|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for PRMT3 |
 Gene summary |
| Basic gene Info. | Gene symbol | PRMT3 |
| Gene name | protein arginine methyltransferase 3 | |
| Synonyms | HRMT1L3 | |
| Cytomap | UCSC genome browser: 11p15.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001145166.1, NM_001145167.1,NM_005788.3, | |
| Description | HMT1 hnRNP methyltransferase-like 3heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3protein arginine N-methyltransferase 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603190 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185238 | ||
| HPRD : 11934 | ||
| Vega : OTTHUMG00000166022 | ||
| Protein | UniProt: O60678 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRMT3 | |
| BioGPS: 10196 | ||
| Pathway | NCI Pathway Interaction Database: PRMT3 | |
| KEGG: PRMT3 | ||
| REACTOME: PRMT3 | ||
| Pathway Commons: PRMT3 | ||
| Context | iHOP: PRMT3 | |
| ligand binding site mutation search in PubMed: PRMT3 | ||
| UCL Cancer Institute: PRMT3 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0031397 | negative regulation of protein ubiquitination | 18573314 |
| Top |
| Ligand binding site mutations for PRMT3 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L407 | P409L | SKCM | 2 | S343 | D342Y | COAD | 1 | D372 | V373M | HNSC | 1 | R379 | I380T | LUAD | 1 | V370 | A369T | LUSC | 1 | R379 | R379I | UCEC | 1 | R239 | R239Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for PRMT3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R379 | I380T | -1.5773539 | D372 | V373M | -1.200957 | R239 | R239Q | -1.1594359 | L407 | P409L | -0.83509727 | V370 | A369T | -0.48598911 | R379 | R379I | -0.43902699 | S343 | D342Y | -0.32423555 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRMT3 from PDB |
| PDB ID | PDB title | PDB structure | 2FYT | Human HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) protein |  |
| Top |
| Differential gene expression and gene-gene network for PRMT3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for PRMT3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for PRMT3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01752 | S-Adenosyl-L-Homocysteine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of PRMT3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of PRMT3 |
| Multiple alignments for O60678 in multiple species |
| LBS | AA sequence | # species | Species | A450 | TAMCTAVAGYF | 2 | Mus musculus, Rattus norvegicus | A450 | TSMCTAIAGYF | 1 | Homo sapiens | A450 | EGPLCAFTLWF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C264 | VLDVGCGTGIL | 4 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus | D285 | KVIAVDQSEIL | 2 | Mus musculus, Rattus norvegicus | D285 | KVLGVDQSEIL | 1 | Homo sapiens | D285 | KVYAVDNSDII | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D372 | LVAVSDVSKHA | 2 | Mus musculus, Rattus norvegicus | D372 | LVAVSDVNKHA | 1 | Homo sapiens | D372 | LTATTNTELLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E314 | IKGKIEEVSLP | 2 | Mus musculus, Rattus norvegicus | E314 | IKGKIEEVHLP | 1 | Homo sapiens | E314 | IRGKIEDISLP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E329 | DVIISEWMGYF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E329 | DIIISEWMGYA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E405 | PEAVVEVVDHK | 2 | Mus musculus, Rattus norvegicus | E405 | PEAVVEVLDPK | 1 | Homo sapiens | E405 | KGVSVQVVPQT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G263 | VVLDVGCGTGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G263 | TVLDVGCGTGI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G265 | LDVGCGTGILS | 4 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus, Rattus norvegicus | G311 | IVLIKGKIEEV | 2 | Mus musculus, Rattus norvegicus | G311 | ITLIKGKIEEV | 1 | Homo sapiens | G311 | ITFIRGKIEDI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H230 | GHYGIHEEMLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H230 | AGNDIHFLMLN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H376 | SDVSKHADRIA | 2 | Mus musculus, Rattus norvegicus | H376 | SDVNKHADRIA | 1 | Homo sapiens | H376 | TNTELLEEPID | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I268 | GCGTGILSMFA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I268 | GCGTGILSMFC | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I313 | LIKGKIEEVSL | 2 | Mus musculus, Rattus norvegicus | I313 | LIKGKIEEVHL | 1 | Homo sapiens | I313 | FIRGKIEDISL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K312 | VLIKGKIEEVS | 2 | Mus musculus, Rattus norvegicus | K312 | TLIKGKIEEVH | 1 | Homo sapiens | K312 | TFIRGKIEDIS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K375 | VSDVSKHADRI | 2 | Mus musculus, Rattus norvegicus | K375 | VSDVNKHADRI | 1 | Homo sapiens | K375 | TTNTELLEEPI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L269 | CGTGILSMFAA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L269 | CGTGILSMFCA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L407 | AVVEVVDHKTL | 2 | Mus musculus, Rattus norvegicus | L407 | AVVEVLDPKTL | 1 | Homo sapiens | L407 | VSVQVVPQTYV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L486 | KQTVFLL-EKP | 2 | Homo sapiens, Mus musculus | L486 | KQCVLLLRNRP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L486 | KQTIFLL-EKP | 1 | Rattus norvegicus | M233 | GIHEEMLKDKV | 2 | Mus musculus, Rattus norvegicus | M233 | GIHEEMLKDKI | 1 | Homo sapiens | M233 | DIHFLMLNDSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M340 | LLFESMLDSVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M340 | LTFESMIDSVL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q286 | VIAVDQSEILY | 2 | Mus musculus, Rattus norvegicus | Q286 | VLGVDQSEILY | 1 | Homo sapiens | Q286 | VYAVDNSDIIQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R239 | LKDKVRTESYR | 2 | Mus musculus, Rattus norvegicus | R239 | LKDKIRTESYR | 1 | Homo sapiens | R239 | LNDSVRTEGYR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R379 | SKHADRIAFWD | 2 | Mus musculus, Rattus norvegicus | R379 | NKHADRIAFWD | 1 | Homo sapiens | R379 | ELLEEPIDFWS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S287 | IAVDQSEILYQ | 2 | Mus musculus, Rattus norvegicus | S287 | LGVDQSEILYQ | 1 | Homo sapiens | S287 | YAVDNSDIIQM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S343 | ESMLDSVLYAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S343 | ESMIDSVLVAR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T449 | KTAMCTAVAGY | 2 | Mus musculus, Rattus norvegicus | T449 | RTSMCTAIAGY | 1 | Homo sapiens | T449 | NEGPLCAFTLW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V370 | ISLVAVSDVSK | 2 | Mus musculus, Rattus norvegicus | V370 | ISLVAVSDVNK | 1 | Homo sapiens | V370 | LVLTATTNTEL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V403 | VIPEAVVEVVD | 2 | Mus musculus, Rattus norvegicus | V403 | VIPEAVVEVLD | 1 | Homo sapiens | V403 | SYKGVSVQVVP | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y224 | VYFSSYGHYGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y224 | YYFESYAGNDI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |