mutLBSgeneDB |
Gene summary for CBX1 |
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Basic gene Info. | Gene symbol | CBX1 |
Gene name | chromobox homolog 1 | |
Synonyms | CBX|HP1-BETA|HP1Hs-beta|HP1Hsbeta|M31|MOD1|p25beta | |
Cytomap | UCSC genome browser: 17q21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001127228.1, NM_006807.4, | |
Description | HP1 beta homologchromobox homolog 1 (HP1 beta homolog Drosophila )chromobox protein homolog 1heterochromatin protein 1 homolog betaheterochromatin protein 1-betaheterochromatin protein p25 betamodifier 1 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 604511 | |
HGNC : HGNC | ||
Ensembl : ENSG00000108468 | ||
HPRD : 05149 | ||
Vega : OTTHUMG00000150417 | ||
Protein | UniProt: P83916 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CBX1 | |
BioGPS: 10951 | ||
Pathway | NCI Pathway Interaction Database: CBX1 | |
KEGG: CBX1 | ||
REACTOME: CBX1 | ||
Pathway Commons: CBX1 | ||
Context | iHOP: CBX1 | |
ligand binding site mutation search in PubMed: CBX1 | ||
UCL Cancer Institute: CBX1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for CBX1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | G124 | G124A | BLCA | 1 | T169 | T169K | LUAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CBX1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T169 | T169K | -1.1119147 | G124 | G124A | -0.71576384 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for CBX1 |
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Phenotype information for CBX1 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CBX1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASN,VAL,SER,LEU,TYR,PRO,VAL,VAL,LYS,ILE,ARG,ARG,LEU,SER) | 3q6s | B | G124 T169 | III | Peptide ligand (THR,ASN,VAL,SER,LEU,TYR,PRO,VAL,VAL,LYS,ILE,ARG,ARG,LEU,SER,LEU) | 3q6s | D | G124 T169 | III | Peptide ligand (THR,ASN,VAL,SER,LEU,TYR,PRO,VAL,VAL,LYS,ILE,ARG,ARG,LEU,SER,LEU) | 3q6s | A | T169 | III | Peptide ligand (ASN,VAL,SER,LEU,TYR,PRO,VAL,VAL,LYS,ILE,ARG,ARG,LEU,SER) | 3q6s | C | T169 |
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Conservation information for LBS of CBX1 |
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LBS | AA sequence | # species | Species |
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