mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RASGRP1
Gene summary
Basic gene Info.Gene symbolRASGRP1
Gene nameRAS guanyl releasing protein 1 (calcium and DAG-regulated)
CytomapUCSC genome browser: 15q14
Type of geneprotein-coding
DescriptionRAS guanyl nucleotide-releasing protein 1RAS guanyl-releasing protein 1calcium and DAG-regulated guanine nucleotide exchange factor IIguanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1Aras activator RasGRP
Modification date20141207
dbXrefs MIM : 603962
Ensembl : ENSG00000172575
HPRD : 04909
Vega : OTTHUMG00000172379
ProteinUniProt: O95267
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RASGRP1
BioGPS: 10125
PathwayNCI Pathway Interaction Database: RASGRP1
Pathway Commons: RASGRP1
ContextiHOP: RASGRP1
ligand binding site mutation search in PubMed: RASGRP1
UCL Cancer Institute: RASGRP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for RASGRP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RASGRP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RASGRP1 from PDB

Differential gene expression and gene-gene network for RASGRP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RASGRP1 and the right PPI network was created from samples without mutations in the LBS of RASGRP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RASGRP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0023467Leukemia, Myeloid, Acute3Biomarker
umls:C0003873Arthritis, Rheumatoid1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RASGRP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RASGRP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)4l9mAH542 C572 C575

Conservation information for LBS of RASGRP1
Multiple alignments for O95267 in multiple species
LBSAA sequence# speciesSpecies
C555LKPTFCDNCAG3Homo sapiens, Mus musculus, Rattus norvegicus
C558TFCDNCAGFLW3Homo sapiens, Mus musculus, Rattus norvegicus
C572KQGYRCKDCGM3Homo sapiens, Mus musculus, Rattus norvegicus
C575YRCKDCGMNCH3Homo sapiens, Mus musculus, Rattus norvegicus
C583NCHKQCKDLVV3Homo sapiens, Mus musculus, Rattus norvegicus
C591LVVFECKKRAK1Homo sapiens
C591LVVFECKKRIK1Mus musculus
C591LVVFECKKRSK1Rattus norvegicus
H542GLGFPHNFQET3Homo sapiens, Mus musculus, Rattus norvegicus
H580CGMNCHKQCKD3Homo sapiens, Mus musculus, Rattus norvegicus

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