mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MSL3
Gene summary
Basic gene Info.Gene symbolMSL3
Gene namemale-specific lethal 3 homolog (Drosophila)
CytomapUCSC genome browser: Xp22.3
Type of geneprotein-coding
DescriptionMSL3-like 1male-specific lethal 3 homologmale-specific lethal-3 protein-like 1
Modification date20141207
dbXrefs MIM : 300609
Ensembl : ENSG00000005302
HPRD : 05344
Vega : OTTHUMG00000021132
ProteinUniProt: Q8N5Y2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MSL3
BioGPS: 10943
PathwayNCI Pathway Interaction Database: MSL3
Pathway Commons: MSL3
ContextiHOP: MSL3
ligand binding site mutation search in PubMed: MSL3
UCL Cancer Institute: MSL3
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0043984histone H4-K16 acetylation20018852

Ligand binding site mutations for MSL3

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MSL3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MSL3 from PDB

Differential gene expression and gene-gene network for MSL3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MSL3 and the right PPI network was created from samples without mutations in the LBS of MSL3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MSL3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MSL3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MSL3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (VAL,THR,SER,PHE,PHE,PRO)2y0nAN250 L253 N476
IIIPeptide ligand (VAL,THR,SER,PHE,PHE,PRO)2y0nBN250 L253 N476

Conservation information for LBS of MSL3
Multiple alignments for Q8N5Y2 in multiple species
LBSAA sequence# speciesSpecies
A27PDPTKARVLYD2Homo sapiens, Mus musculus
A27PDKSKARVLYT1Drosophila melanogaster
A479EKNLKALLKHF2Homo sapiens, Mus musculus
A479NKKLEDLLPHL1Drosophila melanogaster
D23LCFEPDPTKAR2Homo sapiens, Mus musculus
D23LCYEPDKSKAR1Drosophila melanogaster
D64WNRSWDRWAAE2Homo sapiens, Mus musculus
D64WRPSYDRCVRA1Drosophila melanogaster
E256VDLCKEMVDGL2Homo sapiens, Mus musculus
E256VCMLKEVVDGL1Drosophila melanogaster
F472LGKMSFSEKNL2Homo sapiens, Mus musculus
F472LNASPISNKKL1Drosophila melanogaster
F56EYLIHFNGWNR2Homo sapiens, Mus musculus
F56EYKIHFQGWRP1Drosophila melanogaster
G260KEMVDGLRITF2Homo sapiens, Mus musculus
G260KEVVDGLRIYF1Drosophila melanogaster
G58LIHFNGWNRSW2Homo sapiens, Mus musculus
G58KIHFQGWRPSY1Drosophila melanogaster
H55PEYLIHFNGWN2Homo sapiens, Mus musculus
H55YEYKIHFQGWR1Drosophila melanogaster
I263VDGLRITFDYT2Homo sapiens, Mus musculus
I263VDGLRIYFEFH1Drosophila melanogaster
K26EPDPTKARVLY2Homo sapiens, Mus musculus
K26EPDKSKARVLY1Drosophila melanogaster
K462LRLFVKLPEIL2Homo sapiens, Mus musculus
K462VRLMIKMPMFL1Drosophila melanogaster
K469PEILGKMSFSE2Homo sapiens, Mus musculus
K469PMFLNASPISN1Drosophila melanogaster
L253EKNVDLCKEMV2Homo sapiens, Mus musculus
L253MSTVCMLKEVV1Drosophila melanogaster
L261EMVDGLRITFD2Homo sapiens, Mus musculus
L261EVVDGLRIYFE1Drosophila melanogaster
L271DYTLPLVLLYP2Homo sapiens, Mus musculus
L271EFHVDDHLLYT1Drosophila melanogaster
L273TLPLVLLYPYE2Homo sapiens, Mus musculus
L273HVDDHLLYTEE1Drosophila melanogaster
L274LPLVLLYPYEQ2Homo sapiens, Mus musculus
L274VDDHLLYTEEK1Drosophila melanogaster
L480KNLKALLKHFD2Homo sapiens, Mus musculus
L480KKLEDLLPHLD1Drosophila melanogaster
M257DLCKEMVDGLR2Homo sapiens, Mus musculus
M257CMLKEVVDGLR1Drosophila melanogaster
M470EILGKMSFSEK2Homo sapiens, Mus musculus
M470MFLNASPISNK1Drosophila melanogaster
N250IPAEKNVDLCK1Homo sapiens
N250DRVMSTVCMLK1Drosophila melanogaster
N250VPAEKNVDLCK1Mus musculus
N476SFSEKNLKALL2Homo sapiens, Mus musculus
N476PISNKKLEDLL1Drosophila melanogaster
N57YLIHFNGWNRS2Homo sapiens, Mus musculus
N57YKIHFQGWRPS1Drosophila melanogaster
N60HFNGWNRSWDR2Homo sapiens, Mus musculus
N60HFQGWRPSYDR1Drosophila melanogaster
P276LVLLYPYEQAQ1Homo sapiens
P276DHLLYTEEKEY1Drosophila melanogaster
P276LVLLYPYEQTQ1Mus musculus
R458AQHLLRLFVKL2Homo sapiens, Mus musculus
R458APHLVRLMIKM1Drosophila melanogaster
R65NRSWDRWAAED1Homo sapiens
R65RPSYDRCVRAT1Drosophila melanogaster
R65NRSWDRWAAEE1Mus musculus
S471ILGKMSFSEKN2Homo sapiens, Mus musculus
S471FLNASPISNKK1Drosophila melanogaster
S62NGWNRSWDRWA2Homo sapiens, Mus musculus
S62QGWRPSYDRCV1Drosophila melanogaster
T264DGLRITFDYTL2Homo sapiens, Mus musculus
T264DGLRIYFEFHV1Drosophila melanogaster
V272YTLPLVLLYPY2Homo sapiens, Mus musculus
V272FHVDDHLLYTE1Drosophila melanogaster
V461LLRLFVKLPEI2Homo sapiens, Mus musculus
V461LVRLMIKMPMF1Drosophila melanogaster
W63GWNRSWDRWAA2Homo sapiens, Mus musculus
W63GWRPSYDRCVR1Drosophila melanogaster
W66RSWDRWAAEDH1Homo sapiens
W66PSYDRCVRATV1Drosophila melanogaster
W66RSWDRWAAEEH1Mus musculus
Y267RITFDYTLPLV2Homo sapiens, Mus musculus
Y267RIYFEFHVDDH1Drosophila melanogaster
Y275PLVLLYPYEQA1Homo sapiens
Y275DDHLLYTEEKE1Drosophila melanogaster
Y275PLVLLYPYEQT1Mus musculus
Y31KARVLYDAKIV1Homo sapiens
Y31KARVLYTSKVL1Drosophila melanogaster
Y31KARVLYDAKII1Mus musculus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas