3Homo sapiens, Mus musculus, Rattus norvegicus
T222GHIKIADFGSV2Arabidopsis thaliana, Arabidopsis thaliana
T222GHILITDFGSA1Caenorhabditis elegans
T222MHTLIADFGSA1Drosophila melanogaster
T226ITDFGTAKVL-3Homo sapiens, Mus musculus, Rattus norvegicus
T226IADFGSVKPMQ2Arabidopsis thaliana, Arabidopsis thaliana
T226ITDFGSAQAFG1Caenorhabditis elegans
T226IADFGSAKVMT1Drosophila melanogaster
T95EGSFSTVVLAR3Homo sapiens, Mus musculus, Rattus norvegicus
T95VGSYSKVVRAK2Arabidopsis thaliana, Arabidopsis thaliana
T95EGAYSQVFRCR1Caenorhabditis elegans
T95EGSYSIVYLAV1Drosophila melanogaster
V124IKENKVPYVTR3Homo sapiens, Mus musculus, Rattus norvegicus
V124TKENKTAYVKL2Arabidopsis thaliana, Arabidopsis thaliana
V124NRHQKMDAIIR1Caenorhabditis elegans
V124LRERKQDYIKR1Drosophila melanogaster
V127NKVPYVTRERD3Homo sapiens, Mus musculus, Rattus norvegicus
V127NKTAYVKLERI2Arabidopsis thaliana, Arabidopsis thaliana
V127QKMDAIIREKN1Caenorhabditis elegans
V127RKQDYIKRERE1Drosophila melanogaster
V143H-PFFVKLYFT3Homo sapiens, Mus musculus, Rattus norvegicus
V143H-PFVTQLYTH1Caenorhabditis elegans
V143H-PGIIKLYFT1Arabidopsis thaliana
V143H-PGIVKLFFT1Arabidopsis thaliana
V143NVPGFVNLSCT1Drosophila melanogaster
V96GSFSTVVLARE3Homo sapiens, Mus musculus, Rattus norvegicus
V96GSYSKVVRAKK2Arabidopsis thaliana, Arabidopsis thaliana
V96GAYSQVFRCRE1Caenorhabditis elegans
V96GSYSIVYLAVD1Drosophila melanogaster
Y126ENKVPYVTRER3Homo sapiens, Mus musculus, Rattus norvegicus
Y126ENKTAYVKLER2Arabidopsis thaliana, Arabidopsis thaliana
Y126HQKMDAIIREK1Caenorhabditis elegans
Y126ERKQDYIKRER1Drosophila melanogaster
Y146FFVKLYFTFQD3Homo sapiens, Mus musculus, Rattus norvegicus
Y146FVTQLYTHFHD1Caenorhabditis elegans
Y146GIIKLYFTFQD1Arabidopsis thaliana
Y146GIVKLFFTFQD1Arabidopsis thaliana
Y146GFVNLSCTFQD1Drosophila melanogaster
Y156DDEKLYFGLSY3Homo sapiens, Mus musculus, Rattus norvegicus
Y156DQARIYFVIGL1Caenorhabditis elegans
Y156DTSSLYMALES1Arabidopsis thaliana
Y156DTQSLYMALES1Arabidopsis thaliana
Y156DQRSLYFVMTY1Drosophila melanogaster
Y161YFGLSYAKNGE3Homo sapiens, Mus musculus, Rattus norvegicus
Y161YMALESCEGGE2Arabidopsis thaliana, Arabidopsis thaliana
Y161YFVIGLVENGD1Caenorhabditis elegans
Y161YFVMTYARKGD1Drosophila melanogaster
Y170GELLKYIRKIG3Homo sapiens, Mus musculus, Rattus norvegicus
Y170GELFDQITRKG2Arabidopsis thaliana, Arabidopsis thaliana
Y170GDLGESLCHFG1Caenorhabditis elegans
Y170GDMLPYINRVG1Drosophila melanogaster
Y486GPHLYYVDPVN3Homo sapiens, Mus musculus, Rattus norvegicus
Y486GPHLLYIDVPN1Caenorhabditis elegans
Y486KPKLIYVDPSK1Arabidopsis thaliana
Y486KPRLIYVDPSK1Arabidopsis thaliana
Y486GPRLIYIDPVQ1Drosophila melanogaster


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