mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CAPN9
Gene summary
Basic gene Info.Gene symbolCAPN9
Gene namecalpain 9
CytomapUCSC genome browser: 1q42.11-q42.3
Type of geneprotein-coding
Descriptioncalpain-9digestive tract-specific calpainnew calpain 4novel calpain large subunit-4
Modification date20141207
dbXrefs MIM : 606401
Ensembl : ENSG00000135773
HPRD : 05909
Vega : OTTHUMG00000037779
ProteinUniProt: O14815
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CAPN9
BioGPS: 10753
PathwayNCI Pathway Interaction Database: CAPN9
Pathway Commons: CAPN9
ContextiHOP: CAPN9
ligand binding site mutation search in PubMed: CAPN9
UCL Cancer Institute: CAPN9
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for CAPN9

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for CAPN9
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CAPN9 from PDB

Differential gene expression and gene-gene network for CAPN9
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CAPN9 and the right PPI network was created from samples without mutations in the LBS of CAPN9. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for CAPN9
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for CAPN9
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CAPN9 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)1zivAE284 E316
CACALCIUM(2+)2p0rAE284 E316
CACALCIUM(2+)2p0rBE284 E316
IIIPeptide ligand (ACE,LEU,LEU,AR7)2p0rBG190
IIIPeptide ligand (ACE,LEU,LEU,AR7)2p0rAQ91 G190

Conservation information for LBS of CAPN9
Multiple alignments for O14815 in multiple species
LBSAA sequence# speciesSpecies
A255LIKGHAYTVTG2Mus musculus, Rattus norvegicus
A255LIRGHAYSITK2Drosophila melanogaster, Drosophila melanogaster
A255LIKGHAYSVTG1Homo sapiens
C97GELGDCWLLAA5Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Drosophila melanogaster
D291NGPWSDSSPEW3Mus musculus, Rattus norvegicus, Drosophila melanogaster
D291NGSWSDSSPEW1Homo sapiens
D291SGPWSDSSPEW1Drosophila melanogaster
D314HTALDDGEFWM3Homo sapiens, Mus musculus, Rattus norvegicus
D314LNFDRDGEFWM1Drosophila melanogaster
D314LTFDRDGEFWM1Drosophila melanogaster
D88GATRTDICQGE3Homo sapiens, Mus musculus, Rattus norvegicus
D88GYSRFDVQQGE2Drosophila melanogaster, Drosophila melanogaster
E167SADHNEFWSAL3Homo sapiens, Mus musculus, Rattus norvegicus
E167STEKNEFWSAL2Drosophila melanogaster, Drosophila melanogaster
E243SAAESEARTPF1Homo sapiens
E243NASESEARTSL1Mus musculus
E243NASESEARTPL1Rattus norvegicus
E243DPHVLEAETPQ1Drosophila melanogaster
E243DPNVTEAETPQ1Drosophila melanogaster
E284WG-QVEWNGPW2Mus musculus, Rattus norvegicus
E284WG-QVEWNGSW1Homo sapiens
E284WGNDAEWSGPW1Drosophila melanogaster
E284WGNEAEWNGPW1Drosophila melanogaster
E316ALDDGEFWMAF3Homo sapiens, Mus musculus, Rattus norvegicus
E316FDRDGEFWMSF2Drosophila melanogaster, Drosophila melanogaster
F233SLLGCSIDTLN2Mus musculus, Rattus norvegicus
F233SLLGCFIDTRS1Homo sapiens
F233SMMGCSLEP-D1Drosophila melanogaster
F233SMMGCSIEP-D1Drosophila melanogaster
G189YEALKGGSAIE3Homo sapiens, Mus musculus, Rattus norvegicus
G189YEALKGGTTCE1Drosophila melanogaster
G189YEALKGGSTCE1Drosophila melanogaster
G190EALKGGSAIEA3Homo sapiens, Mus musculus, Rattus norvegicus
G190EALKGGTTCEA1Drosophila melanogaster
G190EALKGGSTCEA1Drosophila melanogaster
G253LGLIKGHAYTV2Mus musculus, Rattus norvegicus
G253QGLIRGHAYSI2Drosophila melanogaster, Drosophila melanogaster
G253FGLIKGHAYSV1Homo sapiens
G82PEFILGGATRT3Homo sapiens, Mus musculus, Rattus norvegicus
G82PQFFVEGYSRF2Drosophila melanogaster, Drosophila melanogaster
G83EFILGGATRTD3Homo sapiens, Mus musculus, Rattus norvegicus
G83QFFVEGYSRFD2Drosophila melanogaster, Drosophila melanogaster
G95CQGELGDCWLL3Homo sapiens, Mus musculus, Rattus norvegicus
G95QQGELGDCWLL2Drosophila melanogaster, Drosophila melanogaster
K188SYEALKGGSAI3Homo sapiens, Mus musculus, Rattus norvegicus
K188SYEALKGGTTC1Drosophila melanogaster
K188SYEALKGGSTC1Drosophila melanogaster
L312LGHTALDDGEF2Mus musculus, Rattus norvegicus
L312LCHTALDDGEF1Homo sapiens
L312IGLNFDRDGEF1Drosophila melanogaster
L312IGLTFDRDGEF1Drosophila melanogaster
L81NPEFILGGATR2Homo sapiens, Rattus norvegicus
L81KPEFILGGATR1Mus musculus
L81DPQFFVEGYSR1Drosophila melanogaster
L81NPQFFVEGYSR1Drosophila melanogaster
N52DFPASNSSLFY2Homo sapiens, Rattus norvegicus
N52DFPASNVSLFY1Mus musculus
N52DFPATNASLMY1Drosophila melanogaster
N52LFPASNESLQF1Drosophila melanogaster
Q91RTDICQGELGD3Homo sapiens, Mus musculus, Rattus norvegicus
Q91RFDVQQGELGD2Drosophila melanogaster, Drosophila melanogaster
R60LFYSERPQVPF2Mus musculus, Rattus norvegicus
R60LFYSERPQIPF1Homo sapiens
R60LMYSRRPDRYY1Drosophila melanogaster
R60LQFSRRPDRHI1Drosophila melanogaster
S242RSAAESEARTP1Homo sapiens
S242LNASESEARTS1Mus musculus
S242LNASESEARTP1Rattus norvegicus
S242-DPHVLEAETP1Drosophila melanogaster
S242-DPNVTEAETP1Drosophila melanogaster
W98ELGDCWLLAAI3Homo sapiens, Mus musculus, Rattus norvegicus
W98ELGDCWLLAAA1Drosophila melanogaster
W98ELGDCWLLAAT1Drosophila melanogaster

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