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mutLBSgeneDB |
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| Gene summary for TNK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | TNK2 |
| Gene name | tyrosine kinase, non-receptor, 2 | |
| Synonyms | ACK|ACK-1|ACK1|p21cdc42Hs | |
| Cytomap | UCSC genome browser: 3q29 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001010938.1, NM_005781.4, | |
| Description | activated CDC42 kinase 1activated Cdc42-associated kinase 1activated p21cdc42Hs kinasetyrosine kinase non-receptor protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606994 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000061938 | ||
| HPRD : 06104 | ||
| Vega : OTTHUMG00000155737 | ||
| Protein | UniProt: Q07912 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TNK2 | |
| BioGPS: 10188 | ||
| Pathway | NCI Pathway Interaction Database: TNK2 | |
| KEGG: TNK2 | ||
| REACTOME: TNK2 | ||
| Pathway Commons: TNK2 | ||
| Context | iHOP: TNK2 | |
| ligand binding site mutation search in PubMed: TNK2 | ||
| UCL Cancer Institute: TNK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0016310 | phosphorylation | 20333297 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 10587647 | GO:2000369 | regulation of clathrin-mediated endocytosis | 18262180 |
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| Ligand binding site mutations for TNK2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | A156 | V155L | LUAD | 1 | S212 | S212L | SKCM | 1 | D270 | D270E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for TNK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D270 | D270E | -0.74716874 | A156 | V155L | -0.26518128 | S212 | S212L | -0.14069859 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for TNK2 from PDB |
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| Differential gene expression and gene-gene network for TNK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for TNK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023903 | Liver Neoplasms | 1 | Biomarker |
| umls:C0032927 | Precancerous Conditions | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for TNK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00171 | Adenosine triphosphate | Small molecule |  |
| Experimental | DB04367 | Debromohymenialdisine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of TNK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | T74 | N~3~-(2,6-DIMETHYLPHENYL)-1-(3-METHOXY-3-METHYLBUTYL)-N~6~-(4-PIPERAZIN-1-YLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE-3,6-DIAMINE | 3eqr | A | A156 | T74 | N~3~-(2,6-DIMETHYLPHENYL)-1-(3-METHOXY-3-METHYLBUTYL)-N~6~-(4-PIPERAZIN-1-YLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE-3,6-DIAMINE | 3eqr | B | A156 | T77 | 6-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-N-(1,3-DITHIOLAN- 2-YLMETHYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4- AMINE | 4ewh | B | A156 | 1G0 | CIS-3-[8-AMINO-1-(4-PHENOXYPHENYL)IMIDAZO[1,5- A]PYRAZIN-3-YL]CYCLOBUTANOL | 4id7 | A | A156 | DBQ | DEBROMOHYMENIALDISINE | 1u4d | A | A156 D270 | DBQ | DEBROMOHYMENIALDISINE | 1u4d | B | A156 D270 | ACP | ADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE | 1u54 | A | A156 D270 | T95 | N-(2,6-DIMETHYLPHENYL)-4-(2-ETHOXYPHENOXY)-2-({4-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PHENYL}AMINO)PYRIMIDINE-5-CARBOXAMIDE | 3eqp | B | A156 D270 | T95 | N-(2,6-DIMETHYLPHENYL)-4-(2-ETHOXYPHENOXY)-2-({4-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PHENYL}AMINO)PYRIMIDINE-5-CARBOXAMIDE | 3eqp | A | A156 D270 | T77 | 6-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-N-(1,3-DITHIOLAN- 2-YLMETHYL)-5-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4- AMINE | 4ewh | A | A156 D270 | ACP | ADENOSINE 5'-[BETA,GAMMA-METHYLENE]TRIPHOSPHATE | 1u54 | B | A156 S212 D270 | MG | MAGNESIUM(2+) | 1u54 | A | D270 | MG | MAGNESIUM(2+) | 1u54 | B | D270 |
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| Conservation information for LBS of TNK2 |
| Multiple alignments for Q07912 in multiple species |
| LBS | AA sequence | # species | Species | A156 | KTVSVAVKCLK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A208 | MVTELAPLGSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A208 | TVTELAPLGSL | 1 | Bos taurus | D134 | LEKLGDGSFGV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D134 | FEKLGDGSFGV | 1 | Bos taurus | D270 | LVKIGDFGLMR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E177 | DDFIREVNAMH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E206 | MKMVTELAPLG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E206 | MKTVTELAPLG | 1 | Bos taurus | F137 | LGDGSFGVVRR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | F271 | VKIGDFGLMRA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G133 | LLEKLGDGSFG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G133 | LFEKLGDGSFG | 1 | Bos taurus | G135 | EKLGDGSFGVV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G211 | ELAPLGSLLDR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G269 | DLVKIGDFGLM | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I190 | DHRNLIRLYGV | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K158 | VSVAVKCLKPD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K219 | LDRLRKHQGHF | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L132 | RLLEKLGDGSF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L132 | HLFEKLGDGSF | 1 | Bos taurus | L207 | KMVTELAPLGS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L207 | KTVTELAPLGS | 1 | Bos taurus | L210 | TELAPLGSLLD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | L259 | AARNLLLATRD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M181 | REVNAMHSLDH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | M203 | TPPMKMVTELA | 2 | Homo sapiens, Rattus norvegicus | M203 | TLPMKMVTELA | 1 | Mus musculus | M203 | TPPMKTVTELA | 1 | Bos taurus | N257 | DLAARNLLLAT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | P209 | VTELAPLGSLL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R256 | RDLAARNLLLA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S212 | LAPLGSLLDRL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | T205 | PMKMVTELAPL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T205 | PMKTVTELAPL | 1 | Bos taurus | V140 | GSFGVVRRGEW | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | V157 | TVSVAVKCLKP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus |
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