mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for 10638
Gene summary
Basic gene Info.Gene symbol10638
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt: P20338
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_10638
BioGPS: 10638
PathwayNCI Pathway Interaction Database: 10638
KEGG: 10638
REACTOME: 10638
Pathway Commons: 10638
ContextiHOP: 10638
ligand binding site mutation search in PubMed: 10638
UCL Cancer Institute: 10638
Assigned class in mutLBSgeneDB

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for 10638

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for 10638
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for 10638 from PDB

Top
Differential gene expression and gene-gene network for 10638
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of 10638 and the right PPI network was created from samples without mutations in the LBS of 10638. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for 10638
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for 10638
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of 10638 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of 10638
Multiple alignments for P20338 in multiple species
LBSAA sequence# speciesSpecies
A157L-ETSALTGEN5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A157AHETSSYTGSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A22LVIGNAGTGKS5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A22VLAGPSGTGKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A70QIWDTAGQERF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
A70QIWDTAGQEKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C28GTGKSCLLHQF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
C28GTGKSCLLQRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D129CGNKKDLDADR4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
D129AGSKSDLQNQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D129CGNKKDLDTDR1Bos taurus
F38FIEKKFKDDSN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F38FVKNQWDDQVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F38FIEKRFKDDSN1Danio rerio
G23VIGNAGTGKSC5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G23LAGPSGTGKSC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G25GNAGTGKSCLL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G25GPSGTGKSCLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G71IWDTAGQERFR5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
G71IWDTAGQEKFR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H44KDDSNHTIGVE5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
H44DDQVSHTVGID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K127ILCGNKKDLDA4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
K127VLAGSKSDLQN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K127ILCGNKKDLDT1Bos taurus
K26NAGTGKSCLLH5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
K26PSGTGKSCLLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L130GNKKDLDADRE4Homo sapiens, Danio rerio, Mus musculus, Rattus norvegicus
L130GSKSDLQNQRQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L130GNKKDLDTDRE1Bos taurus
L158-ETSALTGENV5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
L158HETSSYTGSNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N126IILCGNKKDLD4Homo sapiens, Danio rerio, Bos taurus, Rattus norvegicus
N126VVLAGSKSDLQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N126LILCGNKKDLD1Mus musculus
S156FL-ETSALTGE5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
S156SAHETSSYTGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S27AGTGKSCLLHQ5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
S27SGTGKSCLLQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S42KFKDDSNHTIG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S42QWDDQVSHTVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S42RFKDDSNHTIG1Danio rerio
T24IGNAGTGKSCL5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
T24AGPSGTGKSCL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T45DDSNHTIGVEF5Homo sapiens, Danio rerio, Bos taurus, Mus musculus, Rattus norvegicus
T45DQVSHTVGIDF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas