mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for STX6
Gene summary
Basic gene Info.Gene symbolSTX6
Gene namesyntaxin 6
Synonyms-
CytomapUCSC genome browser: 1q25.3
Type of geneprotein-coding
RefGenesNM_001286210.1,
NM_005819.5,
Descriptionsyntaxin-6
Modification date20141207
dbXrefs MIM : 603944
HGNC : HGNC
Ensembl : ENSG00000135823
HPRD : 07231
Vega : OTTHUMG00000035179
ProteinUniProt: O43752
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_STX6
BioGPS: 10228
PathwayNCI Pathway Interaction Database: STX6
KEGG: STX6
REACTOME: STX6
Pathway Commons: STX6
ContextiHOP: STX6
ligand binding site mutation search in PubMed: STX6
UCL Cancer Institute: STX6
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for STX6
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V71E72KBRCA1
I70S69NCOAD1
F78F78LGBM1
D63E62KSKCM1
T67T67ISTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for STX6
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T67T67I-1.0251522
I70S69N-0.99611617
D63E62K-0.87000616
V71E72K-0.76427329
F78F78L-0.48084915
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for STX6 from PDB

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Differential gene expression and gene-gene network for STX6
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of STX6 and the right PPI network was created from samples without mutations in the LBS of STX6. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for STX6
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0038868Supranuclear Palsy, Progressive2Biomarker, GeneticVariation
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for STX6
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of STX6 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ALA,HIS,GLY,MET,LEU,LYS,LEU,TYR,TYR,GLY,LEU,SER)4j2cAD63 T67 I70 V71 F78
IIIPeptide ligand (ALA,HIS,GLY,MET,LEU,LYS,LEU,TYR,TYR,GLY,LEU,SER)4j2cCD63 T67 I70 V71 F78


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Conservation information for LBS of STX6
Multiple alignments for O43752 in multiple species
LBSAA sequence# speciesSpecies
D5-MSMEDPFFVV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D5---MEDPFYEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D5MSSAQDPFYIV1Arabidopsis thaliana
D63EWDLEDLDETI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D63-----DLKAAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D63EWQVDELEKAI1Arabidopsis thaliana
E13FVVKGEVQKAV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E13YEVKADASNQM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E13YIVKEEIQDSI1Arabidopsis thaliana
E46Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Gallus gallus, Mus musculus, Rattus norvegicus
E66LEDLDETISIV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E66--DLKAAVEIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E66VDELEKAITVA1Arabidopsis thaliana
F7SMEDPFFVVKG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F7-MEDPFYEVKA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F7SAQDPFYIVKE1Arabidopsis thaliana
F78ANPRKFNLDAT4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F78KNSEHFGLDEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F78KDPSWYGIDEA1Arabidopsis thaliana
I70DETISIVEANP4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I70KAAVEIAMKNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I70EKAITVAAKDP1Arabidopsis thaliana
L64WDLEDLDETIS4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L64----DLKAAVE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L64WQVDELEKAIT1Arabidopsis thaliana
M36Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Gallus gallus, Mus musculus, Rattus norvegicus
P6MSMEDPFFVVK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
P6--MEDPFYEVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P6SSAQDPFYIVK1Arabidopsis thaliana
R88TELSIRKAFIT3Homo sapiens, Mus musculus, Rattus norvegicus
R88EELKSRRRFVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R88AELEKRRRWTS1Arabidopsis thaliana
R88TELGIRKSFIT1Gallus gallus
T67EDLDETISIVE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
T67-DLKAAVEIAM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T67DELEKAITVAA1Arabidopsis thaliana
V10DPFFVVKGEVQ4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V10DPFYEVKADAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V10DPFYIVKEEIQ1Arabidopsis thaliana
V71ETISIVEANPR4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V71AAVEIAMKNSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V71KAITVAAKDPS1Arabidopsis thaliana
V9EDPFFVVKGEV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V9EDPFYEVKADA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V9QDPFYIVKEEI1Arabidopsis thaliana
W59LRSIEWDLEDL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W59LK-------DL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W59CGSIEWQVDEL1Arabidopsis thaliana


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