mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for KAT5

Gene summary

Basic gene Info.	Gene symbol	KAT5
	Gene name	K(lysine) acetyltransferase 5
	Synonyms	ESA1\|HTATIP\|HTATIP1\|PLIP\|TIP\|TIP60\|ZC2HC5\|cPLA2
	Cytomap	UCSC genome browser: 11q13
	Type of gene	protein-coding
	RefGenes	NM_001206833.1, NM_006388.3,NM_182709.2,NM_182710.2,
	Description	60 kDa Tat-interactive proteinHIV-1 Tat interactive protein, 60kDaK-acetyltransferase 5Tat interacting protein, 60kDacPLA(2)-interacting proteincPLA2 interacting proteinhistone acetyltransferase HTATIPhistone acetyltransferase KAT5
	Modification date	20141217
dbXrefs	MIM : 601409
	HGNC : HGNC
	Ensembl : ENSG00000172977
	HPRD : 03245
	Vega : OTTHUMG00000166617
Protein	UniProt: Q92993 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_KAT5
	BioGPS: 10524
Pathway	NCI Pathway Interaction Database: KAT5
	KEGG: KAT5
	REACTOME: KAT5
	Pathway Commons: KAT5
Context	iHOP: KAT5
	ligand binding site mutation search in PubMed: KAT5
	UCL Cancer Institute: KAT5
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	14966270
GO:0010212	response to ionizing radiation	18397884
GO:0016573	histone acetylation	10966108
GO:0032703	negative regulation of interleukin-2 production	17360565
GO:0045892	negative regulation of transcription, DNA-templated	17360565
GO:0045893	positive regulation of transcription, DNA-templated	14966270
GO:0071392	cellular response to estradiol stimulus	23637611

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Ligand binding site mutations for KAT5

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R378	R378C	HNSC	1
L371	L371P	LUAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for KAT5

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R378	R378C	-1.1371029
L371	L371P	-0.59465044

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KAT5 from PDB

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Differential gene expression and gene-gene network for KAT5

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of KAT5 and the right PPI network was created from samples without mutations in the LBS of KAT5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for KAT5

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for KAT5

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB01992	Coenzyme A	Small molecule
Experimental	DB02039	S-Acetyl-Cysteine	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KAT5 go to BioLip

Ligand ID

Ligand short name

Ligand long name

PDB ID

PDB name

mutLBS

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Conservation information for LBS of KAT5

Multiple alignments for Q92993 in multiple species

LBS	AA sequence	# species	Species
A368	EDYNVACILTL	3	Homo sapiens, Mus musculus, Rattus norvegicus
A368	DGYNVACILTL	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A368	ENYNLACILTL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A368	DAYNVACILTL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A368	EEYNVACILVL	1	Caenorhabditis elegans
A368	EDYNVACILTM	1	Drosophila melanogaster
C263	PVLYLCEFCLK	3	Homo sapiens, Mus musculus, Rattus norvegicus
C263	DVVYIDDFSLQ	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C263	DCIYICEFCLS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C263	DIVYICSFCFC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C263	DFIYIDDFTLQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C263	DCIYICEFCLK	1	Caenorhabditis elegans
C263	PCIYICEFCLK	1	Drosophila melanogaster
C266	YLCEFCLKYGR	3	Homo sapiens, Mus musculus, Rattus norvegicus
C266	YIDDFSLQYFG	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C266	YICEFCLSYYG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C266	YICSFCFCYYG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C266	YIDDFTLQYFG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C266	YICEFCLKYLK	1	Caenorhabditis elegans
C266	YICEFCLKYRK	1	Drosophila melanogaster
C283	RHLTKCDLRHP	3	Homo sapiens, Mus musculus, Rattus norvegicus
C283	RYRKKCTLRHP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C283	RHRQKCTLHHP	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C283	RHREKCTLQHP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C283	RYRQKCTLRHP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C283	RHMEKCAMCHP	1	Caenorhabditis elegans
C283	RHLSKCNLRHP	1	Drosophila melanogaster
C369	DYNVACILTLP	3	Homo sapiens, Mus musculus, Rattus norvegicus
C369	GYNVACILTLP	3	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C369	NYNLACILTLP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C369	AYNVACILTLP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C369	EYNVACILVLP	1	Caenorhabditis elegans
C369	DYNVACILTMP	1	Drosophila melanogaster
E403	KTGTPEKPLSD	3	Homo sapiens, Mus musculus, Rattus norvegicus
E403	KVGSPEKPLSD	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E403	KTGSPEKPLSD	2	Caenorhabditis elegans, Drosophila melanogaster
E403	KLGSPEKPLSD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E403	KHGSPEKPLSD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F323	LLAKCFLDHKT	3	Homo sapiens, Mus musculus, Rattus norvegicus
F323	LLSKLFLDHKT	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F323	LLAKLFLDHKT	2	Caenorhabditis elegans, Drosophila melanogaster
F323	LLSKMFLDHKT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F323	LLSKLFLDHKM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G380	PYQRRGYGKLL	3	Homo sapiens, Mus musculus, Rattus norvegicus
G380	QYQRMGYGRLL	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G380	QYQRKGYGRLL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G380	QYQRHGYGKLL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G380	QYQRMGYGKLL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G380	PFQKKGYGSLL	1	Caenorhabditis elegans
G380	PYQRKGYGKLL	1	Drosophila melanogaster
G382	QRRGYGKLLIE	3	Homo sapiens, Mus musculus, Rattus norvegicus
G382	QRMGYGRLLIE	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G382	QRKGYGRLLIQ	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G382	QRHGYGKLLIQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G382	QRMGYGKLLIE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G382	QKKGYGSLLIE	1	Caenorhabditis elegans
G382	QRKGYGKLLIE	1	Drosophila melanogaster
G410	PLSDLGLLSYR	9	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (s
G410	PLSDLGLISYR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H279	KCLQRHLTKCD	3	Homo sapiens, Mus musculus, Rattus norvegicus
H279	KQYERYRKKCT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H279	KSFVRHRQKCT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H279	RQFQRHREKCT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H279	KQYARYRQKCT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H279	TCLKRHMEKCA	1	Caenorhabditis elegans
H279	KCLERHLSKCN	1	Drosophila melanogaster
I370	YNVACILTLPQ	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 858
I370	YNVACILTLPP	3	Homo sapiens, Mus musculus, Rattus norvegicus
I370	YNLACILTLPQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I370	YNVACILVLPP	1	Caenorhabditis elegans
I370	YNVACILTMPP	1	Drosophila melanogaster
K383	RRGYGKLLIEF	3	Homo sapiens, Mus musculus, Rattus norvegicus
K383	RMGYGRLLIEF	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K383	RKGYGRLLIQF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K383	RHGYGKLLIQF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K383	RMGYGKLLIEF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K383	KKGYGSLLIEF	1	Caenorhabditis elegans
K383	RKGYGKLLIEF	1	Drosophila melanogaster
L324	LAKCFLDHKTL	3	Homo sapiens, Mus musculus, Rattus norvegicus
L324	LSKLFLDHKTL	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L324	LAKLFLDHKTL	2	Caenorhabditis elegans, Drosophila melanogaster
L324	LSKMFLDHKTL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L324	LSKLFLDHKML	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L371	NVACILTLPQY	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 858
L371	NVACILTLPPY	3	Homo sapiens, Mus musculus, Rattus norvegicus
L371	NLACILTLPQY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L371	NVACILVLPPF	1	Caenorhabditis elegans
L371	NVACILTMPPY	1	Drosophila melanogaster
L406	SPEKPLSDLGL	7	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923
L406	TPEKPLSDLGL	3	Homo sapiens, Mus musculus, Rattus norvegicus
L409	KPLSDLGLLSY	9	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (s
L409	KPLSDLGLISY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q377	TLPPYQRRGYG	3	Homo sapiens, Mus musculus, Rattus norvegicus
Q377	TLPQYQRMGYG	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q377	TLPQYQRKGYG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q377	TLPQYQRHGYG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q377	VLPPFQKKGYG	1	Caenorhabditis elegans
Q377	TMPPYQRKGYG	1	Drosophila melanogaster
Q420	RSYWSQTILEI	3	Homo sapiens, Mus musculus, Rattus norvegicus
Q420	RQYWSENIIDI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q420	RAYWAEQIINL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q420	RAYWSDTLITL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q420	RAYWSDTLIKL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q420	RAYWADTLIKL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q420	RSYWSMAIMKE	1	Caenorhabditis elegans
Q420	RSYWAQTILEI	1	Drosophila melanogaster
R378	LPPYQRRGYGK	3	Homo sapiens, Mus musculus, Rattus norvegicus
R378	LPQYQRMGYGR	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R378	LPQYQRKGYGR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R378	LPQYQRHGYGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R378	LPQYQRMGYGK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R378	LPPFQKKGYGS	1	Caenorhabditis elegans
R378	MPPYQRKGYGK	1	Drosophila melanogaster
R379	PPYQRRGYGKL	3	Homo sapiens, Mus musculus, Rattus norvegicus
R379	PQYQRMGYGRL	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R379	PQYQRKGYGRL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R379	PQYQRHGYGKL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R379	PQYQRMGYGKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R379	PPFQKKGYGSL	1	Caenorhabditis elegans
R379	PPYQRKGYGKL	1	Drosophila melanogaster
S407	PEKPLSDLGLL	9	Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (s
S407	PEKPLSDLGLI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S413	DLGLLSYRSYW	5	Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Drosophila melanogaster
S413	DLGLLSYRAYW	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S413	DLGLLSYRQYW	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S413	DLGLISYRAYW	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S416	LLSYRSYWSQT	3	Homo sapiens, Mus musculus, Rattus norvegicus
S416	LLSYRAYWSDT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S416	LLSYRQYWSEN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S416	LISYRAYWAEQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S416	LLSYRAYWADT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S416	LLSYRSYWSMA	1	Caenorhabditis elegans
S416	LLSYRSYWAQT	1	Drosophila melanogaster
T372	VACILTLPQYQ	4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 858
T372	VACILTLPPYQ	3	Homo sapiens, Mus musculus, Rattus norvegicus
T372	LACILTLPQYQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T372	VACILVLPPFQ	1	Caenorhabditis elegans
T372	VACILTMPPYQ	1	Drosophila melanogaster
W245	HRLKPWYFSPY	3	Homo sapiens, Mus musculus, Rattus norvegicus
W245	HEIEPWYFSPY	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W245	YEIEPWYFSPY	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W245	YVLFPWYFSPY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W245	SRIQPWYFAPY	1	Caenorhabditis elegans
W245	HRIKPWYFSPY	1	Drosophila melanogaster