mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for WIF1
Gene summary
Basic gene Info.Gene symbolWIF1
Gene nameWNT inhibitory factor 1
CytomapUCSC genome browser: 12q14.3
Type of geneprotein-coding
Descriptionwnt inhibitory factor 1
Modification date20141207
dbXrefs MIM : 605186
Ensembl : ENSG00000156076
HPRD : 05541
Vega : OTTHUMG00000168832
ProteinUniProt: Q9Y5W5
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_WIF1
BioGPS: 11197
PathwayNCI Pathway Interaction Database: WIF1
Pathway Commons: WIF1
ContextiHOP: WIF1
ligand binding site mutation search in PubMed: WIF1
UCL Cancer Institute: WIF1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for WIF1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for WIF1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for WIF1 from PDB

Differential gene expression and gene-gene network for WIF1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of WIF1 and the right PPI network was created from samples without mutations in the LBS of WIF1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for WIF1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0009404Colorectal Neoplasms2Biomarker
umls:C0014859Esophageal Neoplasms1Biomarker
umls:C0027439Nasopharyngeal Neoplasms1Biomarker
umls:C0038356Stomach Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for WIF1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of WIF1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)2ygpAC182 C186

Conservation information for LBS of WIF1
Multiple alignments for Q9Y5W5 in multiple species
LBSAA sequence# speciesSpecies
C182---AECPGGCR3Homo sapiens, Mus musculus, Rattus norvegicus
C182TTLQECSLKCG1Drosophila melanogaster
C182---AKCPGGCR1Danio rerio
C186ECPGGCRNGGF3Homo sapiens, Mus musculus, Rattus norvegicus
C186ECSLKCGKNGY1Drosophila melanogaster
C186KCPGGCRNGGY1Danio rerio
C192RNGGFCNERRV2Mus musculus, Rattus norvegicus
C192RNGGFCNERRI1Homo sapiens
C192GKNGYCNEHHI1Drosophila melanogaster
C192RNGGYCNERQV1Danio rerio
G185AECPGGCRNGG3Homo sapiens, Mus musculus, Rattus norvegicus
G185QECSLKCGKNG1Drosophila melanogaster
G185AKCPGGCRNGG1Danio rerio
G253TTCFNGGTCFY2Homo sapiens, Mus musculus
G253DKCLNGGKCIQ1Drosophila melanogaster
G253TTCLNGGTCFH1Danio rerio
G253ATCFNGGTCFY1Rattus norvegicus
I231TPGFCICPPGF3Homo sapiens, Mus musculus, Rattus norvegicus
I231APSVCTCPEGY1Drosophila melanogaster
I231SPGVCICPPGY1Danio rerio
T255CFNGGTCFYPG3Homo sapiens, Mus musculus, Rattus norvegicus
T255CLNGGKCIQKD1Drosophila melanogaster
T255CLNGGTCFHPG1Danio rerio

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