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mutLBSgeneDB |
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| Gene summary for WIF1 |
 Gene summary |
| Basic gene Info. | Gene symbol | WIF1 |
| Gene name | WNT inhibitory factor 1 | |
| Synonyms | WIF-1 | |
| Cytomap | UCSC genome browser: 12q14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007191.4, | |
| Description | wnt inhibitory factor 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605186 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000156076 | ||
| HPRD : 05541 | ||
| Vega : OTTHUMG00000168832 | ||
| Protein | UniProt: Q9Y5W5 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WIF1 | |
| BioGPS: 11197 | ||
| Pathway | NCI Pathway Interaction Database: WIF1 | |
| KEGG: WIF1 | ||
| REACTOME: WIF1 | ||
| Pathway Commons: WIF1 | ||
| Context | iHOP: WIF1 | |
| ligand binding site mutation search in PubMed: WIF1 | ||
| UCL Cancer Institute: WIF1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for WIF1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I231 | I231M | BRCA | 1 | C182 | P183T | KIRC | 1 | C182 | P183T | LUSC | 1 | C186 | R187Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for WIF1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | I231 | I231M | -0.94232741 | C186 | R187Q | -0.81576844 | C182 | P183T | -0.73740645 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for WIF1 from PDB |
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| Differential gene expression and gene-gene network for WIF1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for WIF1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0009404 | Colorectal Neoplasms | 2 | Biomarker |
| umls:C0014859 | Esophageal Neoplasms | 1 | Biomarker |
| umls:C0027439 | Nasopharyngeal Neoplasms | 1 | Biomarker |
| umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for WIF1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of WIF1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2ygp | A | C182 C186 |
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| Conservation information for LBS of WIF1 |
| Multiple alignments for Q9Y5W5 in multiple species |
| LBS | AA sequence | # species | Species | C182 | ---AECPGGCR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C182 | TTLQECSLKCG | 1 | Drosophila melanogaster | C182 | ---AKCPGGCR | 1 | Danio rerio | C186 | ECPGGCRNGGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C186 | ECSLKCGKNGY | 1 | Drosophila melanogaster | C186 | KCPGGCRNGGY | 1 | Danio rerio | C192 | RNGGFCNERRV | 2 | Mus musculus, Rattus norvegicus | C192 | RNGGFCNERRI | 1 | Homo sapiens | C192 | GKNGYCNEHHI | 1 | Drosophila melanogaster | C192 | RNGGYCNERQV | 1 | Danio rerio | G185 | AECPGGCRNGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G185 | QECSLKCGKNG | 1 | Drosophila melanogaster | G185 | AKCPGGCRNGG | 1 | Danio rerio | G253 | TTCFNGGTCFY | 2 | Homo sapiens, Mus musculus | G253 | DKCLNGGKCIQ | 1 | Drosophila melanogaster | G253 | TTCLNGGTCFH | 1 | Danio rerio | G253 | ATCFNGGTCFY | 1 | Rattus norvegicus | I231 | TPGFCICPPGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I231 | APSVCTCPEGY | 1 | Drosophila melanogaster | I231 | SPGVCICPPGY | 1 | Danio rerio | T255 | CFNGGTCFYPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T255 | CLNGGKCIQKD | 1 | Drosophila melanogaster | T255 | CLNGGTCFHPG | 1 | Danio rerio |
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