mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for CDK2

Gene summary

Basic gene Info.	Gene symbol	CDK2
	Gene name	cyclin-dependent kinase 2
	Synonyms	CDKN2\|p33(CDK2)
	Cytomap	UCSC genome browser: 12q13
	Type of gene	protein-coding
	RefGenes	NM_001290230.1, NM_001798.4,NM_052827.3,
	Description	cdc2-related protein kinasecell division protein kinase 2p33 protein kinase
	Modification date	20141222
dbXrefs	MIM : 116953
	HGNC : HGNC
	Ensembl : ENSG00000123374
	HPRD : 00310
	Vega : OTTHUMG00000170575
Protein	UniProt: P24941 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_CDK2
	BioGPS: 1017
Pathway	NCI Pathway Interaction Database: CDK2
	KEGG: CDK2
	REACTOME: CDK2
	Pathway Commons: CDK2
Context	iHOP: CDK2
	ligand binding site mutation search in PubMed: CDK2
	UCL Cancer Institute: CDK2
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0008284	positive regulation of cell proliferation	10767298
GO:0016572	histone phosphorylation	8692841
GO:0060968	regulation of gene silencing	20935635

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Ligand binding site mutations for CDK2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
P45	P45L	COAD	2
V69	D68N	BLCA	1
H84	H84Y	COAD	1
V123	R122G	COAD	1
K20	K20E	KIRC	1
V123	R122L	LUAD	1
L219	R217L	LUAD	1
R274	R274L	LUAD	1
P241	P241H	LUSC	1
L219	R217L	OV	1
L124	L124P	STAD	1
G205	P204T	UCEC	1
G13	G13D	UCEC	1
K34	K34T	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for CDK2 from My Cancer Genome.

Cyclin-dependent kinase 2 (CDK2) is a gene that encodes a member of the serine/threonine protein kinase family that functions in cell cycle regulation. Specifically, the protein is important for the progression from G1 to S phase. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer. Related Pathways: Cell cycle control. Modified: December 4, 2015

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Protein structure related information for CDK2

Protein structure of wild type (WT) and mutant type (MT) of CDK2

Wild type CDK2

Mutant type CDK2

Free energy of binding of drugs to wild type and mutant tpye of CDK2

Gene symbol	Drug name	Free energy of binding (kcal/mol) of wild type	Free energy of binding (kcal/mol) of mutant type
CDK2	Bosutinib	-8.1	-7.7

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
P45	P45L	0.42063928
L219	R217L	0.045033943
L124	L124P	-1.3707479
P241	P241H	-1.2499399
V69	D68N	-0.89427726
V123	R122G	-0.8860457
G205	P204T	-0.76476636
R274	R274L	-0.38491845
K20	K20E	-0.37788285
K34	K34T	-0.30952609
G13	G13D	-0.17198355
V123	R122L	-0.10642538
H84	H84Y	-0.020208186

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CDK2 from PDB

PDB ID	PDB title	PDB structure
1B38	HUMAN CYCLIN-DEPENDENT KINASE 2

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Differential gene expression and gene-gene network for CDK2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of CDK2 and the right PPI network was created from samples without mutations in the LBS of CDK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for CDK2

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0025202	Melanoma	40	AlteredExpression, Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for CDK2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Experimental	DB01769	Double Oxidized Cysteine	Small molecule
Experimental	DB01888	4-[5-(Trans-4-Aminocyclohexylamino)-3-Isopropylpyrazolo[1,5-a]Pyrimidin-7-Ylamino]-N,N-Dimethylbenzenesulfonamide	Small molecule
Experimental	DB02010	Staurosporine	Small molecule
Experimental	DB02052	Indirubin-3'-Monoxime	Small molecule
Experimental	DB02091	4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine	Small molecule
Experimental	DB02116	Olomoucine	Small molecule
Experimental	DB02197	4-[(4-Imidazo[1,2-a]Pyridin-3-Ylpyrimidin-2-Yl)Amino]Benzenesulfonamide	Small molecule
Experimental	DB02297	2-Amino-6-Chloropyrazine	Small molecule
Experimental	DB02407	6-O-Cyclohexylmethyl Guanine	Small molecule
Experimental	DB02538	N-[4-(2-Methylimidazo[1,2-a]Pyridin-3-Yl)-2-Pyrimidinyl]Acetamide	Small molecule
Experimental	DB02603	1-Amino-6-Cyclohex-3-Enylmethyloxypurine	Small molecule
Experimental	DB02647	N-(5-Cyclopropyl-1h-Pyrazol-3-Yl)Benzamide	Small molecule
Experimental	DB02733	Purvalanol	Small molecule
Experimental	DB02833	[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine	Small molecule
Experimental	DB02898	5-{[(2-Amino-9h-Purin-6-Yl)Oxy]Methyl}-2-Pyrrolidinone	Small molecule
Experimental	DB02915	4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(4-Trifluoromethyl-Phenyl)-Amine	Small molecule
Experimental	DB02950	Hymenialdisine	Small molecule
Experimental	DB02963	(5-Chloropyrazolo[1,5-a]Pyrimidin-7-Yl)-(4-Methanesulfonylphenyl)Amine	Small molecule
Experimental	DB02973	4-(5-Bromo-2-Oxo-2h-Indol-3-Ylazo)-Benzenesulfonamide	Small molecule
Experimental	DB03019	4-(2,5-Dichloro-Thiophen-3-Yl)-Pyrimidin-2-Ylamine	Small molecule
Experimental	DB03307	4-[(6-Amino-4-Pyrimidinyl)Amino]Benzenesulfonamide	Small molecule
Experimental	DB03365	4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline	Small molecule
Experimental	DB03428	SU9516	Small molecule
Experimental	DB03490	3-Pyridin-4-Yl-2,4-Dihydro-Indeno[1,2-.C.]Pyrazole	Small molecule
Experimental\|investigational	DB03496	Flavopiridol	Small molecule
Experimental	DB03583	(2e,3s)-3-Hydroxy-5'-[(4-Hydroxypiperidin-1-Yl)Sulfonyl]-3-Methyl-1,3-Dihydro-2,3'-Biindol-2'(1'h)-One	Small molecule
Experimental	DB03663	1-[(2-Amino-6,9-Dihydro-1h-Purin-6-Yl)Oxy]-3-Methyl-2-Butanol	Small molecule
Experimental	DB03737	4-((3r,4s,5r)-4-Amino-3,5-Dihydroxy-Hex-1-Ynyl)-5-Fluoro-3-[1-(3-Methoxy-1h-Pyrrol-2-Yl)-Meth-(Z)-Ylidene]-1,3-Dihydro-Indol-2-One	Small molecule
Experimental	DB03801	Lysine Nz-Carboxylic Acid	Small molecule
Experimental	DB04006	[2-Amino-6-(2,6-Difluoro-Benzoyl)-Imidazo[1,2-a]Pyridin-3-Yl]-Phenyl-Methanone	Small molecule
Experimental	DB04101	N-[4-(2,4-Dimethyl-1,3-Thiazol-5-Yl)Pyrimidin-2-Yl]-N'-Hydroxyimidoformamide	Small molecule
Experimental	DB04186	N'-(Pyrrolidino[2,1-B]Isoindolin-4-On-8-Yl)-N-(Pyridin-2-Yl)Urea	Small molecule
Experimental	DB04288	2-[Trans-(4-Aminocyclohexyl)Amino]-6-(Benzyl-Amino)-9-Cyclopentylpurine	Small molecule
Experimental	DB04407	4-[4-(4-Methyl-2-Methylamino-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol	Small molecule
Experimental	DB04518	3-[4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamino]-Phenol	Small molecule
Experimental	DB04607	PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE	Small molecule
Experimental	DB04662	OLOMOUCINE II	Small molecule
Experimental	DB04669	TRIAZOLOPYRIMIDINE	Small molecule
Investigational	DB05037	AT7519	Small molecule
Approved	DB06616	Bosutinib	Small molecule
Experimental	DB06844	4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE	Small molecule
Experimental	DB06888	(13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE	Small molecule
Experimental	DB06944	N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide	Small molecule
Experimental	DB06948	2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE	Small molecule
Experimental	DB06976	1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA	Small molecule
Experimental	DB06983	(5-phenyl-7-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl)methanol	Small molecule
Experimental	DB07024	2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE	Small molecule
Experimental	DB07054	(2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL	Small molecule
Experimental	DB07065	5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)-3-thiocyanatopyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB07126	O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE	Small molecule
Experimental	DB07137	(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE	Small molecule
Experimental	DB07163	5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE	Small molecule
Experimental	DB07164	N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine	Small molecule
Experimental	DB07179	3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide	Small molecule
Experimental	DB07203	6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE	Small molecule
Experimental	DB07210	3-bromo-5-phenyl-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB07220	N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE	Small molecule
Experimental	DB07431	(3R)-3-(aminomethyl)-9-methoxy-1,2,3,4-tetrahydro-5H-[1]benzothieno[3,2-e][1,4]diazepin-5-one	Small molecule
Experimental	DB07471	5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE	Small molecule
Experimental	DB07493	(2Z)-5'-BROMO-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE AMMONIATE	Small molecule
Experimental	DB07501	(2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07504	(2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07529	2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE	Small molecule
Experimental	DB07531	4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE	Small molecule
Experimental	DB07533	4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE	Small molecule
Experimental	DB07534	4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE	Small molecule
Experimental	DB07538	4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE	Small molecule
Experimental	DB07539	4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID	Small molecule
Experimental	DB07540	4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE	Small molecule
Experimental	DB07562	N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE	Small molecule
Experimental	DB07595	(5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDROPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	Small molecule
Experimental	DB07606	6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE	Small molecule
Experimental	DB07612	6-(3-AMINOPHENYL)-N-(TERT-BUTYL)-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE	Small molecule
Experimental	DB07618	2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE	Small molecule
Experimental	DB07622	1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA	Small molecule
Experimental	DB07685	4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	Small molecule
Experimental	DB07686	4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	Small molecule
Experimental	DB07687	4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE	Small molecule
Experimental	DB07688	4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	Small molecule
Experimental	DB07731	4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL	Small molecule
Experimental	DB07750	(2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07751	(2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07755	(2S)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07761	(2R)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	Small molecule
Experimental	DB07790	N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE	Small molecule
Experimental	DB07791	4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE	Small molecule
Experimental	DB07852	1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID	Small molecule
Experimental	DB07889	1-(DIMETHYLAMINO)-3-(4-{{4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL	Small molecule
Experimental	DB07936	N-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-5-fluoro-4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-amine	Small molecule
Experimental	DB07982	2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol	Small molecule
Experimental	DB08066	N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE	Small molecule
Experimental	DB08094	(4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE	Small molecule
Experimental	DB08122	N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE	Small molecule
Experimental	DB08123	N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE	Small molecule
Experimental	DB08124	3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE	Small molecule
Experimental	DB08125	4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE	Small molecule
Experimental	DB08126	3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	Small molecule
Experimental	DB08132	5-hydroxynaphthalene-1-sulfonamide	Small molecule
Experimental	DB08133	N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide	Small molecule
Experimental	DB08134	4-[(6-chloropyrazin-2-yl)amino]benzenesulfonamide	Small molecule
Experimental	DB08135	N-phenyl-1H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08136	4-(acetylamino)-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08137	(4E)-N-(4-fluorophenyl)-4-[(phenylcarbonyl)imino]-4H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08138	{[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08139	5-chloro-7-[(1-methylethyl)amino]pyrazolo[1,5-a]pyrimidine-3-carbonitrile	Small molecule
Experimental	DB08140	5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE	Small molecule
Experimental	DB08141	4-{[(2,6-difluorophenyl)carbonyl]amino}-N-[(3S)-piperidin-3-yl]-1H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08142	4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide	Small molecule
Experimental	DB08178	4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Small molecule
Experimental	DB08182	4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine	Small molecule
Experimental	DB08218	HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM	Small molecule
Experimental	DB08219	4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE	Small molecule
Experimental	DB08233	6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE	Small molecule
Experimental	DB08241	4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE	Small molecule
Experimental	DB08247	6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE	Small molecule
Experimental	DB08248	3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE	Small molecule
Experimental	DB08285	(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol	Small molecule
Experimental	DB08309	3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL	Small molecule
Experimental	DB08312	6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE	Small molecule
Experimental	DB08355	1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid	Small molecule
Experimental	DB08441	6-BROMO-13-THIA-2,4,8,12,19-PENTAAZATRICYCLO[12.3.1.1~3,7~]NONADECA-1(18),3(19),4,6,14,16-HEXAENE 13,13-DIOXIDE	Small molecule
Experimental	DB08463	(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol	Small molecule
Experimental	DB08527	1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE	Small molecule
Experimental	DB08531	5-(2,3-dichlorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB08532	6-(2-fluorophenyl)-N-(pyridin-3-ylmethyl)imidazo[1,2-a]pyrazin-8-amine	Small molecule
Experimental	DB08533	3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine	Small molecule
Experimental	DB08534	5-(2-fluorophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB08535	3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB08536	3-bromo-5-phenyl-N-(pyrimidin-5-ylmethyl)pyrazolo[1,5-a]pyridin-7-amine	Small molecule
Experimental	DB08537	3-bromo-6-phenyl-N-(pyrimidin-5-ylmethyl)imidazo[1,2-a]pyridin-8-amine	Small molecule
Experimental	DB08538	N-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB08539	3-cyclopropyl-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine	Small molecule
Experimental	DB08572	4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE	Small molecule
Experimental	DB08673	4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE	Small molecule
Experimental	DB08677	N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE	Small molecule
Experimental	DB08694	9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol	Small molecule
Experimental	DB08768	N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CDK2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
ATP		ATP	1b38	A	G13
ATP		ATP	1b39	A	G13
CMG		2-AMINO-6-CYCLOHEXYLMETHOXYPURINE	1e1v	A	G13
ATP		ATP	1fin	A	G13
ATP		ATP	1fin	C	G13
ATP		ATP	1fq1	B	G13
ATP		ATP	1gy3	A	G13
ATP		ATP	1gy3	C	G13
MBP		2-AMINO-6-(3'-METHYL-2'-OXO)BUTOXYPURINE	1gz8	A	G13
CMG		2-AMINO-6-CYCLOHEXYLMETHOXYPURINE	1h1p	A	G13
CMG		2-AMINO-6-CYCLOHEXYLMETHOXYPURINE	1h1p	C	G13
ATP		ATP	1hck	A	G13
ATP		ATP	1jst	A	G13
ATP		ATP	1jst	C	G13
ATP		ATP	1qmz	A	G13
ATP		ATP	1qmz	C	G13
3FP		1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL	1v1k	A	G13
D31		2-(4-(AMINOMETHYL)PIPERIDIN-1-YL)-N-(3_CYCLOHEXYL-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)ACETAMIDE	2b55	A	G13
CK2		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE	2c5o	A	G13
CK2		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-AMINE	2c5o	C	G13
ATP		ATP	2cci	A	G13
ATP		ATP	2cci	C	G13
ATP		ATP	2cjm	A	G13
ATP		ATP	2cjm	C	G13
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	2iw8	A	G13
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	2iw8	C	G13
PO5		(2S)-1-(DIMETHYLAMINO)-3-(4-{[4-(6-MORPHOLIN-4-YLPYRAZOLO[1,5-B]PYRIDAZIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL	3eid	A	G13
B98		(3R)-3-(AMINOMETHYL)-9-METHOXY-1,2,3,4-TETRAHYDRO-5H-[1]BENZOTHIENO[3,2-E][1,4]DIAZEPIN-5-ONE	3fz1	A	G13
NS9		(2S,3S)-3-{[7-(BENZYLAMINO)-3-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-5-YL]AMINO}BUTANE-1,2,4-TRIOL	3ns9	A	G13
2AN		8-ANILINO-1-NAPHTHALENE SULFONATE	3pxq	A	G13
III		Peptide ligand (PRO,LYS,THR,PRO,LYS,LYS,ALA,LYS,LYS,LEU)	3qhr	A	G13
ADP		ADP	3qhr	A	G13
MGF		TRIFLUOROMAGNESATE(1-)	3qhr	A	G13
ADP		ADP	3qhr	C	G13
MGF		TRIFLUOROMAGNESATE(1-)	3qhr	C	G13
ADP		ADP	3qhw	A	G13
MGF		TRIFLUOROMAGNESATE(1-)	3qhw	A	G13
ADP		ADP	3qhw	C	G13
MGF		TRIFLUOROMAGNESATE(1-)	3qhw	C	G13
Z31		[4-AMINO-2-(PROP-2-EN-1-YLAMINO)-1,3-THIAZOL-5- YL](NAPHTHALEN-2-YL)METHANONE	3r8u	A	G13
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eoi	A	G13
ATP		ATP	4eoj	A	G13
ATP		ATP	4eoj	C	G13
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eol	A	G13
ATP		ATP	4eom	A	G13
ATP		ATP	4eom	C	G13
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eon	A	G13
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eon	C	G13
ATP		ATP	4eoo	A	G13
ATP		ATP	4eoo	C	G13
ATP		ATP	4eoq	A	G13
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eos	A	G13
ESJ		(4S)-2-(6-HYDROXY-1,3-BENZOTHIAZOL-2-YL)-4,5- DIHYDRO-1,3-THIAZOLE-4-CARBOXYLIC ACID	4d1x	A	G13
STU		STAUROSPORINE	1aq1	A	G13 H84
HMD		HYMENIALDISINE	1dm2	A	G13 H84
I17		2-N-(4-AMINOCYCLOHEXYL)-6-N-BENZYL-9-CYCLOPENTYLPURINE-2,6-DIAMINE	1g5s	A	G13 H84
6CP		6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO)PURINE	1h1r	C	G13 H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	1h1s	A	G13 H84
LS3		3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE	1ke7	A	G13 H84
ST8		4-[[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO]BENZAMIDE	1ogu	A	G13 H84
ST8		4-[[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO]BENZAMIDE	1ogu	C	G13 H84
HDY		1-(DIMETHYLAMINO)-3-(4-{{4-(2-METHYLIMIDAZO[1,2-A]PYRIDIN-3-YL)PYRIMIDIN-2-YL]AMINO}PHENOXY)PROPAN-2-OL	1oir	A	G13 H84
N76		3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE	1oiu	A	G13 H84
N76		3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE	1oiu	C	G13 H84
D42		1-(3-(2,4-DIMETHYLTHIAZOL-5-YL)-4-OXO-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-5-YL)-3-(4-METHYLPIPERAZIN-1-YL)UREA	2b52	A	G13 H84
D23		6-(3-AMINOPHENYL)-N-TERT-BUTYL-2-(TRIFLUOROMETHYL)QUINAZOLIN-4-AMINE	2b53	A	G13 H84
D05		DIN-232305	2b54	A	G13 H84
MTW		HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM	2c5x	A	G13 H84
MTW		HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM	2c5y	A	G13 H84
CT6		TRIAZOLOPYRIMIDINE	2c68	A	G13 H84
CT8		TRIAZOLOPYRIMIDINE	2c69	A	G13 H84
DT1		4-{[5-(CYCLOHEXYLMETHOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	2c6i	A	G13 H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	2c6o	A	G13 H84
DT5		4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	2c6t	A	G13 H84
DT5		4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	2c6t	C	G13 H84
1CD		5H,10H-17,19-(IMINOMETHANO)-4,6:9,12-DIMETHANODIBENZ[B,F][1,4,8,9,12]OXATETRAAZACYCLOPENTADECINE-20,23-DIONE,7,8,11,12-TETRAHYDRO-10-METHYL-,(10R,12S)	2ds1	A	G13 H84
NU5		3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL	2g9x	A	G13 H84
NU5		3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL	2g9x	C	G13 H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	2iw9	A	G13 H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	2iw9	C	G13 H84
SC8		5-(2,3-DICHLOROPHENYL)-N-(PYRIDIN-4-YLMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3f	A	G13 H84
SC9		6-(2-FLUOROPHENYL)-N-(PYRIDIN-3-YLMETHYL)IMIDAZO[1,2-A]PYRAZIN-8-AMINE	2r3g	A	G13 H84
5SC		3-((3-BROMO-5-O-TOLYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YLAMINO)METHYL)PYRIDINE 1-OXIDE	2r3q	A	G13 H84
740		N-[5-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-1H-INDAZOL-3-YL]-2-(4-PIPERIDIN-1-YLPHENYL)ACETAMIDE	2r64	A	G13 H84
MTZ		4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE	2uue	C	G13 H84
C95		2-IMINO-THIAZOLIDIN-4-ONE ANALOG	2uze	A	G13 H84
C95		2-IMINO-THIAZOLIDIN-4-ONE ANALOG	2uze	C	G13 H84
C94		4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE	2uzl	C	G13 H84
LZ8		N-(4-FLUOROPHENYL)-4-[(PHENYLCARBONYL)AMINO]-1H-PYRAZOLE-3-CARBOXAMIDE	2vto	A	G13 H84
LZC		5-[(4-AMINOCYCLOHEXYL)AMINO]-7-(PROPAN-2-YLAMINO)PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE	2vts	A	G13 H84
CK7		CDK2/9 INHIBITOR	2wev	A	G13 H84
X1N		2-METHYL-N-[(1Z)-3-NITROCYCLOHEXA-2,4-DIEN-1-YLIDENE]-4DIHYDRO[1,3]THIAZOLO[4,5-H]QUINAZOLIN-8-AMINE	2x1n	A	G13 H84
X1N		2-METHYL-N-[(1Z)-3-NITROCYCLOHEXA-2,4-DIEN-1-YLIDENE]-4DIHYDRO[1,3]THIAZOLO[4,5-H]QUINAZOLIN-8-AMINE	2x1n	C	G13 H84
RC8		(2R)-2-({9-(1-METHYLETHYL)-6-[(4-PYRIDIN-2-YLBENZYL)AMINO]-9H-PURIN-2-YL}AMINO)BUTAN-1-OL	3ddp	C	G13 H84
NNN		(2R)-2-{[4-(BENZYLAMINO)-8-(1-METHYLETHYL)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YL]AMINO}BUTAN-1-OL	3dog	A	G13 H84
NNN		(2R)-2-{[4-(BENZYLAMINO)-8-(1-METHYLETHYL)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YL]AMINO}BUTAN-1-OL	3dog	C	G13 H84
2BZ		5-(2-CHLOROPHENYL)-3-METHYL-7-NITROPYRAZOLO[3,4-B][1,4]BENZODIAZEPINE	3le6	A	G13 H84
A28		N-(6,7-DIFLUORO-5-PHENYL-1H-INDAZOL-3-YL)BUTANAMIDE	3lfq	A	G13 H84
X44		4-{[4-AMINO-5-(4-SULFAMOYLBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3qtu	A	G13 H84
X43		4-{[4-AMINO-5-(3-NITROBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3qtx	A	G13 H84
X42		4-{[4-AMINO-5-(3-FLUOROBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3qtz	A	G13 H84
Z68		[4-AMINO-2-(CYCLOHEXYLAMINO)-1,3-THIAZOL-5-YL](3- NITROPHENYL)METHANONE	3r9n	A	G13 H84
Z71		4-AMINO-N-(3,5-DIFLUOROPHENYL)-2-[(4-SULFAMOYLPHENYL) AMINO]-1,3-THIAZOLE-5-CARBOXAMIDE	3r9o	A	G13 H84
O1Z		[4-AMINO-2-(CYCLOHEXYLAMINO)-1,3-THIAZOL-5- YL](NAPHTHALEN-2-YL)METHANONE	3rah	A	G13 H84
04Z		4-{[4-AMINO-5-(3-METHOXYBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3ral	A	G13 H84
06Z		{4-AMINO-2-[(3-FLUOROPHENYL)AMINO]-1,3-THIAZOL-5- YL}(PHENYL)METHANONE	3rjc	A	G13 H84
25Z		[4-AMINO-2-(PHENYLAMINO)-1,3-THIAZOL-5-YL][3- (TRIFLUOROMETHYL)PHENYL]METHANONE	3rpr	A	G13 H84
T6Q		2-[[3-(4-ETHANOYL-1,4-DIAZEPAN-1-YL)PHENYL] AMINO]-4-[4-METHYL-2-(METHYLAMINO)-1,3-THIAZOL- 5-YL]PYRIMIDINE-5-CARBONITRILE	4bco	C	G13 H84
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eoi	C	G13 H84
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eop	A	G13 H84
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eop	C	G13 H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	4eor	C	G13 H84
1RO		(5E)-5-(QUINOLIN-6-YLMETHYLIDENE)-2-[(THIOPHEN-2- YLMETHYL)AMINO]-1,3-THIAZOL-4(5H)-ONE	4eos	C	G13 H84
STU		STAUROSPORINE	4erw	A	G13 H84
STU		STAUROSPORINE	4ez7	A	G13 H84
T3C		2-[[3-(1,4-DIAZEPAN-1-YL)PHENYL]AMINO]-4-[4- METHYL-2-(METHYLAMINO)-1,3-THIAZOL-5-YL] PYRIMIDINE-5-CARBONITRILE	4bcp	A	G13 H84
61K		(3Z)-N-[2-(1H-IMIDAZOL-4-YL)ETHYL]-2-OXO-3-[2-(4- SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2,3-DIHYDRO-1H- INDOLE-5-CARBOXAMIDE	4fkv	A	G13 H84
1YG		(2S)-N-(5-{[(5-TERT-BUTYL-1,3-OXAZOL-2-YL) METHYL]SULFANYL}-1,3-THIAZOL-2-YL)-2-PHENYLPROPANAMIDE	4lyn	A	G13 H84
PDY		{5-[((3S)(3-PIPERIDYL))AMINO]-6-METHYL(PYRAZOLO[1,5-A]PYRIMIDIN-7-YL)}(4-ETHOXYPHENYL)AMINE	3wbl	A	G13 H84
JYM		6-(CYCLOHEXYLMETHOXY)-8-(TRIFLUOROMETHYL)-9H- PURIN-2-AMINE	4cfn	C	G13 H84
4QE		6-(CYCLOHEXYLMETHOXY)-8-(2-METHYLPHENYL)-9H- PURIN-2-AMINE	4cfm	A	G13 H84
55S		6-(CYCLOHEXYLMETHOXY)-N-[4-(ETHYLSULFONYL)PHENYL]-9H- PURIN-2-AMINE	5cyi	C	G13 H84
T6Q		2-[[3-(4-ETHANOYL-1,4-DIAZEPAN-1-YL)PHENYL] AMINO]-4-[4-METHYL-2-(METHYLAMINO)-1,3-THIAZOL- 5-YL]PYRIMIDINE-5-CARBONITRILE	4bco	A	G13 K20 H84
PTR		O(4)-PHOSPHO-L-TYROSINE	2cjm	C	G13 K34 P45
PTR		O(4)-PHOSPHO-L-TYROSINE	2cjm	A	G13 P45
III		Peptide ligand (HIS,HIS,ALA,SER,PRO,ARG,LYS)	1gy3	C	G205
III		Peptide ligand (HIS,HIS,ALA,SER,PRO,ARG,LYS)	1qmz	A	G205
III		Peptide ligand (HIS,HIS,ALA,SER,PRO,ARG,LYS)	1qmz	C	G205
PVB		PURVALANOL B	1ckp	A	H84
DTQ		3-[(6,7-DIMETHOXYQUINAZOLIN-4-YL)AMINO]PHENOL	1di8	A	H84
INR		INDIRUBIN-5-SULFONATE	1e9h	A	H84
INR		INDIRUBIN-5-SULFONATE	1e9h	C	H84
106		4-(5-BROMO-2-OXO-2H-INDOL-3-YLAZO)-BENZENESULFONAMIDE	1fvt	A	H84
107		4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE	1fvv	A	H84
107		4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE	1fvv	C	H84
1PU		N'-(PYRROLIDINO[2,1-B]ISOINDOLIN-4-ON-8-YL)-N-(PYRIDIN-2-YL)UREA	1gih	A	H84
FAL		(2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	1h01	A	H84
FBL		(2S)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL	1h01	A	H84
MFP		((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE	1h07	A	H84
MFQ		((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2S)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE	1h07	A	H84
2A6		2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE	1h1q	A	H84
2A6		2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE	1h1q	C	H84
6CP		6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO)PURINE	1h1r	A	H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	1h1s	C	H84
U55		4-[(6-AMINOPYRIMIDIN-4-YL)AMINO]BENZENESULFONAMIDE	1jsv	A	H84
LIG		3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE	1jvp	P	H84
LS1		N-METHYL-4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE	1ke5	A	H84
LS2		N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE	1ke6	A	H84
LS4		4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE	1ke8	A	H84
LS5		3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	1ke9	A	H84
N20		6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE	1oi9	A	H84
N20		6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE	1oi9	C	H84
HDT		4-[(4-IMIDAZO[1,2-A]PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]BENZENESULFONAMIDE	1oit	A	H84
N41		4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE	1oiy	A	H84
5BN		5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE	1p2a	A	H84
SU9		SU9516	1pf8	A	H84
UCN		7-HYDROXYSTAUROSPORINE	1pkd	A	H84
UCN		7-HYDROXYSTAUROSPORINE	1pkd	C	H84
CK3		N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-N'-HYDROXYIMIDOFORMAMIDE	1pxk	A	H84
CK4		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE	1pxl	A	H84
CK5		3-[[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]AMINO]PHENOL	1pxm	A	H84
CK6		4-[4-(4-METHYL-2-METHYLAMINOTHIAZOL-5-YL)PYRIMIDIN-2-YLAMINO]PHENOL	1pxn	A	H84
CK8		1-N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-4-N,4-N-DIMETHYLBENZENE-1,4-DIAMINE	1pxp	A	H84
I1P		IMIDAZO[1,2-B]PYRIDAZINE DERIV. 2E	1urw	A	H84
292		PNU-292137 INHIBITOR	1vyw	A	H84
292		PNU-292137 INHIBITOR	1vyw	C	H84
N5B		N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZAMIDE	1vyz	A	H84
N69		INHIBITOR OF CDK2	1w8c	A	H84
CT7		SULFONYLPHENYLAMINO ANALOGUE 8A	1y8y	A	H84
CT9		4-[[5-[(4-AMINOCYCLOHEXYL)AMINO]-3-PROPAN-2-YLPYRAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO]-N,N-DIMETHYLBENZENESULFONAMIDE	1y91	A	H84
628		PHENYLAMINOIMIDAZO(1,2-ALPHA)PYRIDINE	1ykr	A	H84
CK9		OLOMOUCINE II	2a0c	X	H84
RRC		ROSCOVITINE	2a4l	A	H84
BRY		(2Z)-5'-BROMO-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE AMMONIATE	2bhe	A	H84
RYU		(2E,3S)-3-HYDROXY-5'-[(4-HYDROXYPIPERIDIN-1-YL)SULFONYL]-3-METHYL-1,3-DIHYDRO-2,3'-BIINDOL-2'(1'H)-ONE	2bhh	A	H84
SBC		DIHYDRO-BENZODIPYRAZOLE DERIV. 7A	2bkz	A	H84
SBC		DIHYDRO-BENZODIPYRAZOLE DERIV. 7A	2bkz	C	H84
529		(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE	2bpm	A	H84
529		(2S)-N-[(3Z)-5-CYCLOPROPYL-3H-PYRAZOL-3-YLIDENE]-2-[4-(2-OXOIMIDAZOLIDIN-1-YL)PHENYL]PROPANAMIDE	2bpm	C	H84
U73		N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE	2btr	A	H84
U32		4-[(5-ISOPROPYL-1,3-THIAZOL-2-YL)AMINO]BENZENESULFONAMIDE	2bts	A	H84
514		(3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM	2c4g	A	H84
514		(3Z)-5-ACETYL-3-(BENZOYLIMINO)-3,6-DIHYDROPYRROLO[3,4-C]PYRAZOL-5-IUM	2c4g	C	H84
CK8		1-N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-4-N,4-N-DIMETHYLBENZENE-1,4-DIAMINE	2c5n	A	H84
CK8		1-N-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]-4-N,4-N-DIMETHYLBENZENE-1,4-DIAMINE	2c5n	C	H84
CK4		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE	2c5v	A	H84
CK4		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE	2c5v	C	H84
MTW		HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM	2c5x	C	H84
DT2		4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	2c6k	A	H84
DT4		4-({5-[(4-AMINOCYCLOHEXYL)AMINO][1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)BENZENESULFONAMIDE	2c6l	A	H84
DT5		4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE	2c6m	A	H84
371		2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE	2duv	A	H84
LIA		(4-AMINO-2-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}PYRIMIDIN-5-YL)(2,3-DIFLUORO-6-METHOXYPHENYL)METHANONE	2fvd	A	H84
BLZ		5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE	2i40	A	H84
BLZ		5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE	2i40	C	H84
QQ2		[(2-CHLORO-5-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO]ACETONITRILE	2iw6	A	H84
QQ2		[(2-CHLORO-5-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO]ACETONITRILE	2iw6	C	H84
PY8		1(5)-BROMO-4-THIA-2,5,9-TRIAZA-1(2,4)-PYRIMIDINA-3(1,3)-BENZENACYLCLANONAPHANE-4,4-DIOXIDE	2j9m	A	H84
SCE		3-METHYL-N-(PYRIDIN-4-YLMETHYL)IMIDAZO[1,2-A]PYRAZIN-8-AMINE	2r3h	A	H84
SCF		5-(2-FLUOROPHENYL)-N-(PYRIDIN-4-YLMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3i	A	H84
SCJ		3-BROMO-5-PHENYL-N-(PYRIDIN-3-YLMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3j	A	H84
SCQ		3-BROMO-5-PHENYL-N-(PYRIMIDIN-5-YLMETHYL)PYRAZOLO[1,5-A]PYRIDIN-7-AMINE	2r3k	A	H84
SCW		3-BROMO-6-PHENYL-N-(PYRIMIDIN-5-YLMETHYL)IMIDAZO[1,2-A]PYRIDIN-8-AMINE	2r3l	A	H84
SCX		N-((2-AMINOPYRIMIDIN-5-YL)METHYL)-5-(2,6-DIFLUOROPHENYL)-3-ETHYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3m	A	H84
SCZ		3-CYCLOPROPYL-5-PHENYL-N-(PYRIDIN-3-YLMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3n	A	H84
2SC		(5-PHENYL-7-(PYRIDIN-3-YLMETHYLAMINO)PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)METHANOL	2r3o	A	H84
3SC		5-(2,3-DICHLOROPHENYL)-N-(PYRIDIN-4-YLMETHYL)-3-THIOCYANATOPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3p	A	H84
6SC		3-BROMO-5-PHENYL-N-(PYRIDIN-4-YLMETHYL)PYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE	2r3r	A	H84
MTZ		4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE	2uue	A	H84
C75		4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE	2uzb	C	H84
C85		4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE	2uzd	A	H84
C85		4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE	2uzd	C	H84
C94		4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE	2uzl	A	H84
C96		4-{5-[(1Z)-1-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)ETHYL]-2-FURYL}BENZENESULFONAMIDE	2uzn	A	H84
C62		4-{5-[(Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE	2uzo	A	H84
LZ3		N-(4-SULFAMOYLPHENYL)-1H-INDAZOLE-3-CARBOXAMIDE	2vti	A	H84
LZ4		4-[(6-CHLOROPYRAZIN-2-YL)AMINO]BENZENESULFONAMIDE	2vtj	A	H84
LZ5		N-PHENYL-1H-PYRAZOLE-3-CARBOXAMIDE	2vtl	A	H84
LZ7		4-(ACETYLAMINO)-N-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE	2vtn	A	H84
LZ9		{[(2,6-DIFLUOROPHENYL)CARBONYL]AMINO}-N-(4-FLUOROPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE	2vtp	A	H84
LZA		{[(2,6-DIFLUOROPHENYL)CARBONYL]AMINO}-N-PIPERIDIN-4-YL-1H-PYRAZOLE-3-CARBOXAMIDE	2vtq	A	H84
LZB		5-CHLORO-7-[(1-METHYLETHYL)AMINO]PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE	2vtr	A	H84
LZD		4-{[(2,6-DIFLUOROPHENYL)CARBONYL]AMINO}-N-[(3S)-PIPERIDIN-3-YL]-1H-PYRAZOLE-3-CARBOXAMIDE	2vtt	A	H84
LZE		4-{[(2,6-DICHLOROPHENYL)CARBONYL]AMINO}-N-PIPERIDIN-4-YL-1H-PYRAZOLE-3-CARBOXAMIDE	2vu3	A	H84
IM9		2-{4-[4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)PHENYL]PIPERAZIN-1-YL}-2-OXOETHANOL	2vv9	A	H84
FRT		N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE	2w05	A	H84
FRV		4-{[4-(1-CYCLOPROPYL-2-METHYL-1H-IMIDAZOL-5-YL)PYRIMIDIN-2-YL]AMINO}-N-METHYLBENZENESULFONAMIDE	2w06	A	H84
I19		N-(4-{[(3S)-3-(DIMETHYLAMINO)PYRROLIDIN-1-YL]CARBONYL}PHENYL)-5-FLUORO-4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-AMINE	2w17	A	H84
L0F		N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE	2w1h	A	H84
CK7		CDK2/9 INHIBITOR	2wev	C	H84
P48		N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE	2wih	A	H84
P48		N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE	2wih	C	H84
P49		1-METHYL-8-(PHENYLAMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXYLIC ACID	2wip	A	H84
P49		1-METHYL-8-(PHENYLAMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXYLIC ACID	2wip	C	H84
889		N-{6,6-DIMETHYL-5-[(1-METHYLPIPERIDIN-4-YL)CARBONYL]-1,4,5,6-TETRAHYDROPYRROLO[3,4-C]PYRAZOL-3-YL}-3-METHYLBUTANAMIDE	2wpa	C	H84
WXV		N,1-DIMETHYL-8-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE	2wxv	A	H84
CDK		CDK INHIBITOR	2xmy	A	H84
RC8		(2R)-2-({9-(1-METHYLETHYL)-6-[(4-PYRIDIN-2-YLBENZYL)AMINO]-9H-PURIN-2-YL}AMINO)BUTAN-1-OL	3ddp	A	H84
RRC		ROSCOVITINE	3ddq	A	H84
RRC		ROSCOVITINE	3ddq	C	H84
5BP		N-CYCLOPROPYL-4-PYRAZOLO[1,5-B]PYRIDAZIN-3-YLPYRIMIDIN-2-AMINE	3ej1	A	H84
T2A		5-METHYL-7-PHENYL-N-(3,4,5-TRIMETHOXYPHENYL)IMIDAZO[5,1-F][1,2,4]TRIAZIN-2-AMINE	3eoc	A	H84
T2A		5-METHYL-7-PHENYL-N-(3,4,5-TRIMETHOXYPHENYL)IMIDAZO[5,1-F][1,2,4]TRIAZIN-2-AMINE	3eoc	C	H84
EZR		3-METHOXY-4-{3-[4-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-INDAZOL-6-YL}ANILINE	3ezr	A	H84
EZV		4-{3-[7-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-INDAZOL-6-YL}ANILINE	3ezv	A	H84
EZV		4-{3-[7-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-INDAZOL-6-YL}ANILINE	3f5x	A	H84
EZV		4-{3-[7-(4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]-1H-INDAZOL-6-YL}ANILINE	3f5x	C	H84
EFP		N-{1-[CIS-3-(ACETYLAMINO)CYCLOBUTYL]-1H-IMIDAZOL-4-YL}-2-(4-METHOXYPHENYL)ACETAMIDE	3ig7	A	H84
EFQ		N-[1-(CIS-3-HYDROXYCYCLOBUTYL)-1H-IMIDAZOL-4-YL]-2-(4-METHOXYPHENYL)ACETAMIDE	3igg	A	H84
A27		N-[6-(4-HYDROXYPHENYL)-5-PHENYL-1H-INDAZOL-3-YL]BUTANAMIDE	3lfn	A	H84
A07		N-(6-CHLORO-5-PHENYL-1H-INDAZOL-3-YL)BUTANAMIDE	3lfs	A	H84
404		(2R)-2-{[7-(BENZYLAMINO)-3-(PROPAN-2-YL)-1H-PYRAZOLO[4,3-D]PYRIMIDIN-5-YL]AMINO}BUTAN-1-OL	3pj8	A	H84
JWS		2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)-4-METHOXYPHENOL	3pxy	A	H84
JWS		2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)-4-METHOXYPHENOL	3pxz	A	H84
SU9		SU9516	3py0	A	H84
SU9		SU9516	3py1	A	H84
X01		3-(4-AMINO-1,3,5-TRIAZIN-2-YL)-4-HYDROXYBENZONITRILE	3ql8	A	H84
X07		5-NITRO-2-[(PYRIDIN-3-YLMETHYL)AMINO]BENZAMIDE	3qqf	A	H84
X06		4-CHLORO-2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)PHENOL	3qqg	A	H84
X0A		2-[4-AMINO-6-(PHENYLAMINO)-1,3,5-TRIAZIN-2-YL]-4- CHLOROPHENOL	3qqh	A	H84
X11		2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)PHENOL	3qqj	A	H84
X03		(5R)-5-(2-METHYLBUTAN-2-YL)-4,5,6,7-TETRAHYDRO-1H- INDAZOLE-3-CARBOHYDRAZIDE	3qql	A	H84
X14		(5R)-5-(2-METHYLBUTAN-2-YL)-N-(4-SULFAMOYLBENZYL)-4,5, 6,7-TETRAHYDRO-2H-INDAZOLE-3-CARBOXAMIDE	3qrt	A	H84
X19		(5S)-N-METHYL-5-(2-METHYLBUTAN-2-YL)-4,5,6,7- TETRAHYDRO-2H-INDAZOLE-3-CARBOXAMIDE	3qru	A	H84
X36		[4-AMINO-2-(PHENYLAMINO)-1,3-THIAZOL-5-YL](PHENYL) METHANONE	3qtr	A	H84
X46		[4-AMINO-2-(PHENYLAMINO)-1,3-THIAZOL-5-YL](3- METHOXYPHENYL)METHANONE	3qts	A	H84
X3A		[4-AMINO-2-(PHENYLAMINO)-1,3-THIAZOL-5-YL](PYRIDIN-3- YL)METHANONE	3qtw	A	H84
X40		4-{[4-AMINO-5-(PYRIDIN-3-YLCARBONYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3qu0	A	H84
X6A		2-{[(2-AMINOPYRIMIDIN-5-YL)METHYL]AMINO}-4-CHLORO-5- NITROBENZAMIDE	3qwj	A	H84
X62		4-CHLORO-2-{[(2-CHLOROPYRIMIDIN-5-YL)METHYL]AMINO}-5- NITROBENZAMIDE	3qwk	A	H84
X63		2-{[(2-AMINOPYRIMIDIN-5-YL)METHYL]AMINO}-4-[(2- HYDROXYETHYL)AMINO]-5-NITROBENZAMIDE	3qx2	A	H84
X4B		4-CHLORO-5-NITRO-2-[(PYRIDIN-3-YLMETHYL)AMINO]BENZAMIDE	3qx4	A	H84
X65		5-NITRO-2-[(4-SULFAMOYLBENZYL)AMINO]BENZAMIDE	3qxo	A	H84
X64		4-{[4-AMINO-5-(2-NITROBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3qxp	A	H84
X66		2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)BENZENE-1,4-DIOL	3qzf	A	H84
X67		2-(4,6-DIAMINO-1,3,5-TRIAZIN-2-YL)-4-FLUOROPHENOL	3qzg	A	H84
X69		4-METHOXY-5-NITRO-2-[(PYRIDIN-3-YLMETHYL) AMINO]BENZAMIDE	3qzh	A	H84
X72		4-CHLORO-5-NITRO-2-[(PYRIMIDIN-5-YLMETHYL) AMINO]BENZAMIDE	3qzi	A	H84
X75		4-CHLORO-2-{[(6-CHLOROPYRIDIN-3-YL)METHYL]AMINO}-5- NITROBENZAMIDE	3r1q	A	H84
X73		2-{[(6-CHLOROPYRIDIN-3-YL)METHYL]AMINO}-5- NITROBENZAMIDE	3r1s	A	H84
X76		2-[(PYRIDIN-3-YLMETHYL)AMINO]BENZAMIDE	3r1y	A	H84
XA0		4-CHLORO-5-NITRO-2-[(3,4,5-TRIFLUOROBENZYL) AMINO]BENZAMIDE	3r28	A	H84
X84		4-[(3-HYDROXYPROPYL)AMINO]-5-NITRO-2-[(PYRIDIN-3- YLMETHYL)AMINO]BENZAMIDE	3r6x	A	H84
X86		4-[(3-METHOXYPROPYL)AMINO]-5-NITRO-2-[(PYRIDIN-3- YLMETHYL)AMINO]BENZAMIDE	3r71	A	H84
X87		4-[(3-AMINOPROPYL)AMINO]-5-NITRO-2-[(PYRIDIN-3- YLMETHYL)AMINO]BENZAMIDE	3r73	A	H84
X88		5-NITRO-2-[(PYRAZIN-2-YLMETHYL)AMINO]BENZAMIDE	3r7e	A	H84
X9I		4-{[(2-CARBAMOYL-4-NITROPHENYL)AMINO]METHYL}BENZOIC ACID	3r7i	A	H84
X96		2-{[4-(AMINOMETHYL)BENZYL]AMINO}-5-NITROBENZAMIDE	3r7u	A	H84
Z02		5-NITRO-2-[(PYRIDIN-2-YLMETHYL)AMINO]BENZAMIDE	3r7v	A	H84
Z04		2-{[(2-AMINOPYRIMIDIN-5-YL)METHYL]AMINO}-4-(MORPHOLIN- 4-YL)-5-NITROBENZAMIDE	3r7y	A	H84
Z14		4-(4-AMINOPIPERIDIN-1-YL)-2-{[(2-AMINOPYRIMIDIN-5-YL) METHYL]AMINO}-5-NITROBENZAMIDE	3r83	A	H84
Z30		(5R)-5-TERT-BUTYL-4,5,6,7-TETRAHYDRO-1H-INDAZOLE-3- CARBOHYDRAZIDE	3r8l	A	H84
X6B		4-AMINO-N-(3-FLUOROPHENYL)-2-[(4-SULFAMOYLPHENYL) AMINO]-1,3-THIAZOLE-5-CARBOXAMIDE	3r9d	A	H84
Z67		4-AMINO-N-(2,6-DIFLUOROPHENYL)-2-[(4-SULFAMOYLPHENYL) AMINO]-1,3-THIAZOLE-5-CARBOXAMIDE	3r9h	A	H84
X85		4-{[3-(MORPHOLIN-4-YL)PROPYL]AMINO}-5-NITRO-2- [(PYRIDIN-3-YLMETHYL)AMINO]BENZAMIDE	3rai	A	H84
03Z		4-[(4-AMINO-5-BENZOYL-1,3-THIAZOL-2-YL) AMINO]BENZENESULFONAMIDE	3rak	A	H84
07Z		4-{[4-AMINO-5-(PYRIDIN-3-YLCARBONYL)-1,3-THIAZOL-2- YL]AMINO}BENZOIC ACID	3rk5	A	H84
08Z		4-{[4-AMINO-5-(PYRIDIN-3-YLCARBONYL)-1,3-THIAZOL-2- YL]AMINO}BENZAMIDE	3rk7	A	H84
18Z		2-{[(2-AMINOPYRIMIDIN-5-YL)METHYL]AMINO}-5-NITRO-4-{[2- (PIPERAZIN-1-YL)ETHYL]AMINO}BENZAMIDE	3rm6	A	H84
19Z		2-[(4-HYDROXYBENZYL)AMINO]-5-NITROBENZAMIDE	3rm7	A	H84
20Z		4-{[4-AMINO-5-(NAPHTHALEN-2-YLCARBONYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3rmf	A	H84
21Z		3-[(4-AMINO-5-BENZOYL-1,3-THIAZOL-2-YL) AMINO]BENZENESULFONAMIDE	3rni	A	H84
22Z		4-(HEXYLAMINO)-5-NITRO-2-[(PYRIDIN-3-YLMETHYL) AMINO]BENZAMIDE	3roy	A	H84
24Z		4-({4-CARBAMOYL-2-NITRO-5-[(PYRIDIN-3-YLMETHYL) AMINO]PHENYL}AMINO)BUTANOIC ACID	3rpo	A	H84
26Z		4-{[4-AMINO-5-(3-AMINOBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3rpv	A	H84
27Z		4-AMINO-2-[(4-SULFAMOYLPHENYL)AMINO]-1,3-THIAZOLE-5- CARBOXAMIDE	3rpy	A	H84
02Z		4-AMINO-2-(PHENYLAMINO)-1,3-THIAZOLE-5-CARBOXAMIDE	3rzb	A	H84
Z60		[4-AMINO-2-(PROP-2-EN-1-YLAMINO)-1,3-THIAZOL-5-YL](5- CHLOROTHIOPHEN-2-YL)METHANONE	3s00	A	H84
56Z		4-{[4-AMINO-5-(4-METHOXYBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3s1h	A	H84
PMU		(3S,4S)-1-{3-[2-AMINO-6-(PROPAN-2-YL)PYRIMIDIN-4-YL]-4-HYDROXYPHENYL}PYRROLIDINE-3,4-DIOL	3s2p	A	H84
99Z		4-{[4-AMINO-5-(2-METHYLBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	3sqq	A	H84
18K		N'-[4-(2-AMINO-4-METHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2- YL]-N,N-DIMETHYLBENZENE-1,4-DIAMINE	3sw4	A	H84
19K		N~4~-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)PYRIMIDIN-2-YL]- N~1~,N~1~-DIMETHYL-2-NITROBENZENE-1,4-DIAMINE	3sw7	A	H84
B49		SUNITINIB	3ti1	A	H84
3TI		1-{(E)-[(4-HYDROXYPHENYL)IMINO]METHYL}NAPHTHALEN-2-OL	3tiz	A	H84
0BX		4-{[4-(PHENYLAMINO)PYRIMIDIN-2-YL]AMINO}BENZOIC ACID	3unj	A	H84
0BY		4-({4-[(2-CHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZOIC ACID	3unk	A	H84
T3E		3-[[5-CYANO-4-[4-METHYL-2-(METHYLAMINO)-1,3- THIAZOL-5-YL]PYRIMIDIN-2-YL]AMINO] BENZENESULFONAMIDE	4bck	A	H84
T3E		3-[[5-CYANO-4-[4-METHYL-2-(METHYLAMINO)-1,3- THIAZOL-5-YL]PYRIMIDIN-2-YL]AMINO] BENZENESULFONAMIDE	4bck	C	H84
T7Z		4-(4-METHYL-2-METHYLIMINO-3H-1,3-THIAZOL-5- YL)-2-[(4-METHYL-3-MORPHOLIN-4-YLSULFONYL- PHENYL)AMINO]PYRIMIDINE-5-CARBONITRILE	4bcm	A	H84
T7Z		4-(4-METHYL-2-METHYLIMINO-3H-1,3-THIAZOL-5- YL)-2-[(4-METHYL-3-MORPHOLIN-4-YLSULFONYL- PHENYL)AMINO]PYRIMIDINE-5-CARBONITRILE	4bcm	C	H84
T9N		2-[(3-HYDROXYPHENYL)AMINO]-4-[4-METHYL-2- (METHYLAMINO)-1,3-THIAZOL-5-YL]PYRIMIDINE-5- CARBONITRILE	4bcn	A	H84
T9N		2-[(3-HYDROXYPHENYL)AMINO]-4-[4-METHYL-2- (METHYLAMINO)-1,3-THIAZOL-5-YL]PYRIMIDINE-5- CARBONITRILE	4bcn	C	H84
TJF		4-[4-METHYL-2-(METHYLAMINO)-1,3-THIAZOL-5-YL] -2-{[3-(MORPHOLIN-4-YLCARBONYL)PHENYL]AMINO} PYRIMIDINE-5-CARBONITRILE	4bcq	C	H84
4SP		O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO)PURINE	4eor	A	H84
0S0		4-[(E)-(6-HYDROXY-2-OXO-1,2-DIHYDROPYRIDIN-3-YL) DIAZENYL]BENZENESULFONAMIDE	4ez3	A	H84
X64		4-{[4-AMINO-5-(2-NITROBENZOYL)-1,3-THIAZOL-2- YL]AMINO}BENZENESULFONAMIDE	4gcj	A	H84
T3C		2-[[3-(1,4-DIAZEPAN-1-YL)PHENYL]AMINO]-4-[4- METHYL-2-(METHYLAMINO)-1,3-THIAZOL-5-YL] PYRIMIDINE-5-CARBONITRILE	4bcp	C	H84
1CK		4-BROMO-N-(5-METHYL-1H-PYRAZOL-3-YL)BENZAMIDE	4ek4	A	H84
03K		N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)BENZENE-1,4- DICARBOXAMIDE	4ek5	A	H84
10K		N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-[4-(THIOPHEN-2-YL) PHENYL]ACETAMIDE	4ek6	A	H84
16K		4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-(3-NITROPHENYL) PYRIMIDIN-2-AMINE	4ek8	A	H84
4CK		4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)CARBAMOYL]BENZOIC ACID	4fkg	A	H84
09K		N-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)-2-[4- (TRIFLUOROMETHOXY)PHENYL]ACETAMIDE	4fki	A	H84
11K		N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-[4-(2-PYRROLIDIN-1- YLETHOXY)PHENYL]ACETAMIDE	4fkj	A	H84
20K		2-CHLORO-N~4~-[4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL) PYRIMIDIN-2-YL]-N~1~,N~1~-DIMETHYLBENZENE-1,4-DIAMINE	4fko	A	H84
LS5		3-{[4-([AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	4fkp	A	H84
42K		(8Z)-8-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIOPHEN-5- YL)AMINO]METHYLIDENE}-6,8-DIHYDRO-7H-[1,3]THIAZOLO[5, 4-E]INDOL-7-ONE	4fkq	A	H84
45K		(8Z)-8-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIOPHEN-5- YL)AMINO]METHYLIDENE}-6,8-DIHYDRO-7H-[1,3]THIAZOLO[5, 4-E]INDOL-7-ONE	4fkr	A	H84
46K		N-[(4-{[(Z)-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4- E]INDOL-8-YLIDENE)METHYL]AMINO}PHENYL) SULFONYL]ACETAMIDE	4fks	A	H84
48K		N-[2-(DIMETHYLAMINO)ETHYL]-4-{[(Z)-(2-OXO-1,2-DIHYDRO- 3H-INDOL-3-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE	4fkt	A	H84
60K		(3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2, 3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID	4fku	A	H84
62K		2-METHYLPROPYL (3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL) HYDRAZINYLIDENE]-2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLATE	4fkw	A	H84
60K		(3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2, 3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID	4fx3	A	H84
60K		(3Z)-2-OXO-3-[2-(4-SULFAMOYLPHENYL)HYDRAZINYLIDENE]-2, 3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID	4fx3	C	H84
1N3		1-(AMINOMETHYL)-N-(3-{[6-BROMO-2-(4-METHOXYPHENYL)-3H- IMIDAZO[4,5-B]PYRIDIN-7-YL]AMINO}PROPYL) CYCLOPROPANECARBOXAMIDE	3uli	A	H84
3I6		4-((5-BROMO-4-(PROP-2-YN-1-YLAMINO)PYRIMIDIN- 2-YL)AMINO)BENZENESULFONAMIDE	4bgh	A	H84
1QK		3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1- YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1- HYDROXYPYRIDINIUM	4kd1	A	H84
JYM		6-(CYCLOHEXYLMETHOXY)-8-(TRIFLUOROMETHYL)-9H- PURIN-2-AMINE	4cfn	A	H84
SQ9		3-[2-AMINO-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]-2-METHYLBENZENESULFONAMIDE	4cfw	A	H84
D6I		6-(BENZIMIDAZOL-1-YL)-N-[5-[3-(DIMETHYLAMINO) PROPOXY]PYRIDIN-2-YL]PYRIMIDIN-4-AMINE	4bzd	A	H84
3QS		1-CYCLOPENTYL-N-[2-(4-METHOXYPIPERIDIN-1-YL)PYRIMIDIN- 4-YL]-1H-PYRROLO[3,2-C]PYRIDIN-6-AMINE	4rj3	A	H84
2WC		3-[2-AZANYL-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]-2-METHYL-BENZOIC ACID	4cfu	A	H84
2WC		3-[2-AZANYL-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]-2-METHYL-BENZOIC ACID	4cfu	C	H84
75X		3-[2-AMINO-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]-2-METHYLPHENOL	4cfv	A	H84
75X		3-[2-AMINO-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]-2-METHYLPHENOL	4cfv	C	H84
G6T		3-[2-AMINO-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]BENZENESULFONAMIDE	4cfx	A	H84
G6T		3-[2-AMINO-6-(CYCLOHEXYLMETHOXY)-7H-PURIN-8- YL]BENZENESULFONAMIDE	4cfx	C	H84
WG8		(4S)-2-(8-HYDROXYQUINOLIN-2-YL)-4,5-DIHYDRO- 1,3-THIAZOLE-4-CARBOXYLIC ACID	4d1z	A	H84
56H		N-(5-{[(5-TERT-BUTYL-1,3-OXAZOL-2-YL)METHYL]SULFANYL}- 1,3-THIAZOL-2-YL)PIPERIDINE-4-CARBOXAMIDE	5d1j	A	H84
55S		6-(CYCLOHEXYLMETHOXY)-N-[4-(ETHYLSULFONYL)PHENYL]-9H- PURIN-2-AMINE	5cyi	A	H84
WG8		(4S)-2-(8-HYDROXYQUINOLIN-2-YL)-4,5-DIHYDRO- 1,3-THIAZOLE-4-CARBOXYLIC ACID	4d1z	A	L219
LQ5		1-[4-(2-AZANYLPYRIMIDIN-4-YL)OXYPHENYL]-3-[4- [(4-METHYLPIPERAZIN-1-YL)METHYL]-3- (TRIFLUOROMETHYL)PHENYL]UREA	5a14	A	P241
MFZ		3-(4,7-DICHLORO-1H-INDOL-3-YL)PROP-2-YN-1-OL	5fp6	A	P45 V69
MG		MAGNESIUM(2+)	4cfu	A	R274
2KD		6-(3-CHLOROPHENYL)-2-{[(2S)-3-(4-HYDROXYPHENYL)-1- METHOXY-1-OXOPROPAN-2-YL]CARBAMOYL}QUINOLINE-4- CARBOXYLIC ACID	4nj3	A	V123
LQ5		1-[4-(2-AZANYLPYRIMIDIN-4-YL)OXYPHENYL]-3-[4- [(4-METHYLPIPERAZIN-1-YL)METHYL]-3- (TRIFLUOROMETHYL)PHENYL]UREA	5a14	A	V123 L124
2AN		8-ANILINO-1-NAPHTHALENE SULFONATE	3py1	A	V69
2AN		8-ANILINO-1-NAPHTHALENE SULFONATE	4ez7	A	V69

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Conservation information for LBS of CDK2

Multiple alignments for P24941 in multiple species

LBS	AA sequence	# species	Species
A144	GSIKLADFGLA	2	Bos taurus, Mus musculus
A144	NSLKLADFGLA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
A144	GAIKLADFGLA	1	Homo sapiens
A144	GKIKLADFGLA	1	Drosophila melanogaster
A144	GNLKLGDFGLA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A144	GNLKLADFGLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A144	NALKLADFGLA	1	Oryza sativa subsp. japonica
A244	SFPKWARQDFS	3	Homo sapiens, Bos taurus, Mus musculus
A244	KFPRWEGTNMP	1	Drosophila melanogaster
A244	SFPQWRRKDLS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A244	TFPRWKRMDLH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A244	AFPKWKPTDLE	1	Arabidopsis thaliana
A244	AFPKWQAQDLA	1	Oryza sativa subsp. japonica
A244	TFPKWPSVDLA	1	Oryza sativa subsp. japonica
A31	---VVALKKIR	3	Homo sapiens, Bos taurus, Mus musculus
A31	---TIALKKIR	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
A31	---DVALKKIR	1	Drosophila melanogaster
A31	GQRVVALKKIR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A31	---IVAMKKIR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A48	GVPSTAIREIS	9	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
D127	RVLHRDLKPQN	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
D127	RILHRDLKPQN	2	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D127	RIIHRDLKPQN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D145	SIKLADFGLAR	2	Bos taurus, Mus musculus
D145	SLKLADFGLAR	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
D145	AIKLADFGLAR	1	Homo sapiens
D145	KIKLADFGLAR	1	Drosophila melanogaster
D145	NLKLGDFGLAR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D145	NLKLADFGLAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D145	ALKLADFGLAR	1	Oryza sativa subsp. japonica
D86	EFLHQDLKKFM	3	Homo sapiens, Bos taurus, Mus musculus
D86	EYLDLDLKKHM	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
D86	EYLNMDLKKLM	1	Drosophila melanogaster
D86	EFLDLDLKRYM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D86	EFLDMDLKKYM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D86	EYLDLDLKKFM	1	Oryza sativa subsp. japonica
E12	VEKIGEGTYGV	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica
E12	AEKIGEGTYGI	1	Drosophila melanogaster
E12	LEKVGEGTYGV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E12	EEKIGEGTYGV	1	Oryza sativa subsp. japonica
E162	RTYTHEVVTLW	3	Homo sapiens, Bos taurus, Mus musculus
E162	RTFTHEVVTLW	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E162	RAYTHEVVTLW	1	Drosophila melanogaster
E162	RAYTHEIVTLW	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E162	RNYTHEIVTLW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E28	NKLTGE---VV	3	Homo sapiens, Bos taurus, Mus musculus
E28	DKVTNE---TI	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
E28	SNSTGQ---DV	1	Drosophila melanogaster
E28	DLRPGQGQRVV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E28	HKLSGR---IV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E28	HRHTNE---TI	1	Oryza sativa subsp. japonica
E42	LDTETEGVPST	3	Homo sapiens, Bos taurus, Mus musculus
E42	LEQEDEGVPST	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E42	LEGETEGVPST	1	Drosophila melanogaster
E42	LESEDEGVPST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E42	LEDESEGVPST	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E51	STAIREISLLK	9	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E8	NFQKVEKIGEG	3	Homo sapiens, Bos taurus, Mus musculus
E8	QYEKVEKIGEG	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
E8	NFQRAEKIGEG	1	Drosophila melanogaster
E8	NYKRLEKVGEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E8	NYQKVEKIGEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E8	QYEKEEKIGEG	1	Oryza sativa subsp. japonica
E81	LYLVFEFLHQD	3	Homo sapiens, Bos taurus, Mus musculus
E81	IYLVFEYLDLD	2	Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E81	LYMIFEYLNMD	1	Drosophila melanogaster
E81	LYLVFEFLDLD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E81	LYLVFEFLDMD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E81	LYLVFEYLDLD	1	Arabidopsis thaliana
F146	IKLADFGLARA	4	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus
F146	LKLADFGLARA	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F146	LKLGDFGLARA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F146	LKLADFGLARS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F152	GLARAFGVPVR	3	Homo sapiens, Bos taurus, Mus musculus
F152	GLARAFGIPVR	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F152	GLARAFNVPMR	1	Drosophila melanogaster
F152	GLARAFGVPLR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F152	GLARSFGVPLR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F213	EIDQLFRIFRT	3	Homo sapiens, Bos taurus, Mus musculus
F213	EIDQLYRIFRT	1	Drosophila melanogaster
F213	EIDQIFKIFRV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F213	EIDEIFKIFQV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F213	EIDQLFKIFRI	1	Arabidopsis thaliana
F213	EIDELFKIFRV	1	Oryza sativa subsp. japonica
F213	EIDELFKIFSI	1	Oryza sativa subsp. japonica
F240	DYKPSFPKWAR	3	Homo sapiens, Bos taurus, Mus musculus
F240	DFKTKFPRWEG	1	Drosophila melanogaster
F240	DFKPSFPQWRR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F240	DYKSTFPRWKR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F240	DYKSAFPKWKP	1	Arabidopsis thaliana
F240	DYKSAFPKWQA	1	Oryza sativa subsp. japonica
F240	DYISTFPKWPS	1	Oryza sativa subsp. japonica
F80	KLYLVFEFLHQ	3	Homo sapiens, Bos taurus, Mus musculus
F80	NLYMIFEYLNM	1	Drosophila melanogaster
F80	KLYLVFEFLDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F80	KLYLVFEFLDM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F80	RLYLVFEYLDL	1	Arabidopsis thaliana
F80	RIYLVFEYLDL	1	Oryza sativa subsp. japonica
F80	CIYLVFEYLDL	1	Oryza sativa subsp. japonica
F82	YLVFEFLHQDL	3	Homo sapiens, Bos taurus, Mus musculus
F82	YLVFEYLDLDL	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F82	YMIFEYLNMDL	1	Drosophila melanogaster
F82	YLVFEFLDLDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F82	YLVFEFLDMDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G11	KVEKIGEGTYG	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica
G11	RAEKIGEGTYG	1	Drosophila melanogaster
G11	RLEKVGEGTYG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G11	KEEKIGEGTYG	1	Oryza sativa subsp. japonica
G13	EKIGEGTYGVV	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G13	EKIGEGTYGIV	1	Drosophila melanogaster
G13	EKVGEGTYGVV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G147	KLADFGLARAF	7	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G147	KLGDFGLARAF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G147	KLADFGLARSF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G16	GEGTYGVVYKA	6	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana
G16	GEGTYGIVYKA	1	Drosophila melanogaster
G16	GEGTYGVVYRA	1	Oryza sativa subsp. japonica
G16	GEGTYGVVYKG	1	Oryza sativa subsp. japonica
G205	RALFPGDSEID	3	Homo sapiens, Bos taurus, Mus musculus
G205	KPLFPGDSEID	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G205	RSLFPGDSEID	1	Drosophila melanogaster
G205	KPIFSGDSEID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G205	SPLFPGDSEID	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G220	IFRTLGTPDEV	3	Homo sapiens, Bos taurus, Mus musculus
G220	IFRTLSTPDET	1	Drosophila melanogaster
G220	IFRVLGTPNEA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G220	IFQVLGTPNEE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G220	IFRIMGTPYED	1	Arabidopsis thaliana
G220	IFRVLGTPNEQ	1	Oryza sativa subsp. japonica
G220	IFSIMGTPNEE	1	Oryza sativa subsp. japonica
H125	SHRVLHRDLKP	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
H125	TNRILHRDLKP	1	Drosophila melanogaster
H125	SHRILHRDLKP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H125	SRRIIHRDLKP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H268	LSQMLHYDPNK	3	Homo sapiens, Bos taurus, Mus musculus
H268	IMSMLCYDPNL	1	Drosophila melanogaster
H268	LDKLLAYDPIN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H268	LSAMLVYDPAH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H268	LSKMLLMDPTK	1	Arabidopsis thaliana
H268	LSKMLRYEPNK	1	Oryza sativa subsp. japonica
H268	LSKMLRLDPSK	1	Oryza sativa subsp. japonica
H71	LLDVIHTE-NK	3	Homo sapiens, Bos taurus, Mus musculus
H71	LFDVVISG-NN	1	Drosophila melanogaster
H71	LYDIVHSDAHK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H71	LLDILHAE-SK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H71	LQDVVHSE-KR	1	Arabidopsis thaliana
H71	LHDVIHSE-KR	1	Oryza sativa subsp. japonica
H71	LQDVVHKE-KC	1	Oryza sativa subsp. japonica
H84	VFEFLHQDLKK	3	Homo sapiens, Bos taurus, Mus musculus
H84	VFEYLDLDLKK	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
H84	IFEYLNMDLKK	1	Drosophila melanogaster
H84	VFEFLDLDLKR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H84	VFEFLDMDLKK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I10	QKVEKIGEGTY	4	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus
I10	EKVEKIGEGTY	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
I10	QRAEKIGEGTY	1	Drosophila melanogaster
I10	KRLEKVGEGTY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I10	EKEEKIGEGTY	1	Oryza sativa subsp. japonica
I209	PGDSEIDQLFR	3	Homo sapiens, Bos taurus, Mus musculus
I209	PGDSEIDELFK	2	Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
I209	PGDSEIDQLYR	1	Drosophila melanogaster
I209	SGDSEIDQIFK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I209	PGDSEIDEIFK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I209	PGDSEIDQLFK	1	Arabidopsis thaliana
I35	VALKKIRLDTE	3	Homo sapiens, Bos taurus, Mus musculus
I35	IALKKIRLEQE	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
I35	VALKKIRLEGE	1	Drosophila melanogaster
I35	VALKKIRLESE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I35	VAMKKIRLEDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I49	VPSTAIREISL	9	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
I52	TAIREISLLKE	8	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
I52	TAIREISLLKN	1	Drosophila melanogaster
I63	-NHPNIVKLLD	3	Homo sapiens, Bos taurus, Mus musculus
I63	-KHPNVVQLFD	1	Drosophila melanogaster
I63	-KDDNIVRLYD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I63	NNRSNCVRLLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I63	-QHSNIVKLQD	1	Arabidopsis thaliana
I63	-HHGNIVRLHD	1	Oryza sativa subsp. japonica
I63	-QHRNIVRLQD	1	Oryza sativa subsp. japonica
K129	LHRDLKPQNLL	8	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K129	IHRDLKPQNLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K20	YGVVYKAKNKL	2	Bos taurus, Mus musculus
K20	YGVVYKARNKL	1	Homo sapiens
K20	YGIVYKARSNS	1	Drosophila melanogaster
K20	YGVVYKALDLR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K20	YGVVYKARHKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K20	YGVVYKARDKV	1	Arabidopsis thaliana
K20	YGVVYRARDKV	1	Oryza sativa subsp. japonica
K20	YGVVYKGKHRH	1	Oryza sativa subsp. japonica
K237	SMPDYKPSFPK	3	Homo sapiens, Bos taurus, Mus musculus
K237	SLPDYKSAFPK	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
K237	QLPDFKTKFPR	1	Drosophila melanogaster
K237	YLPDFKPSFPQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K237	LLQDYKSTFPR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K237	SLPDYISTFPK	1	Oryza sativa subsp. japonica
K242	KPSFPKWARQD	3	Homo sapiens, Bos taurus, Mus musculus
K242	KTKFPRWEGTN	1	Drosophila melanogaster
K242	KPSFPQWRRKD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K242	KSTFPRWKRMD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K242	KSAFPKWKPTD	1	Arabidopsis thaliana
K242	KSAFPKWQAQD	1	Oryza sativa subsp. japonica
K242	ISTFPKWPSVD	1	Oryza sativa subsp. japonica
K33	-VVALKKIRLD	3	Homo sapiens, Bos taurus, Mus musculus
K33	-TIALKKIRLE	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K33	-DVALKKIRLE	1	Drosophila melanogaster
K33	RVVALKKIRLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K33	-IVAMKKIRLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K34	VVALKKIRLDT	3	Homo sapiens, Bos taurus, Mus musculus
K34	TIALKKIRLEQ	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K34	DVALKKIRLEG	1	Drosophila melanogaster
K34	VVALKKIRLES	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K34	IVAMKKIRLED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K56	EISLLKEL---	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus
K56	EISLLKEM---	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K56	EISLLKNL---	1	Drosophila melanogaster
K56	EISLLKEVNDE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K88	LHQDLKKFMDA	3	Homo sapiens, Bos taurus, Mus musculus
K88	LDLDLKKHMDS	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
K88	LNMDLKKLMDK	1	Drosophila melanogaster
K88	LDLDLKRYMEG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K88	LDMDLKKYMDR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K88	LDLDLKKFMDS	1	Oryza sativa subsp. japonica
K89	HQDLKKFMDAS	3	Homo sapiens, Bos taurus, Mus musculus
K89	NMDLKKLMDKK	1	Drosophila melanogaster
K89	DLDLKRYMEGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K89	DMDLKKYMDRI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K89	DLDLKKHMDST	1	Arabidopsis thaliana
K89	DLDLKKFMDSC	1	Oryza sativa subsp. japonica
K89	DLDLKKHMDSS	1	Oryza sativa subsp. japonica
K9	FQKVEKIGEGT	3	Homo sapiens, Bos taurus, Mus musculus
K9	YEKVEKIGEGT	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
K9	FQRAEKIGEGT	1	Drosophila melanogaster
K9	YKRLEKVGEGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K9	YQKVEKIGEGT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K9	YEKEEKIGEGT	1	Oryza sativa subsp. japonica
L124	HSHRVLHRDLK	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L124	HTNRILHRDLK	1	Drosophila melanogaster
L124	HSHRILHRDLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L124	HSRRIIHRDLK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L134	KPQNLLIDRRT	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L134	KPQNLLIN-TE	1	Homo sapiens
L134	KPQNLLVD-TA	1	Drosophila melanogaster
L134	KPQNLLIN-KD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L134	KPQNLLID-KE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L134	KPQNLLIN-AD	1	Bos taurus
L134	KPQNLLIN-AE	1	Mus musculus
L143	TNSLKLADFGL	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
L143	EGAIKLADFGL	1	Homo sapiens
L143	AGKIKLADFGL	1	Drosophila melanogaster
L143	DGNLKLGDFGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L143	EGNLKLADFGL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L143	DGSIKLADFGL	1	Bos taurus
L143	EGSIKLADFGL	1	Mus musculus
L143	TNALKLADFGL	1	Oryza sativa subsp. japonica
L148	LADFGLARAFG	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L148	LADFGLARAFN	1	Drosophila melanogaster
L148	LGDFGLARAFG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L148	LADFGLARSFG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L166	HEVVTLWYRAP	7	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L166	HEIVTLWYRAP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L219	RIFRTLGTPDE	3	Homo sapiens, Bos taurus, Mus musculus
L219	KIFRVLGTPNE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Oryza sativa subsp. japonica
L219	RIFRTLSTPDE	1	Drosophila melanogaster
L219	KIFQVLGTPNE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L219	KIFRIMGTPYE	1	Arabidopsis thaliana
L219	KIFSIMGTPNE	1	Oryza sativa subsp. japonica
L25	KAKNKLTGE--	2	Bos taurus, Mus musculus
L25	KARNKLTGE--	1	Homo sapiens
L25	KARSNSTGQ--	1	Drosophila melanogaster
L25	KALDLRPGQGQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L25	KARHKLSGR--	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L25	KARDKVTNE--	1	Arabidopsis thaliana
L25	RARDKVTNE--	1	Oryza sativa subsp. japonica
L25	KGKHRHTNE--	1	Oryza sativa subsp. japonica
L37	LKKIRLDTETE	3	Homo sapiens, Bos taurus, Mus musculus
L37	LKKIRLEQEDE	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L37	LKKIRLEGETE	1	Drosophila melanogaster
L37	LKKIRLESEDE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L37	MKKIRLEDESE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L54	IREISLLKEL-	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus
L54	IREISLLKEM-	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L54	IREISLLKNL-	1	Drosophila melanogaster
L54	IREISLLKEVN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L55	REISLLKEL--	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus
L55	REISLLKEM--	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L55	REISLLKNL--	1	Drosophila melanogaster
L55	REISLLKEVND	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L58	SLLKEL----N	3	Homo sapiens, Bos taurus, Mus musculus
L58	SLLKEM----Q	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
L58	SLLKNL----K	1	Drosophila melanogaster
L58	SLLKEL----K	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L58	SLLKEVNDENN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L58	SLLKEM----H	1	Oryza sativa subsp. japonica
L66	PNIVKLLDVIH	3	Homo sapiens, Bos taurus, Mus musculus
L66	PNVVQLFDVVI	1	Drosophila melanogaster
L66	DNIVRLYDIVH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L66	SNCVRLLDILH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L66	SNIVKLQDVVH	1	Arabidopsis thaliana
L66	GNIVRLHDVIH	1	Oryza sativa subsp. japonica
L66	RNIVRLQDVVH	1	Oryza sativa subsp. japonica
L76	TE-NKLYLVFE	3	Homo sapiens, Bos taurus, Mus musculus
L76	SG-NNLYMIFE	1	Drosophila melanogaster
L76	SDAHKLYLVFE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L76	AE-SKLYLVFE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L76	SE-KRLYLVFE	1	Arabidopsis thaliana
L76	SE-KRIYLVFE	1	Oryza sativa subsp. japonica
L76	KE-KCIYLVFE	1	Oryza sativa subsp. japonica
L78	-NKLYLVFEFL	3	Homo sapiens, Bos taurus, Mus musculus
L78	-NNLYMIFEYL	1	Drosophila melanogaster
L78	AHKLYLVFEFL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L78	-SKLYLVFEFL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L78	-KRLYLVFEYL	1	Arabidopsis thaliana
L78	-KRIYLVFEYL	1	Oryza sativa subsp. japonica
L78	-KCIYLVFEYL	1	Oryza sativa subsp. japonica
L83	LVFEFLHQDLK	3	Homo sapiens, Bos taurus, Mus musculus
L83	LVFEYLDLDLK	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L83	MIFEYLNMDLK	1	Drosophila melanogaster
L83	LVFEFLDLDLK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L83	LVFEFLDMDLK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N132	DLKPQNLLIN-	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus
N132	DLKPQNLLIDR	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
N132	DLKPQNLLVD-	1	Drosophila melanogaster
N132	DLKPQNLLID-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P241	YKPSFPKWARQ	3	Homo sapiens, Bos taurus, Mus musculus
P241	FKTKFPRWEGT	1	Drosophila melanogaster
P241	FKPSFPQWRRK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P241	YKSTFPRWKRM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P241	YKSAFPKWKPT	1	Arabidopsis thaliana
P241	YKSAFPKWQAQ	1	Oryza sativa subsp. japonica
P241	YISTFPKWPSV	1	Oryza sativa subsp. japonica
P271	MLHYDPNKRIS	3	Homo sapiens, Bos taurus, Mus musculus
P271	MLCYDPNLRIS	1	Drosophila melanogaster
P271	LLAYDPINRIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P271	MLVYDPAHRIS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P271	MLLMDPTKRIN	1	Arabidopsis thaliana
P271	MLRYEPNKRIT	1	Oryza sativa subsp. japonica
P271	MLRLDPSKRIN	1	Oryza sativa subsp. japonica
P45	ETEGVPSTAIR	4	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus
P45	EDEGVPSTAIR	4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
P45	ESEGVPSTAIR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q131	RDLKPQNLLIN	4	Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Bos taurus, Mus musculus
Q131	RDLKPQNLLID	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Q131	RDLKPQNLLVD	1	Drosophila melanogaster
Q85	FEFLHQDLKKF	3	Homo sapiens, Bos taurus, Mus musculus
Q85	FEYLDLDLKKH	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
Q85	FEYLNMDLKKL	1	Drosophila melanogaster
Q85	FEFLDLDLKRY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q85	FEFLDMDLKKY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q85	FEYLDLDLKKF	1	Oryza sativa subsp. japonica
R126	HRVLHRDLKPQ	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R126	NRILHRDLKPQ	1	Drosophila melanogaster
R126	HRILHRDLKPQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R126	RRIIHRDLKPQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R169	VTLWYRAPEIL	7	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R169	VTLWYRAPEVL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R245	FPKWARQDFSK	3	Homo sapiens, Bos taurus, Mus musculus
R245	FPRWEGTNMPQ	1	Drosophila melanogaster
R245	FPQWRRKDLSQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R245	FPRWKRMDLHK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R245	FPKWKPTDLET	1	Arabidopsis thaliana
R245	FPKWQAQDLAT	1	Oryza sativa subsp. japonica
R245	FPKWPSVDLAT	1	Oryza sativa subsp. japonica
R274	YDPNKRISAKA	3	Homo sapiens, Bos taurus, Mus musculus
R274	YDPNLRISAKD	1	Drosophila melanogaster
R274	YDPINRISARR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R274	YDPAHRISAKR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R274	MDPTKRINARA	1	Arabidopsis thaliana
R274	YEPNKRITARQ	1	Oryza sativa subsp. japonica
R274	LDPSKRINARA	1	Oryza sativa subsp. japonica
R36	ALKKIRLDTET	3	Homo sapiens, Bos taurus, Mus musculus
R36	ALKKIRLEQED	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R36	ALKKIRLEGET	1	Drosophila melanogaster
R36	ALKKIRLESED	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R36	AMKKIRLEDES	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R50	PSTAIREISLL	9	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
S239	PDYKPSFPKWA	3	Homo sapiens, Bos taurus, Mus musculus
S239	PDFKTKFPRWE	1	Drosophila melanogaster
S239	PDFKPSFPQWR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S239	QDYKSTFPRWK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S239	PDYKSAFPKWK	1	Arabidopsis thaliana
S239	PDYKSAFPKWQ	1	Oryza sativa subsp. japonica
S239	PDYISTFPKWP	1	Oryza sativa subsp. japonica
T14	KIGEGTYGVVY	7	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T14	KIGEGTYGIVY	1	Drosophila melanogaster
T14	KVGEGTYGVVY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T160	PVRTYTHEVVT	3	Homo sapiens, Bos taurus, Mus musculus
T160	PVRTFTHEVVT	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T160	PMRAYTHEVVT	1	Drosophila melanogaster
T160	PLRAYTHEIVT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T160	PLRNYTHEIVT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T165	THEVVTLWYRA	7	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T165	THEIVTLWYRA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T221	FRTLGTPDEVV	3	Homo sapiens, Bos taurus, Mus musculus
T221	FRTLSTPDETN	1	Drosophila melanogaster
T221	FRVLGTPNEAI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T221	FQVLGTPNEEV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T221	FRIMGTPYEDT	1	Arabidopsis thaliana
T221	FRVLGTPNEQS	1	Oryza sativa subsp. japonica
T221	FSIMGTPNEET	1	Oryza sativa subsp. japonica
T26	AKNKLTGE---	2	Bos taurus, Mus musculus
T26	ARDKVTNE---	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
T26	ARNKLTGE---	1	Homo sapiens
T26	ARSNSTGQ---	1	Drosophila melanogaster
T26	ALDLRPGQGQR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T26	ARHKLSGR---	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T26	GKHRHTNE---	1	Oryza sativa subsp. japonica
T41	RLDTETEGVPS	3	Homo sapiens, Bos taurus, Mus musculus
T41	RLEQEDEGVPS	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T41	RLEGETEGVPS	1	Drosophila melanogaster
T41	RLESEDEGVPS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T41	RLEDESEGVPS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T47	EGVPSTAIREI	9	Homo sapiens, Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V123	CHSHRVLHRDL	6	Homo sapiens, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V123	CHTNRILHRDL	1	Drosophila melanogaster
V123	CHSHRILHRDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V123	CHSRRIIHRDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V163	TYTHEVVTLWY	3	Homo sapiens, Bos taurus, Mus musculus
V163	TFTHEVVTLWY	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V163	AYTHEVVTLWY	1	Drosophila melanogaster
V163	AYTHEIVTLWY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V163	NYTHEIVTLWY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V164	YTHEVVTLWYR	4	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus
V164	FTHEVVTLWYR	3	Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V164	YTHEIVTLWYR	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V18	GTYGVVYKAKN	2	Bos taurus, Mus musculus
V18	GTYGVVYKARN	1	Homo sapiens
V18	GTYGIVYKARS	1	Drosophila melanogaster
V18	GTYGVVYKALD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V18	GTYGVVYKARH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V18	GTYGVVYKARD	1	Arabidopsis thaliana
V18	GTYGVVYRARD	1	Oryza sativa subsp. japonica
V18	GTYGVVYKGKH	1	Oryza sativa subsp. japonica
V226	TPDEVVWPGVT	3	Homo sapiens, Bos taurus, Mus musculus
V226	TPDETNWPGVT	1	Drosophila melanogaster
V226	TPNEAIWPDIV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V226	TPNEEVWPGVT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V226	TPYEDTWRGVT	1	Arabidopsis thaliana
V226	TPNEQSWPGVS	1	Oryza sativa subsp. japonica
V226	TPNEETWPGVA	1	Oryza sativa subsp. japonica
V64	NHPNIVKLLDV	3	Homo sapiens, Bos taurus, Mus musculus
V64	KHPNVVQLFDV	1	Drosophila melanogaster
V64	KDDNIVRLYDI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V64	NRSNCVRLLDI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V64	QHSNIVKLQDV	1	Arabidopsis thaliana
V64	HHGNIVRLHDV	1	Oryza sativa subsp. japonica
V64	QHRNIVRLQDV	1	Oryza sativa subsp. japonica
V69	VKLLDVIHTE-	3	Homo sapiens, Bos taurus, Mus musculus
V69	VQLFDVVISG-	1	Drosophila melanogaster
V69	VRLYDIVHSDA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V69	VRLLDILHAE-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V69	VKLQDVVHSE-	1	Arabidopsis thaliana
V69	VRLHDVIHSE-	1	Oryza sativa subsp. japonica
V69	VRLQDVVHKE-	1	Oryza sativa subsp. japonica
W167	EVVTLWYRAPE	7	Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
W167	EIVTLWYRAPE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W243	PSFPKWARQDF	3	Homo sapiens, Bos taurus, Mus musculus
W243	TKFPRWEGTNM	1	Drosophila melanogaster
W243	PSFPQWRRKDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W243	STFPRWKRMDL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W243	SAFPKWKPTDL	1	Arabidopsis thaliana
W243	SAFPKWQAQDL	1	Oryza sativa subsp. japonica
W243	STFPKWPSVDL	1	Oryza sativa subsp. japonica
Y15	IGEGTYGVVYK	6	Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Arabidopsis thaliana, Oryza sativa subsp. japonica
Y15	IGEGTYGIVYK	1	Drosophila melanogaster
Y15	VGEGTYGVVYK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y15	IGEGTYGVVYR	1	Oryza sativa subsp. japonica
Y269	SQMLHYDPNKR	3	Homo sapiens, Bos taurus, Mus musculus
Y269	MSMLCYDPNLR	1	Drosophila melanogaster
Y269	DKLLAYDPINR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y269	SAMLVYDPAHR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y269	SKMLLMDPTKR	1	Arabidopsis thaliana
Y269	SKMLRYEPNKR	1	Oryza sativa subsp. japonica
Y269	SKMLRLDPSKR	1	Oryza sativa subsp. japonica