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mutLBSgeneDB |
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| Gene summary for STX6 |
 Gene summary |
| Basic gene Info. | Gene symbol | STX6 |
| Gene name | syntaxin 6 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001286210.1, NM_005819.5, | |
| Description | syntaxin-6 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603944 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135823 | ||
| HPRD : 07231 | ||
| Vega : OTTHUMG00000035179 | ||
| Protein | UniProt: O43752 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STX6 | |
| BioGPS: 10228 | ||
| Pathway | NCI Pathway Interaction Database: STX6 | |
| KEGG: STX6 | ||
| REACTOME: STX6 | ||
| Pathway Commons: STX6 | ||
| Context | iHOP: STX6 | |
| ligand binding site mutation search in PubMed: STX6 | ||
| UCL Cancer Institute: STX6 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for STX6 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V71 | E72K | BRCA | 1 | I70 | S69N | COAD | 1 | F78 | F78L | GBM | 1 | D63 | E62K | SKCM | 1 | T67 | T67I | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STX6 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T67 | T67I | -1.0251522 | I70 | S69N | -0.99611617 | D63 | E62K | -0.87000616 | V71 | E72K | -0.76427329 | F78 | F78L | -0.48084915 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STX6 from PDB |
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| Differential gene expression and gene-gene network for STX6 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STX6 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0038868 | Supranuclear Palsy, Progressive | 2 | Biomarker, GeneticVariation |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STX6 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STX6 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ALA,HIS,GLY,MET,LEU,LYS,LEU,TYR,TYR,GLY,LEU,SER) | 4j2c | A | D63 T67 I70 V71 F78 | III | Peptide ligand (ALA,HIS,GLY,MET,LEU,LYS,LEU,TYR,TYR,GLY,LEU,SER) | 4j2c | C | D63 T67 I70 V71 F78 |
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| Conservation information for LBS of STX6 |
| Multiple alignments for O43752 in multiple species |
| LBS | AA sequence | # species | Species | D5 | -MSMEDPFFVV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D5 | ---MEDPFYEV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D5 | MSSAQDPFYIV | 1 | Arabidopsis thaliana | D63 | EWDLEDLDETI | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | D63 | -----DLKAAV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | D63 | EWQVDELEKAI | 1 | Arabidopsis thaliana | E13 | FVVKGEVQKAV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E13 | YEVKADASNQM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E13 | YIVKEEIQDSI | 1 | Arabidopsis thaliana | E4 | 6 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Gallus gallus, Mus musculus, Rattus norvegicus | E66 | LEDLDETISIV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | E66 | --DLKAAVEIA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E66 | VDELEKAITVA | 1 | Arabidopsis thaliana | F7 | SMEDPFFVVKG | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | F7 | -MEDPFYEVKA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F7 | SAQDPFYIVKE | 1 | Arabidopsis thaliana | F78 | ANPRKFNLDAT | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | F78 | KNSEHFGLDEE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F78 | KDPSWYGIDEA | 1 | Arabidopsis thaliana | I70 | DETISIVEANP | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | I70 | KAAVEIAMKNS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I70 | EKAITVAAKDP | 1 | Arabidopsis thaliana | L64 | WDLEDLDETIS | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | L64 | ----DLKAAVE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L64 | WQVDELEKAIT | 1 | Arabidopsis thaliana | M3 | 6 | Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Gallus gallus, Mus musculus, Rattus norvegicus | P6 | MSMEDPFFVVK | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | P6 | --MEDPFYEVK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P6 | SSAQDPFYIVK | 1 | Arabidopsis thaliana | R88 | TELSIRKAFIT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R88 | EELKSRRRFVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R88 | AELEKRRRWTS | 1 | Arabidopsis thaliana | R88 | TELGIRKSFIT | 1 | Gallus gallus | T67 | EDLDETISIVE | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | T67 | -DLKAAVEIAM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T67 | DELEKAITVAA | 1 | Arabidopsis thaliana | V10 | DPFFVVKGEVQ | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | V10 | DPFYEVKADAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V10 | DPFYIVKEEIQ | 1 | Arabidopsis thaliana | V71 | ETISIVEANPR | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | V71 | AAVEIAMKNSE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V71 | KAITVAAKDPS | 1 | Arabidopsis thaliana | V9 | EDPFFVVKGEV | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | V9 | EDPFYEVKADA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V9 | QDPFYIVKEEI | 1 | Arabidopsis thaliana | W59 | LRSIEWDLEDL | 4 | Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus | W59 | LK-------DL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W59 | CGSIEWQVDEL | 1 | Arabidopsis thaliana |
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