mutLBSgeneDB |
Gene summary for ZNF268 |
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Basic gene Info. | Gene symbol | ZNF268 |
Gene name | zinc finger protein 268 | |
Synonyms | HZF3 | |
Cytomap | UCSC genome browser: 12q24.33 | |
Type of gene | protein-coding | |
RefGenes | NM_001165881.2, NM_001165882.2,NM_001165883.1,NM_001165884.2,NM_001165885.1, NM_001165886.1,NM_001165887.1,NM_003415.2,NM_152943.2, | |
Description | zinc finger protein 3zinc finger protein HZF3 | |
Modification date | 20141207 | |
dbXrefs | MIM : 604753 | |
HGNC : HGNC | ||
HPRD : 05300 | ||
Protein | UniProt: Q14587 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF268 | |
BioGPS: 10795 | ||
Pathway | NCI Pathway Interaction Database: ZNF268 | |
KEGG: ZNF268 | ||
REACTOME: ZNF268 | ||
Pathway Commons: ZNF268 | ||
Context | iHOP: ZNF268 | |
ligand binding site mutation search in PubMed: ZNF268 | ||
UCL Cancer Institute: ZNF268 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 12822888 | GO:0001934 | positive regulation of protein phosphorylation | 23091055 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB | 23091055 | GO:0043497 | regulation of protein heterodimerization activity | 23091055 | GO:0045732 | positive regulation of protein catabolic process | 23091055 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 23091055 | GO:0071356 | cellular response to tumor necrosis factor | 23091055 | GO:0090073 | positive regulation of protein homodimerization activity | 23091055 |
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Ligand binding site mutations for ZNF268 |
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LBS | AAchange of nsSNV | Cancer type | # samples | H326,H322 | R324I | UCEC | 2 | H518 | R520G | BRCA | 1 | H326,H322 | R324I | COAD | 1 | C306 | N307Y | LUAD | 1 | H406 | R408K | UCEC | 1 | H942 | R940I | UCEC | 1 | C922 | C920F | UCEC | 1 | H354 | R352K | UCEC | 1 | H826 | R828Q | UCEC | 1 | H490 | R492I | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZNF268 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H406 | R408K | -1.2998692 | C922 | C920F | -1.2724858 | H826 | R828Q | -1.257921 | H354 | R352K | -1.1328306 | H518 | R520G | -0.9090802 | H322 | R324I | -0.89347415 | H326 | R324I | -0.89347415 | H490 | R492I | -0.86635889 | H942 | R940I | -0.5691362 | C306 | N307Y | -0.029890914 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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PDB ID | PDB title | PDB structure | 2EL4 | Solution structure of the 15th zf-C2H2 domain from human Zinc finger protein 268 | ![]() |
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Differential gene expression and gene-gene network for ZNF268 |
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Phenotype information for ZNF268 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZNF268 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 2epw | A | C922 H942 | ZN | ZINC(2+) | 2epv | A | H826 |
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Conservation information for LBS of ZNF268 |
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LBS | AA sequence | # species | Species |
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