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mutLBSgeneDB |
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| Gene summary for CALCRL |
 Gene summary |
| Basic gene Info. | Gene symbol | CALCRL |
| Gene name | calcitonin receptor-like | |
| Synonyms | CGRPR|CRLR | |
| Cytomap | UCSC genome browser: 2q32.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001271751.1, NM_005795.5, | |
| Description | CGRP type 1 receptorcalcitonin gene-related peptide type 1 receptorcalcitonin receptor-like receptor | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 114190 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000064989 | ||
| HPRD : 11809 | ||
| Vega : OTTHUMG00000132636 | ||
| Protein | UniProt: Q16602 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CALCRL | |
| BioGPS: 10203 | ||
| Pathway | NCI Pathway Interaction Database: CALCRL | |
| KEGG: CALCRL | ||
| REACTOME: CALCRL | ||
| Pathway Commons: CALCRL | ||
| Context | iHOP: CALCRL | |
| ligand binding site mutation search in PubMed: CALCRL | ||
| UCL Cancer Institute: CALCRL | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001525 | angiogenesis | 20596610 | GO:0006171 | cAMP biosynthetic process | 20074556 | GO:0006816 | calcium ion transport | 10882736 | GO:0015031 | protein transport | 9620797 | GO:0030819 | positive regulation of cAMP biosynthetic process | 10882736 | GO:0031623 | receptor internalization | 20074556 | GO:0071329 | cellular response to sucrose stimulus | 10882736 |
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| Ligand binding site mutations for CALCRL |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Q86 | Q86K | LUAD | 1 | S117 | S117C | LUAD | 1 | E47 | Y46F | LUAD | 1 | Q59 | A60P | LUSC | 1 | D94 | D94N | SKCM | 1 | N76 | V78A | STAD | 1 | T122 | T122I | UCEC | 1 | N76 | D77N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CALCRL |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | N76 | V78A | -1.0882628 | Q86 | Q86K | -1.0627696 | E47 | Y46F | -0.83282827 | N76 | D77N | -0.81363589 | S117 | S117C | -0.76329811 | D94 | D94N | -0.70128541 | Q59 | A60P | -0.54392626 | T122 | T122I | -0.50117396 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CALCRL from PDB |
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| Differential gene expression and gene-gene network for CALCRL |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CALCRL |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CALCRL |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CALCRL go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 3N6 | OLCEGEPANT | 3n7r | A | D94 T122 | 3N6 | OLCEGEPANT | 3n7s | A | D94 T122 | 3N7 | N~4~-(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)-N~2~-1H-INDAZOL-5-YL-6-METHYLPYRIMIDINE-2,4-DIAMINE | 3n7s | B | E47 N76 Q86 | N7R | N-[(3R,6S)-6-(2,3-DIFLUOROPHENYL)-2-OXO-1-(2,2,2-TRIFLUOROETHYL)AZEPAN-3-YL]-4-(2-OXO-2,3-DIHYDRO-1H-IMIDAZO[4,5-B]PYRIDIN-1-YL)PIPERIDINE-1-CARBOXAMIDE | 3n7r | B | T122 |
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| Conservation information for LBS of CALCRL |
| Multiple alignments for Q16602 in multiple species |
| LBS | AA sequence | # species | Species | A116 | WFRHPDSNRTW | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | A116 | WFRHPASNRTW | 2 | Homo sapiens, Bos taurus | A116 | WFLHPESNRTW | 1 | Danio rerio | A44 | NKIMTAQYECY | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | A44 | NKIVTAQFECY | 1 | Danio rerio | C48 | TAQYECYQKIM | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | C48 | TAQFECYQKIM | 1 | Danio rerio | C74 | WDGWLCWNDVA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | C74 | WDGWLCWDDTE | 1 | Danio rerio | C74 | WDGWLCWGDVS | 1 | Xenopus tropicalis | D70 | CNRTWDGWLCW | 6 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | D90 | MQYCPDYFQDF | 2 | Mus musculus, Rattus norvegicus | D90 | MQLCPDYFQDF | 1 | Homo sapiens | D90 | EQHCPDYFQDF | 1 | Danio rerio | D90 | EQRCPDYFQDF | 1 | Xenopus tropicalis | D90 | MQHCPDYFQDF | 1 | Bos taurus | D94 | PDYFQDFDPSE | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | D94 | PDYFQDFDPTE | 1 | Danio rerio | E47 | MTAQYECYQKI | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | E47 | VTAQFECYQKI | 1 | Danio rerio | F92 | HCPDYFQDFDP | 2 | Danio rerio, Bos taurus | F92 | YCPDYFQDFDP | 2 | Mus musculus, Rattus norvegicus | F92 | LCPDYFQDFDP | 1 | Homo sapiens | F92 | RCPDYFQDFDP | 1 | Xenopus tropicalis | F95 | DYFQDFDPSEK | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | F95 | DYFQDFDPTEM | 1 | Danio rerio | G71 | NRTWDGWLCWN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G71 | NRTWDGWLCWD | 1 | Danio rerio | G71 | NRTWDGWLCWG | 1 | Xenopus tropicalis | H114 | GNWFRHPASNR | 2 | Homo sapiens, Bos taurus | H114 | GHWFRHPDSNR | 2 | Xenopus tropicalis, Mus musculus | H114 | GQWFLHPESNR | 1 | Danio rerio | H114 | GNWFRHPDSNR | 1 | Rattus norvegicus | I41 | VTRNKIMTAQY | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | I41 | VTRNKIVTAQF | 1 | Danio rerio | K51 | YECYQKIMQDP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K51 | FECYQKIMKDN | 1 | Danio rerio | K51 | YECYQKIMQEP | 1 | Xenopus tropicalis | M42 | TRNKIMTAQYE | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | M42 | TRNKIVTAQFE | 1 | Danio rerio | M85 | AGTESMQYCPD | 2 | Mus musculus, Rattus norvegicus | M85 | AGTESMQLCPD | 1 | Homo sapiens | M85 | AGITSEQHCPD | 1 | Danio rerio | M85 | AGVISEQRCPD | 1 | Xenopus tropicalis | M85 | AGTESMQHCPD | 1 | Bos taurus | N128 | NYTQCNVNTHE | 2 | Homo sapiens, Bos taurus | N128 | NYTLCNNSTHE | 2 | Mus musculus, Rattus norvegicus | N128 | NFTRCNLHTTE | 1 | Danio rerio | N128 | NYTRCNTFTHE | 1 | Xenopus tropicalis | N66 | EGLYCNRTWDG | 2 | Mus musculus, Rattus norvegicus | N66 | EGVYCNRTWDG | 1 | Homo sapiens | N66 | RGPVCNRTWDG | 1 | Danio rerio | N66 | EGHFCNRTWDG | 1 | Xenopus tropicalis | N66 | EGIYCNRTWDG | 1 | Bos taurus | N76 | GWLCWNDVAAG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | N76 | GWLCWDDTEAG | 1 | Danio rerio | N76 | GWLCWGDVSAG | 1 | Xenopus tropicalis | Q59 | QDPIQQAEGVY | 1 | Homo sapiens | Q59 | KDNSQDRRGPV | 1 | Danio rerio | Q59 | QEPANGKEGHF | 1 | Xenopus tropicalis | Q59 | QDPIQQAEGLY | 1 | Mus musculus | Q59 | QDPIQQGEGLY | 1 | Rattus norvegicus | Q59 | QDPVQQTEGIY | 1 | Bos taurus | Q86 | GTESMQYCPDY | 2 | Mus musculus, Rattus norvegicus | Q86 | GTESMQLCPDY | 1 | Homo sapiens | Q86 | GITSEQHCPDY | 1 | Danio rerio | Q86 | GVISEQRCPDY | 1 | Xenopus tropicalis | Q86 | GTESMQHCPDY | 1 | Bos taurus | Q93 | CPDYFQDFDPS | 5 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | Q93 | CPDYFQDFDPT | 1 | Danio rerio | R119 | HPDSNRTWTNY | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | R119 | HPASNRTWTNY | 2 | Homo sapiens, Bos taurus | R119 | HPESNRTWTNF | 1 | Danio rerio | R38 | QLGVTRNKIMT | 2 | Homo sapiens, Bos taurus | R38 | DLGVTRNKIMT | 2 | Mus musculus, Rattus norvegicus | R38 | DIGVTRNKIVT | 1 | Danio rerio | R38 | QVGVTRNKIMT | 1 | Xenopus tropicalis | S117 | FRHPDSNRTWT | 3 | Xenopus tropicalis, Mus musculus, Rattus norvegicus | S117 | FRHPASNRTWT | 2 | Homo sapiens, Bos taurus | S117 | FLHPESNRTWT | 1 | Danio rerio | S84 | AAGTESMQYCP | 2 | Mus musculus, Rattus norvegicus | S84 | AAGTESMQLCP | 1 | Homo sapiens | S84 | EAGITSEQHCP | 1 | Danio rerio | S84 | SAGVISEQRCP | 1 | Xenopus tropicalis | S84 | AAGTESMQHCP | 1 | Bos taurus | T122 | SNRTWTNYTQC | 2 | Homo sapiens, Bos taurus | T122 | SNRTWTNYTLC | 2 | Mus musculus, Rattus norvegicus | T122 | SNRTWTNFTRC | 1 | Danio rerio | T122 | SNRTWTNYTRC | 1 | Xenopus tropicalis | T125 | TWTNYTQCNVN | 2 | Homo sapiens, Bos taurus | T125 | TWTNYTLCNNS | 2 | Mus musculus, Rattus norvegicus | T125 | TWTNFTRCNLH | 1 | Danio rerio | T125 | TWTNYTRCNTF | 1 | Xenopus tropicalis | T37 | -QLGVTRNKIM | 2 | Homo sapiens, Bos taurus | T37 | -DLGVTRNKIM | 2 | Mus musculus, Rattus norvegicus | T37 | HDIGVTRNKIV | 1 | Danio rerio | T37 | IQVGVTRNKIM | 1 | Xenopus tropicalis | V36 | I-QLGVTRNKI | 2 | Homo sapiens, Bos taurus | V36 | --DLGVTRNKI | 2 | Mus musculus, Rattus norvegicus | V36 | YHDIGVTRNKI | 1 | Danio rerio | V36 | IIQVGVTRNKI | 1 | Xenopus tropicalis | W121 | ASNRTWTNYTQ | 2 | Homo sapiens, Bos taurus | W121 | DSNRTWTNYTL | 2 | Mus musculus, Rattus norvegicus | W121 | ESNRTWTNFTR | 1 | Danio rerio | W121 | DSNRTWTNYTR | 1 | Xenopus tropicalis | W72 | RTWDGWLCWND | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | W72 | RTWDGWLCWDD | 1 | Danio rerio | W72 | RTWDGWLCWGD | 1 | Xenopus tropicalis | W75 | DGWLCWNDVAA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | W75 | DGWLCWDDTEA | 1 | Danio rerio | W75 | DGWLCWGDVSA | 1 | Xenopus tropicalis | Y124 | RTWTNYTQCNV | 2 | Homo sapiens, Bos taurus | Y124 | RTWTNYTLCNN | 2 | Mus musculus, Rattus norvegicus | Y124 | RTWTNFTRCNL | 1 | Danio rerio | Y124 | RTWTNYTRCNT | 1 | Xenopus tropicalis | Y91 | QHCPDYFQDFD | 2 | Danio rerio, Bos taurus | Y91 | QYCPDYFQDFD | 2 | Mus musculus, Rattus norvegicus | Y91 | QLCPDYFQDFD | 1 | Homo sapiens | Y91 | QRCPDYFQDFD | 1 | Xenopus tropicalis |
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