mutLBSgeneDB |
Gene summary for NEBL |
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Basic gene Info. | Gene symbol | NEBL |
Gene name | nebulette | |
Synonyms | LASP2|LNEBL | |
Cytomap | UCSC genome browser: 10p12 | |
Type of gene | protein-coding | |
RefGenes | NM_001173484.1, NM_006393.2,NM_213569.2,NM_016365.1, | |
Description | LIM-nebuletteactin-binding Z-disk protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 605491 | |
HGNC : HGNC | ||
Ensembl : ENSG00000078114 | ||
HPRD : 10403 | ||
Vega : OTTHUMG00000017788 | ||
Protein | UniProt: O76041 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NEBL | |
BioGPS: 10529 | ||
Pathway | NCI Pathway Interaction Database: NEBL | |
KEGG: NEBL | ||
REACTOME: NEBL | ||
Pathway Commons: NEBL | ||
Context | iHOP: NEBL | |
ligand binding site mutation search in PubMed: NEBL | ||
UCL Cancer Institute: NEBL | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for NEBL |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | D969 | D969N | COAD | 1 | D989 | D989Y | LUAD | 1 | Y963,Y965 | D964N | SKCM | 1 | Y963,Y965 | D964Y | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for NEBL |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Y965 | D964N | -0.73857855 | Y963 | D964N | -0.73857855 | Y965 | D964Y | -0.40332699 | Y963 | D964Y | -0.40332699 | D989 | D989Y | -0.29776084 | D969 | D969N | -0.13817622 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for NEBL |
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Phenotype information for NEBL |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for NEBL |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4f14 | A | D969 | III | Peptide ligand (PRO,PRO,PRO,THR,LEU,PRO,LYS,PRO,LYS,LEU,PRO) | 4f14 | A | Y963 Y965 D969 D989 |
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Conservation information for LBS of NEBL |
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LBS | AA sequence | # species | Species |
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