|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for KIF2C |
 Gene summary |
| Basic gene Info. | Gene symbol | KIF2C |
| Gene name | kinesin family member 2C | |
| Synonyms | CT139|KNSL6|MCAK | |
| Cytomap | UCSC genome browser: 1p34.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001297655.1, NM_001297656.1,NM_001297657.1,NM_006845.3, | |
| Description | kinesin-like protein 6kinesin-like protein KIF2Cmitotic centromere-associated kinesin | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604538 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000142945 | ||
| HPRD : 05172 | ||
| Vega : OTTHUMG00000008416 | ||
| Protein | UniProt: Q99661 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KIF2C | |
| BioGPS: 11004 | ||
| Pathway | NCI Pathway Interaction Database: KIF2C | |
| KEGG: KIF2C | ||
| REACTOME: KIF2C | ||
| Pathway Commons: KIF2C | ||
| Context | iHOP: KIF2C | |
| ligand binding site mutation search in PubMed: KIF2C | ||
| UCL Cancer Institute: KIF2C | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007019 | microtubule depolymerization | 21820309 |
| Top |
| Ligand binding site mutations for KIF2C |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D312 | D312H | HNSC | 1 | S468 | S470F | SKCM | 1 | R266 | R266C | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for KIF2C |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R266 | R266C | -0.9084867 | D312 | D312H | -0.73268644 | S468 | S470F | -0.58546875 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for KIF2C from PDB |
| Top |
| Differential gene expression and gene-gene network for KIF2C |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for KIF2C |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for KIF2C |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB04395 | Phosphoaminophosphonic Acid-Adenylate Ester | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of KIF2C go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (LEU,GLU,GLU,GLN,ALA,SER,ARG) | 4ubf | B | D312 | ADP | ADP | 2heh | A | R266 | ADP | ADP | 4ubf | B | R266 | ADP | ADP | 4ubf | C | R266 | ADP | ADP | 4ubf | D | R266 | ADP | ADP | 4y05 | A | R266 | MG | MAGNESIUM(2+) | 4ubf | D | S468 |
| Top |
| Conservation information for LBS of KIF2C |
| Multiple alignments for Q99661 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |