mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CHI3L1
Gene summary
Basic gene Info.Gene symbolCHI3L1
Gene namechitinase 3-like 1 (cartilage glycoprotein-39)
SynonymsASRT7|CGP-39|GP-39|GP39|HC-gp39|HCGP-3P|YKL-40|YKL40|YYL-40|hCGP-39
CytomapUCSC genome browser: 1q32.1
Type of geneprotein-coding
RefGenesNM_001276.2,
Description39 kDa synovial proteincartilage glycoprotein 39chitinase-3-like protein 1
Modification date20141222
dbXrefs MIM : 601525
HGNC : HGNC
Ensembl : ENSG00000133048
HPRD : 03314
Vega : OTTHUMG00000042122
ProteinUniProt: P36222
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CHI3L1
BioGPS: 1116
PathwayNCI Pathway Interaction Database: CHI3L1
KEGG: CHI3L1
REACTOME: CHI3L1
Pathway Commons: CHI3L1
ContextiHOP: CHI3L1
ligand binding site mutation search in PubMed: CHI3L1
UCL Cancer Institute: CHI3L1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CHI3L1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D207D207YSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CHI3L1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D207D207Y-0.39478302
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CHI3L1 from PDB

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Differential gene expression and gene-gene network for CHI3L1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CHI3L1 and the right PPI network was created from samples without mutations in the LBS of CHI3L1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CHI3L1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017636Glioblastoma16AlteredExpression, Biomarker, GeneticVariation
umls:C0017638Glioma12AlteredExpression, Biomarker
umls:C0036341Schizophrenia8Biomarker, GeneticVariation
umls:C0029408Osteoarthritis4Biomarker
umls:C0027626Neoplasm Invasiveness2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CHI3L1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CHI3L1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtBD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtBD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtDD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtDD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwtDD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuAD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuBD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuBD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuCD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuDD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuDD207
NAGALDEHYDO-N-ACETYL-D-GLUCOSAMINE1nwuDD207


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Conservation information for LBS of CHI3L1
Multiple alignments for P36222 in multiple species
LBSAA sequence# speciesSpecies
A138DGLDLAWLYPG2Homo sapiens, Bos taurus
A138DGLDLAWLYPR1Mus musculus
A177LLLSAALSAGK2Homo sapiens, Mus musculus
A177LLLSAAVPAGK1Bos taurus
D207SIMTYDFHGAW1Homo sapiens
D207NLMTYDFHGVW1Mus musculus
D207SLLTYDFHGAW1Bos taurus
E290GRFTKEAGTLA2Homo sapiens, Mus musculus
E290GQFTKEKGILA1Bos taurus
E70-IDTWEWNDVT2Homo sapiens, Bos taurus
E70MLSTWEWNDES1Mus musculus
F208IMTYDFHGAWR1Homo sapiens
F208LMTYDFHGVWR1Mus musculus
F208LLTYDFHGAWR1Bos taurus
F261MGIPTFGRSFT1Homo sapiens
F261MGIPTFGKSFT1Mus musculus
F261MGIPTFGRSYT1Bos taurus
F58HIIYSFANISN1Homo sapiens
F58HIIYSFANISS1Mus musculus
F58HVIYSFANISN1Bos taurus
G181AALSAGKVTID1Homo sapiens
G181AALSAGKVAID1Mus musculus
G181AAVPAGKIAID1Bos taurus
G98LLSVGGWNFGS2Homo sapiens, Bos taurus
G98LLSVGGWKFGE1Mus musculus
I61YSFANISNDH-1Homo sapiens
I61YSFANISSDNM1Mus musculus
I61YSFANISNNE-1Bos taurus
L140LDLAWLYPGRR1Homo sapiens
L140LDLAWLYPRLR1Mus musculus
L140LDLAWLYPGWR1Bos taurus
M204DFISIMTYDFH1Homo sapiens
M204DFINLMTYDFH1Mus musculus
M204DFISLLTYDFH1Bos taurus
N100SVGGWNFGSQR2Homo sapiens, Bos taurus
N100SVGGWKFGEKR1Mus musculus
N60IYSFANISNDH1Homo sapiens
N60IYSFANISSDN1Mus musculus
N60IYSFANISNNE1Bos taurus
R105NFGSQRFSKIA2Homo sapiens, Bos taurus
R105KFGEKRFSEIA1Mus musculus
R263IPTFGRSFTLA1Homo sapiens
R263IPTFGKSFTLA1Mus musculus
R263IPTFGRSYTLA1Bos taurus
S62SFANISNDH-I1Homo sapiens
S62SFANISSDNML1Mus musculus
S62SFANISNNE-I1Bos taurus
W212DFHGAWRGTTG1Homo sapiens
W212DFHGVWRQITG1Mus musculus
W212DFHGAWRQTVG1Bos taurus
W31CYYTSWSQYRE2Homo sapiens, Bos taurus
W31CYFTSWSQYRE1Mus musculus
W352AGAMVWALDLD3Homo sapiens, Mus musculus, Bos taurus
W69H-IDTWEWNDV1Homo sapiens
W69NMLSTWEWNDE1Mus musculus
W69E-IDTWEWNDV1Bos taurus
W71IDTWEWNDVTL2Homo sapiens, Bos taurus
W71LSTWEWNDESN1Mus musculus
W99LSVGGWNFGSQ2Homo sapiens, Bos taurus
W99LSVGGWKFGEK1Mus musculus
Y141DLAWLYPGRRD1Homo sapiens
Y141DLAWLYPRLRD1Mus musculus
Y141DLAWLYPGWRD1Bos taurus
Y206ISIMTYDFHGA1Homo sapiens
Y206INLMTYDFHGV1Mus musculus
Y206ISLLTYDFHGA1Bos taurus
Y27YKLVCYYTSWS1Homo sapiens
Y27YKLVCYFTSWS1Mus musculus
Y27YKLICYYTSWS1Bos taurus
Y34TSWSQYREGDG2Homo sapiens, Bos taurus
Y34TSWSQYREGVG1Mus musculus


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