mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CHEK1
Gene summary
Basic gene Info.Gene symbolCHEK1
Gene namecheckpoint kinase 1
SynonymsCHK1
CytomapUCSC genome browser: 11q24.2
Type of geneprotein-coding
RefGenesNM_001114121.2,
NM_001114122.2,NM_001244846.1,NM_001274.5,NR_045204.1,
NR_045205.1,
DescriptionCHK1 checkpoint homologCheckpoint, S. pombe, homolog of, 1Chk1-Scell cycle checkpoint kinasecheckpoint kinase-1serine/threonine-protein kinase Chk1
Modification date20141222
dbXrefs MIM : 603078
HGNC : HGNC
Ensembl : ENSG00000149554
HPRD : 04356
Vega : OTTHUMG00000165853
ProteinUniProt: O14757
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CHEK1
BioGPS: 1111
PathwayNCI Pathway Interaction Database: CHEK1
KEGG: CHEK1
REACTOME: CHEK1
Pathway Commons: CHEK1
ContextiHOP: CHEK1
ligand binding site mutation search in PubMed: CHEK1
UCL Cancer Institute: CHEK1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000077DNA damage checkpoint16963448
GO:0006975DNA damage induced protein phosphorylation16963448
GO:0010569regulation of double-strand break repair via homologous recombination15665856
GO:0018107peptidyl-threonine phosphorylation15665856
GO:0045839negative regulation of mitosis15311285
GO:0046602regulation of mitotic centrosome separation15311285


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Ligand binding site mutations for CHEK1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y173P172QLUAD1
F93F93VSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CHEK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y173P172Q-1.3223925
F93F93V-0.76040052
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CHEK1 from PDB

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Differential gene expression and gene-gene network for CHEK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CHEK1 and the right PPI network was created from samples without mutations in the LBS of CHEK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CHEK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CHEK1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
InvestigationalDB05149XL844Small molecule
ExperimentalDB068524-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONESmall molecule
ExperimentalDB06876N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDESmall molecule
ExperimentalDB070253-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONESmall molecule
ExperimentalDB070342,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACIDSmall molecule
ExperimentalDB07037(2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OLSmall molecule
ExperimentalDB070382-(cyclohexylamino)benzoic acidSmall molecule
ExperimentalDB070753-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILESmall molecule
ExperimentalDB07078(3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONESmall molecule
ExperimentalDB071585-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONESmall molecule
ExperimentalDB07213(5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOLSmall molecule
ExperimentalDB072281-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREASmall molecule
ExperimentalDB07243(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATESmall molecule
ExperimentalDB0731118-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONESmall molecule
ExperimentalDB073141-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREASmall molecule
ExperimentalDB073204-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACIDSmall molecule
ExperimentalDB073364-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOLSmall molecule
ExperimentalDB07647(2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OLSmall molecule
ExperimentalDB07648(2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOLSmall molecule
ExperimentalDB07653N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINESmall molecule
ExperimentalDB07654(5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETICSmall molecule
ExperimentalDB076553-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONESmall molecule
ExperimentalDB079593-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLESmall molecule
ExperimentalDB083922-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOLSmall molecule
ExperimentalDB083932-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOLSmall molecule
ExperimentalDB08683REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONESmall molecule
ExperimentalDB087741-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamineSmall molecule
ExperimentalDB08776N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDESmall molecule
ExperimentalDB087775,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONESmall molecule
ExperimentalDB08778[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanoneSmall molecule
ExperimentalDB087792-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-olSmall molecule
ExperimentalDB087806-MORPHOLIN-4-YL-9H-PURINESmall molecule
ExperimentalDB087811-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CHEK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
38M3-(3-CHLOROPHENYL)-2-({(1S)-1-[(6S)-2,8-DIAZASPIRO[5.5]UNDEC-2-YLCARBONYL]PENTYL}SULFANYL)QUINAZOLIN-4(3H)-ONE3f9nAF93
AGX(1S)-1-(1H-BENZIMIDAZOL-2-YL)ETHYL (3,4-DICHLOROPHENYL)CARBAMATE3jvrAF93 Y173
AGY2-[(4-TERT-BUTYL-3-NITROPHENYL)CARBONYL]-N-NAPHTHALEN-1-YLHYDRAZINECARBOXAMIDE3jvsAF93 Y173


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Conservation information for LBS of CHEK1
Multiple alignments for O14757 in multiple species
LBSAA sequence# speciesSpecies
A19TLGEGAYGEVQ4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
A19TLGEGAFGEVL1Caenorhabditis elegans
A19TLGEGAYGEVK1Drosophila melanogaster
A19TVGQGAFACVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A19EIGTGAFASVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A200GIVLTAMLAGE3Homo sapiens, Mus musculus, Rattus norvegicus
A200GIVLIAMLTGE1Caenorhabditis elegans
A200GVILVTMLAGE1Drosophila melanogaster
A200GVVLTAMLAGE1Gallus gallus
A200GILLFVLLTGQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A200GIILFALLLGN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A34RITEEAV-AVK2Mus musculus, Rattus norvegicus
A34RVTEEAV-AVK1Homo sapiens
A34TKNPEVAAAMK1Caenorhabditis elegans
A34RQTGEAV-AMK1Drosophila melanogaster
A34RRTEEAV-AVK1Gallus gallus
A34QMDPSIILAVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A34--DNAKIYAVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A36EEAV-AVKIVD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
A36PEVAAAMKKIN1Caenorhabditis elegans
A36GEAV-AMKMVD1Drosophila melanogaster
A36PSIILAVKFI-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A36NAKIYAVKFVN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C87LFLEYCSGGEL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
C87LFLEYADGGEL1Caenorhabditis elegans
C87IFLEYAAGGEL1Drosophila melanogaster
C87IILEMADGGDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C87VVLEFAQGGDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D148NLKISDFGLAT4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D148VLKISDFGMAT1Caenorhabditis elegans
D148NVKISDFGMAT1Drosophila melanogaster
D148NLKLADFGLAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D148NLKISDFGFAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D94GGELFDRIEPD5Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
D94GGDLFDKIEPD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D94GGELFDKIEPD1Caenorhabditis elegans
D99DRIEPDIGMPE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
D99DKIEPDCGMSP1Caenorhabditis elegans
D99DRIEPDVGMPQ1Drosophila melanogaster
D99DKIEPDVGVDS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D99DKIEPDVGIDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E134RDIKPENLLLD3Homo sapiens, Mus musculus, Rattus norvegicus
E134RDLKPENLLLD2Drosophila melanogaster, Gallus gallus
E134RDIKPENLLLT1Caenorhabditis elegans
E134RDIKPENILLD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E134RDLKPENILLD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E17VQTLGEGAYGE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E17VQTLGEGAFGE1Caenorhabditis elegans
E17AQTLGEGAYGE1Drosophila melanogaster
E17GDTVGQGAFAC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E17GREIGTGAFAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E205AMLAGELPWDQ4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E205AMLTGELPWDR1Caenorhabditis elegans
E205TMLAGELPWDQ1Drosophila melanogaster
E205VLLTGQTPWEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E205ALLLGNTPWDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E33NRITEEAV-AV2Mus musculus, Rattus norvegicus
E33NRVTEEAV-AV1Homo sapiens
E33NTKNPEVAAAM1Caenorhabditis elegans
E33NRQTGEAV-AM1Drosophila melanogaster
E33NRRTEEAV-AV1Gallus gallus
E33LQMDPSIILAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E33D--DNAKIYAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E55-NIKKEICINK4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E55-NIRKEYLLQK1Caenorhabditis elegans
E55-SVRKEVCIQK1Drosophila melanogaster
E55KDITKEVVLQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E55RRMASEIQLHK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E7AVPFVED--WD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E7VAPQQPESLYR1Caenorhabditis elegans
E7TREFVEG--WT1Drosophila melanogaster
E7PLPHIKD--VV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E7NFPY------H1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E85QYLFLEYCSGG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E85YYLFLEYADGG1Caenorhabditis elegans
E85EYIFLEYAAGG1Drosophila melanogaster
E85MWIILEMADGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E85RWVVLEFAQGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E91YCSGGELFDRI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E91YADGGELFDKI1Caenorhabditis elegans
E91YAAGGELFDRI1Drosophila melanogaster
E91MADGGDLFDKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E91FAQGGDLFDKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E97LFDRIEPDIGM4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
E97LFDKIEPDCGM1Caenorhabditis elegans
E97LFDRIEPDVGM1Drosophila melanogaster
E97LFDKIEPDVGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E97LFDKIEPDVGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F149LKISDFGLATV4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F149LKISDFGMATL1Caenorhabditis elegans
F149VKISDFGMATM1Drosophila melanogaster
F149LKLADFGLASQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F149LKISDFGFASL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F83NIQYLFLEYCS2Homo sapiens, Rattus norvegicus
F83QFYYLFLEYAD1Caenorhabditis elegans
F83SVEYIFLEYAA1Drosophila melanogaster
F83ATQYLFLEYCS1Gallus gallus
F83HIQYLFLEYCS1Mus musculus
F83EYMWIILEMAD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F83QWRWVVLEFAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F93SGGELFDRIEP4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
F93DGGELFDKIEP1Caenorhabditis elegans
F93AGGELFDRIEP1Drosophila melanogaster
F93DGGDLFDKIEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F93QGGDLFDKIEP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G16LVQTLGEGAYG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G16VVQTLGEGAFG1Caenorhabditis elegans
G16LAQTLGEGAYG1Drosophila melanogaster
G16LGDTVGQGAFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G16IGREIGTGAFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G18QTLGEGAYGEV5Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
G18QTLGEGAFGEV1Caenorhabditis elegans
G18DTVGQGAFACV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G18REIGTGAFASV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G204TAMLAGELPWD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G204IAMLTGELPWD1Caenorhabditis elegans
G204VTMLAGELPWD1Drosophila melanogaster
G204FVLLTGQTPWE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G204FALLLGNTPWD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G21GEGAYGEVQLA4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G21GEGAFGEVLLI1Caenorhabditis elegans
G21GEGAYGEVKLL1Drosophila melanogaster
G21GQGAFACVKNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G21GTGAFASVRLC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G89LEYCSGGELFD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G89LEYADGGELFD1Caenorhabditis elegans
G89LEYAAGGELFD1Drosophila melanogaster
G89LEMADGGDLFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G89LEFAQGGDLFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G90EYCSGGELFDR4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
G90EYADGGELFDK1Caenorhabditis elegans
G90EYAAGGELFDR1Drosophila melanogaster
G90EMADGGDLFDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G90EFAQGGDLFDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I96ELFDRIEPDIG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
I96DLFDKIEPDVG2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I96ELFDKIEPDCG1Caenorhabditis elegans
I96ELFDRIEPDVG1Drosophila melanogaster
K38AV-AVKIVDM-4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
K38VAAAMKKINIA1Caenorhabditis elegans
K38AV-AMKMVDL-1Drosophila melanogaster
K38IILAVKFI---1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K38KIYAVKFVNK-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L11D--WDLVQTLG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L11ESLYRVVQTLG1Caenorhabditis elegans
L11G--WTLAQTLG1Drosophila melanogaster
L11D--VVLGDTVG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L11----HIGREIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L137KPENLLLDERD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L137KPENLLLTGTH1Caenorhabditis elegans
L137KPENLLLDEHD1Drosophila melanogaster
L137KPENILLDKNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L137KPENILLDYNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L15DLVQTLGEGAY4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
L15RVVQTLGEGAF1Caenorhabditis elegans
L15TLAQTLGEGAY1Drosophila melanogaster
L15VLGDTVGQGAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L15HIGREIGTGAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L206MLAGELPWDQP5Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
L206MLTGELPWDRA1Caenorhabditis elegans
L206LLTGQTPWELP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L206LLLGNTPWDEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L84IQYLFLEYCSG3Homo sapiens, Mus musculus, Rattus norvegicus
L84FYYLFLEYADG1Caenorhabditis elegans
L84VEYIFLEYAAG1Drosophila melanogaster
L84TQYLFLEYCSG1Gallus gallus
L84YMWIILEMADG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L84WRWVVLEFAQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N135DIKPENLLLDE3Homo sapiens, Mus musculus, Rattus norvegicus
N135DLKPENLLLDE2Drosophila melanogaster, Gallus gallus
N135DIKPENLLLTG1Caenorhabditis elegans
N135DIKPENILLDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N135DLKPENILLDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N59KEICINKMLN-3Homo sapiens, Gallus gallus, Rattus norvegicus
N59KEYLLQKRVSA1Caenorhabditis elegans
N59KEVCIQKMLQ-1Drosophila melanogaster
N59KEICINKMLS-1Mus musculus
N59KEVVLQSKCS-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N59SEIQLHKLCN-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P133HRDIKPENLLL4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
P133HRDLKPENLLL2Drosophila melanogaster, Gallus gallus
P133HRDIKPENILL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P133HRDLKPENILL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P207LAGELPWDQPS5Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus, Rattus norvegicus
P207LTGELPWDRAS1Caenorhabditis elegans
P207LTGQTPWELPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P207LLGNTPWDEAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P98FDRIEPDIGMP4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
P98FDKIEPDCGMS1Caenorhabditis elegans
P98FDRIEPDVGMP1Drosophila melanogaster
P98FDKIEPDVGVD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P98FDKIEPDVGID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q13-WDLVQTLGEG4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Q13LYRVVQTLGEG1Caenorhabditis elegans
Q13-WTLAQTLGEG1Drosophila melanogaster
Q13-VVLGDTVGQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q13--HIGREIGTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R74KFYGHRREGNI2Homo sapiens, Rattus norvegicus
R74RMIGMRNDPQF1Caenorhabditis elegans
R74RFFGKRSQGSV1Drosophila melanogaster
R74KFYGHRREGAT1Gallus gallus
R74KFYGHRREGHI1Mus musculus
R74RLIDCNVSKEY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R74HFYNTAENPQW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R95GELFDRIEPDI4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
R95GDLFDKIEPDV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R95GELFDKIEPDC1Caenorhabditis elegans
R95GELFDRIEPDV1Drosophila melanogaster
S147DNLKISDFGLA4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
S147HVLKISDFGMA1Caenorhabditis elegans
S147DNVKISDFGMA1Drosophila melanogaster
S147GNLKLADFGLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147GNLKISDFGFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S88FLEYCSGGELF4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
S88FLEYADGGELF1Caenorhabditis elegans
S88FLEYAAGGELF1Drosophila melanogaster
S88ILEMADGGDLF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S88VLEFAQGGDLF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T14WDLVQTLGEGA4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
T14YRVVQTLGEGA1Caenorhabditis elegans
T14WTLAQTLGEGA1Drosophila melanogaster
T14VVLGDTVGQGA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T14-HIGREIGTGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V23GAYGEVQLAVN4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V23GAFGEVLLIVN1Caenorhabditis elegans
V23GAYGEVKLLIN1Drosophila melanogaster
V23GAFACVKNAHL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V23GAFASVRLCYD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V68-HENVVKFYGH4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
V68GHDNVIRMIGM1Caenorhabditis elegans
V68-DKHILRFFGK1Drosophila melanogaster
V68KHPNVLRLIDC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V68GHKNIIHFYNT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W208AGELPWDQPSD4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W208TGELPWDRASD1Caenorhabditis elegans
W208AGELPWDQPST1Drosophila melanogaster
W208TGQTPWELPSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W208LGNTPWDEAIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W9VED--WDLVQT4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
W9QPESLYRVVQT1Caenorhabditis elegans
W9VEG--WTLAQT1Drosophila melanogaster
W9IKD--VVLGDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W9------HIGRE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y173CGTLPYVAPEL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Y173CGTIPYAAPEL1Caenorhabditis elegans
Y173CGTLPYVAPEV1Drosophila melanogaster
Y173RGSPPYMAPEV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y173VGSPPYAAPEI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y20LGEGAYGEVQL4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Y20LGEGAFGEVLL1Caenorhabditis elegans
Y20LGEGAYGEVKL1Drosophila melanogaster
Y20VGQGAFACVKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y20IGTGAFASVRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y71NVVKFYGHRRE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Y71NVIRMIGMRND1Caenorhabditis elegans
Y71HILRFFGKRSQ1Drosophila melanogaster
Y71NVLRLIDCNVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y71NIIHFYNTAEN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y81EGNIQYLFLEY2Homo sapiens, Rattus norvegicus
Y81DPQFYYLFLEY1Caenorhabditis elegans
Y81QGSVEYIFLEY1Drosophila melanogaster
Y81EGATQYLFLEY1Gallus gallus
Y81EGHIQYLFLEY1Mus musculus
Y81SKEYMWIILEM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y81NPQWRWVVLEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y86YLFLEYCSGGE4Homo sapiens, Gallus gallus, Mus musculus, Rattus norvegicus
Y86YLFLEYADGGE1Caenorhabditis elegans
Y86YIFLEYAAGGE1Drosophila melanogaster
Y86WIILEMADGGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y86WVVLEFAQGGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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