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mutLBSgeneDB |
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| Gene summary for SEC24B |
 Gene summary |
| Basic gene Info. | Gene symbol | SEC24B |
| Gene name | SEC24 family member B | |
| Synonyms | SEC24 | |
| Cytomap | UCSC genome browser: 4q25 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001042734.2, NM_001300813.1,NM_006323.3, | |
| Description | SEC24 related gene family, member Bprotein transport protein Sec24Bsecretory protein 24 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607184 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138802 | ||
| HPRD : 06216 | ||
| Vega : OTTHUMG00000161372 | ||
| Protein | UniProt: O95487 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SEC24B | |
| BioGPS: 10427 | ||
| Pathway | NCI Pathway Interaction Database: SEC24B | |
| KEGG: SEC24B | ||
| REACTOME: SEC24B | ||
| Pathway Commons: SEC24B | ||
| Context | iHOP: SEC24B | |
| ligand binding site mutation search in PubMed: SEC24B | ||
| UCL Cancer Institute: SEC24B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for SEC24B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C605 | R606Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SEC24B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | C605 | R606Q | -1.5029061 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SEC24B from PDB |
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| Differential gene expression and gene-gene network for SEC24B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SEC24B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SEC24B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SEC24B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 3eh1 | A | C605 |
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| Conservation information for LBS of SEC24B |
| Multiple alignments for O95487 in multiple species |
| LBS | AA sequence | # species | Species | C605 | QVISRCRRCRS | 2 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C605 | NTIVRCRSCRT | 1 | Homo sapiens | C605 | GLIVRCRRCRS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C605 | GVVVRCRRCRA | 1 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | C605 | GCIVRCRRCRS | 1 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | C605 | TIISRCRRCRM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C608 | SRCRRCRSYIN | 2 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C608 | VRCRSCRTYIN | 1 | Homo sapiens | C608 | VRCRRCRSYMN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C608 | VRCRRCRAYLN | 1 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | C608 | VRCRRCRSYIN | 1 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | C608 | SRCRRCRMYIN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C626 | GHRWRCNMCNL | 2 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C626 | -RRWKCNLCYR | 1 | Homo sapiens | C626 | GRRWRCNFCRL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C626 | GLRWRCNFCNL | 1 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | C626 | GRRWRCNFCNL | 1 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | C626 | GHRYRCNSCGI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C629 | WRCNMCNLTND | 2 | Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C629 | WKCNLCYRVND | 1 | Homo sapiens | C629 | WRCNFCRLAND | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C629 | WRCNFCNLANN | 1 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | C629 | WRCNFCNLAND | 1 | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) | C629 | YRCNSCGIVNE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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