mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 102466747
Gene summary
Basic gene Info.Gene symbol102466747
Gene name
CytomapUCSC genome browser:
Type of gene
Modification date
ProteinUniProt: Q9UKJ0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_102466747
BioGPS: 102466747
PathwayNCI Pathway Interaction Database: 102466747
KEGG: 102466747
REACTOME: 102466747
Pathway Commons: 102466747
ContextiHOP: 102466747
ligand binding site mutation search in PubMed: 102466747
UCL Cancer Institute: 102466747
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for 102466747

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for 102466747
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 102466747 from PDB

Differential gene expression and gene-gene network for 102466747
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 102466747 and the right PPI network was created from samples without mutations in the LBS of 102466747. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for 102466747
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for 102466747
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 102466747 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of 102466747
Multiple alignments for Q9UKJ0 in multiple species
LBSAA sequence# speciesSpecies
I142QQLQSIKGTKL1Homo sapiens
I142KFWQSLPGTQL1Mus musculus
I142KLWQSIPGTQL1Mus musculus
Q140GRQQLQSIKGT1Homo sapiens
Q140GIKFWQSLPGT1Mus musculus
Q140GMKLWQSIPGT1Mus musculus
R126SVYFCRVELDT1Homo sapiens
R126TWYFCRVFLQT1Mus musculus
R126AQYFSRVNLQS1Mus musculus
W59SFYFPWKLAKD2Mus musculus, Mus musculus
W59SFYYPWELAIV1Homo sapiens
Y33GPSYLYGVTQP1Homo sapiens
Y33NGGNDFGVNQP1Mus musculus
Y33NRKNGFGVNQP1Mus musculus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas