mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DHRS4
Gene summary
Basic gene Info.Gene symbolDHRS4
Gene namedehydrogenase/reductase (SDR family) member 4
CytomapUCSC genome browser: 14q11.2
Type of geneprotein-coding
DescriptionNADPH-dependent carbonyl reductase/NADP-retinol dehydrogenaseNADPH-dependent retinol dehydrogenase/reductasedehydrogenase/reductase (SDR family) member 4 like 2Adehydrogenase/reductase SDR family member 4peroxisomal short-chain alcohol dehydrogenases
Modification date20141207
dbXrefs MIM : 611596
Ensembl : ENSG00000157326
HPRD : 07484
Vega : OTTHUMG00000028777
ProteinUniProt: Q9BTZ2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DHRS4
BioGPS: 10901
PathwayNCI Pathway Interaction Database: DHRS4
Pathway Commons: DHRS4
ContextiHOP: DHRS4
ligand binding site mutation search in PubMed: DHRS4
UCL Cancer Institute: DHRS4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006066alcohol metabolic process18571493
GO:0008202steroid metabolic process18571493
GO:0042180cellular ketone metabolic process18571493
GO:0051262protein tetramerization18571493
GO:0055114oxidation-reduction process19442656

Ligand binding site mutations for DHRS4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DHRS4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DHRS4 from PDB

Differential gene expression and gene-gene network for DHRS4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DHRS4 and the right PPI network was created from samples without mutations in the LBS of DHRS4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DHRS4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DHRS4

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceutical|vet_approvedDB00162Vitamin ASmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DHRS4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of DHRS4
Multiple alignments for Q9BTZ2 in multiple species
LBSAA sequence# speciesSpecies
A118LVSNAAVNPFF3Homo sapiens, Mus musculus, Rattus norvegicus
A118VVCNAAANPST1Arabidopsis thaliana
A118LISNAAVSPFF1Bos taurus
A39VALVTASTDGI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A39VAIVTASTQGI1Arabidopsis thaliana
C88VTGTVCHVGKA2Homo sapiens, Bos taurus
C88AYGIVCHVSNA1Arabidopsis thaliana
C88VTGIVCHVGKA1Mus musculus
C88VTGVVCHVGKA1Rattus norvegicus
D42VTASTDGIGFA3Homo sapiens, Mus musculus, Bos taurus
D42VTASTQGIGFG1Arabidopsis thaliana
D42VTASTDGIGLA1Rattus norvegicus
F219LIKTSFSRMLW1Homo sapiens
F219FVPTHFASFIT1Arabidopsis thaliana
F219LIKTRFSSVLW1Mus musculus
F219LIKTHFSSVLW1Rattus norvegicus
F219LIRTSFSRVLW1Bos taurus
G213NCLAPGLIKTS1Homo sapiens
G213NAVAPGFVPTH1Arabidopsis thaliana
G213NCLAPGLIKTR1Mus musculus
G213NCLAPGLIKTH1Rattus norvegicus
G213NCLAPGLIRTS1Bos taurus
G43TASTDGIGFAI3Homo sapiens, Mus musculus, Bos taurus
G43TASTQGIGFGI1Arabidopsis thaliana
G43TASTDGIGLAI1Rattus norvegicus
H89TGTVCHVGKAE2Homo sapiens, Bos taurus
H89YGIVCHVSNAQ1Arabidopsis thaliana
H89TGIVCHVGKAE1Mus musculus
H89TGVVCHVGKAE1Rattus norvegicus
I215LAPGLIKTSFS1Homo sapiens
I215VAPGFVPTHFA1Arabidopsis thaliana
I215LAPGLIKTRFS1Mus musculus
I215LAPGLIKTHFS1Rattus norvegicus
I215LAPGLIRTSFS1Bos taurus
I44ASTDGIGFAIA3Homo sapiens, Mus musculus, Bos taurus
I44ASTQGIGFGIT1Arabidopsis thaliana
I44ASTDGIGLAIA1Rattus norvegicus
K186PYNVSKTALLG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K186MYGVTKTALLG1Arabidopsis thaliana
K65VVSSRKQQNVD3Homo sapiens, Mus musculus, Bos taurus
K65VVSSRKQANVD1Arabidopsis thaliana
K65VISSRKQQNVD1Rattus norvegicus
L214CLAPGLIKTSF1Homo sapiens
L214AVAPGFVPTHF1Arabidopsis thaliana
L214CLAPGLIKTRF1Mus musculus
L214CLAPGLIKTHF1Rattus norvegicus
L214CLAPGLIRTSF1Bos taurus
N116DILVSNAAVNP3Homo sapiens, Mus musculus, Rattus norvegicus
N116DIVVCNAAANP1Arabidopsis thaliana
N116DILISNAAVSP1Bos taurus
N68SRKQQNVDRAV3Mus musculus, Rattus norvegicus, Bos taurus
N68SRKQQNVDQAV1Homo sapiens
N68SRKQANVDEAV1Arabidopsis thaliana
P212VNCLAPGLIKT3Homo sapiens, Mus musculus, Rattus norvegicus
P212VNAVAPGFVPT1Arabidopsis thaliana
P212VNCLAPGLIRT1Bos taurus
R64VVVSSRKQQNV3Homo sapiens, Mus musculus, Bos taurus
R64VVVSSRKQANV1Arabidopsis thaliana
R64VVISSRKQQNV1Rattus norvegicus
S168SVVIVSSIAAF1Homo sapiens
S168SVIFITSIAGF1Arabidopsis thaliana
S168SVVIVGSVAGF1Mus musculus
S168SVVIVSSVAGF1Rattus norvegicus
S168SIVIVSSIAAY1Bos taurus
S169VVIVSSIAAFS1Homo sapiens
S169VIFITSIAGFS1Arabidopsis thaliana
S169VVIVGSVAGFT1Mus musculus
S169VVIVSSVAGFV1Rattus norvegicus
S169IVIVSSIAAYS1Bos taurus
S220IKTSFSRMLWM1Homo sapiens
S220VPTHFASFITG1Arabidopsis thaliana
S220IKTRFSSVLWE1Mus musculus
S220IKTHFSSVLWK1Rattus norvegicus
S220IRTSFSRVLWE1Bos taurus
S63HVVVSSRKQQN3Homo sapiens, Mus musculus, Bos taurus
S63SVVVSSRKQAN1Arabidopsis thaliana
S63HVVISSRKQQN1Rattus norvegicus
T217PGLIKTSFSRM1Homo sapiens
T217PGFVPTHFASF1Arabidopsis thaliana
T217PGLIKTRFSSV1Mus musculus
T217PGLIKTHFSSV1Rattus norvegicus
T217PGLIRTSFSRV1Bos taurus
T41LVTASTDGIGF3Homo sapiens, Mus musculus, Bos taurus
T41IVTASTQGIGF1Arabidopsis thaliana
T41LVTASTDGIGL1Rattus norvegicus
V90GTVCHVGKAED2Homo sapiens, Bos taurus
V90GIVCHVSNAQH1Arabidopsis thaliana
V90GIVCHVGKAED1Mus musculus
V90GVVCHVGKAED1Rattus norvegicus
Y182PSLGPYNVSKT3Mus musculus, Rattus norvegicus, Bos taurus
Y182PGFSPYNVSKT1Homo sapiens
Y182GAMAMYGVTKT1Arabidopsis thaliana

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