mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GLRX3
Gene summary
Basic gene Info.Gene symbolGLRX3
Gene nameglutaredoxin 3
CytomapUCSC genome browser: 10q26
Type of geneprotein-coding
DescriptionPKC-interacting cousin of thioredoxinPKC-theta-interacting proteinPKCq-interacting proteinglutaredoxin 4glutaredoxin-3thioredoxin-like protein 2
Modification date20141207
dbXrefs MIM : 612754
Ensembl : ENSG00000108010
HPRD : 10153
Vega : OTTHUMG00000019267
ProteinUniProt: O76003
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GLRX3
BioGPS: 10539
PathwayNCI Pathway Interaction Database: GLRX3
Pathway Commons: GLRX3
ContextiHOP: GLRX3
ligand binding site mutation search in PubMed: GLRX3
UCL Cancer Institute: GLRX3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for GLRX3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GLRX3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GLRX3 from PDB

Differential gene expression and gene-gene network for GLRX3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GLRX3 and the right PPI network was created from samples without mutations in the LBS of GLRX3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GLRX3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GLRX3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GLRX3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of GLRX3
Multiple alignments for O76003 in multiple species
LBSAA sequence# speciesSpecies
C159PQEPRCGFSKQ4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C159PQEPRCGFSRQ2Danio rerio, Xenopus tropicalis
C159-----------2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C159PEEPRCGFSRK1Arabidopsis thaliana
C159PEQPRCGFSRK1Oryza sativa subsp. japonica
F263EAKCGFSKQIL3Homo sapiens, Mus musculus, Rattus norvegicus
F263AAKCGFSRQIL1Danio rerio
F263MAKCGFSRQIL1Xenopus tropicalis
F263EAKCGFSRQIL1Bos taurus
F263EPKCGFSSKVV1Arabidopsis thaliana
F263APRCGFSSKVV1Oryza sativa subsp. japonica
F263EPACGFSRKLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F263EPKCGFSRQLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K253VMLFMKGNKQE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K253VMLFMKGNKEA1Danio rerio
K253VMLFMKGNKEM1Xenopus tropicalis
K253VMLFMKGSPDE1Arabidopsis thaliana
K253VMLFMKGTPDA1Oryza sativa subsp. japonica
K253VMLFLKGTPSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K253VMLFMKGSPSE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K260NKQEAKCGFSK3Homo sapiens, Mus musculus, Rattus norvegicus
K260NKEAAKCGFSR1Danio rerio
K260NKEMAKCGFSR1Xenopus tropicalis
K260NKQEAKCGFSR1Bos taurus
K260SPDEPKCGFSS1Arabidopsis thaliana
K260TPDAPRCGFSS1Oryza sativa subsp. japonica
K260TPSEPACGFSR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K260SPSEPKCGFSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R188SDEEVRQGLKT5Danio rerio, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R188-----------2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R188SDEEVRQGLKA1Homo sapiens
R188SDNEVREGLKK1Arabidopsis thaliana
R188TDNDVREGMKK1Oryza sativa subsp. japonica

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