mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CETN2
Gene summary
Basic gene Info.Gene symbolCETN2
Gene namecentrin, EF-hand protein, 2
SynonymsCALT|CEN2
CytomapUCSC genome browser: Xq28
Type of geneprotein-coding
RefGenesNM_004344.1,
Descriptioncaltractin (20kD calcium-binding protein)centrin-2
Modification date20141207
dbXrefs MIM : 300006
HGNC : HGNC
HPRD : 02051
ProteinUniProt: P41208
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CETN2
BioGPS: 1069
PathwayNCI Pathway Interaction Database: CETN2
KEGG: CETN2
REACTOME: CETN2
Pathway Commons: CETN2
ContextiHOP: CETN2
ligand binding site mutation search in PubMed: CETN2
UCL Cancer Institute: CETN2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006289nucleotide-excision repair15964821


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Ligand binding site mutations for CETN2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E132E132DBLCA1
I146I146VCOAD1
D154,E156G155RLUAD1
S122S122LSKCM1
K108,I106L107MSTAD1
K120K120TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CETN2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
I106L107M-1.2277159
K108L107M-1.2277159
I146I146V-1.1326004
E132E132D-0.99118582
K120K120T-0.71481522
S122S122L-0.53935349
E156G155R-0.054314781
D154G155R-0.054314781
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CETN2 from PDB

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Differential gene expression and gene-gene network for CETN2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CETN2 and the right PPI network was created from samples without mutations in the LBS of CETN2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CETN2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CETN2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CETN2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)2ggmAD154 E156
CACALCIUM(2+)2ggmBD154 E156
CACALCIUM(2+)2obhAD154 E156
CACALCIUM(2+)2obhBD154 E156
IIIPeptide ligand (ASN,TRP,LYS,LEU,LEU,ALA,LYS,GLY,LEU,LEU,ILE,ARG,GLU,ARG,LEU,LYS,ARG)2ggmAE132
IIIPeptide ligand (ARG,ALA,ASP,LEU,HIS,HIS,GLN,HIS,SER,VAL,LEU,HIS,ARG,ALA,LEU,GLN,ALA,TRP,VAL,THR)2k2iAE132
IIIPeptide ligand (ASN,TRP,LYS,LEU,LEU,ALA,LYS,GLY,LEU,LEU,ILE,ARG,GLU,ARG,LEU,LYS,ARG)2a4jAI106 K108 I146
IIIPeptide ligand (ASN,TRP,LYS,LEU,LEU,ALA,LYS,GLY,LEU,LEU,ILE,ARG,GLU,ARG,LEU,LYS,ARG)2ggmBK108 E132
IIIPeptide ligand (ACE,ASN,TRP,LYS,LEU,LEU,ALA,LYS,GLY,LEU,LEU,ILE,ARG,GLU,ARG,LEU,LYS)2obhAK108 E132
IIIPeptide ligand (ACE,ASN,TRP,LYS,LEU,LEU,ALA,LYS,GLY,LEU,LEU,ILE,ARG,GLU,ARG,LEU,LYS,ARG)2obhBK108 E132
CACALCIUM(2+)2ggmBK120
CACALCIUM(2+)2obhAK120
CACALCIUM(2+)2obhBK120
CACALCIUM(2+)2ggmAK120 S122


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Conservation information for LBS of CETN2
Multiple alignments for P41208 in multiple species
LBSAA sequence# speciesSpecies
A109EEILKAFKLFD3Homo sapiens, Mus musculus, Bos taurus
A109EELTKAFQIID1Arabidopsis thaliana
A109EELTKAFSIID1Oryza sativa subsp. japonica
A130NLKRVAKELGE3Homo sapiens, Mus musculus, Bos taurus
A130DIKRMAKDLGE1Arabidopsis thaliana
A130DIQRIAKELGE1Oryza sativa subsp. japonica
A149EMIDEADRDGD3Homo sapiens, Mus musculus, Bos taurus
A149EMVEEADRDRD1Arabidopsis thaliana
A149EMVQEADRNGD1Oryza sativa subsp. japonica
D114AFKLFDDDETG3Homo sapiens, Mus musculus, Bos taurus
D114AFQIIDLDKNG1Arabidopsis thaliana
D114AFSIIDQDKNG1Oryza sativa subsp. japonica
D116KLFDDDETGKI3Homo sapiens, Mus musculus, Bos taurus
D116QIIDLDKNGKI1Arabidopsis thaliana
D116SIIDQDKNGKI1Oryza sativa subsp. japonica
D150MIDEADRDGDG3Homo sapiens, Mus musculus, Bos taurus
D150MVEEADRDRDG1Arabidopsis thaliana
D150MVQEADRNGDG1Oryza sativa subsp. japonica
D152DEADRDGDGEV3Homo sapiens, Mus musculus, Bos taurus
D152EEADRDRDGEV1Arabidopsis thaliana
D152QEADRNGDGEI1Oryza sativa subsp. japonica
D154ADRDGDGEVNE2Mus musculus, Bos taurus
D154ADRDGDGEVSE1Homo sapiens
D154ADRDRDGEVNM1Arabidopsis thaliana
D154ADRNGDGEIDF1Oryza sativa subsp. japonica
E104EKDTKEEILKA3Homo sapiens, Mus musculus, Bos taurus
E104ERDTKEELTKA1Arabidopsis thaliana
E104ERDSKEELTKA1Oryza sativa subsp. japonica
E105KDTKEEILKAF3Homo sapiens, Mus musculus, Bos taurus
E105RDTKEELTKAF1Arabidopsis thaliana
E105RDSKEELTKAF1Oryza sativa subsp. japonica
E132KRVAKELGENL3Homo sapiens, Mus musculus, Bos taurus
E132KRMAKDLGENF1Arabidopsis thaliana
E132QRIAKELGENF1Oryza sativa subsp. japonica
E135AKELGENLTDE2Homo sapiens, Mus musculus
E135AKELGENLSDE1Bos taurus
E135AKDLGENFTDA1Arabidopsis thaliana
E135AKELGENFTYQ1Oryza sativa subsp. japonica
E148QEMIDEADRDG3Homo sapiens, Mus musculus, Bos taurus
E148REMVEEADRDR1Arabidopsis thaliana
E148QEMVQEADRNG1Oryza sativa subsp. japonica
E156RDGDGEVNEQE2Mus musculus, Bos taurus
E156RDGDGEVSEQE1Homo sapiens
E156RDRDGEVNMDE1Arabidopsis thaliana
E156RNGDGEIDFDE1Oryza sativa subsp. japonica
E161EVNEQEFLRIM2Mus musculus, Bos taurus
E161EVSEQEFLRIM1Homo sapiens
E161EVNMDEFMRMM1Arabidopsis thaliana
E161EIDFDEFIRMM1Oryza sativa subsp. japonica
F113KAFKLFDDDET3Homo sapiens, Mus musculus, Bos taurus
F113KAFQIIDLDKN1Arabidopsis thaliana
F113KAFSIIDQDKN1Oryza sativa subsp. japonica
F162VNEQEFLRIMK2Mus musculus, Bos taurus
F162VSEQEFLRIMK1Homo sapiens
F162VNMDEFMRMMR1Arabidopsis thaliana
F162IDFDEFIRMMR1Oryza sativa subsp. japonica
G134VAKELGENLTD2Homo sapiens, Mus musculus
G134VAKELGENLSD1Bos taurus
G134MAKDLGENFTD1Arabidopsis thaliana
G134IAKELGENFTY1Oryza sativa subsp. japonica
I106DTKEEILKAFK3Homo sapiens, Mus musculus, Bos taurus
I106DTKEELTKAFQ1Arabidopsis thaliana
I106DSKEELTKAFS1Oryza sativa subsp. japonica
I121DETGKISFKNL3Homo sapiens, Mus musculus, Bos taurus
I121DKNGKISPDDI1Arabidopsis thaliana
I121DKNGKISDVDI1Oryza sativa subsp. japonica
I146ELQEMIDEADR3Homo sapiens, Mus musculus, Bos taurus
I146EIREMVEEADR1Arabidopsis thaliana
I146EIQEMVQEADR1Oryza sativa subsp. japonica
I165QEFLRIMKKTS3Homo sapiens, Mus musculus, Bos taurus
I165DEFMRMMRRTA1Arabidopsis thaliana
I165DEFIRMMRRTG1Oryza sativa subsp. japonica
K108KEEILKAFKLF3Homo sapiens, Mus musculus, Bos taurus
K108KEELTKAFQII1Arabidopsis thaliana
K108KEELTKAFSII1Oryza sativa subsp. japonica
K120DDETGKISFKN3Homo sapiens, Mus musculus, Bos taurus
K120LDKNGKISPDD1Arabidopsis thaliana
K120QDKNGKISDVD1Oryza sativa subsp. japonica
K127SFKNLKRVAKE3Homo sapiens, Mus musculus, Bos taurus
K127SPDDIKRMAKD1Arabidopsis thaliana
K127SDVDIQRIAKE1Oryza sativa subsp. japonica
K6MASNFKKANMA2Homo sapiens, Bos taurus
K6MASNFKKTTMA1Mus musculus
K6MSSIYRT---V1Arabidopsis thaliana
K6MSTV-KG---Q1Oryza sativa subsp. japonica
L112LKAFKLFDDDE3Homo sapiens, Mus musculus, Bos taurus
L112TKAFQIIDLDK1Arabidopsis thaliana
L112TKAFSIIDQDK1Oryza sativa subsp. japonica
L126ISFKNLKRVAK3Homo sapiens, Mus musculus, Bos taurus
L126ISPDDIKRMAK1Arabidopsis thaliana
L126ISDVDIQRIAK1Oryza sativa subsp. japonica
L133RVAKELGENLT2Homo sapiens, Mus musculus
L133RVAKELGENLS1Bos taurus
L133RMAKDLGENFT1Arabidopsis thaliana
L133RIAKELGENFT1Oryza sativa subsp. japonica
L137ELGENLTDEEL2Homo sapiens, Mus musculus
L137ELGENLSDEEL1Bos taurus
L137DLGENFTDAEI1Arabidopsis thaliana
L137ELGENFTYQEI1Oryza sativa subsp. japonica
L142LTDEELQEMID2Homo sapiens, Mus musculus
L142LSDEELQEMID1Bos taurus
L142FTDAEIREMVE1Arabidopsis thaliana
L142FTYQEIQEMVQ1Oryza sativa subsp. japonica
L171MKKTSL-Y-3Homo sapiens, Mus musculus, Bos taurus
L171MRRTAYGGN1Arabidopsis thaliana
L171MRRTGYGY-1Oryza sativa subsp. japonica
M145EELQEMIDEAD3Homo sapiens, Mus musculus, Bos taurus
M145AEIREMVEEAD1Arabidopsis thaliana
M145QEIQEMVQEAD1Oryza sativa subsp. japonica
M166EFLRIMKKTSL3Homo sapiens, Mus musculus, Bos taurus
M166EFMRMMRRTAY1Arabidopsis thaliana
M166EFIRMMRRTGY1Oryza sativa subsp. japonica
N125KISFKNLKRVA3Homo sapiens, Mus musculus, Bos taurus
N125KISPDDIKRMA1Arabidopsis thaliana
N125KISDVDIQRIA1Oryza sativa subsp. japonica
R128FKNLKRVAKEL3Homo sapiens, Mus musculus, Bos taurus
R128PDDIKRMAKDL1Arabidopsis thaliana
R128DVDIQRIAKEL1Oryza sativa subsp. japonica
S122ETGKISFKNLK3Homo sapiens, Mus musculus, Bos taurus
S122KNGKISPDDIK1Arabidopsis thaliana
S122KNGKISDVDIQ1Oryza sativa subsp. japonica
S170IMKKTSL-Y-3Homo sapiens, Mus musculus, Bos taurus
S170MMRRTAYGGN1Arabidopsis thaliana
S170MMRRTGYGY-1Oryza sativa subsp. japonica
T118FDDDETGKISF3Homo sapiens, Mus musculus, Bos taurus
T118IDLDKNGKISP1Arabidopsis thaliana
T118IDQDKNGKISD1Oryza sativa subsp. japonica
T169RIMKKTSL-Y-3Homo sapiens, Mus musculus, Bos taurus
T169RMMRRTAYGGN1Arabidopsis thaliana
T169RMMRRTGYGY-1Oryza sativa subsp. japonica
V129KNLKRVAKELG3Homo sapiens, Mus musculus, Bos taurus
V129DDIKRMAKDLG1Arabidopsis thaliana
V129VDIQRIAKELG1Oryza sativa subsp. japonica
V157DGDGEVNEQEF2Mus musculus, Bos taurus
V157DGDGEVSEQEF1Homo sapiens
V157DRDGEVNMDEF1Arabidopsis thaliana
V157NGDGEIDFDEF1Oryza sativa subsp. japonica
Y172KTSL-Y-3Homo sapiens, Mus musculus, Bos taurus
Y172RTAYGGN1Arabidopsis thaliana
Y172RTGYGY-1Oryza sativa subsp. japonica


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