mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for NXF1
Gene summary
Basic gene Info.Gene symbolNXF1
Gene namenuclear RNA export factor 1
CytomapUCSC genome browser: 11q12-q13
Type of geneprotein-coding
DescriptionmRNA export factor TAPtip associating proteintip-associated proteintip-associating protein
Modification date20141207
dbXrefs MIM : 602647
Ensembl : ENSG00000162231
HPRD : 04035
Vega : OTTHUMG00000167612
ProteinUniProt: Q9UBU9
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_NXF1
BioGPS: 10482
PathwayNCI Pathway Interaction Database: NXF1
Pathway Commons: NXF1
ContextiHOP: NXF1
ligand binding site mutation search in PubMed: NXF1
UCL Cancer Institute: NXF1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006406mRNA export from nucleus19165146

Ligand binding site mutations for NXF1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for NXF1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for NXF1 from PDB

Differential gene expression and gene-gene network for NXF1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of NXF1 and the right PPI network was created from samples without mutations in the LBS of NXF1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for NXF1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for NXF1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of NXF1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (ASP,SER,GLY,PHE,SER,PHE,GLY,SER,LYS)1oaiAK587 A602 L606
NUCNucleic Acids3rw6BN156 R158 Q160 H198 V246 R279 R307
NUCNucleic Acids3rw6AN156 R158 Q160 V246 R279

Conservation information for LBS of NXF1
Multiple alignments for Q9UBU9 in multiple species
LBSAA sequence# speciesSpecies
A519TRTFIAVPASN3Homo sapiens, Mus musculus, Rattus norvegicus
A519DRTLLILPGGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A519DRTWVIVPMNN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A519SRSFLVSPREN1Caenorhabditis elegans
A519TRTFMVAPRGE1Caenorhabditis elegans
A519ARTYVVVPQNN1Drosophila melanogaster
A519TRTFVAVPASN1Bos taurus
A602TRSAQAFTHLK3Homo sapiens, Bos taurus, Rattus norvegicus
A602NSALASFLELK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A602EVAIKGFQ--S1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A602DFACQKFNEIK1Caenorhabditis elegans
A602-RGDQYRMLVE1Caenorhabditis elegans
A602NHAAFVFEKLF1Drosophila melanogaster
A602TRSAQAFTLLK1Mus musculus
C588EWSQKCLQDNN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C588YYAHMCCEQNN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C588EYTFMLAEQSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C588PFSEKCLADCA1Caenorhabditis elegans
C588-----------1Caenorhabditis elegans
C588IWSRKCLEETN1Drosophila melanogaster
D131-GRKYDKAWLL1Homo sapiens
D131MNISYSPASVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D131---------LI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D131AAKKVDAKWLI1Caenorhabditis elegans
D131-----------1Caenorhabditis elegans
D131-AQIYEKETLL1Drosophila melanogaster
D131-GRKYDKSWLL1Bos taurus
D131-GRKYDKTWLL1Mus musculus
D131-GKKYDKMWLL1Rattus norvegicus
D591QKCLQDNNWDY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D591HMCCEQNNWDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D591FMLAEQSNWNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D591EKCLADCAWNF1Caenorhabditis elegans
D591-----------1Caenorhabditis elegans
D591RKCLEETNWDF1Drosophila melanogaster
E151PFTPIEFHYEN2Homo sapiens, Bos taurus
E151PFNPIEFHYEN2Mus musculus, Rattus norvegicus
E151DFSRLNGLNGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E151AV--YDAHVEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E151NFKPL-LWTDN1Caenorhabditis elegans
E151--------YRN1Caenorhabditis elegans
E151VFIPQYWRVER1Drosophila melanogaster
E611LKAKGEIPEVA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E611LKSRNVIPAEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E611-SSMNGIPREA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E611IKS--SVPAEA1Caenorhabditis elegans
E611VETATDIDQ--1Caenorhabditis elegans
E611LFKENKIPPEA1Drosophila melanogaster
F152FTPIEFHYENT2Homo sapiens, Bos taurus
F152FNPIEFHYENT2Mus musculus, Rattus norvegicus
F152FSRLNGLNGAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F152V--YDAHVEGP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F152FKPL-LWTDNA1Caenorhabditis elegans
F152-------YRNI1Caenorhabditis elegans
F152FIPQYWRVERN1Drosophila melanogaster
H153TPIEFHYENTR2Homo sapiens, Bos taurus
H153NPIEFHYENTR2Mus musculus, Rattus norvegicus
H153SRLNGLNGAAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H153--YDAHVEGPL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H153KPL-LWTDNAR1Caenorhabditis elegans
H153------YRNIE1Caenorhabditis elegans
H153IPQYWRVERNC1Drosophila melanogaster
H198SSAPPHTILNE1Homo sapiens
H198LSALATQAQRN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H198NGA------SA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H198SKVPAPWMK--1Caenorhabditis elegans
H198---------TN1Caenorhabditis elegans
H198SGIPLVAIDDA1Drosophila melanogaster
H198SSSPPHSVQNE1Bos taurus
H198ASAPPYTVQNE1Mus musculus
H198SSAPPYIVQNE1Rattus norvegicus
I190RRISIIINSSA1Homo sapiens
I190FRSVSAPSLSA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I190LKFELLDNNGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I190GTRVEFYTSKV1Caenorhabditis elegans
I190-----------1Caenorhabditis elegans
I190YRLMPRVRSGI1Drosophila melanogaster
I190RRISIIINSSS1Bos taurus
I190RRISIIINASA1Mus musculus
I190GRISIIINSSA1Rattus norvegicus
K121SKNWFKITIPY2Homo sapiens, Bos taurus
K121TKNWFKITIPY2Mus musculus, Rattus norvegicus
K121SFVWRKVKVRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K121VRNWQNATMND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K121NTGVRNADIVY1Caenorhabditis elegans
K121-----------1Caenorhabditis elegans
K121SFGWYQVTLQN1Drosophila melanogaster
K304----LKSEREL2Homo sapiens, Bos taurus
K304----ITSLSDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K304----IFRFRSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K304----ISTEKEL1Caenorhabditis elegans
K304FFSKISSGEEL1Caenorhabditis elegans
K304----IPSLAHL1Drosophila melanogaster
K304----LKTEREL1Mus musculus
K304----LKSEWEL1Rattus norvegicus
K587LEWSQKCLQDN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K587DYYAHMCCEQN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K587AEYTFMLAEQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K587PPFSEKCLADC1Caenorhabditis elegans
K587-----------1Caenorhabditis elegans
K587VIWSRKCLEET1Drosophila melanogaster
L490AQTSTLLCFSV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L490PSVGAAIKIVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L490YPQINGFVITL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L490LQSNDLLGFTV1Caenorhabditis elegans
L490LVSATLLGFTL1Caenorhabditis elegans
L490IYNTSMMVFTV1Drosophila melanogaster
L491QTSTLLCFSVN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L491SVGAAIKIVVH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L491PQINGFVITLH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L491QSNDLLGFTVQ1Caenorhabditis elegans
L491VSATLLGFTLH1Caenorhabditis elegans
L491YNTSMMVFTVT1Drosophila melanogaster
L527ASNSGLCIVND4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L527GGSTGILIIND1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L527MNNS-VIIASD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L527RENDSVAVISD1Caenorhabditis elegans
L527RGEGKVAIVSD1Caenorhabditis elegans
L527QNN-GFCIRNE1Drosophila melanogaster
L606QAFTHLKAKGE3Homo sapiens, Bos taurus, Rattus norvegicus
L606ASFLELKSRNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L606KGFQ--SSMNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L606QKFNEIKS--S1Caenorhabditis elegans
L606QYRMLVETATD1Caenorhabditis elegans
L606FVFEKLFKENK1Drosophila melanogaster
L606QAFTLLKAKGE1Mus musculus
M580STQSGMNLEWS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M580KAETGLNDYYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M580HLETKLNAEYT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M580CQFSGMIPPFS1Caenorhabditis elegans
M580-----------1Caenorhabditis elegans
M580SAQSQMNVIWS1Drosophila melanogaster
N156EFHYENTRA--4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N156NGLNGAAFAGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N156DAHVEGPLV--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N156-LWTDNARGDF1Caenorhabditis elegans
N156---YRNIEG--1Caenorhabditis elegans
N156YWRVERNCV--1Drosophila melanogaster
N192ISIIINSSAPP2Homo sapiens, Rattus norvegicus
N192SVSAPSLSALA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N192FELLDNNGA--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N192RVEFYTSKVPA1Caenorhabditis elegans
N192-----------1Caenorhabditis elegans
N192LMPRVRSGIPL1Drosophila melanogaster
N192ISIIINSSSPP1Bos taurus
N192ISIIINASAPP1Mus musculus
N202PHTILNEL---1Homo sapiens
N202ATQAQRNVSKT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N202-----SAG---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N202APWMK--L---1Caenorhabditis elegans
N202-----TNL---1Caenorhabditis elegans
N202LVAIDDAF---1Drosophila melanogaster
N202PHSVQNEL---1Bos taurus
N202PYTVQNEL---1Mus musculus
N202PYIVQNEL---1Rattus norvegicus
N248IDVVLNRRS-C3Homo sapiens, Bos taurus, Mus musculus
N248ILAEASTKSKM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N248VFSSISTQSKM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N248MMMNLTKGN-V1Caenorhabditis elegans
N248MLMCLTKTR-V1Caenorhabditis elegans
N248VFCPLFRQN-V1Drosophila melanogaster
N248IDVVLNRRG-C1Rattus norvegicus
N275LNLSNNRLYRL1Homo sapiens
N275VSLSDNNLQSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N275VNLADNQLKDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N275LSLSNNRIRHL1Caenorhabditis elegans
N275ISFSNNRLCHL1Caenorhabditis elegans
N275LNLNDNSISSM1Drosophila melanogaster
N275LNLSNNKLYRL1Bos taurus
N275LNLSSNRLYKL1Mus musculus
N275LNLSNNRLYKL1Rattus norvegicus
N592KCLQDNNWDYT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N592MCCEQNNWDYN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N592MLAEQSNWNYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N592KCLADCAWNFD1Caenorhabditis elegans
N592-----------1Caenorhabditis elegans
N592KCLEETNWDFN1Drosophila melanogaster
N593CLQDNNWDYTR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N593CCEQNNWDYNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N593LAEQSNWNYEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N593CLADCAWNFDF1Caenorhabditis elegans
N593----------R1Caenorhabditis elegans
N593CLEETNWDFNH1Drosophila melanogaster
P125FKITIPY----4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P125RKVKVRL----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P125QNATMND----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P125RNADIVYKCRA1Caenorhabditis elegans
P125-----------1Caenorhabditis elegans
P125YQVTLQN----1Drosophila melanogaster
P521TFIAVPASNSG3Homo sapiens, Mus musculus, Rattus norvegicus
P521TLLILPGGSTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P521TWVIVPMNNS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P521SFLVSPRENDS1Caenorhabditis elegans
P521TFMVAPRGEGK1Caenorhabditis elegans
P521TYVVVPQNN-G1Drosophila melanogaster
P521TFVAVPASNSG1Bos taurus
Q160TRA--QFFVED2Homo sapiens, Bos taurus
Q160AFAGDHLAIRR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q160PLV--IGYVNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q160ARGDFEWYVRD1Caenorhabditis elegans
Q160IEG--RLSLSS1Caenorhabditis elegans
Q160NCV--IFFTDD1Drosophila melanogaster
Q160TRA--HFFVED1Mus musculus
Q160TRA--HFFVEN1Rattus norvegicus
Q486--ISAQTSTLL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q486NLVLPSVGAAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q486-TISYPQINGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q486--VFLQSNDLL1Caenorhabditis elegans
Q486--VFLVSATLL1Caenorhabditis elegans
Q486--LTIYNTSMM1Drosophila melanogaster
R128-----------2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Caenorhabditis elegans
R128----GRKYDKA1Homo sapiens
R128---MNISYSPA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R128ATGAAKKVDAK1Caenorhabditis elegans
R128----AQIYEKE1Drosophila melanogaster
R128----GRKYDKS1Bos taurus
R128----GRKYDKT1Mus musculus
R128----GKKYDKM1Rattus norvegicus
R158HYENTRA--QF2Homo sapiens, Bos taurus
R158HYENTRA--HF2Mus musculus, Rattus norvegicus
R158LNGAAFAGDHL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R158HVEGPLV--IG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R158WTDNARGDFEW1Caenorhabditis elegans
R158-YRNIEG--RL1Caenorhabditis elegans
R158RVERNCV--IF1Drosophila melanogaster
R233DLKGLRSDPDL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R233DLGNLQQDPLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R233NLGALHSDPEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R233DLSNFHEDEEF1Caenorhabditis elegans
R233NLSNFSKNTEF1Caenorhabditis elegans
R233DLSRFHADPDL1Drosophila melanogaster
R276NLSNNRLYRLD1Homo sapiens
R276SLSDNNLQSVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R276NLADNQLKDIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R276SLSNNRIRHLD1Caenorhabditis elegans
R276SFSNNRLCHLD1Caenorhabditis elegans
R276NLNDNSISSME1Drosophila melanogaster
R276NLSNNKLYRLD1Bos taurus
R276NLSSNRLYKLD1Mus musculus
R276NLSNNRLYKLD1Rattus norvegicus
R279NNRLYRLDDMS1Homo sapiens
R279DNNLQSVTAVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R279DNQLKDISAIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R279NNRIRHLDYAS1Caenorhabditis elegans
R279NNRLCHLDHLS1Caenorhabditis elegans
R279DNSISSMEAFK1Drosophila melanogaster
R279NNKLYRLDDLS1Bos taurus
R279SNRLYKLDDMS1Mus musculus
R279NNRLYKLDDMS1Rattus norvegicus
R307-LKSERELD--2Homo sapiens, Bos taurus
R307-ITSLSDLDPW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R307-IFRFRSLEVW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R307-ISTEKELE--1Caenorhabditis elegans
R307KISSGEELK--1Caenorhabditis elegans
R307-IPSLAHLV--1Drosophila melanogaster
R307-LKTERELD--1Mus musculus
R307-LKSEWELD--1Rattus norvegicus
R598NWDYTRSAQAF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R598NWDYNSALASF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R598NWNYEVAIKGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R598AWNFDFACQKF1Caenorhabditis elegans
R598-----RGDQYR1Caenorhabditis elegans
R598NWDFNHAAFVF1Drosophila melanogaster
S188ENRRISIIINS2Homo sapiens, Bos taurus
S188RSFRSVSAPSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S188SNLKFELLDNN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S188ESGTRVEFYTS1Caenorhabditis elegans
S188-----------1Caenorhabditis elegans
S188DGYRLMPRVRS1Drosophila melanogaster
S188ENRRISIIINA1Mus musculus
S188ENGRISIIINS1Rattus norvegicus
S305---LKSERELD2Homo sapiens, Bos taurus
S305---ITSLSDLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S305---IFRFRSLE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S305---ISTEKELE1Caenorhabditis elegans
S305FSKISSGEELK1Caenorhabditis elegans
S305---IPSLAHLV1Drosophila melanogaster
S305---LKTERELD1Mus musculus
S305---LKSEWELD1Rattus norvegicus
S488ISAQTSTLLCF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S488VLPSVGAAIKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S488ISYPQINGFVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S488VFLQSNDLLGF1Caenorhabditis elegans
S488VFLVSATLLGF1Caenorhabditis elegans
S488LTIYNTSMMVF1Drosophila melanogaster
T123NWFKITIPY--4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T123VWRKVKVRL--1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T123NWQNATMND--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T123GVRNADIVYKC1Caenorhabditis elegans
T123-----------1Caenorhabditis elegans
T123GWYQVTLQN--1Drosophila melanogaster
T199SAPPHTILNEL1Homo sapiens
T199SALATQAQRNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T199GA------SAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T199KVPAPWMK--L1Caenorhabditis elegans
T199--------TNL1Caenorhabditis elegans
T199GIPLVAIDDAF1Drosophila melanogaster
T199SSPPHSVQNEL1Bos taurus
T199SAPPYTVQNEL1Mus musculus
T199SAPPYIVQNEL1Rattus norvegicus
T487-ISAQTSTLLC4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T487LVLPSVGAAIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T487TISYPQINGFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T487-VFLQSNDLLG1Caenorhabditis elegans
T487-VFLVSATLLG1Caenorhabditis elegans
T487-LTIYNTSMMV1Drosophila melanogaster
T489SAQTSTLLCFS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T489LPSVGAAIKIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T489SYPQINGFVIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T489FLQSNDLLGFT1Caenorhabditis elegans
T489FLVSATLLGFT1Caenorhabditis elegans
T489TIYNTSMMVFT1Drosophila melanogaster
V246QNIDVVLNRRS3Homo sapiens, Bos taurus, Mus musculus
V246MGILAEASTKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V246KGVFSSISTQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V246KDMMMNLTKGN1Caenorhabditis elegans
V246RDMLMCLTKTR1Caenorhabditis elegans
V246KQVFCPLFRQN1Drosophila melanogaster
V246QNIDVVLNRRG1Rattus norvegicus
V520RTFIAVPASNS3Homo sapiens, Mus musculus, Rattus norvegicus
V520RTLLILPGGST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V520RTWVIVPMNNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V520RSFLVSPREND1Caenorhabditis elegans
V520RTFMVAPRGEG1Caenorhabditis elegans
V520RTYVVVPQNN-1Drosophila melanogaster
V520RTFVAVPASNS1Bos taurus
W584GMNLEWSQKCL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W584GLNDYYAHMCC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W584KLNAEYTFMLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W584GMIPPFSEKCL1Caenorhabditis elegans
W584-----------1Caenorhabditis elegans
W584QMNVIWSRKCL1Drosophila melanogaster
Y126KITIPY-----4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y126KVKVRL-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y126NATMND-----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y126NADIVYKCRAT1Caenorhabditis elegans
Y126-----------1Caenorhabditis elegans
Y126QVTLQN-----1Drosophila melanogaster
Y154PIEFHYENTRA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y154RLNGLNGAAFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y154-YDAHVEGPLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y154PL-LWTDNARG1Caenorhabditis elegans
Y154-----YRNIEG1Caenorhabditis elegans
Y154PQYWRVERNCV1Drosophila melanogaster
Y177LKAVNYKILDR2Homo sapiens, Bos taurus
Y177VTQDYRKAKTK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y177LMKWNGVRFAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y177IRANNRRVVHK1Caenorhabditis elegans
Y177PRQTHV-----1Caenorhabditis elegans
Y177IQHLGKNGHLP1Drosophila melanogaster
Y177LKGVNHKIQDR1Mus musculus
Y177LKAVNYKIQDR1Rattus norvegicus
Y278SNNRLYRLDDM1Homo sapiens
Y278SDNNLQSVTAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y278ADNQLKDISAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y278SNNRIRHLDYA1Caenorhabditis elegans
Y278SNNRLCHLDHL1Caenorhabditis elegans
Y278NDNSISSMEAF1Drosophila melanogaster
Y278SNNKLYRLDDL1Bos taurus
Y278SSNRLYKLDDM1Mus musculus
Y278SNNRLYKLDDM1Rattus norvegicus

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