mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for WDR5

Gene summary

Basic gene Info.	Gene symbol	WDR5
	Gene name	WD repeat domain 5
	Synonyms	BIG-3\|CFAP89\|SWD3
	Cytomap	UCSC genome browser: 9q34
	Type of gene	protein-coding
	RefGenes	NM_017588.2, NM_052821.3,
	Description	BMP2-induced 3-kb gene proteinSWD3, Set1c WD40 repeat protein, homologWD repeat-containing protein 5WD-repeat protein 5cilia and flagella associated protein 89
	Modification date	20141207
dbXrefs	MIM : 609012
	HGNC : HGNC
	Ensembl : ENSG00000196363
	HPRD : 10614
	Vega : OTTHUMG00000131707
Protein	UniProt: P61964 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_WDR5
	BioGPS: 11091
Pathway	NCI Pathway Interaction Database: WDR5
	KEGG: WDR5
	REACTOME: WDR5
	Pathway Commons: WDR5
Context	iHOP: WDR5
	ligand binding site mutation search in PubMed: WDR5
	UCL Cancer Institute: WDR5
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0043966	histone H3 acetylation	18838386
GO:0043981	histone H4-K5 acetylation	20018852
GO:0043982	histone H4-K8 acetylation	20018852
GO:0043984	histone H4-K16 acetylation	20018852
GO:0051568	histone H3-K4 methylation	17355966

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Ligand binding site mutations for WDR5

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
D192	D192N	COAD	2
F149	G147E	KIRC	1
F133	F133L	KIRC	1
P224	P224Q	LUAD	1
D172	S171L	SKCM	1
F149	D150G	STAD	1
D92	D92N	UCEC	1
P216	V217M	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for WDR5

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
D172	S171L	0.12040453
P216	V217M	-1.2550669
P224	P224Q	-0.99498578
F133	F133L	-0.87512861
D92	D92N	-0.86435842
F149	D150G	-0.77603404
D192	D192N	-0.35972077
F149	G147E	-0.24501839

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for WDR5 from PDB

PDB ID	PDB title	PDB structure
2GNQ	Structure of wdr5

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Differential gene expression and gene-gene network for WDR5

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of WDR5 and the right PPI network was created from samples without mutations in the LBS of WDR5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for WDR5

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for WDR5

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of WDR5 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NP7		2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE	3smr	A	D92 F133
NP7		2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE	3smr	B	D92 F133
NP7		2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE	3smr	C	D92 F133
NP7		2-CHLORO-N-[2-(4-METHYLPIPERAZIN-1-YL)-5-NITROPHENYL]BENZAMIDE	3smr	D	D92 F133
0BW		METHYL 3-[(3-METHOXYBENZOYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE	3ur4	B	D92 F133
IA9		2-CHLORO-4-FLUORO-3-METHYL-N-[2-(4-METHYLPIPERAZIN-1- YL)-5-NITROPHENYL]BENZAMIDE	4ia9	A	D92 F133
35Q		N-{4-(4-METHYLPIPERAZIN-1-YL)-3'-[(TETRAHYDRO-2H-PYRAN- 4-YLAMINO)METHYL]BIPHENYL-3-YL}-6-OXO-4- (TRIFLUOROMETHYL)-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE	4ql1	A	D92 F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR)	4a7j	A	D92 F133 F149
5ML		3-METHYL-~{N}-[2-(4-METHYLPIPERAZIN-1-YL)-5-QUINOLIN-3- YL-PHENYL]BENZAMIDE	5eal	A	D92 F133 F149
5ML		3-METHYL-~{N}-[2-(4-METHYLPIPERAZIN-1-YL)-5-QUINOLIN-3- YL-PHENYL]BENZAMIDE	5eal	B	D92 F133 F149
5MN		~{N}-[5-(1~{H}-INDOL-5-YL)-2-(4-METHYLPIPERAZIN-1-YL) PHENYL]-3-METHYL-BENZAMIDE	5eam	A	D92 F133 F149
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2cnx	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2co0	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2co0	C	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2g99	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2g99	B	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2g9a	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2h13	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR)	2h9m	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2h9m	C	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2h9n	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2h9n	C	F133
III		Peptide ligand (ALA,ARG,THR,LYS)	2h9p	A	F133
III		Peptide ligand (ALA,ARG,THR,LYS,GLN)	2o9k	C	F133
III		Peptide ligand (ACE,ALA,ARG,THR,LYS)	3psl	A	F133
III		Peptide ligand (ACE,ALA,ARG,THR,LYS)	3psl	B	F133
0BW		METHYL 3-[(3-METHOXYBENZOYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL)BENZOATE	3ur4	A	F133
III		Peptide ligand (GLY,SER,ALA,ARG,ALA,GLU,PRO,LYS,MET)	3uvl	A	F133
III		Peptide ligand (VAL,ASN,PRO,THR,GLY,CYS,ALA,ARG,SER,GLU,PRO,LYS,MET,SER)	4ery	A	F133
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	D	F133
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	E	F133
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	G	F133
III		Peptide ligand (ALQ,0XO,ARG,ALA,PG9)	4gm9	A	F133
III		Peptide ligand (ALQ,0XO,ARG,ALA,PG9)	4gm9	B	F133
III		Peptide ligand (ALA,ARG,THR,ALA,ARG)	4o45	A	F133
III		Peptide ligand (GLY,THR,CYS,VAL,ALA,ALA,ARG,THR,ARG,PRO,VAL,LEU,SER,TYR)	4cy1	A	F133
III		Peptide ligand (GLY,THR,CYS,VAL,ALA,ALA,ARG,THR,ARG,PRO,VAL,LEU,SER,TYR)	4cy1	B	F133
III		Peptide ligand (ASP,GLY,THR,CYS,VAL,ALA,ALA,ARG,THR,ARG,PRO,VAL)	4cy2	A	F133
35Q		N-{4-(4-METHYLPIPERAZIN-1-YL)-3'-[(TETRAHYDRO-2H-PYRAN- 4-YLAMINO)METHYL]BIPHENYL-3-YL}-6-OXO-4- (TRIFLUOROMETHYL)-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE	4ql1	B	F133
5MQ		~{N}-[5-(1-BENZOFURAN-7-YL)-2-(4-METHYLPIPERAZIN-1-YL) PHENYL]-3-METHYL-BENZAMIDE	5ear	B	F133
III		Peptide ligand (LEU,ASN,PRO,HIS,GLY,ALA,ALA,ARG,ALA,GLU,VAL,TYR)	4erz	A	F133 D172
III		Peptide ligand (LEU,ASN,PRO,HIS,GLY,ALA,ALA,ARG,ALA,GLU,VAL,TYR)	4erz	B	F133 D172
III		Peptide ligand (LEU,ASN,PRO,HIS,GLY,ALA,ALA,ARG,ALA,GLU,VAL,TYR)	4erz	C	F133 D172
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA)	2h6q	A	F133 F149
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA)	2h6q	B	F133 F149
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR)	2o9k	A	F133 F149
III		Peptide ligand (ACE,GLY,SER,ALA,ARG,ALA,GLU,VAL,HIS,LEU)	3eg6	A	F133 F149
III		Peptide ligand (ALA,ARG,ALA,GLU,VAL,HIS)	3emh	A	F133 F149
III		Peptide ligand (GLY,ALA,ALA,ARG,ALA,GLU,VAL,HIS,LEU)	3p4f	A	F133 F149
III		Peptide ligand (GLY,CYS,ALA,ARG,SER,GLU,PRO,LYS,ILE,LEU,THR)	3uvk	A	F133 F149
III		Peptide ligand (GLY,SER,ALA,ARG,SER,GLU,GLY,TYR)	3uvn	C	F133 F149
III		Peptide ligand (CYS,ALA,ARG,SER,GLU,GLY,PHE,TYR,THR)	3uvo	A	F133 F149
III		Peptide ligand (GLY,CYS,ALA,ARG,SER,GLU,GLY)	4es0	A	F133 F149
III		Peptide ligand (GLU,PRO,PRO,LEU,ASN,PRO,HIS,GLY,SER,ALA,ARG,ALA,GLU,VAL,HIS,LEU)	4esg	A	F133 F149
III		Peptide ligand (GLU,PRO,PRO,LEU,ASN,PRO,HIS,GLY,SER,ALA,ARG,ALA,GLU,VAL,HIS,LEU)	4esg	B	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	A	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	B	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	C	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	F	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XM)	4gm3	H	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XN)	4gm8	A	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XN)	4gm8	B	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XN)	4gm8	C	F133 F149
III		Peptide ligand (ALQ,0XL,ARG,AC5,0XN)	4gm8	D	F133 F149
III		Peptide ligand (ALQ,0XQ,ARG,ALA,PG9)	4gmb	A	F133 F149
5MN		~{N}-[5-(1~{H}-INDOL-5-YL)-2-(4-METHYLPIPERAZIN-1-YL) PHENYL]-3-METHYL-BENZAMIDE	5eam	B	F133 F149
5MO		~{N}-[5-(1-BENZOFURAN-5-YL)-2-(4-METHYLPIPERAZIN-1-YL) PHENYL]-3-METHYL-BENZAMIDE	5eap	A	F133 F149
5MQ		~{N}-[5-(1-BENZOFURAN-7-YL)-2-(4-METHYLPIPERAZIN-1-YL) PHENYL]-3-METHYL-BENZAMIDE	5ear	A	F133 F149
III		Peptide ligand (GLY,ALA,ALA,ARG,ALA,GLU,VAL,TYR,LEU,ARG)	3uvm	A	F133 F149 D172 D192 P216
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG)	2h6k	B	F133 F149 D192 P216
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG)	2h6n	A	F133 F149 D192 P216
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG)	2h6n	B	F133 F149 D192 P216
III		Peptide ligand (ALA,ARG,THR,LYS,GLN,THR,ALA,ARG,LYS)	2h6k	A	F133 F149 P216
III		Peptide ligand (GLY,SER,ALA,ARG,SER,GLU,GLY,TYR,TYR)	3uvn	A	F133 F149 P216
III		Peptide ligand (GLN,THR,GLY,SER,ALA,ARG,SER,GLU,GLY,TYR)	4ewr	A	F133 F149 P216
III		Peptide ligand (ILE,ASN,PRO,THR,GLY,CYS,ALA,ARG,SER,GLU,PRO,LYS,ILE)	4erq	A	F133 P216
III		Peptide ligand (ILE,ASN,PRO,THR,GLY,CYS,ALA,ARG,SER,GLU,PRO,LYS,ILE)	4erq	B	F133 P216
III		Peptide ligand (ILE,ASN,PRO,THR,GLY,CYS,ALA,ARG,SER,GLU,PRO,LYS,ILE)	4erq	C	F133 P216
III		Peptide ligand (GLU,GLU,VAL,ASP,VAL,THR,SER,VAL,TYR)	3p4f	A	P224
III		Peptide ligand (SER,ASP,ASP,LEU,ASP,VAL,VAL,GLY,ASP)	4cy2	A	P224
III		Peptide ligand (GLU,GLU,ILE,ASP,VAL,VAL,SER,VAL)	4y7r	A	P224

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Conservation information for LBS of WDR5

Multiple alignments for P61964 in multiple species

LBS	AA sequence	# species	Species
A47	AGHTKAVSSVK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A47	TSHNRAVSSVK	1	Arabidopsis thaliana
A47	EGHTKSISSAK	1	Caenorhabditis elegans
A47	AGHTKAVSAVK	1	Drosophila melanogaster
A65	LASSSADKLIK	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A65	LASASADKTIR	1	Arabidopsis thaliana
A65	LGTSSADKTVK	1	Caenorhabditis elegans
C261	KNEKYCIFANF	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
C261	VNAQYCISSAF	1	Arabidopsis thaliana
C261	ENSKYCIFANF	1	Caenorhabditis elegans
D107	LVSASDDKTLK	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D107	IVSASDDKTLK	1	Arabidopsis thaliana
D107	VVSASDDKTLK	1	Caenorhabditis elegans
D107	LVSGSDDKTLK	1	Drosophila melanogaster
D172	LPAHSDPVSAV	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D172	LPAHSDPVTAV	1	Arabidopsis thaliana
D192	VSSSYDGLCRI	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D192	ASGSYDGLVRI	1	Caenorhabditis elegans
D92	KLGISDVAWSS	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D92	ENGISDVAFSS	1	Arabidopsis thaliana
D92	KLGVNDIAWSS	1	Caenorhabditis elegans
E258	TGHKNEKYCIF	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
E258	TGHVNAQYCIS	1	Arabidopsis thaliana
E258	TGHENSKYCIF	1	Caenorhabditis elegans
E258	TCHKNEKYCIF	1	Xenopus tropicalis
E322	ASAALENDKTI	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E322	ASGSL--DKTV	1	Arabidopsis thaliana
E322	ASGALEPDNKI	1	Caenorhabditis elegans
F133	HSNYVFCCNFN	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F133	HTNYAFCVNFN	1	Arabidopsis thaliana
F133	HNNYVFCCNFN	1	Caenorhabditis elegans
F149	IVSGSFDESVR	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F149	IVSGSFDETVR	1	Arabidopsis thaliana
F149	VVSGSFDESVR	1	Caenorhabditis elegans
F219	NPPVSFVKFSP	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F219	NPPVSFVRFSP	1	Arabidopsis thaliana
F219	NPPVAFVKFSP	1	Caenorhabditis elegans
F263	EKYCIFANFSV	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F263	AQYCISSAFSV	1	Arabidopsis thaliana
F263	SKYCIFANFSV	1	Caenorhabditis elegans
F266	CIFANFSVTGG	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F266	CISSAFSVTNG	1	Arabidopsis thaliana
G193	SSSYDGLCRIW	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G193	SGSYDGLVRIW	1	Caenorhabditis elegans
G89	SGHKLGISDVA	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G89	TGHENGISDVA	1	Arabidopsis thaliana
G89	TGHKLGVNDIA	1	Caenorhabditis elegans
I305	HTDVVISTACH	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
I305	HTETVMNVACH	1	Arabidopsis thaliana
I305	HTQPVLASDCH	1	Caenorhabditis elegans
I305	HTDTVLCTACH	1	Drosophila melanogaster
I90	GHKLGISDVAW	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
I90	GHENGISDVAF	1	Arabidopsis thaliana
I90	GHKLGVNDIAW	1	Caenorhabditis elegans
K250	KGKCLKTYTGH	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
K250	SAKFLKTYTGH	1	Arabidopsis thaliana
K250	KGKTLKQYTGH	1	Caenorhabditis elegans
K250	KGKCLKTYTCH	1	Xenopus tropicalis
K259	GHKNEKYCIFA	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
K259	GHVNAQYCISS	1	Arabidopsis thaliana
K259	GHENSKYCIFA	1	Caenorhabditis elegans
K259	CHKNEKYCIFA	1	Xenopus tropicalis
K46	LAGHTKAVSSV	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K46	LTSHNRAVSSV	1	Arabidopsis thaliana
K46	LEGHTKSISSA	1	Caenorhabditis elegans
K46	LAGHTKAVSAV	1	Drosophila melanogaster
K67	SSSADKLIKIW	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K67	SASADKTIRTY	1	Arabidopsis thaliana
K67	TSSADKTVKIW	1	Caenorhabditis elegans
K87	TISGHKLGISD	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K87	EFTGHENGISD	1	Arabidopsis thaliana
K87	TLTGHKLGVND	1	Caenorhabditis elegans
L234	ILAATLDNTLK	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L234	ILVGTLDNTLR	1	Arabidopsis thaliana
L234	ILASNLDSTLK	1	Caenorhabditis elegans
L240	DNTLKLWDYSK	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L240	DNTLRLWNISS	1	Arabidopsis thaliana
L240	DSTLKLWDFSK	1	Caenorhabditis elegans
L249	SKGKCLKTYTG	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
L249	SSAKFLKTYTG	1	Arabidopsis thaliana
L249	SKGKTLKQYTG	1	Caenorhabditis elegans
L249	SKGKCLKTYTC	1	Xenopus tropicalis
L321	IASAALENDKT	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L321	IASGSL--DKT	1	Arabidopsis thaliana
L321	IASGALEPDNK	1	Caenorhabditis elegans
L88	ISGHKLGISDV	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L88	FTGHENGISDV	1	Arabidopsis thaliana
L88	LTGHKLGVNDI	1	Caenorhabditis elegans
N214	LIDDDNPPVSF	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
N214	LIDDENPPVSF	1	Arabidopsis thaliana
N214	LVDDENPPVAF	1	Caenorhabditis elegans
N225	VKFSPNGKYIL	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
N225	VRFSPNGKFIL	1	Arabidopsis thaliana
P173	PAHSDPVSAVH	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P173	PAHSDPVTAVD	1	Arabidopsis thaliana
P173	PAHSDPVSAVS	1	Caenorhabditis elegans
P215	IDDDNPPVSFV	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P215	IDDENPPVSFV	1	Arabidopsis thaliana
P215	VDDENPPVAFV	1	Caenorhabditis elegans
P216	DDDNPPVSFVK	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P216	DDENPPVSFVR	1	Arabidopsis thaliana
P216	DDENPPVAFVK	1	Caenorhabditis elegans
P224	FVKFSPNGKYI	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
P224	FVRFSPNGKFI	1	Arabidopsis thaliana
Q289	YIWNLQTKEIV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q289	HMWELNSKKLL	1	Arabidopsis thaliana
Q289	YIWNLQTREIV	1	Caenorhabditis elegans
Q289	YIWNLQSKEVV	1	Drosophila melanogaster
Q289	YIWNLQTKEVV	1	Xenopus tropicalis
R181	AVHFNRDGSLI	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R181	AVDFNRDGSLI	1	Arabidopsis thaliana
R181	AVSFNRDGSLI	1	Caenorhabditis elegans
S175	HSDPVSAVHFN	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S175	HSDPVTAVDFN	1	Arabidopsis thaliana
S175	HSDPVSAVSFN	1	Caenorhabditis elegans
S223	SFVKFSPNGKY	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S223	SFVRFSPNGKF	1	Arabidopsis thaliana
S223	AFVKFSPNGKY	1	Caenorhabditis elegans
S49	HTKAVSSVKFS	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S49	HNRAVSSVKFS	1	Arabidopsis thaliana
S49	HTKSISSAKFS	1	Caenorhabditis elegans
S49	HTKAVSAVKFS	1	Drosophila melanogaster
S50	TKAVSSVKFSP	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S50	NRAVSSVKFSS	1	Arabidopsis thaliana
S50	TKSISSAKFSP	1	Caenorhabditis elegans
S50	TKAVSAVKFSP	1	Drosophila melanogaster
S91	HKLGISDVAWS	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S91	HENGISDVAFS	1	Arabidopsis thaliana
S91	HKLGVNDIAWS	1	Caenorhabditis elegans
V268	FANFSVTGGKW	7	Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V268	SSAFSVTNGKR	1	Arabidopsis thaliana
V48	GHTKAVSSVKF	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V48	SHNRAVSSVKF	1	Arabidopsis thaliana
V48	GHTKSISSAKF	1	Caenorhabditis elegans
V48	GHTKAVSAVKF	1	Drosophila melanogaster
Y131	KGHSNYVFCCN	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y131	IGHTNYAFCVN	1	Arabidopsis thaliana
Y131	KGHNNYVFCCN	1	Caenorhabditis elegans
Y191	IVSSSYDGLCR	7	Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y191	IASGSYDGLVR	1	Caenorhabditis elegans
Y228	SPNGKYILAAT	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y228	SPNGKFILVGT	1	Arabidopsis thaliana
Y228	SPNGKYILASN	1	Caenorhabditis elegans
Y260	HKNEKYCIFAN	6	Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y260	HVNAQYCISSA	1	Arabidopsis thaliana
Y260	HENSKYCIFAN	1	Caenorhabditis elegans