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mutLBSgeneDB |
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| Gene summary for HRSP12 |
 Gene summary |
| Basic gene Info. | Gene symbol | HRSP12 |
| Gene name | heat-responsive protein 12 | |
| Synonyms | P14.5|PSP|UK114 | |
| Cytomap | UCSC genome browser: 8q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005836.2, | |
| Description | 14.5 kDa translational inhibitor proteinUK114 antigen homologperchloric acid-soluble proteinribonuclease UK114translational inhibitor p14.5translational inhibitor protein p14.5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602487 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132541 | ||
| HPRD : 03924 | ||
| Vega : OTTHUMG00000164670 | ||
| Protein | UniProt: P52758 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HRSP12 | |
| BioGPS: 10247 | ||
| Pathway | NCI Pathway Interaction Database: HRSP12 | |
| KEGG: HRSP12 | ||
| REACTOME: HRSP12 | ||
| Pathway Commons: HRSP12 | ||
| Context | iHOP: HRSP12 | |
| ligand binding site mutation search in PubMed: HRSP12 | ||
| UCL Cancer Institute: HRSP12 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for HRSP12 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E122 | R120Q | COAD | 4 | Y21 | P20L | COAD | 1 | G35,I37 | Q36H | LUAD | 1 | I37 | G38C | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HRSP12 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I37 | Q36H | -1.0741231 | G35 | Q36H | -1.0741231 | E122 | R120Q | -0.78337706 | I37 | G38C | -0.61477874 | Y21 | P20L | -0.53343588 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HRSP12 from PDB |
| PDB ID | PDB title | PDB structure | 1ONI | Crystal structure of a human p14.5, a translational inhibitor reveals different mode of ligand binding near the invariant residues of the Yjgf/UK114 protein family |  |
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| Differential gene expression and gene-gene network for HRSP12 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HRSP12 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HRSP12 |
| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB03793 | Benzoic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HRSP12 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | BEZ | BENZOIC ACID | 1oni | I | G35 I37 | BEZ | BENZOIC ACID | 1oni | H | G35 I37 E122 | BEZ | BENZOIC ACID | 1oni | B | Y21 G35 E122 | BEZ | BENZOIC ACID | 1oni | E | Y21 G35 E122 | BEZ | BENZOIC ACID | 1oni | A | Y21 G35 I37 | BEZ | BENZOIC ACID | 1oni | D | Y21 G35 I37 | BEZ | BENZOIC ACID | 1oni | C | Y21 G35 I37 E122 | BEZ | BENZOIC ACID | 1oni | F | Y21 G35 I37 E122 | BEZ | BENZOIC ACID | 1oni | G | Y21 G35 I37 E122 |
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| Conservation information for LBS of HRSP12 |
| Multiple alignments for P52758 in multiple species |
| LBS | AA sequence | # species | Species | A109 | FPARAAYQVAA | 2 | Homo sapiens, Bos taurus | A109 | LPARAAYQVAA | 2 | Mus musculus, Rattus norvegicus | A109 | KPARSCVAVAA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A109 | SPARSTYQVAA | 1 | Arabidopsis thaliana | A109 | YPARAAYQVAA | 1 | Caenorhabditis elegans | E122 | KGSRIEIEAVA | 1 | Homo sapiens | E122 | LGVDMEMEAIA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E122 | LNAKIEIECIA | 1 | Arabidopsis thaliana | E122 | KGGLVEIEAVA | 1 | Caenorhabditis elegans | E122 | KGGRVEIEAIA | 1 | Bos taurus | E122 | RGSRVEIEAIA | 1 | Mus musculus | E122 | KGSRIEIEAIA | 1 | Rattus norvegicus | F89 | ADINDFNTVNE | 1 | Homo sapiens | F89 | ADINHFAEFNS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F89 | ADLADFKTVNE | 1 | Arabidopsis thaliana | F89 | QNIADFAAVNE | 1 | Caenorhabditis elegans | F89 | ADINDFSTVND | 1 | Bos taurus | F89 | ADMNDFGTVNE | 1 | Mus musculus | F89 | ADINDFGTVNE | 1 | Rattus norvegicus | G35 | TIYISGQIGMD | 1 | Homo sapiens | G35 | LIFLSGQIPVT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G35 | LVFLSGVLGLI | 1 | Arabidopsis thaliana | G35 | TIYLSGSLGLD | 1 | Caenorhabditis elegans | G35 | TIYISGQLGMD | 1 | Bos taurus | G35 | TIYISGQVGLD | 1 | Mus musculus | G35 | TIYVSGQIGMD | 1 | Rattus norvegicus | I18 | KAPAAIGPYSQ | 2 | Bos taurus, Mus musculus | I18 | KAPGAIGPYSQ | 1 | Homo sapiens | I18 | -APAAAASYSH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I18 | KAPAALGPYSQ | 1 | Arabidopsis thaliana | I18 | NAPGAIGPYSQ | 1 | Caenorhabditis elegans | I18 | KAPAAIGAYSQ | 1 | Rattus norvegicus | I37 | YISGQIGMDPS | 1 | Homo sapiens | I37 | FLSGQIPVTPD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I37 | FLSGVLGLIPE | 1 | Arabidopsis thaliana | I37 | YLSGSLGLDPK | 1 | Caenorhabditis elegans | I37 | YISGQLGMDPA | 1 | Bos taurus | I37 | YISGQVGLDPS | 1 | Mus musculus | I37 | YVSGQIGMDPS | 1 | Rattus norvegicus | I86 | VLLADINDFNT | 1 | Homo sapiens | I86 | IFLADINHFAE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I86 | IMLADLADFKT | 1 | Arabidopsis thaliana | I86 | VLLQNIADFAA | 1 | Caenorhabditis elegans | I86 | VLLADINDFST | 1 | Bos taurus | I86 | VLLADMNDFGT | 1 | Mus musculus | I86 | VLLADINDFGT | 1 | Rattus norvegicus | L83 | KTTVLLADIND | 2 | Homo sapiens, Rattus norvegicus | L83 | KVNIFLADINH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L83 | KTTIMLADLAD | 1 | Arabidopsis thaliana | L83 | KTTVLLQNIAD | 1 | Caenorhabditis elegans | L83 | KATVLLADIND | 1 | Bos taurus | L83 | KTTVLLADMND | 1 | Mus musculus | N90 | DINDFNTVNEI | 1 | Homo sapiens | N90 | DINHFAEFNSV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N90 | DLADFKTVNEI | 1 | Arabidopsis thaliana | N90 | NIADFAAVNEV | 1 | Caenorhabditis elegans | N90 | DINDFSTVNDV | 1 | Bos taurus | N90 | DMNDFGTVNEI | 1 | Mus musculus | N90 | DINDFGTVNEI | 1 | Rattus norvegicus | N93 | DFGTVNEIYKT | 2 | Mus musculus, Rattus norvegicus | N93 | DFNTVNEIYKQ | 1 | Homo sapiens | N93 | HFAEFNSVYAK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N93 | DFKTVNEIYAK | 1 | Arabidopsis thaliana | N93 | DFAAVNEVYGQ | 1 | Caenorhabditis elegans | N93 | DFSTVNDVYKQ | 1 | Bos taurus | P116 | QVAALPKGSRI | 2 | Homo sapiens, Rattus norvegicus | P116 | AVAALPLGVDM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P116 | QVAALPLNAKI | 1 | Arabidopsis thaliana | P116 | QVAALPKGGLV | 1 | Caenorhabditis elegans | P116 | QVAALPKGGRV | 1 | Bos taurus | P116 | QVAALPRGSRV | 1 | Mus musculus | R107 | SNFPARAAYQV | 1 | Homo sapiens | R107 | THKPARSCVAV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R107 | APSPARSTYQV | 1 | Arabidopsis thaliana | R107 | SPYPARAAYQV | 1 | Caenorhabditis elegans | R107 | SSFPARAAYQV | 1 | Bos taurus | R107 | GSLPARAAYQV | 1 | Mus musculus | R107 | GNLPARAAYQV | 1 | Rattus norvegicus | Y21 | GAIGPYSQAVL | 1 | Homo sapiens | Y21 | AAAASYSHAMK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y21 | AALGPYSQAIK | 1 | Arabidopsis thaliana | Y21 | GAIGPYSQAVR | 1 | Caenorhabditis elegans | Y21 | AAIGPYSQAVL | 1 | Bos taurus | Y21 | AAIGPYSQAVQ | 1 | Mus musculus | Y21 | AAIGAYSQAVL | 1 | Rattus norvegicus |
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