mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for FARS2
Gene summary
Basic gene Info.Gene symbolFARS2
Gene namephenylalanyl-tRNA synthetase 2, mitochondrial
CytomapUCSC genome browser: 6p25.1
Type of geneprotein-coding
DescriptiondJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))phenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine--tRNA ligase, mitochondrialphenylalanine-tRNA synthetase 1 (mitochondrial)
Modification date20141207
dbXrefs MIM : 611592
Ensembl : ENSG00000145982
HPRD : 09946
Vega : OTTHUMG00000014178
ProteinUniProt: O95363
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FARS2
BioGPS: 10667
PathwayNCI Pathway Interaction Database: FARS2
Pathway Commons: FARS2
ContextiHOP: FARS2
ligand binding site mutation search in PubMed: FARS2
UCL Cancer Institute: FARS2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006432phenylalanyl-tRNA aminoacylation10329163
GO:0008033tRNA processing10329163

Ligand binding site mutations for FARS2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for FARS2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FARS2 from PDB

Differential gene expression and gene-gene network for FARS2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of FARS2 and the right PPI network was created from samples without mutations in the LBS of FARS2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for FARS2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
211258R330HLikely pathogenicGermlineMedGen:CN221809

Pharmacological information for FARS2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00120L-PhenylalanineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of FARS2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of FARS2
Multiple alignments for O95363 in multiple species
LBSAA sequence# speciesSpecies
A311DRIGWAFGLGL3Homo sapiens, Mus musculus, Rattus norvegicus
A311ETIGWAFGLGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A311QSIGYAFGVGL1Drosophila melanogaster
A311NNVAWAFGLGL1Arabidopsis thaliana
A311NYIGWAFGIGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A362LSKYPAVINDI1Homo sapiens
A362YSKHPGSFRDV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A362ISHYPQCTNDL1Drosophila melanogaster
A362LSKYPAVFNDI1Mus musculus
A362FSKYPAVFNDI1Rattus norvegicus
A362YSKYPPCYKDI1Arabidopsis thaliana
A362FSKYPACFKDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C291LEVLGCGVMEQ3Homo sapiens, Mus musculus, Rattus norvegicus
C291LELCGCGLIRQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C291LEVLGCGIMRH1Drosophila melanogaster
C291LEVLGCGVTEQ1Arabidopsis thaliana
C291LEILGCGVVQD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C413HRTSHCYRITY2Mus musculus, Rattus norvegicus
C413HKTSHCYRITY1Homo sapiens
C413GRKSMCYRINY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C413GKSSVCFRIVY1Drosophila melanogaster
C413GLTSHCYRIVF1Arabidopsis thaliana
C413GKTSLCYRVNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D181DVYRRDQIDSQ2Homo sapiens, Rattus norvegicus
D181DVYRRDEIDKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D181EVYRRDEIDST1Drosophila melanogaster
D181DVYRRDQIDCQ1Mus musculus
D181DVYRRDSIDST1Arabidopsis thaliana
D181DVYRRDEVDSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D366PAVFNDISFWL2Mus musculus, Rattus norvegicus
D366PAVINDISFWL1Homo sapiens
D366PGSFRDVAFWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D366PQCTNDLSFWL1Drosophila melanogaster
D366PPCYKDISFWI1Arabidopsis thaliana
D366PACFKDIAFWI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D400KVDLIDKFEHP2Mus musculus, Rattus norvegicus
D400KVDLIDKFVHP1Homo sapiens
D400SVKLVDSFTHP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D400QISLVDKFKHP1Drosophila melanogaster
D400EVKLIDQFTNK1Arabidopsis thaliana
D400SVNLIDQYT-A1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E195VFHQLEGVRLF2Mus musculus, Rattus norvegicus
E195IFHQLEAVRLF1Homo sapiens
E195VFHQMEGATIW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E195VFHQADAVRLV1Drosophila melanogaster
E195VFHQMEGFCVF1Arabidopsis thaliana
E195IFHQMEGALVW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E287RGEWLEVLGCG2Mus musculus, Rattus norvegicus
E287HGEWLEVLGCG1Homo sapiens
E287QGEWLELCGCG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E287KDNWLEVLGCG1Drosophila melanogaster
E287KEDWLEVLGCG1Arabidopsis thaliana
E287KGKWLEILGCG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F191THYPVFHQMEG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Arabidopsis thaliana
F191QHYPVFHQLEG2Mus musculus, Rattus norvegicus
F191QHYPIFHQLEA1Homo sapiens
F191THYPVFHQADA1Drosophila melanogaster
F191SHYPIFHQMEG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F268WVDCYFPFTHP3Homo sapiens, Mus musculus, Rattus norvegicus
F268WINAYFPWTAP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F268WVDTYFPFTQP1Drosophila melanogaster
F268WVDTYFPFTNP1Arabidopsis thaliana
F268WTYDSFPFTKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F270DCYFPFTHPSF3Homo sapiens, Mus musculus, Rattus norvegicus
F270NAYFPWTAPSW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F270DTYFPFTQPSW1Drosophila melanogaster
F270DTYFPFTNPSF1Arabidopsis thaliana
F270YDSFPFTKPSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F312RIGWAFGLGLE3Homo sapiens, Mus musculus, Rattus norvegicus
F312TIGWAFGLGLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F312SIGYAFGVGLE1Drosophila melanogaster
F312NVAWAFGLGLE1Arabidopsis thaliana
F312YIGWAFGIGLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F402DLIDKFEHPKT2Mus musculus, Rattus norvegicus
F402DLIDKFVHPKT1Homo sapiens
F402KLVDSFTHPKT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F402SLVDKFKHPKT1Drosophila melanogaster
F402KLIDQFTNKKK1Arabidopsis thaliana
F402NLIDQYT-AKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G290WLEVLGCGVME3Homo sapiens, Mus musculus, Rattus norvegicus
G290WLELCGCGLIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G290WLEVLGCGIMR1Drosophila melanogaster
G290WLEVLGCGVTE1Arabidopsis thaliana
G290WLEILGCGVVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G292EVLGCGVMEQQ3Homo sapiens, Mus musculus, Rattus norvegicus
G292ELCGCGLIRQD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G292EVLGCGIMRHE1Drosophila melanogaster
G292EVLGCGVTEQV1Arabidopsis thaliana
G292EILGCGVVQDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G313IGWAFGLGLER3Homo sapiens, Mus musculus, Rattus norvegicus
G313IGWAFGLGLDR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G313IGYAFGVGLER1Drosophila melanogaster
G313VAWAFGLGLER1Arabidopsis thaliana
G313IGWAFGIGLER1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H155HMLRAHTSAHQ3Homo sapiens, Mus musculus, Rattus norvegicus
H155HLLRTHTSAHE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H155HLLRAHTTAHQ1Drosophila melanogaster
H155TVLRCHTSAHQ1Arabidopsis thaliana
H155TCLRTHTSAHQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H187QIDSQHYPIFH1Homo sapiens
H187EIDKTHYPVFH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H187EIDSTHYPVFH1Drosophila melanogaster
H187QIDCQHYPVFH1Mus musculus
H187QIDSQHYPVFH1Rattus norvegicus
H187SIDSTHYPVFH1Arabidopsis thaliana
H187EVDSSHYPIFH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I329YDIPDIRLFWS2Mus musculus, Rattus norvegicus
I329YDIPDIRLFWC1Homo sapiens
I329FEIPDIRLLWS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I329FDIPDIRLFWS1Drosophila melanogaster
I329FDIPDIRFFWS1Arabidopsis thaliana
I329YGIPDIRLFWS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I364KYPAVFNDISF2Mus musculus, Rattus norvegicus
I364KYPAVINDISF1Homo sapiens
I364KHPGSFRDVAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I364HYPQCTNDLSF1Drosophila melanogaster
I364KYPPCYKDISF1Arabidopsis thaliana
I364KYPACFKDIAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K359--PLSKYPAVI1Homo sapiens
K359--PYSKHPGSF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K359--PISHYPQCT1Drosophila melanogaster
K359--PLSKYPAVF1Mus musculus
K359LCPFSKYPAVF1Rattus norvegicus
K359--PYSKYPPCY1Arabidopsis thaliana
K359--PFSKYPACF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K69TNLTQKVLSKV2Mus musculus, Rattus norvegicus
K69SNLTRKVLTRV1Homo sapiens
K69TNVTDSIIKLT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K69TNVTPKILSYV1Drosophila melanogaster
K69NNVPDSIFSKL1Arabidopsis thaliana
K69SNVPEHIHSKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L289EWLEVLGCGVM3Homo sapiens, Mus musculus, Rattus norvegicus
L289EWLELCGCGLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L289NWLEVLGCGIM1Drosophila melanogaster
L289DWLEVLGCGVT1Arabidopsis thaliana
L289KWLEILGCGVV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L425HMERTLSQREV3Homo sapiens, Mus musculus, Rattus norvegicus
L425SMDRNLTNAEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L425HMERTLTQAEV1Drosophila melanogaster
L425SMERSLTDEEV1Arabidopsis thaliana
L425SMERSLRNEEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N365YPAVFNDISFW2Mus musculus, Rattus norvegicus
N365YPAVINDISFW1Homo sapiens
N365HPGSFRDVAFW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N365YPQCTNDLSFW1Drosophila melanogaster
N365YPPCYKDISFW1Arabidopsis thaliana
N365YPACFKDIAFW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P361PLSKYPAVIND1Homo sapiens
P361PYSKHPGSFRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P361PISHYPQCTND1Drosophila melanogaster
P361PLSKYPAVFND1Mus musculus
P361PFSKYPAVFND1Rattus norvegicus
P361PYSKYPPCYKD1Arabidopsis thaliana
P361PFSKYPACFKD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q160HTSAHQWD---3Homo sapiens, Mus musculus, Rattus norvegicus
Q160HTSAHELECFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q160HTTAHQVE---1Drosophila melanogaster
Q160HTSAHQAE---1Arabidopsis thaliana
Q160HTSAHQPEEFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q182VYRRDQIDSQH2Homo sapiens, Rattus norvegicus
Q182VYRRDEIDKTH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q182VYRRDEIDSTH1Drosophila melanogaster
Q182VYRRDQIDCQH1Mus musculus
Q182VYRRDSIDSTH1Arabidopsis thaliana
Q182VYRRDEVDSSH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q186DQIDSQHYPIF1Homo sapiens
Q186DEIDKTHYPVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q186DEIDSTHYPVF1Drosophila melanogaster
Q186DQIDCQHYPVF1Mus musculus
Q186DQIDSQHYPVF1Rattus norvegicus
Q186DSIDSTHYPVF1Arabidopsis thaliana
Q186DEVDSSHYPIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q193YPVFHQLEGVR2Mus musculus, Rattus norvegicus
Q193YPIFHQLEAVR1Homo sapiens
Q193YPVFHQMEGAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q193YPVFHQADAVR1Drosophila melanogaster
Q193YPVFHQMEGFC1Arabidopsis thaliana
Q193YPIFHQMEGAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q427ERTLSQREVRH1Homo sapiens
Q427DRNLTNAEVNT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q427ERTLTQAEVNE1Drosophila melanogaster
Q427ERTLSQREVGN1Mus musculus
Q427ERTLSQREVSS1Rattus norvegicus
Q427ERSLTDEEVND1Arabidopsis thaliana
Q427ERSLRNEEIDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R104KQYVGRFGTPL1Homo sapiens
R104SVDNT------1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R104GAYRNQRGNPL1Drosophila melanogaster
R104QQYMVRSRTPL1Mus musculus
R104QQYMGRSRTPL1Rattus norvegicus
R104SNYSNK-----1Arabidopsis thaliana
R104KFEMNN-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R179VGDVYRRDQID3Homo sapiens, Mus musculus, Rattus norvegicus
R179SADVYRRDEID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R179VGEVYRRDEID1Drosophila melanogaster
R179TGDVYRRDSID1Arabidopsis thaliana
R179TADVYRRDEVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R318GLGLERLAMVL3Mus musculus, Rattus norvegicus, Arabidopsis thaliana
R318GLGLERLAMIL1Homo sapiens
R318GLGLDRIAMLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R318GVGLERLAMVL1Drosophila melanogaster
R318GIGLERLAMIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R330DIPDIRLFWSE2Mus musculus, Rattus norvegicus
R330DIPDIRLFWCE1Homo sapiens
R330EIPDIRLLWSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R330DIPDIRLFWSN1Drosophila melanogaster
R330DIPDIRFFWSS1Arabidopsis thaliana
R330GIPDIRLFWSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R431SQREVRHIHQA1Homo sapiens
R431TNAEVNTLQDM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R431TQAEVNEIHKQ1Drosophila melanogaster
R431SQREVGNVHQA1Mus musculus
R431SQREVSSVHQA1Rattus norvegicus
R431TDEEVNDLQSK1Arabidopsis thaliana
R431RNEEIDKLQEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S157LRAHTSAHQWD3Homo sapiens, Mus musculus, Rattus norvegicus
S157LRTHTSAHELE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S157LRAHTTAHQVE1Drosophila melanogaster
S157LRCHTSAHQAE1Arabidopsis thaliana
S157LRTHTSAHQPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S368VFNDISFWLPS2Mus musculus, Rattus norvegicus
S368VINDISFWLPS1Homo sapiens
S368SFRDVAFWLPE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S368CTNDLSFWLPQ1Drosophila melanogaster
S368CYKDISFWISD1Arabidopsis thaliana
S368CFKDIAFWINN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T271CYFPFTHPSFE3Homo sapiens, Mus musculus, Rattus norvegicus
T271AYFPWTAPSWE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T271TYFPFTQPSWE1Drosophila melanogaster
T271TYFPFTNPSFE1Arabidopsis thaliana
T271DSFPFTKPSFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V363SKYPAVFNDIS2Mus musculus, Rattus norvegicus
V363SKYPAVINDIS1Homo sapiens
V363SKHPGSFRDVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V363SHYPQCTNDLS1Drosophila melanogaster
V363SKYPPCYKDIS1Arabidopsis thaliana
V363SKYPACFKDIA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y188IDSTHYPVFHQ2Drosophila melanogaster, Arabidopsis thaliana
Y188IDSQHYPIFHQ1Homo sapiens
Y188IDKTHYPVFHQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y188IDCQHYPVFHQ1Mus musculus
Y188IDSQHYPVFHQ1Rattus norvegicus
Y188VDSSHYPIFHQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y360-PLSKYPAVIN1Homo sapiens
Y360-PYSKHPGSFR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y360-PISHYPQCTN1Drosophila melanogaster
Y360-PLSKYPAVFN1Mus musculus
Y360CPFSKYPAVFN1Rattus norvegicus
Y360-PYSKYPPCYK1Arabidopsis thaliana
Y360-PFSKYPACFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

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