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mutLBSgeneDB |
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| Gene summary for COPS5 |
 Gene summary |
| Basic gene Info. | Gene symbol | COPS5 |
| Gene name | COP9 signalosome subunit 5 | |
| Synonyms | CSN5|JAB1|MOV-34|SGN5 | |
| Cytomap | UCSC genome browser: 8q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006837.2, | |
| Description | 38 kDa Mov34 homologCOP9 constitutive photomorphogenic homolog subunit 5COP9 signalosome complex subunit 5jun activation domain-binding protein 1signalosome subunit 5 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604850 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121022 | ||
| HPRD : 06888 | ||
| Vega : OTTHUMG00000164563 | ||
| Protein | UniProt: Q92905 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_COPS5 | |
| BioGPS: 10987 | ||
| Pathway | NCI Pathway Interaction Database: COPS5 | |
| KEGG: COPS5 | ||
| REACTOME: COPS5 | ||
| Pathway Commons: COPS5 | ||
| Context | iHOP: COPS5 | |
| ligand binding site mutation search in PubMed: COPS5 | ||
| UCL Cancer Institute: COPS5 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0010388 | cullin deneddylation | 19141280 | GO:0016579 | protein deubiquitination | 19246649 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16410250 | GO:0046328 | regulation of JNK cascade | 16410250 | GO:1990182 | exosomal secretion | 19246649 |
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| Ligand binding site mutations for COPS5 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H140 | H140R | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for COPS5 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H140 | H140R | -0.64791433 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for COPS5 from PDB |
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| Differential gene expression and gene-gene network for COPS5 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for COPS5 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2239176 | Carcinoma, Hepatocellular | 8 | AlteredExpression, Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for COPS5 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of COPS5 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 4f7o | A | H140 | ZN | ZINC(2+) | 4f7o | B | H140 | ZN | ZINC(2+) | 4d10 | E | H140 | ZN | ZINC(2+) | 4d10 | M | H140 | ZN | ZINC(2+) | 4d18 | E | H140 | ZN | ZINC(2+) | 4d18 | M | H140 |
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| Conservation information for LBS of COPS5 |
| Multiple alignments for Q92905 in multiple species |
| LBS | AA sequence | # species | Species | D151 | WLSGIDVSTQM | 6 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Xenopus tropicalis | D151 | WLSGIDVGTQS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | D151 | WLSGIDVSTQT | 1 | Caenorhabditis elegans | D151 | WLSGIDVSTQR | 1 | Arabidopsis thaliana | E104 | PVEGTETRVNA | 9 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Xenopus tropicalis | H138 | AIGWYHSHPGY | 4 | Homo sapiens, Danio rerio, Mus musculus, Xenopus tropicalis | H138 | VVGWYHSHPGY | 3 | Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana | H138 | VIGWYHSHPGY | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | H138 | AVGWYHSHPGY | 1 | Drosophila melanogaster | H140 | GWYHSHPGYGC | 9 | Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Xenopus tropicalis | S148 | YGCWLSGIDVS | 8 | Homo sapiens, Caenorhabditis elegans, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Danio rerio, Mus musculus, Xenopus tropicalis | S148 | YGCWLSGIDVG | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
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