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mutLBSgeneDB |
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| Gene summary for INMT |
 Gene summary |
| Basic gene Info. | Gene symbol | INMT |
| Gene name | indolethylamine N-methyltransferase | |
| Synonyms | TEMT | |
| Cytomap | UCSC genome browser: 7p14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199219.1, NM_006774.4, | |
| Description | amine N-methyltransferasearomatic alkylamine N-methyltransferasearylamine N-methyltransferaseindolamine N-methyltransferasenicotine N-methyltransferasethioether S-methyltransferase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604854 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000241644 | ||
| HPRD : 06890 | ||
| Vega : OTTHUMG00000167163 | ||
| Protein | UniProt: O95050 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_INMT | |
| BioGPS: 11185 | ||
| Pathway | NCI Pathway Interaction Database: INMT | |
| KEGG: INMT | ||
| REACTOME: INMT | ||
| Pathway Commons: INMT | ||
| Context | iHOP: INMT | |
| ligand binding site mutation search in PubMed: INMT | ||
| UCL Cancer Institute: INMT | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0009308 | amine metabolic process | 10552930 | GO:0032259 | methylation | 10552930 |
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| Ligand binding site mutations for INMT |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N90 | R91W | COAD | 1 | L163 | L161F | COAD | 1 | T67,G65 | P66L | KIRC | 1 | T87 | T87N | LUAD | 1 | Y20 | D19Y | LUAD | 1 | D85 | L83V | LUAD | 1 | D85 | D85E | LUSC | 1 | Y25 | T23A | LUSC | 1 | N90 | R91Q | PRAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for INMT |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y25 | T23A | -1.5343249 | T87 | T87N | -1.4375862 | D85 | L83V | -0.90624286 | D85 | D85E | -0.74880644 | T67 | P66L | -0.50877166 | G65 | P66L | -0.50877166 | N90 | R91Q | -0.50148913 | Y20 | D19Y | -0.40381341 | L163 | L161F | -0.17626607 | N90 | R91W | -0.17241707 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for INMT from PDB |
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| Differential gene expression and gene-gene network for INMT |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for INMT |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for INMT |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of INMT go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SAH | S-ADENOSYL-L-HOMOCYSTEINE | 2a14 | A | Y20 Y25 G65 T67 D85 T87 N90 L163 |
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| Conservation information for LBS of INMT |
| Multiple alignments for O95050 in multiple species |
| LBS | AA sequence | # species | Species |
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