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mutLBSgeneDB |
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| Gene summary for STK25 |
 Gene summary |
| Basic gene Info. | Gene symbol | STK25 |
| Gene name | serine/threonine kinase 25 | |
| Synonyms | SOK1|YSK1 | |
| Cytomap | UCSC genome browser: 2q37.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001271977.1, NM_001271978.1,NM_001271979.1,NM_001271980.1,NM_001282305.1, NM_001282306.1,NM_001282307.1,NM_001282308.1,NM_006374.4, | |
| Description | Ste20, yeast homologserine/threonine-protein kinase 25ste20-like kinaseste20/oxidant stress response kinase 1sterile 20/oxidant stress-response kinase 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602255 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000115694 | ||
| HPRD : 03770 | ||
| Vega : OTTHUMG00000133408 | ||
| Protein | UniProt: O00506 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_STK25 | |
| BioGPS: 10494 | ||
| Pathway | NCI Pathway Interaction Database: STK25 | |
| KEGG: STK25 | ||
| REACTOME: STK25 | ||
| Pathway Commons: STK25 | ||
| Context | iHOP: STK25 | |
| ligand binding site mutation search in PubMed: STK25 | ||
| UCL Cancer Institute: STK25 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 17657516 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 22652780 | GO:0042542 | response to hydrogen peroxide | 22291017 | GO:0046777 | protein autophosphorylation | 17657516 | GO:0051645 | Golgi localization | 15037601 |
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| Ligand binding site mutations for STK25 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G101,G99 | G100S | BRCA | 1 | R25 | R25H | COAD | 1 | Y287 | R286S | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for STK25 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y287 | R286S | -2.0144311 | R25 | R25H | -1.5728593 | G101 | G100S | -0.38821725 | G99 | G100S | -0.38821725 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for STK25 from PDB |
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| Differential gene expression and gene-gene network for STK25 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for STK25 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for STK25 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of STK25 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | J60 | 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE | 2xik | A | R25 G99 G101 Y287 |
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| Conservation information for LBS of STK25 |
| Multiple alignments for O00506 in multiple species |
| LBS | AA sequence | # species | Species | A47 | TKEVVAIKIID | 3 | Homo sapiens, Bos taurus, Mus musculus | A47 | TGRVVAIKIID | 1 | Caenorhabditis elegans | D105 | GGSALDLLKPG | 3 | Homo sapiens, Bos taurus, Mus musculus | D105 | GGSALDLTKSG | 1 | Caenorhabditis elegans | E96 | LWIIMEYLGGG | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus | G101 | EYLGGGSALDL | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus | G99 | IMEYLGGGSAL | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus | I26 | TKLDRIGKGSF | 3 | Homo sapiens, Bos taurus, Mus musculus | I26 | TKQERIGRGSF | 1 | Caenorhabditis elegans | K108 | ALDLLKPGPLE | 3 | Homo sapiens, Bos taurus, Mus musculus | K108 | ALDLTKSGKLD | 1 | Caenorhabditis elegans | L147 | KAANVLLSEQG | 3 | Homo sapiens, Bos taurus, Mus musculus | L147 | KAANVLVSEHG | 1 | Caenorhabditis elegans | L98 | IIMEYLGGGSA | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus | M95 | KLWIIMEYLGG | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus | R25 | FTKLDRIGKGS | 3 | Homo sapiens, Bos taurus, Mus musculus | R25 | FTKQERIGRGS | 1 | Caenorhabditis elegans | Y287 | ELIDRYKRWKS | 2 | Homo sapiens, Mus musculus | Y287 | DLIERAAEYRL | 1 | Caenorhabditis elegans | Y287 | ELIDRYKRWRS | 1 | Bos taurus | Y97 | WIIMEYLGGGS | 4 | Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus |
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