mutLBSgeneDB |
Gene summary for ADAP1 |
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Basic gene Info. | Gene symbol | ADAP1 |
Gene name | ArfGAP with dual PH domains 1 | |
Synonyms | CENTA1|GCS1L|p42IP4 | |
Cytomap | UCSC genome browser: 7p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001284308.1, NM_001284309.1,NM_001284310.1,NM_001284311.1,NM_006869.3, | |
Description | arf-GAP with dual PH domain-containing protein 1centaurin, alpha 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608114 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105963 | ||
HPRD : 09733 | ||
Vega : OTTHUMG00000023380 | ||
Protein | UniProt: O75689 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAP1 | |
BioGPS: 11033 | ||
Pathway | NCI Pathway Interaction Database: ADAP1 | |
KEGG: ADAP1 | ||
REACTOME: ADAP1 | ||
Pathway Commons: ADAP1 | ||
Context | iHOP: ADAP1 | |
ligand binding site mutation search in PubMed: ADAP1 | ||
UCL Cancer Institute: ADAP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0043547 | positive regulation of GTPase activity | 10333475 |
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Ligand binding site mutations for ADAP1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | R226 | K227E | GBM | 1 | E67 | K67M | KIRC | 1 | V219 | R217S | LUAD | 1 | L289 | D289Y | SKCM | 1 | Y284 | R282W | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ADAP1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for ADAP1 |
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Phenotype information for ADAP1 |
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Disease ID | Disease name | # PubMed | Association type |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ADAP1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | UNX | UNKNOWN ATOM OR LIGAND | 3feh | A | E67 | UNX | UNKNOWN ATOM OR LIGAND | 3feh | A | L289 | UNX | UNKNOWN ATOM OR LIGAND | 3fm8 | D | R226 | UNX | UNKNOWN ATOM OR LIGAND | 3fm8 | D | V219 | IP9 | L-A-PHOSPHATIDYL-D-MYO-INOSITOL 3,4,5-TRIPHOSPHATE,DIOCTANOYL | 3lju | X | Y284 |
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Conservation information for LBS of ADAP1 |
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LBS | AA sequence | # species | Species |
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