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mutLBSgeneDB |
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| Gene summary for DHRS4 |
 Gene summary |
| Basic gene Info. | Gene symbol | DHRS4 |
| Gene name | dehydrogenase/reductase (SDR family) member 4 | |
| Synonyms | CR|NRDR|PHCR|PSCD|SCAD-SRL|SDR-SRL|SDR25C1|SDR25C2 | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001282987.1, NM_001282988.1,NM_001282989.1,NM_001282990.1,NM_001282991.1, NM_021004.3, | |
| Description | NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Adehydrogenase/reductase SDR family member 4peroxisomal short-chain alcohol dehydrogenases | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611596 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157326 | ||
| HPRD : 07484 | ||
| Vega : OTTHUMG00000028777 | ||
| Protein | UniProt: Q9BTZ2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DHRS4 | |
| BioGPS: 10901 | ||
| Pathway | NCI Pathway Interaction Database: DHRS4 | |
| KEGG: DHRS4 | ||
| REACTOME: DHRS4 | ||
| Pathway Commons: DHRS4 | ||
| Context | iHOP: DHRS4 | |
| ligand binding site mutation search in PubMed: DHRS4 | ||
| UCL Cancer Institute: DHRS4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006066 | alcohol metabolic process | 18571493 | GO:0008202 | steroid metabolic process | 18571493 | GO:0042180 | cellular ketone metabolic process | 18571493 | GO:0051262 | protein tetramerization | 18571493 | GO:0055114 | oxidation-reduction process | 19442656 |
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| Ligand binding site mutations for DHRS4 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G213 | G213E | LUSC | 1 | I44 | I44N | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DHRS4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I44 | I44N | -1.7081195 | G213 | G213E | -0.018763584 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DHRS4 from PDB |
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| Differential gene expression and gene-gene network for DHRS4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DHRS4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DHRS4 |
| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical|vet_approved | DB00162 | Vitamin A | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DHRS4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NAP | NADP ZWITTERION | 3o4r | A | I44 G213 | NAP | NADP ZWITTERION | 3o4r | B | I44 G213 | NAP | NADP ZWITTERION | 3o4r | C | I44 G213 | NAP | NADP ZWITTERION | 3o4r | D | I44 G213 |
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| Conservation information for LBS of DHRS4 |
| Multiple alignments for Q9BTZ2 in multiple species |
| LBS | AA sequence | # species | Species | A118 | LVSNAAVNPFF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A118 | VVCNAAANPST | 1 | Arabidopsis thaliana | A118 | LISNAAVSPFF | 1 | Bos taurus | A39 | VALVTASTDGI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | A39 | VAIVTASTQGI | 1 | Arabidopsis thaliana | C88 | VTGTVCHVGKA | 2 | Homo sapiens, Bos taurus | C88 | AYGIVCHVSNA | 1 | Arabidopsis thaliana | C88 | VTGIVCHVGKA | 1 | Mus musculus | C88 | VTGVVCHVGKA | 1 | Rattus norvegicus | D42 | VTASTDGIGFA | 3 | Homo sapiens, Mus musculus, Bos taurus | D42 | VTASTQGIGFG | 1 | Arabidopsis thaliana | D42 | VTASTDGIGLA | 1 | Rattus norvegicus | F219 | LIKTSFSRMLW | 1 | Homo sapiens | F219 | FVPTHFASFIT | 1 | Arabidopsis thaliana | F219 | LIKTRFSSVLW | 1 | Mus musculus | F219 | LIKTHFSSVLW | 1 | Rattus norvegicus | F219 | LIRTSFSRVLW | 1 | Bos taurus | G213 | NCLAPGLIKTS | 1 | Homo sapiens | G213 | NAVAPGFVPTH | 1 | Arabidopsis thaliana | G213 | NCLAPGLIKTR | 1 | Mus musculus | G213 | NCLAPGLIKTH | 1 | Rattus norvegicus | G213 | NCLAPGLIRTS | 1 | Bos taurus | G43 | TASTDGIGFAI | 3 | Homo sapiens, Mus musculus, Bos taurus | G43 | TASTQGIGFGI | 1 | Arabidopsis thaliana | G43 | TASTDGIGLAI | 1 | Rattus norvegicus | H89 | TGTVCHVGKAE | 2 | Homo sapiens, Bos taurus | H89 | YGIVCHVSNAQ | 1 | Arabidopsis thaliana | H89 | TGIVCHVGKAE | 1 | Mus musculus | H89 | TGVVCHVGKAE | 1 | Rattus norvegicus | I215 | LAPGLIKTSFS | 1 | Homo sapiens | I215 | VAPGFVPTHFA | 1 | Arabidopsis thaliana | I215 | LAPGLIKTRFS | 1 | Mus musculus | I215 | LAPGLIKTHFS | 1 | Rattus norvegicus | I215 | LAPGLIRTSFS | 1 | Bos taurus | I44 | ASTDGIGFAIA | 3 | Homo sapiens, Mus musculus, Bos taurus | I44 | ASTQGIGFGIT | 1 | Arabidopsis thaliana | I44 | ASTDGIGLAIA | 1 | Rattus norvegicus | K186 | PYNVSKTALLG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K186 | MYGVTKTALLG | 1 | Arabidopsis thaliana | K65 | VVSSRKQQNVD | 3 | Homo sapiens, Mus musculus, Bos taurus | K65 | VVSSRKQANVD | 1 | Arabidopsis thaliana | K65 | VISSRKQQNVD | 1 | Rattus norvegicus | L214 | CLAPGLIKTSF | 1 | Homo sapiens | L214 | AVAPGFVPTHF | 1 | Arabidopsis thaliana | L214 | CLAPGLIKTRF | 1 | Mus musculus | L214 | CLAPGLIKTHF | 1 | Rattus norvegicus | L214 | CLAPGLIRTSF | 1 | Bos taurus | N116 | DILVSNAAVNP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N116 | DIVVCNAAANP | 1 | Arabidopsis thaliana | N116 | DILISNAAVSP | 1 | Bos taurus | N68 | SRKQQNVDRAV | 3 | Mus musculus, Rattus norvegicus, Bos taurus | N68 | SRKQQNVDQAV | 1 | Homo sapiens | N68 | SRKQANVDEAV | 1 | Arabidopsis thaliana | P212 | VNCLAPGLIKT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P212 | VNAVAPGFVPT | 1 | Arabidopsis thaliana | P212 | VNCLAPGLIRT | 1 | Bos taurus | R64 | VVVSSRKQQNV | 3 | Homo sapiens, Mus musculus, Bos taurus | R64 | VVVSSRKQANV | 1 | Arabidopsis thaliana | R64 | VVISSRKQQNV | 1 | Rattus norvegicus | S168 | SVVIVSSIAAF | 1 | Homo sapiens | S168 | SVIFITSIAGF | 1 | Arabidopsis thaliana | S168 | SVVIVGSVAGF | 1 | Mus musculus | S168 | SVVIVSSVAGF | 1 | Rattus norvegicus | S168 | SIVIVSSIAAY | 1 | Bos taurus | S169 | VVIVSSIAAFS | 1 | Homo sapiens | S169 | VIFITSIAGFS | 1 | Arabidopsis thaliana | S169 | VVIVGSVAGFT | 1 | Mus musculus | S169 | VVIVSSVAGFV | 1 | Rattus norvegicus | S169 | IVIVSSIAAYS | 1 | Bos taurus | S220 | IKTSFSRMLWM | 1 | Homo sapiens | S220 | VPTHFASFITG | 1 | Arabidopsis thaliana | S220 | IKTRFSSVLWE | 1 | Mus musculus | S220 | IKTHFSSVLWK | 1 | Rattus norvegicus | S220 | IRTSFSRVLWE | 1 | Bos taurus | S63 | HVVVSSRKQQN | 3 | Homo sapiens, Mus musculus, Bos taurus | S63 | SVVVSSRKQAN | 1 | Arabidopsis thaliana | S63 | HVVISSRKQQN | 1 | Rattus norvegicus | T217 | PGLIKTSFSRM | 1 | Homo sapiens | T217 | PGFVPTHFASF | 1 | Arabidopsis thaliana | T217 | PGLIKTRFSSV | 1 | Mus musculus | T217 | PGLIKTHFSSV | 1 | Rattus norvegicus | T217 | PGLIRTSFSRV | 1 | Bos taurus | T41 | LVTASTDGIGF | 3 | Homo sapiens, Mus musculus, Bos taurus | T41 | IVTASTQGIGF | 1 | Arabidopsis thaliana | T41 | LVTASTDGIGL | 1 | Rattus norvegicus | V90 | GTVCHVGKAED | 2 | Homo sapiens, Bos taurus | V90 | GIVCHVSNAQH | 1 | Arabidopsis thaliana | V90 | GIVCHVGKAED | 1 | Mus musculus | V90 | GVVCHVGKAED | 1 | Rattus norvegicus | Y182 | PSLGPYNVSKT | 3 | Mus musculus, Rattus norvegicus, Bos taurus | Y182 | PGFSPYNVSKT | 1 | Homo sapiens | Y182 | GAMAMYGVTKT | 1 | Arabidopsis thaliana |
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