mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ZNF268
Gene summary
Basic gene Info.Gene symbolZNF268
Gene namezinc finger protein 268
SynonymsHZF3
CytomapUCSC genome browser: 12q24.33
Type of geneprotein-coding
RefGenesNM_001165881.2,
NM_001165882.2,NM_001165883.1,NM_001165884.2,NM_001165885.1,
NM_001165886.1,NM_001165887.1,NM_003415.2,NM_152943.2,
Descriptionzinc finger protein 3zinc finger protein HZF3
Modification date20141207
dbXrefs MIM : 604753
HGNC : HGNC
HPRD : 05300
ProteinUniProt: Q14587
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ZNF268
BioGPS: 10795
PathwayNCI Pathway Interaction Database: ZNF268
KEGG: ZNF268
REACTOME: ZNF268
Pathway Commons: ZNF268
ContextiHOP: ZNF268
ligand binding site mutation search in PubMed: ZNF268
UCL Cancer Institute: ZNF268
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoter12822888
GO:0001934positive regulation of protein phosphorylation23091055
GO:0008588release of cytoplasmic sequestered NF-kappaB23091055
GO:0043497regulation of protein heterodimerization activity23091055
GO:0045732positive regulation of protein catabolic process23091055
GO:0045944positive regulation of transcription from RNA polymerase II promoter23091055
GO:0071356cellular response to tumor necrosis factor23091055
GO:0090073positive regulation of protein homodimerization activity23091055


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Ligand binding site mutations for ZNF268

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
H326,H322R324IUCEC2
H518R520GBRCA1
H326,H322R324ICOAD1
C306N307YLUAD1
H406R408KUCEC1
H942R940IUCEC1
C922C920FUCEC1
H354R352KUCEC1
H826R828QUCEC1
H490R492IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ZNF268
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H406R408K-1.2998692
C922C920F-1.2724858
H826R828Q-1.257921
H354R352K-1.1328306
H518R520G-0.9090802
H322R324I-0.89347415
H326R324I-0.89347415
H490R492I-0.86635889
H942R940I-0.5691362
C306N307Y-0.029890914
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ZNF268 from PDB
PDB IDPDB titlePDB structure
2EL4Solution structure of the 15th zf-C2H2 domain from human Zinc finger protein 268

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Differential gene expression and gene-gene network for ZNF268
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ZNF268 and the right PPI network was created from samples without mutations in the LBS of ZNF268. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ZNF268
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ZNF268
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ZNF268 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)2epwAC922 H942
ZNZINC(2+)2epvAH826


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Conservation information for LBS of ZNF268
Multiple alignments for Q14587 in multiple species
LBSAA sequence# speciesSpecies


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