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mutLBSgeneDB |
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| Gene summary for ADARB1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ADARB1 |
| Gene name | adenosine deaminase, RNA-specific, B1 | |
| Synonyms | ADAR2|DRABA2|DRADA2|RED1 | |
| Cytomap | UCSC genome browser: 21q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001033049.1, NM_001112.3,NM_001160230.1,NM_015833.3,NM_015834.3, NR_027672.1,NR_027673.1,NR_027674.1,NR_073200.1, | |
| Description | RED1 homologRNA editaseRNA editing deaminase 1RNA-editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)double-stranded RNA-specific editase 1dsRNA | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601218 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197381 | ||
| HPRD : 06777 | ||
| Vega : OTTHUMG00000090295 | ||
| Protein | UniProt: P78563 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADARB1 | |
| BioGPS: 104 | ||
| Pathway | NCI Pathway Interaction Database: ADARB1 | |
| KEGG: ADARB1 | ||
| REACTOME: ADARB1 | ||
| Pathway Commons: ADARB1 | ||
| Context | iHOP: ADARB1 | |
| ligand binding site mutation search in PubMed: ADARB1 | ||
| UCL Cancer Institute: ADARB1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006382 | adenosine to inosine editing | 18178553 | GO:0006396 | RNA processing | 9149227 | GO:0008285 | negative regulation of cell proliferation | 18178553 | GO:0030336 | negative regulation of cell migration | 18178553 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 21289159 | GO:0051726 | regulation of cell cycle | 18178553 |
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| Ligand binding site mutations for ADARB1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C451 | D453V | COAD | 1 | Y708 | E707D | LUAD | 1 | K730 | K730N | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ADARB1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K730 | K730N | -0.9207551 | Y708 | E707D | -0.57330707 | C451 | D453V | -0.30049928 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ADARB1 from PDB |
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| Differential gene expression and gene-gene network for ADARB1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ADARB1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ADARB1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ADARB1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 1zy7 | A | C451 | ZN | ZINC(2+) | 1zy7 | B | C451 |
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| Conservation information for LBS of ADARB1 |
| Multiple alignments for P78563 in multiple species |
| LBS | AA sequence | # species | Species | C451 | ISTSPCGDARI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C451 | INTAPCGVARI | 1 | Caenorhabditis elegans | C556 | LLTMSCSDKIA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C556 | MRTMSCSDKLL | 1 | Caenorhabditis elegans | E729 | LGAWVEKPTEQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E729 | LGIWQRKPREF | 1 | Caenorhabditis elegans | G570 | VVGIQGSLLSI | 2 | Homo sapiens, Mus musculus | G570 | VLGVQGAILSH | 1 | Caenorhabditis elegans | G570 | VVGIQGALLSI | 1 | Rattus norvegicus | H394 | ALNDCHAEIIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H394 | ALIDCHAEILA | 1 | Caenorhabditis elegans | I397 | DCHAEIISRRS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I397 | DCHAEILARRG | 1 | Caenorhabditis elegans | K523 | GQLRTKIESGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K523 | SRLRFKIDKGM | 1 | Caenorhabditis elegans | K559 | MSCSDKIARWN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K559 | MSCSDKLLRAN | 1 | Caenorhabditis elegans | K669 | PSRLCKHALYC | 2 | Mus musculus, Rattus norvegicus | K669 | ASRLCKHALYC | 1 | Homo sapiens | K669 | PSRLCKKNMAE | 1 | Caenorhabditis elegans | K702 | VYHESKLAAKE | 1 | Homo sapiens | K702 | SYEELKAGSQE | 1 | Caenorhabditis elegans | K702 | TYHESKLAARE | 1 | Mus musculus | K702 | TYHESKLAAKE | 1 | Rattus norvegicus | K712 | EYQAAKARLFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K712 | EYAAAKKSFIT | 1 | Caenorhabditis elegans | K730 | GAWVEKPTEQD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K730 | GIWQRKPREFQ | 1 | Caenorhabditis elegans | N391 | RGLALNDCHAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N391 | DGTALIDCHAE | 1 | Caenorhabditis elegans | R400 | AEIISRRSLLR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R400 | AEILARRGLLR | 1 | Caenorhabditis elegans | R401 | EIISRRSLLRF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R401 | EILARRGLLRF | 1 | Caenorhabditis elegans | R562 | SDKIARWNVVG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R562 | SDKLLRANVLG | 1 | Caenorhabditis elegans | S571 | VGIQGSLLSIF | 2 | Homo sapiens, Mus musculus | S571 | LGVQGAILSHF | 1 | Caenorhabditis elegans | S571 | VGIQGALLSIF | 1 | Rattus norvegicus | T553 | GERLLTMSCSD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T553 | GERMRTMSCSD | 1 | Caenorhabditis elegans | W727 | AGLGAWVEKPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W727 | KDLGIWQRKPR | 1 | Caenorhabditis elegans | Y698 | TKPTTYHESKL | 2 | Mus musculus, Rattus norvegicus | Y698 | TKPNVYHESKL | 1 | Homo sapiens | Y698 | DYPISYEELKA | 1 | Caenorhabditis elegans | Y708 | LAAKEYQAAKA | 2 | Homo sapiens, Rattus norvegicus | Y708 | AGSQEYAAAKK | 1 | Caenorhabditis elegans | Y708 | LAAREYQAAKA | 1 | Mus musculus |
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