mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ADARB1
Gene summary
Basic gene Info.Gene symbolADARB1
Gene nameadenosine deaminase, RNA-specific, B1
CytomapUCSC genome browser: 21q22.3
Type of geneprotein-coding
DescriptionRED1 homologRNA editaseRNA editing deaminase 1RNA-editing deaminase 1RNA-editing enzyme 1adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)adenosine deaminase, RNA-specific, B1 (homolog of rat RED1)double-stranded RNA-specific editase 1dsRNA
Modification date20141207
dbXrefs MIM : 601218
Ensembl : ENSG00000197381
HPRD : 06777
Vega : OTTHUMG00000090295
ProteinUniProt: P78563
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADARB1
BioGPS: 104
PathwayNCI Pathway Interaction Database: ADARB1
Pathway Commons: ADARB1
ContextiHOP: ADARB1
ligand binding site mutation search in PubMed: ADARB1
UCL Cancer Institute: ADARB1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006382adenosine to inosine editing18178553
GO:0006396RNA processing9149227
GO:0008285negative regulation of cell proliferation18178553
GO:0030336negative regulation of cell migration18178553
GO:0044387negative regulation of protein kinase activity by regulation of protein phosphorylation21289159
GO:0051726regulation of cell cycle18178553

Ligand binding site mutations for ADARB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ADARB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ADARB1 from PDB

Differential gene expression and gene-gene network for ADARB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ADARB1 and the right PPI network was created from samples without mutations in the LBS of ADARB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ADARB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0032460Polycystic Ovary Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ADARB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ADARB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ADARB1
Multiple alignments for P78563 in multiple species
LBSAA sequence# speciesSpecies
C451ISTSPCGDARI3Homo sapiens, Mus musculus, Rattus norvegicus
C451INTAPCGVARI1Caenorhabditis elegans
C556LLTMSCSDKIA3Homo sapiens, Mus musculus, Rattus norvegicus
C556MRTMSCSDKLL1Caenorhabditis elegans
E729LGAWVEKPTEQ3Homo sapiens, Mus musculus, Rattus norvegicus
E729LGIWQRKPREF1Caenorhabditis elegans
G570VVGIQGSLLSI2Homo sapiens, Mus musculus
G570VLGVQGAILSH1Caenorhabditis elegans
G570VVGIQGALLSI1Rattus norvegicus
H394ALNDCHAEIIS3Homo sapiens, Mus musculus, Rattus norvegicus
H394ALIDCHAEILA1Caenorhabditis elegans
I397DCHAEIISRRS3Homo sapiens, Mus musculus, Rattus norvegicus
I397DCHAEILARRG1Caenorhabditis elegans
K523GQLRTKIESGE3Homo sapiens, Mus musculus, Rattus norvegicus
K523SRLRFKIDKGM1Caenorhabditis elegans
K559MSCSDKIARWN3Homo sapiens, Mus musculus, Rattus norvegicus
K559MSCSDKLLRAN1Caenorhabditis elegans
K669PSRLCKHALYC2Mus musculus, Rattus norvegicus
K669ASRLCKHALYC1Homo sapiens
K669PSRLCKKNMAE1Caenorhabditis elegans
K702VYHESKLAAKE1Homo sapiens
K702SYEELKAGSQE1Caenorhabditis elegans
K702TYHESKLAARE1Mus musculus
K702TYHESKLAAKE1Rattus norvegicus
K712EYQAAKARLFT3Homo sapiens, Mus musculus, Rattus norvegicus
K712EYAAAKKSFIT1Caenorhabditis elegans
K730GAWVEKPTEQD3Homo sapiens, Mus musculus, Rattus norvegicus
K730GIWQRKPREFQ1Caenorhabditis elegans
N391RGLALNDCHAE3Homo sapiens, Mus musculus, Rattus norvegicus
N391DGTALIDCHAE1Caenorhabditis elegans
R400AEIISRRSLLR3Homo sapiens, Mus musculus, Rattus norvegicus
R400AEILARRGLLR1Caenorhabditis elegans
R401EIISRRSLLRF3Homo sapiens, Mus musculus, Rattus norvegicus
R401EILARRGLLRF1Caenorhabditis elegans
R562SDKIARWNVVG3Homo sapiens, Mus musculus, Rattus norvegicus
R562SDKLLRANVLG1Caenorhabditis elegans
S571VGIQGSLLSIF2Homo sapiens, Mus musculus
S571LGVQGAILSHF1Caenorhabditis elegans
S571VGIQGALLSIF1Rattus norvegicus
T553GERLLTMSCSD3Homo sapiens, Mus musculus, Rattus norvegicus
T553GERMRTMSCSD1Caenorhabditis elegans
W727AGLGAWVEKPT3Homo sapiens, Mus musculus, Rattus norvegicus
W727KDLGIWQRKPR1Caenorhabditis elegans
Y698TKPTTYHESKL2Mus musculus, Rattus norvegicus
Y698TKPNVYHESKL1Homo sapiens
Y698DYPISYEELKA1Caenorhabditis elegans
Y708LAAKEYQAAKA2Homo sapiens, Rattus norvegicus
Y708AGSQEYAAAKK1Caenorhabditis elegans
Y708LAAREYQAAKA1Mus musculus

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