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mutLBSgeneDB |
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| Gene summary for GLRX3 |
 Gene summary |
| Basic gene Info. | Gene symbol | GLRX3 |
| Gene name | glutaredoxin 3 | |
| Synonyms | GLRX4|GRX3|GRX4|PICOT|TXNL2|TXNL3 | |
| Cytomap | UCSC genome browser: 10q26 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199868.1, NM_006541.4, | |
| Description | PKC-interacting cousin of thioredoxinPKC-theta-interacting proteinPKCq-interacting proteinglutaredoxin 4glutaredoxin-3thioredoxin-like protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612754 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000108010 | ||
| HPRD : 10153 | ||
| Vega : OTTHUMG00000019267 | ||
| Protein | UniProt: O76003 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GLRX3 | |
| BioGPS: 10539 | ||
| Pathway | NCI Pathway Interaction Database: GLRX3 | |
| KEGG: GLRX3 | ||
| REACTOME: GLRX3 | ||
| Pathway Commons: GLRX3 | ||
| Context | iHOP: GLRX3 | |
| ligand binding site mutation search in PubMed: GLRX3 | ||
| UCL Cancer Institute: GLRX3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for GLRX3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C159 | C159R | COAD | 1 | R188 | Q189H | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GLRX3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R188 | Q189H | 0.1423352 | C159 | C159R | -0.75081629 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GLRX3 from PDB |
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| Differential gene expression and gene-gene network for GLRX3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GLRX3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0018800 | Cardiomegaly | 1 | Therapeutic |
| umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GLRX3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GLRX3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of GLRX3 |
| Multiple alignments for O76003 in multiple species |
| LBS | AA sequence | # species | Species | C159 | PQEPRCGFSKQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | C159 | PQEPRCGFSRQ | 2 | Danio rerio, Xenopus tropicalis | C159 | ----------- | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C159 | PEEPRCGFSRK | 1 | Arabidopsis thaliana | C159 | PEQPRCGFSRK | 1 | Oryza sativa subsp. japonica | F263 | EAKCGFSKQIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F263 | AAKCGFSRQIL | 1 | Danio rerio | F263 | MAKCGFSRQIL | 1 | Xenopus tropicalis | F263 | EAKCGFSRQIL | 1 | Bos taurus | F263 | EPKCGFSSKVV | 1 | Arabidopsis thaliana | F263 | APRCGFSSKVV | 1 | Oryza sativa subsp. japonica | F263 | EPACGFSRKLV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F263 | EPKCGFSRQLV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K253 | VMLFMKGNKQE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K253 | VMLFMKGNKEA | 1 | Danio rerio | K253 | VMLFMKGNKEM | 1 | Xenopus tropicalis | K253 | VMLFMKGSPDE | 1 | Arabidopsis thaliana | K253 | VMLFMKGTPDA | 1 | Oryza sativa subsp. japonica | K253 | VMLFLKGTPSE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K253 | VMLFMKGSPSE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K260 | NKQEAKCGFSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K260 | NKEAAKCGFSR | 1 | Danio rerio | K260 | NKEMAKCGFSR | 1 | Xenopus tropicalis | K260 | NKQEAKCGFSR | 1 | Bos taurus | K260 | SPDEPKCGFSS | 1 | Arabidopsis thaliana | K260 | TPDAPRCGFSS | 1 | Oryza sativa subsp. japonica | K260 | TPSEPACGFSR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K260 | SPSEPKCGFSR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R188 | SDEEVRQGLKT | 5 | Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus | R188 | ----------- | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R188 | SDEEVRQGLKA | 1 | Homo sapiens | R188 | SDNEVREGLKK | 1 | Arabidopsis thaliana | R188 | TDNDVREGMKK | 1 | Oryza sativa subsp. japonica |
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