mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PITRM1
Gene summary
Basic gene Info.Gene symbolPITRM1
Gene namepitrilysin metallopeptidase 1
SynonymsMP1|PreP
CytomapUCSC genome browser: 10p15.2
Type of geneprotein-coding
RefGenesNM_014968.1,
NM_001242307.1,NM_001242309.1,NM_014889.3,
DescriptionPreP peptidasomemetalloprotease 1 (pitrilysin family)pitrilysin metalloproteinase 1presequence protease, mitochondrial
Modification date20141207
dbXrefs HGNC : HGNC
Ensembl : ENSG00000107959
HPRD : 07142
Vega : OTTHUMG00000017557
ProteinUniProt: Q5JRX3
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PITRM1
BioGPS: 10531
PathwayNCI Pathway Interaction Database: PITRM1
KEGG: PITRM1
REACTOME: PITRM1
Pathway Commons: PITRM1
ContextiHOP: PITRM1
ligand binding site mutation search in PubMed: PITRM1
UCL Cancer Institute: PITRM1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for PITRM1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L111V110ICOAD1
Q470N469ISKCM1
L127L127FSKCM1
M446L445PSTAD1
S351L352FUCEC1
L60E59KUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for PITRM1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q470N469I0.38867347
S351L352F-1.2996025
M446L445P-1.1687493
L111V110I-1.0559314
L127L127F-1.0446659
L60E59K-0.77020826
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PITRM1 from PDB

Top
Differential gene expression and gene-gene network for PITRM1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PITRM1 and the right PPI network was created from samples without mutations in the LBS of PITRM1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for PITRM1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for PITRM1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PITRM1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLN,LYS,LEU,VAL,PHE,PHE,ALA,GLU,ASP)4ngeAL111 L127
IIIPeptide ligand (VAL,PHE,PHE,ALA,GLU)4ngeDL127
3UE[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL](3-METHYL-4- NITROPHENYL)METHANONE4rpuBL60 M446
3UE[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL](3-METHYL-4- NITROPHENYL)METHANONE4rpuAM446
3UE[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL](3-METHYL-4- NITROPHENYL)METHANONE4rpuBQ470
3UE[4-(DIPHENYLMETHYL)PIPERAZIN-1-YL](3-METHYL-4- NITROPHENYL)METHANONE4rpuAS351 Q470


Top
Conservation information for LBS of PITRM1
Multiple alignments for Q5JRX3 in multiple species
LBSAA sequence# speciesSpecies
A137STFMNAFTASD3Homo sapiens, Danio rerio, Xenopus tropicalis
A137HTFLNAFTYPD2Arabidopsis thaliana, Arabidopsis thaliana
A137ANFMNAMTAHD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A137SNFMNAFTASD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A137ATFMNAMTGPD1Drosophila melanogaster
A137STFMNAMTASD1Mus musculus
A343TDTFEAFTLSL3Homo sapiens, Xenopus tropicalis, Mus musculus
A343LDLQTQLALGF2Arabidopsis thaliana, Arabidopsis thaliana
A343NDVYETFLLKI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A343NNVVESFSLAL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A343TNIQESFELHV1Drosophila melanogaster
A343TDTFEMFTLSL1Danio rerio
E205GVVFNEMKGAF2Homo sapiens, Mus musculus
E205GVVFNEMKGVY2Arabidopsis thaliana, Arabidopsis thaliana
E205GVVYNEMKGQV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E205GVVYNEMKGQM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E205GVVYNEMKGAF1Drosophila melanogaster
E205GVVFNEMKGVF1Danio rerio
E205GIVFNEMKGAF1Xenopus tropicalis
E463DGDPVELLKLG1Homo sapiens
E463DMDPFEPLKYT1Arabidopsis thaliana
E463DMDPFEPLKYE1Arabidopsis thaliana
E463NTDPFDLLSLN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E463GVDPFDSLAWN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E463DGDVVSNLRVS1Drosophila melanogaster
E463DGDPVQLLKIS1Danio rerio
E463EGDPVDLLKIG1Xenopus tropicalis
E463DGDPVELLQIG1Mus musculus
E634DLTFVQLNQLI2Arabidopsis thaliana, Arabidopsis thaliana
E634LLDYREQAQQI1Homo sapiens
E634LEDASAIEEQI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E634DMTMEQLEDLI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E634NYNYREFDKHI1Drosophila melanogaster
E634MLDYRQQAQRI1Danio rerio
E634VYNYREQAQQM1Xenopus tropicalis
E634ILNYREQAQQI1Mus musculus
F123PCRDPFFKMLN4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
F123PVRDPFFKMLN2Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Drosophila melanogaster
F123PVKEPFVELLK1Arabidopsis thaliana
F123PMKEPFVELLK1Arabidopsis thaliana
F123PIRDPFFKMLP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F124CRDPFFKMLNR4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
F124VRDPFFKMLNR2Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Drosophila melanogaster
F124VKEPFVELLKG1Arabidopsis thaliana
F124MKEPFVELLKG1Arabidopsis thaliana
F124IRDPFFKMLPR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F134RSLSTFMNAFT3Homo sapiens, Danio rerio, Xenopus tropicalis
F134GSLHTFLNAFT2Arabidopsis thaliana, Arabidopsis thaliana
F134RSLANFMNAMT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F134RTLSNFMNAFT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F134RSVATFMNAMT1Drosophila melanogaster
F134RSLSTFMNAMT1Mus musculus
F138TFMNAFTASDY3Homo sapiens, Danio rerio, Xenopus tropicalis
F138TFLNAFTYPDR2Arabidopsis thaliana, Arabidopsis thaliana
F138NFMNAMTAHDH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F138NFMNAFTASDH1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F138TFMNAMTGPDY1Drosophila melanogaster
F138TFMNAMTASDY1Mus musculus
F344DTFEAFTLSLL3Homo sapiens, Xenopus tropicalis, Mus musculus
F344DLQTQLALGFL2Arabidopsis thaliana, Arabidopsis thaliana
F344DVYETFLLKIL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F344NVVESFSLALI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F344NIQESFELHVL1Drosophila melanogaster
F344DTFEMFTLSLL1Danio rerio
F443HQSTSF---GL3Homo sapiens, Danio rerio, Xenopus tropicalis
F443ENNTGSFPRGL1Arabidopsis thaliana
F443ENNTGSSPRGL1Arabidopsis thaliana
F443DQKSDF---GL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F443HKTANF---GM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F443HQNPNF---GN1Drosophila melanogaster
F443HQSASF---GL1Mus musculus
G236YSVVSGGDPLC2Homo sapiens, Mus musculus
G236YGVDSGGDPKD2Arabidopsis thaliana, Arabidopsis thaliana
G236--HNSGGDPEH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G236--HNSGGDPQK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G236YRHVSGGNPLE1Drosophila melanogaster
G236YSVVSGGEPLA1Danio rerio
G236YSVVSGGEPLN1Xenopus tropicalis
G382DVGYNGYTREA2Homo sapiens, Mus musculus
G382SSGLSDELLQP1Arabidopsis thaliana
G382NSGMEDELLQP1Arabidopsis thaliana
G382NTGVESQTAAN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G382NTGYDSSGKLG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G382TTGYSSDTKDT1Drosophila melanogaster
G382SAGFDGSTRQA1Danio rerio
G382DTGFNNYTRET1Xenopus tropicalis
H108PHILEHTVLCG3Homo sapiens, Danio rerio, Xenopus tropicalis
H108PHILEHSVLCG2Arabidopsis thaliana, Arabidopsis thaliana
H108PHILEHTTLCG2Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H108PHILEHLSLCG1Drosophila melanogaster
H108PHVLEHTVLCG1Mus musculus
I337LLPD-ITDTFE2Homo sapiens, Mus musculus
I337LLSEKPLDLQT1Arabidopsis thaliana
I337LLSDKPLDLQT1Arabidopsis thaliana
I337ICGN-PNDVYE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I337VLGE-TNNVVE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I337LMCD-ATNIQE1Drosophila melanogaster
I337LLGD-ITDTFE1Danio rerio
I337LLSE-ITDTFE1Xenopus tropicalis
I432ALLHKIEIQMK2Homo sapiens, Danio rerio
I432ASMNTIEFSLR2Arabidopsis thaliana, Arabidopsis thaliana
I432AILHQLELSKK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I432GYLHQLELGLK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I432SVLHNLELSLK1Drosophila melanogaster
I432ALLHKLEIQMK1Xenopus tropicalis
I432ALLHKIEIQTK1Mus musculus
I451MLTSYIASCWN1Homo sapiens
I451SLMLQSISKWI1Arabidopsis thaliana
I451SLMLQSIAKWI1Arabidopsis thaliana
I451QLLYGILPGWV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I451SLLHRLKPKWF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I451TLLFNSTALWN1Drosophila melanogaster
I451ALASYIASLWN1Danio rerio
I451TLASYVASCWN1Xenopus tropicalis
I451TLTSYIASCWN1Mus musculus
K431EALLHKIEIQM2Homo sapiens, Danio rerio
K431EASMNTIEFSL2Arabidopsis thaliana, Arabidopsis thaliana
K431EAILHQLELSK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K431DGYLHQLELGL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K431ESVLHNLELSL1Drosophila melanogaster
K431EALLHKLEIQM1Xenopus tropicalis
K431EALLHKIEIQT1Mus musculus
L111LEHTVLCGSQK3Homo sapiens, Xenopus tropicalis, Mus musculus
L111LEHSVLCGSRK2Arabidopsis thaliana, Arabidopsis thaliana
L111LEHTTLCGSQK2Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L111LEHLSLCGSQK1Drosophila melanogaster
L111LEHTVLCGSQR1Danio rerio
L127PFFKMLNRSLS4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
L127PFVELLKGSLH2Arabidopsis thaliana, Arabidopsis thaliana
L127PFFKMLNRSLA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L127PFFKMLPRTLS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L127PFFKMLNRSVA1Drosophila melanogaster
L348AFTLSLLSSLL2Homo sapiens, Mus musculus
L348QLALGFLDHLM2Arabidopsis thaliana, Arabidopsis thaliana
L348TFLLKILGSLL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L348SFSLALISALL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L348SFELHVLSEVL1Drosophila melanogaster
L348MFTLSLLSSLM1Danio rerio
L348AFTLSLLSSLM1Xenopus tropicalis
L428DRIEALLHKIE2Homo sapiens, Mus musculus
L428DAVEASMNTIE2Arabidopsis thaliana, Arabidopsis thaliana
L428HRVEAILHQLE1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L428SKIDGYLHQLE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L428QHVESVLHNLE1Drosophila melanogaster
L428EQIEALLHKIE1Danio rerio
L428ERIEALLHKLE1Xenopus tropicalis
L447PRGLSLMLQSI2Arabidopsis thaliana, Arabidopsis thaliana
L447--GLMLTSYIA1Homo sapiens
L447--GLQLLYGIL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L447--GMSLLHRLK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L447--GNTLLFNST1Drosophila melanogaster
L447--GLALASYIA1Danio rerio
L447--GLTLASYVA1Xenopus tropicalis
L447--GLTLTSYIA1Mus musculus
L464GDPVELLKLGN1Homo sapiens
L464MDPFEPLKYTE1Arabidopsis thaliana
L464MDPFEPLKYEE1Arabidopsis thaliana
L464TDPFDLLSLNS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L464VDPFDSLAWND1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L464GDVVSNLRVSD1Drosophila melanogaster
L464GDPVQLLKISE1Danio rerio
L464GDPVDLLKIGD1Xenopus tropicalis
L464GDPVELLQIGS1Mus musculus
L467VELLKLGNQLA1Homo sapiens
L467FEPLKYTEPLK1Arabidopsis thaliana
L467FEPLKYEEPLK1Arabidopsis thaliana
L467FDLLSLNSALQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L467FDSLAWNDTIA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L467VSNLRVSDMIS1Drosophila melanogaster
L467VQLLKISESVS1Danio rerio
L467VDLLKIGDKIS1Xenopus tropicalis
L467VELLQIGSQLT1Mus musculus
L60EKVSEEFISEC2Arabidopsis thaliana, Arabidopsis thaliana
L60TPVPELFLT--2Xenopus tropicalis, Mus musculus
L60TSVPELFLT--1Homo sapiens
L60QEIPEMRMA--1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L60KHVPELELT--1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L60EHISEFELT--1Drosophila melanogaster
L60TAVPDLFLT--1Danio rerio
L629KLGCGLLDYRE1Homo sapiens
L629EMGTKDLTFVQ1Arabidopsis thaliana
L629EMGTQDLTFVQ1Arabidopsis thaliana
L629NIGTLLEDASA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L629RLGTKDMTMEQ1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L629AMGTTNYNYRE1Drosophila melanogaster
L629KMGSGMLDYRQ1Danio rerio
L629KLGCGVYNYRE1Xenopus tropicalis
L629KLGCGILNYRE1Mus musculus
M135SLSTFMNAFTA3Homo sapiens, Danio rerio, Xenopus tropicalis
M135SLHTFLNAFTY2Arabidopsis thaliana, Arabidopsis thaliana
M135SLANFMNAMTA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M135TLSNFMNAFTA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M135SVATFMNAMTG1Drosophila melanogaster
M135SLSTFMNAMTA1Mus musculus
M206VVFNEMKGAFT2Homo sapiens, Mus musculus
M206VVFNEMKGVYS2Arabidopsis thaliana, Arabidopsis thaliana
M206VVYNEMKGQVS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M206VVYNEMKGQMS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M206VVYNEMKGAFS1Drosophila melanogaster
M206VVFNEMKGVFS1Danio rerio
M206IVFNEMKGAFT1Xenopus tropicalis
M446---GLMLTSYI1Homo sapiens
M446FPRGLSLMLQS1Arabidopsis thaliana
M446SPRGLSLMLQS1Arabidopsis thaliana
M446---GLQLLYGI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M446---GMSLLHRL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M446---GNTLLFNS1Drosophila melanogaster
M446---GLALASYI1Danio rerio
M446---GLTLASYV1Xenopus tropicalis
M446---GLTLTSYI1Mus musculus
N136LSTFMNAFTAS3Homo sapiens, Danio rerio, Xenopus tropicalis
N136LHTFLNAFTYP2Arabidopsis thaliana, Arabidopsis thaliana
N136LANFMNAMTAH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N136LSNFMNAFTAS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N136VATFMNAMTGP1Drosophila melanogaster
N136LSTFMNAMTAS1Mus musculus
Q435HKIEIQMKHQS2Homo sapiens, Danio rerio
Q435NTIEFSLRENN2Arabidopsis thaliana, Arabidopsis thaliana
Q435HQLELSKKDQK1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q435HQLELGLKHKT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q435HNLELSLKHQN1Drosophila melanogaster
Q435HKLEIQMKHQS1Xenopus tropicalis
Q435HKIEIQTKHQS1Mus musculus
Q470LKLGNQLAKFR1Homo sapiens
Q470LKYTEPLKALK1Arabidopsis thaliana
Q470LKYEEPLKSLK1Arabidopsis thaliana
Q470LSLNSALQRFR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q470LAWNDTIAAFE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q470LRVSDMISGLR1Drosophila melanogaster
Q470LKISESVSRFR1Danio rerio
Q470LKIGDKISRFR1Xenopus tropicalis
Q470LQIGSQLTRFR1Mus musculus
R215FTDNERIFSQH2Homo sapiens, Mus musculus
R215YSQPDNILGRI1Arabidopsis thaliana
R215YSQPDNILGRV1Arabidopsis thaliana
R215VSNADYYFWIR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R215MSDAAYLFWIR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R215FSENAQVFSQN1Drosophila melanogaster
R215FSDNERLYAQH1Danio rerio
R215FTDNEKVFSQH1Xenopus tropicalis
R900LHTEIREKGGA2Homo sapiens, Mus musculus
R900LWDRVRVSGGA2Arabidopsis thaliana, Arabidopsis thaliana
R900LHGEIREKGGA2Danio rerio, Xenopus tropicalis
R900LHREVREKGGA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R900LHHEIREKGGA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R900LLPVIREKNGA1Drosophila melanogaster
S130KMLNRSLSTFM4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
S130ELLKGSLHTFL2Arabidopsis thaliana, Arabidopsis thaliana
S130KMLNRSLANFM1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S130KMLPRTLSNFM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S130KMLNRSVATFM1Drosophila melanogaster
S132LNRSLSTFMNA4Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus
S132LKGSLHTFLNA2Arabidopsis thaliana, Arabidopsis thaliana
S132LNRSLANFMNA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S132LPRTLSNFMNA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S132LNRSVATFMNA1Drosophila melanogaster
S347EAFTLSLLSSL3Homo sapiens, Xenopus tropicalis, Mus musculus
S347TQLALGFLDHL2Arabidopsis thaliana, Arabidopsis thaliana
S347ETFLLKILGSL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S347ESFSLALISAL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S347ESFELHVLSEV1Drosophila melanogaster
S347EMFTLSLLSSL1Danio rerio
S351LGFLDHLMLGT2Arabidopsis thaliana, Arabidopsis thaliana
S351LSLLSSLLTSG1Homo sapiens
S351LKILGSLLFDG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S351LALISALLMDG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S351LHVLSEVLIRG1Drosophila melanogaster
S351LSLLSSLMMSG1Danio rerio
S351LSLLSSLMVDG1Xenopus tropicalis
S351LSLLSSLLIAG1Mus musculus
S449GLMLTSYIASC1Homo sapiens
S449GLSLMLQSISK1Arabidopsis thaliana
S449GLSLMLQSIAK1Arabidopsis thaliana
S449GLQLLYGILPG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S449GMSLLHRLKPK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S449GNTLLFNSTAL1Drosophila melanogaster
S449GLALASYIASL1Danio rerio
S449GLTLASYVASC1Xenopus tropicalis
S449GLTLTSYIASC1Mus musculus
S453TSYIASCWNHD2Homo sapiens, Mus musculus
S453MLQSISKWIYD1Arabidopsis thaliana
S453MLQSIAKWIYD1Arabidopsis thaliana
S453LYGILPGWVNN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S453LHRLKPKWFVG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S453LFNSTALWNHD1Drosophila melanogaster
S453ASYIASLWNHD1Danio rerio
S453ASYVASCWNHE1Xenopus tropicalis
S961IIGTIGDVDSY2Arabidopsis thaliana, Arabidopsis thaliana
S961KLSVFSTVDAP1Homo sapiens
S961KLSIFQRVDAP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S961KISVFQGVDAP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S961KLGVLQQLDTP1Drosophila melanogaster
S961KLSVFSAVDAP1Danio rerio
S961KLSVFSAVDSP1Xenopus tropicalis
S961KLSVFSTVDSP1Mus musculus
T133NRSLSTFMNAF3Homo sapiens, Danio rerio, Xenopus tropicalis
T133KGSLHTFLNAF2Arabidopsis thaliana, Arabidopsis thaliana
T133NRSLANFMNAM1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T133PRTLSNFMNAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T133NRSVATFMNAM1Drosophila melanogaster
T133NRSLSTFMNAM1Mus musculus
T139FMNAFTASDYT3Homo sapiens, Danio rerio, Xenopus tropicalis
T139FLNAFTYPDRT2Arabidopsis thaliana, Arabidopsis thaliana
T139FMNAMTAHDHT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T139FMNAFTASDHT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T139FMNAMTGPDYT1Drosophila melanogaster
T139FMNAMTASDYT1Mus musculus
T340D-ITDTFEAFT2Homo sapiens, Mus musculus
T340EKPLDLQTQLA1Arabidopsis thaliana
T340DKPLDLQTQLA1Arabidopsis thaliana
T340N-PNDVYETFL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T340E-TNNVVESFS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T340D-ATNIQESFE1Drosophila melanogaster
T340D-ITDTFEMFT1Danio rerio
T340E-ITDTFEAFT1Xenopus tropicalis
Y143FTYPDRTCYPV2Arabidopsis thaliana, Arabidopsis thaliana
Y143FTASDYTMYPF2Danio rerio, Xenopus tropicalis
Y143FTASDYTLYPF1Homo sapiens
Y143MTAHDHTFYPF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y143FTASDHTFYPF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y143MTGPDYTIYPF1Drosophila melanogaster
Y143MTASDYTIYPF1Mus musculus
Y380SPDVGYNGYTR2Homo sapiens, Mus musculus
Y380-VSSGLSDELL1Arabidopsis thaliana
Y380-VNSGMEDELL1Arabidopsis thaliana
Y380SVNTGVESQTA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y380SPNTGYDSSGK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y380NQTTGYSSDTK1Drosophila melanogaster
Y380SSSAGFDGSTR1Danio rerio
Y380SPDTGFNNYTR1Xenopus tropicalis
Y383VGYNGYTREAY2Homo sapiens, Mus musculus
Y383SGLSDELLQPQ1Arabidopsis thaliana
Y383SGMEDELLQPQ1Arabidopsis thaliana
Y383TGVESQTAANF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y383TGYDSSGKLGI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y383TGYSSDTKDTT1Drosophila melanogaster
Y383AGFDGSTRQAS1Danio rerio
Y383TGFNNYTRETY1Xenopus tropicalis
Y450LMLTSYIASCW1Homo sapiens
Y450LSLMLQSISKW1Arabidopsis thaliana
Y450LSLMLQSIAKW1Arabidopsis thaliana
Y450LQLLYGILPGW1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y450MSLLHRLKPKW1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y450NTLLFNSTALW1Drosophila melanogaster
Y450LALASYIASLW1Danio rerio
Y450LTLASYVASCW1Xenopus tropicalis
Y450LTLTSYIASCW1Mus musculus
Y906EKGGAYGGGAK3Homo sapiens, Xenopus tropicalis, Mus musculus
Y906VSGGAYGGFCD1Arabidopsis thaliana
Y906VSGGAYGGSCD1Arabidopsis thaliana
Y906EKGGAYGGGAT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y906EKGGAYGGGSY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y906EKNGAYGAGAK1Drosophila melanogaster
Y906EKGGAYGGGAR1Danio rerio


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas