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mutLBSgeneDB |
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| Gene summary for SPIN1 |
 Gene summary |
| Basic gene Info. | Gene symbol | SPIN1 |
| Gene name | spindlin 1 | |
| Synonyms | SPIN | |
| Cytomap | UCSC genome browser: 9q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006717.2, | |
| Description | ovarian cancer-related proteinspindlin-1spindlin1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609936 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106723 | ||
| HPRD : 18096 | ||
| Vega : OTTHUMG00000020168 | ||
| Protein | UniProt: Q9Y657 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPIN1 | |
| BioGPS: 10927 | ||
| Pathway | NCI Pathway Interaction Database: SPIN1 | |
| KEGG: SPIN1 | ||
| REACTOME: SPIN1 | ||
| Pathway Commons: SPIN1 | ||
| Context | iHOP: SPIN1 | |
| ligand binding site mutation search in PubMed: SPIN1 | ||
| UCL Cancer Institute: SPIN1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0009303 | rRNA transcription | 21960006 | GO:0030177 | positive regulation of Wnt signaling pathway | 24589551 |
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| Ligand binding site mutations for SPIN1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | W165 | Y167C | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for SPIN1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W165 | Y167C | -1.0719794 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SPIN1 from PDB |
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| Differential gene expression and gene-gene network for SPIN1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for SPIN1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for SPIN1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of SPIN1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of SPIN1 |
| Multiple alignments for Q9Y657 in multiple species |
| LBS | AA sequence | # species | Species | A119 | LPDRVATSRIS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | A119 | LPDRVASSRIS | 2 | Gallus gallus, Gallus gallus | C96 | YDGFDCVYGLE | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D173 | ITYEKDPVLYM | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D184 | YQLLDDYKEGD | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D189 | DYKEGDLRIMP | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D249 | FIKFDDDFHIY | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D250 | IKFDDDFHIYV | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | D95 | KYDGFDCVYGL | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | E142 | VEHMFETEDGS | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | E64 | QHGWREGNGPV | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | E64 | QHGWKEGNGPV | 1 | Homo sapiens | E64 | QHGWKEGSGPV | 1 | Gallus gallus | E64 | QHGWKEGSGPI | 1 | Gallus gallus | F141 | AVEHMFETEDG | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | F251 | KFDDDFHIYVY | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | F94 | IKYDGFDCVYG | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | G93 | LIKYDGFDCVY | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | H252 | FDDDFHIYVYD | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | I123 | VATSRISDAHL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | I123 | VASSRISDAHL | 2 | Gallus gallus, Gallus gallus | M140 | KAVEHMFETED | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | M162 | ARAPVMNTWFY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | M162 | ARAPIMNTWFY | 2 | Gallus gallus, Gallus gallus | N163 | RAPVMNTWFYI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | N163 | RAPIMNTWFYI | 2 | Gallus gallus, Gallus gallus | Q180 | VLYMYQLLDDY | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | R117 | EVLPDRVATSR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | R117 | EVLPDRVASSR | 2 | Gallus gallus, Gallus gallus | R122 | RVATSRISDAH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | R122 | RVASSRISDAH | 2 | Gallus gallus, Gallus gallus | R158 | GMVLARAPVMN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | R158 | GMVLARAPIMN | 2 | Gallus gallus, Gallus gallus | T120 | PDRVATSRISD | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | T120 | PDRVASSRISD | 2 | Gallus gallus, Gallus gallus | T164 | APVMNTWFYIT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | T164 | APIMNTWFYIT | 2 | Gallus gallus, Gallus gallus | W151 | GSKDEWRGMVL | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | W165 | PVMNTWFYITY | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | W165 | PIMNTWFYITY | 2 | Gallus gallus, Gallus gallus | W62 | RIQHGWREGNG | 3 | Mus musculus, Rattus norvegicus, Rattus norvegicus | W62 | RIQHGWKEGSG | 2 | Gallus gallus, Gallus gallus | W62 | RIQHGWKEGNG | 1 | Homo sapiens | W72 | GPVTQWKGTVL | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus | W72 | GPITQWKGTVL | 1 | Gallus gallus | Y170 | WFYITYEKDPV | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | Y177 | KDPVLYMYQLL | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | Y179 | PVLYMYQLLDD | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | Y91 | LYLIKYDGFDC | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus, Gallus gallus, Gallus gallus | Y98 | GFDCVYGLELN | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus | Y98 | GFDCVYGLELH | 2 | Gallus gallus, Gallus gallus |
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