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mutLBSgeneDB |
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| Gene summary for YAP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | YAP1 |
| Gene name | Yes-associated protein 1 | |
| Synonyms | COB1|YAP|YAP2|YAP65|YKI | |
| Cytomap | UCSC genome browser: 11q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001130145.2, NM_001195044.1,NM_001195045.1,NM_001282097.1,NM_001282098.1, NM_001282099.1,NM_001282100.1,NM_001282101.1,NM_006106.4, | |
| Description | 65 kDa Yes-associated proteinprotein yorkie homologtranscriptional coactivator YAP1yes-associated protein 2yes-associated protein YAP65 homologyorkie homolog | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 606608 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137693 | ||
| HPRD : 09424 | ||
| Vega : OTTHUMG00000167322 | ||
| Protein | UniProt: P46937 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_YAP1 | |
| BioGPS: 10413 | ||
| Pathway | NCI Pathway Interaction Database: YAP1 | |
| KEGG: YAP1 | ||
| REACTOME: YAP1 | ||
| Pathway Commons: YAP1 | ||
| Context | iHOP: YAP1 | |
| ligand binding site mutation search in PubMed: YAP1 | ||
| UCL Cancer Institute: YAP1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006974 | cellular response to DNA damage stimulus | 18280240 | GO:0008283 | cell proliferation | 17974916 | GO:0060242 | contact inhibition | 17974916 | GO:0071480 | cellular response to gamma radiation | 18280240 | GO:1903507 | negative regulation of nucleic acid-templated transcription | 18158288 |
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| Ligand binding site mutations for YAP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E237 | W236L | LUSC | 1 | S257 | S257F | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for YAP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E237 | W236L | -0.41916966 | S257 | S257F | -0.33600547 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for YAP1 from PDB |
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| Differential gene expression and gene-gene network for YAP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for YAP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1168401 | Carcinoma, squamous cell of head and neck | 1 | Biomarker |
| umls:C0919267 | Ovarian Neoplasms | 1 | Biomarker |
| umls:C0009363 | Coloboma | 1 | GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for YAP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of YAP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (THR,PRO,PRO,PRO,ALA,TYR,LEU,PRO,PRO,GLU,ASP,PRO) | 2law | A | E237 | III | Peptide ligand (SER,PRO,PRO,PRO,PRO,TYR,SER,ARG,TYR,PRO,MET,ASP) | 2ltv | A | S257 |
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| Conservation information for LBS of YAP1 |
| Multiple alignments for P46937 in multiple species |
| LBS | AA sequence | # species | Species | A239 | DGWEQAMTQDG | 2 | Homo sapiens, Mus musculus | A239 | DGWEQAITSEG | 1 | Danio rerio | A239 | ----------- | 1 | Gallus gallus | D243 | QAMTQDGEIYY | 1 | Homo sapiens | D243 | QAITSEGEIYY | 1 | Danio rerio | D243 | ----------- | 1 | Gallus gallus | D243 | QAMTQDGEVYY | 1 | Mus musculus | E178 | LPAGWEMAKTS | 2 | Homo sapiens, Mus musculus | E178 | LPPGWEMAKTP | 2 | Danio rerio, Gallus gallus | E237 | LPDGWEQAMTQ | 2 | Homo sapiens, Mus musculus | E237 | LPDGWEQAITS | 1 | Danio rerio | E237 | ----------- | 1 | Gallus gallus | H192 | RYFLNHIDQTT | 2 | Homo sapiens, Gallus gallus | H192 | RYFLNHNDQTT | 2 | Danio rerio, Mus musculus | H251 | IYYINHKNKTT | 2 | Homo sapiens, Danio rerio | H251 | ----------- | 1 | Gallus gallus | H251 | VYYINHKNKTT | 1 | Mus musculus | I249 | GEIYYINHKNK | 2 | Homo sapiens, Danio rerio | I249 | ----------- | 1 | Gallus gallus | I249 | GEVYYINHKNK | 1 | Mus musculus | K254 | INHKNKTTSWL | 3 | Homo sapiens, Danio rerio, Mus musculus | K254 | ----------- | 1 | Gallus gallus | L190 | GQRYFLNHIDQ | 2 | Homo sapiens, Gallus gallus | L190 | GQRYFLNHNDQ | 2 | Danio rerio, Mus musculus | N191 | QRYFLNHIDQT | 2 | Homo sapiens, Gallus gallus | N191 | QRYFLNHNDQT | 2 | Danio rerio, Mus musculus | N250 | EIYYINHKNKT | 2 | Homo sapiens, Danio rerio | N250 | ----------- | 1 | Gallus gallus | N250 | EVYYINHKNKT | 1 | Mus musculus | Q186 | KTSSGQRYFLN | 2 | Homo sapiens, Mus musculus | Q186 | KTPSGQRYFLN | 2 | Danio rerio, Gallus gallus | Q195 | LNHIDQTTTWQ | 2 | Homo sapiens, Gallus gallus | Q195 | LNHNDQTTTWQ | 2 | Danio rerio, Mus musculus | Q242 | EQAMTQDGEIY | 1 | Homo sapiens | Q242 | EQAITSEGEIY | 1 | Danio rerio | Q242 | ----------- | 1 | Gallus gallus | Q242 | EQAMTQDGEVY | 1 | Mus musculus | S257 | KNKTTSWLDPR | 3 | Homo sapiens, Danio rerio, Mus musculus | S257 | ----------- | 1 | Gallus gallus | T182 | WEMAKTSSGQR | 2 | Homo sapiens, Mus musculus | T182 | WEMAKTPSGQR | 2 | Danio rerio, Gallus gallus | T196 | NHIDQTTTWQD | 2 | Homo sapiens, Gallus gallus | T196 | NHNDQTTTWQD | 2 | Danio rerio, Mus musculus | T197 | HIDQTTTWQDP | 2 | Homo sapiens, Gallus gallus | T197 | HNDQTTTWQDP | 2 | Danio rerio, Mus musculus | T198 | IDQTTTWQDPR | 2 | Homo sapiens, Gallus gallus | T198 | NDQTTTWQDPR | 2 | Danio rerio, Mus musculus | T241 | WEQAMTQDGEI | 1 | Homo sapiens | T241 | WEQAITSEGEI | 1 | Danio rerio | T241 | ----------- | 1 | Gallus gallus | T241 | WEQAMTQDGEV | 1 | Mus musculus | T256 | HKNKTTSWLDP | 3 | Homo sapiens, Danio rerio, Mus musculus | T256 | ----------- | 1 | Gallus gallus | W199 | DQTTTWQDPRK | 4 | Homo sapiens, Danio rerio, Gallus gallus, Mus musculus | W258 | NKTTSWLDPRL | 3 | Homo sapiens, Danio rerio, Mus musculus | W258 | ----------- | 1 | Gallus gallus | Y188 | SSGQRYFLNHI | 1 | Homo sapiens | Y188 | PSGQRYFLNHN | 1 | Danio rerio | Y188 | PSGQRYFLNHI | 1 | Gallus gallus | Y188 | SSGQRYFLNHN | 1 | Mus musculus | Y247 | QDGEIYYINHK | 1 | Homo sapiens | Y247 | SEGEIYYINHK | 1 | Danio rerio | Y247 | ----------- | 1 | Gallus gallus | Y247 | QDGEVYYINHK | 1 | Mus musculus |
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