mutLBSgeneDB |
Gene summary for CGA |
Gene summary |
Basic gene Info. | Gene symbol | CGA |
Gene name | glycoprotein hormones, alpha polypeptide | |
Synonyms | CG-ALPHA|FSHA|GPHA1|GPHa|HCG|LHA|TSHA | |
Cytomap | UCSC genome browser: 6q12-q21 | |
Type of gene | protein-coding | |
RefGenes | NM_000735.3, NM_001252383.1, | |
Description | FSH-alphaLSH-alphaTSH-alphaanterior pituitary glycoprotein hormones common subunit alphachoriogonadotropin alpha chainchorionic gonadotrophin subunit alphachorionic gonadotropin, alpha polypeptidefollicle-stimulating hormone alpha chainfollicle-st | |
Modification date | 20141207 | |
dbXrefs | MIM : 118850 | |
HGNC : HGNC | ||
Ensembl : ENSG00000135346 | ||
HPRD : 00342 | ||
Vega : OTTHUMG00000015161 | ||
Protein | UniProt: P01215 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CGA | |
BioGPS: 1081 | ||
Pathway | NCI Pathway Interaction Database: CGA | |
KEGG: CGA | ||
REACTOME: CGA | ||
Pathway Commons: CGA | ||
Context | iHOP: CGA | |
ligand binding site mutation search in PubMed: CGA | ||
UCL Cancer Institute: CGA | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CGA |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | T104 | A105V | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CGA |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T104 | A105V | -0.36673197 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CGA from PDB |
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Differential gene expression and gene-gene network for CGA |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CGA |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0001621 | Adrenal Gland Diseases | 1 | Therapeutic |
umls:C0242656 | Disease Progression | 1 | Biomarker |
umls:C0018991 | Hemiplegia | 1 | Biomarker |
umls:C0028960 | Oligospermia | 1 | Therapeutic |
umls:C0029928 | Ovarian Diseases | 1 | Therapeutic |
umls:C2931367 | Thyroid cancer, follicular | 1 | Biomarker |
umls:C0042131 | Uterine Diseases | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CGA |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CGA go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of CGA |
Multiple alignments for P01215 in multiple species |
LBS | AA sequence | # species | Species | A47 | FSKLGAPIYQC | 2 | Mus musculus, Canis lupus familiaris | A47 | FSQPGAPILQC | 1 | Homo sapiens | A47 | FSKPDAPIYQC | 1 | Bos taurus | H103 | FKVENHTACHC | 1 | Homo sapiens | H103 | ARVENHTECHC | 1 | Mus musculus | H103 | VRVENHTECHC | 1 | Bos taurus | H103 | AKVENHTECHC | 1 | Canis lupus familiaris | I49 | KLGAPIYQCMG | 2 | Mus musculus, Canis lupus familiaris | I49 | QPGAPILQCMG | 1 | Homo sapiens | I49 | KPDAPIYQCMG | 1 | Bos taurus | L50 | LGAPIYQCMGC | 2 | Mus musculus, Canis lupus familiaris | L50 | PGAPILQCMGC | 1 | Homo sapiens | L50 | PDAPIYQCMGC | 1 | Bos taurus | N102 | GFKVENHTACH | 1 | Homo sapiens | N102 | NARVENHTECH | 1 | Mus musculus | N102 | NVRVENHTECH | 1 | Bos taurus | N102 | NAKVENHTECH | 1 | Canis lupus familiaris | N90 | VAKAFTKATVM | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | N90 | VAKSYNRVTVM | 1 | Homo sapiens | P48 | SKLGAPIYQCM | 2 | Mus musculus, Canis lupus familiaris | P48 | SQPGAPILQCM | 1 | Homo sapiens | P48 | SKPDAPIYQCM | 1 | Bos taurus | T104 | RVENHTECHCS | 2 | Mus musculus, Bos taurus | T104 | KVENHTACHCS | 1 | Homo sapiens | T104 | KVENHTECHCS | 1 | Canis lupus familiaris | V92 | KAFTKATVMGN | 3 | Mus musculus, Bos taurus, Canis lupus familiaris | V92 | KSYNRVTVMGG | 1 | Homo sapiens |
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