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mutLBSgeneDB |
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| Gene summary for PLK2 |
 Gene summary |
| Basic gene Info. | Gene symbol | PLK2 |
| Gene name | polo-like kinase 2 | |
| Synonyms | SNK|hPlk2|hSNK | |
| Cytomap | UCSC genome browser: 5q12.1-q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001252226.1, NM_006622.3, | |
| Description | PLK-2serine/threonine-protein kinase PLK2serine/threonine-protein kinase SNKserum-inducible kinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607023 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000145632 | ||
| HPRD : 06118 | ||
| Vega : OTTHUMG00000097047 | ||
| Protein | UniProt: Q9NYY3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PLK2 | |
| BioGPS: 10769 | ||
| Pathway | NCI Pathway Interaction Database: PLK2 | |
| KEGG: PLK2 | ||
| REACTOME: PLK2 | ||
| Pathway Commons: PLK2 | ||
| Context | iHOP: PLK2 | |
| ligand binding site mutation search in PubMed: PLK2 | ||
| UCL Cancer Institute: PLK2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 20352051 | GO:0007052 | mitotic spindle organization | 19001868 | GO:0046599 | regulation of centriole replication | 19001868 |
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| Ligand binding site mutations for PLK2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C96 | A96T | GBM | 1 | V143 | I143V | OV | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PLK2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PLK2 from PDB |
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| Differential gene expression and gene-gene network for PLK2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PLK2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007097 | Carcinoma | 2 | Biomarker |
| umls:C3658338 | Drug-Related Side Effects and Adverse Reactions | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PLK2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PLK2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 1C8 | (7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-2-[2-(1,3-THIAZOL- 4-YL)-1H-IMIDAZOL-1-YL]-7,8-DIHYDROPTERIDIN-6(5H)-ONE | 4i6h | A | C96 V143 | 11G | (7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-7,8- DIHYDROPTERIDIN-6(5H)-ONE | 4i6b | A | C96 V143 | 1C7 | (7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-2-(2-PHENYL-1H- IMIDAZOL-1-YL)-7,8-DIHYDROPTERIDIN-6(5H)-ONE | 4i6f | A | C96 V143 | 1D1 | (7R)-8-CYCLOPENTYL-7-ETHYL-5-METHYL-2-(1H-PYRROL-2-YL)- 7,8-DIHYDROPTERIDIN-6(5H)-ONE | 4i5p | A | C96 V143 |
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| Conservation information for LBS of PLK2 |
| Multiple alignments for Q9NYY3 in multiple species |
| LBS | AA sequence | # species | Species | A109 | NNKVYAAKIIP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C162 | ILLEYCSRRSM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C96 | GGFAKCYEMTD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E160 | IYILLEYCSRR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H169 | RRSMAHILKAR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K111 | KVYAAKIIPHS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K90 | GKVLGKGGFAK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L159 | NIYILLEYCSR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L88 | CRGKVLGKGGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R165 | EYCSRRSMAHI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S163 | LLEYCSRRSMA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V143 | HHKHVVQFYHY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y161 | YILLEYCSRRS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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