mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HRSP12
Gene summary
Basic gene Info.Gene symbolHRSP12
Gene nameheat-responsive protein 12
SynonymsP14.5|PSP|UK114
CytomapUCSC genome browser: 8q22
Type of geneprotein-coding
RefGenesNM_005836.2,
Description14.5 kDa translational inhibitor proteinUK114 antigen homologperchloric acid-soluble proteinribonuclease UK114translational inhibitor p14.5translational inhibitor protein p14.5
Modification date20141207
dbXrefs MIM : 602487
HGNC : HGNC
Ensembl : ENSG00000132541
HPRD : 03924
Vega : OTTHUMG00000164670
ProteinUniProt: P52758
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HRSP12
BioGPS: 10247
PathwayNCI Pathway Interaction Database: HRSP12
KEGG: HRSP12
REACTOME: HRSP12
Pathway Commons: HRSP12
ContextiHOP: HRSP12
ligand binding site mutation search in PubMed: HRSP12
UCL Cancer Institute: HRSP12
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for HRSP12

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E122R120QCOAD4
Y21P20LCOAD1
G35,I37Q36HLUAD1
I37G38CSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HRSP12
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I37Q36H-1.0741231
G35Q36H-1.0741231
E122R120Q-0.78337706
I37G38C-0.61477874
Y21P20L-0.53343588
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HRSP12 from PDB
PDB IDPDB titlePDB structure
1ONICrystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family

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Differential gene expression and gene-gene network for HRSP12
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HRSP12 and the right PPI network was created from samples without mutations in the LBS of HRSP12. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HRSP12
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HRSP12

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB03793Benzoic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HRSP12 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
BEZBENZOIC ACID1oniIG35 I37
BEZBENZOIC ACID1oniHG35 I37 E122
BEZBENZOIC ACID1oniBY21 G35 E122
BEZBENZOIC ACID1oniEY21 G35 E122
BEZBENZOIC ACID1oniAY21 G35 I37
BEZBENZOIC ACID1oniDY21 G35 I37
BEZBENZOIC ACID1oniCY21 G35 I37 E122
BEZBENZOIC ACID1oniFY21 G35 I37 E122
BEZBENZOIC ACID1oniGY21 G35 I37 E122


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Conservation information for LBS of HRSP12
Multiple alignments for P52758 in multiple species
LBSAA sequence# speciesSpecies
A109FPARAAYQVAA2Homo sapiens, Bos taurus
A109LPARAAYQVAA2Mus musculus, Rattus norvegicus
A109KPARSCVAVAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A109SPARSTYQVAA1Arabidopsis thaliana
A109YPARAAYQVAA1Caenorhabditis elegans
E122KGSRIEIEAVA1Homo sapiens
E122LGVDMEMEAIA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E122LNAKIEIECIA1Arabidopsis thaliana
E122KGGLVEIEAVA1Caenorhabditis elegans
E122KGGRVEIEAIA1Bos taurus
E122RGSRVEIEAIA1Mus musculus
E122KGSRIEIEAIA1Rattus norvegicus
F89ADINDFNTVNE1Homo sapiens
F89ADINHFAEFNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F89ADLADFKTVNE1Arabidopsis thaliana
F89QNIADFAAVNE1Caenorhabditis elegans
F89ADINDFSTVND1Bos taurus
F89ADMNDFGTVNE1Mus musculus
F89ADINDFGTVNE1Rattus norvegicus
G35TIYISGQIGMD1Homo sapiens
G35LIFLSGQIPVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G35LVFLSGVLGLI1Arabidopsis thaliana
G35TIYLSGSLGLD1Caenorhabditis elegans
G35TIYISGQLGMD1Bos taurus
G35TIYISGQVGLD1Mus musculus
G35TIYVSGQIGMD1Rattus norvegicus
I18KAPAAIGPYSQ2Bos taurus, Mus musculus
I18KAPGAIGPYSQ1Homo sapiens
I18-APAAAASYSH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I18KAPAALGPYSQ1Arabidopsis thaliana
I18NAPGAIGPYSQ1Caenorhabditis elegans
I18KAPAAIGAYSQ1Rattus norvegicus
I37YISGQIGMDPS1Homo sapiens
I37FLSGQIPVTPD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I37FLSGVLGLIPE1Arabidopsis thaliana
I37YLSGSLGLDPK1Caenorhabditis elegans
I37YISGQLGMDPA1Bos taurus
I37YISGQVGLDPS1Mus musculus
I37YVSGQIGMDPS1Rattus norvegicus
I86VLLADINDFNT1Homo sapiens
I86IFLADINHFAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I86IMLADLADFKT1Arabidopsis thaliana
I86VLLQNIADFAA1Caenorhabditis elegans
I86VLLADINDFST1Bos taurus
I86VLLADMNDFGT1Mus musculus
I86VLLADINDFGT1Rattus norvegicus
L83KTTVLLADIND2Homo sapiens, Rattus norvegicus
L83KVNIFLADINH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L83KTTIMLADLAD1Arabidopsis thaliana
L83KTTVLLQNIAD1Caenorhabditis elegans
L83KATVLLADIND1Bos taurus
L83KTTVLLADMND1Mus musculus
N90DINDFNTVNEI1Homo sapiens
N90DINHFAEFNSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N90DLADFKTVNEI1Arabidopsis thaliana
N90NIADFAAVNEV1Caenorhabditis elegans
N90DINDFSTVNDV1Bos taurus
N90DMNDFGTVNEI1Mus musculus
N90DINDFGTVNEI1Rattus norvegicus
N93DFGTVNEIYKT2Mus musculus, Rattus norvegicus
N93DFNTVNEIYKQ1Homo sapiens
N93HFAEFNSVYAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N93DFKTVNEIYAK1Arabidopsis thaliana
N93DFAAVNEVYGQ1Caenorhabditis elegans
N93DFSTVNDVYKQ1Bos taurus
P116QVAALPKGSRI2Homo sapiens, Rattus norvegicus
P116AVAALPLGVDM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P116QVAALPLNAKI1Arabidopsis thaliana
P116QVAALPKGGLV1Caenorhabditis elegans
P116QVAALPKGGRV1Bos taurus
P116QVAALPRGSRV1Mus musculus
R107SNFPARAAYQV1Homo sapiens
R107THKPARSCVAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R107APSPARSTYQV1Arabidopsis thaliana
R107SPYPARAAYQV1Caenorhabditis elegans
R107SSFPARAAYQV1Bos taurus
R107GSLPARAAYQV1Mus musculus
R107GNLPARAAYQV1Rattus norvegicus
Y21GAIGPYSQAVL1Homo sapiens
Y21AAAASYSHAMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y21AALGPYSQAIK1Arabidopsis thaliana
Y21GAIGPYSQAVR1Caenorhabditis elegans
Y21AAIGPYSQAVL1Bos taurus
Y21AAIGPYSQAVQ1Mus musculus
Y21AAIGAYSQAVL1Rattus norvegicus


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