mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CHEK2
Gene summary
Basic gene Info.Gene symbolCHEK2
Gene namecheckpoint kinase 2
SynonymsCDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1
CytomapUCSC genome browser: 22q12.1
Type of geneprotein-coding
RefGenesNM_001005735.1,
NM_001257387.1,NM_007194.3,NM_145862.2,
DescriptionCHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2serine/threonine-protein kinase Chk2
Modification date20141222
dbXrefs MIM : 604373
HGNC : HGNC
Ensembl : ENSG00000183765
HPRD : 05084
Vega : OTTHUMG00000151023
ProteinUniProt: O96017
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CHEK2
BioGPS: 11200
PathwayNCI Pathway Interaction Database: CHEK2
KEGG: CHEK2
REACTOME: CHEK2
Pathway Commons: CHEK2
ContextiHOP: CHEK2
ligand binding site mutation search in PubMed: CHEK2
UCL Cancer Institute: CHEK2
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006355regulation of transcription, DNA-templated12717439
GO:0006468protein phosphorylation12717439
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage12402044
GO:0042770signal transduction in response to DNA damage14744935
GO:0045893positive regulation of transcription, DNA-templated17101782
GO:0046777protein autophosphorylation16794575
GO:0050821protein stabilization12717439


Top
Ligand binding site mutations for CHEK2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D347R346SCOAD2
E308E308QBRCA1
D347R346CBRCA1
H371S372PCOAD1
Q358E359KCOAD1
V234K235QCOAD1
D347R346CCOAD1
N166N166SHNSC1
T138T138ALUAD1
D347R346GLUSC1
D347R346HOV1
L277I276SUCEC1
Y136D134YUCEC1
Y136K135TUCEC1
L354L354VUCEC1
E351E351DUCEC1
L277K279TUCEC1
A247A247TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for CHEK2 from My Cancer Genome.
Checkpoint kinase 2 (CHEK2) is a gene that encodes a protein that functions as a regulator of the cell cycle as well as a tumor suppressor. The protein is activated in the presence of DNA damage in order to prevent entry into mitosis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cancers of the central nervous system, endometrial cancer, and intestinal cancer. Related Pathways: Cell cycle control. Modified: December 4, 2015

Top
Protein structure related information for CHEK2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H371S372P0.11994636
L277I276S-1.9131647
T138T138A-1.2662486
E308E308Q-1.1503516
E351E351D-1.0962361
A247A247T-1.035712
Y136K135T-0.91798137
L354L354V-0.91437388
Q358E359K-0.86492378
D347R346G-0.77762988
N166N166S-0.75494454
L277K279T-0.67140456
D347R346H-0.56094838
D347R346S-0.54625954
Y136D134Y-0.5192295
V234K235Q-0.38140914
D347R346C-0.37926413
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CHEK2 from PDB
PDB IDPDB titlePDB structure
2CN5CRYSTAL STRUCTURE OF HUMAN CHK2 IN COMPLEX WITH ADP

Top
Differential gene expression and gene-gene network for CHEK2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CHEK2 and the right PPI network was created from samples without mutations in the LBS of CHEK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for CHEK2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms53AlteredExpression, Biomarker, GeneticVariation
umls:C0346153Breast Cancer, Familial22Biomarker, GeneticVariation
umls:C0376358Malignant neoplasm of prostate21Biomarker, GeneticVariation
umls:C0085390Li-Fraumeni Syndrome20Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms9Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms8Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms4Biomarker, GeneticVariation
umls:C2931456Prostate cancer, familial3Biomarker, GeneticVariation
umls:C0242788Breast Neoplasms, Male2Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms2Biomarker, GeneticVariation
umls:C0027819Neuroblastoma2Biomarker
umls:C0029463Osteosarcoma1Biomarker, GeneticVariation
umls:C0242656Disease Progression1Biomarker
umls:C0206720Neoplasms, Squamous Cell1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
151865E351DUncertain significanceGermlineMedGen:C0027672
SNOMED CT:699346009
151936R346CUncertain significanceGermlineMedGen:C0027672
SNOMED CT:699346009
152085N166SUncertain significanceGermlineGeneReviews:NBK1247
MedGen:C0346153
OMIM:114480
SNOMED CT:254843006
MedGen:C0027672
SNOMED CT:699346009
181105R346HUncertain significanceGermlineGeneReviews:NBK1247
MedGen:C0346153
OMIM:114480
SNOMED CT:254843006
MedGen:C0027672
SNOMED CT:699346009

Top
Pharmacological information for CHEK2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
InvestigationalDB05149XL844Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CHEK2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
B4W2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL2xm8AA247 E308 E351
LWH4-(1H-PYRAZOL-5-YL)-2-{4-[(3S)-PYRROLIDIN-3-YLAMINO]QUINAZOLIN-2-YL}PHENOL2xm9AA247 E308 E351 L354
P3J3-(PYRIDIN-3-YL)-1H-PYRAZOL-5-AMINE4bdgAA247 E308 L354
VGM4-[2-AMINO-5-(4-HYDROXY-3-METHOXYPHENYL)PYRIDIN-3-YL]BENZAMIDE2wtcAA247 L354
WTI4-[2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)PYRIDIN-3-YL]BENZAMIDE2wtiAA247 L354
MGMAGNESIUM(2+)2ycfAD347
MGMAGNESIUM(2+)2cn8AD347 H371
MGMAGNESIUM(2+)2w7xAD347 H371
RU92-(4-(3-HYDROXYPHENOXY)PHENYL)-1H-BENZO[D] IMIDAZOLE-5-CARBOXAMIDE4a9sAE308 L354
ZAT4,4'-DIACETYLDIPHENYLUREA-BIS(GUANYLHYDRAZONE)2w0jAL354
ZZK4-[2-AMINO-5-(1,3-BENZODIOXOL-4-YL)PYRIDIN-3-YL]BENZAMIDE2wtdAL354
IIIPeptide ligand (HIS,PHE,ASP,THR,TYR,LEU,ILE,ARG)1gxcGT138 N166
ADPADP2cn5AV234 A247 E308 E351 L354
DBQDEBROMOHYMENIALDISINE2cn8AV234 A247 E308 E351 L354
XBJ4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL2xbjAV234 A247 E308 E351 L354
WVI3-METHYL-4-(THIOPHEN-2-YL)-1H-PYRAZOL-5-AMINE4bdhAV234 A247 E308 L354
Z2M3-CYCLOPROPYL-4-(FURAN-2-YL)-1H-PYRAZOLO[3,4- B]PYRIDINE4bdjAV234 A247 E308 L354
WTJ2-AMINO-5-(2,3-DIHYDROTHIENO[3,4-B][1,4]DIOXIN-5-YL)-N-[2-(DIMETHYLAMINO)ETHYL]PYRIDINE-3-CARBOXAMIDE2wtjAV234 A247 E351 L354
YIR(E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE2yirAV234 A247 L354
VFB3,4-DIHYDRO[1,2,4]TRIAZOLO[1,5-A][3,1] BENZIMIDAZOL-9-IUM4bdaAV234 A247 L354
ODO4-[(E)-C-METHYL-N-OXIDANYL-CARBONIMIDOYL] BENZENE-1,3-DIOL4bdbAV234 A247 L354
ODHN-(FURAN-2-YLMETHYL)QUINOXALINE-6-CARBOXAMIDE4bdcAV234 A247 L354
Z0O1-(TERT-BUTYL)-3-(QUINOXALIN-6-YL)UREA4bddAV234 A247 L354
CWS6-METHYLQUINAZOLIN-4-AMINE4bdeAV234 A247 L354
H3R5-METHYL-3-PHENYL-1H-PYRAZOLE4bdfAV234 A247 L354
HAU1-ACETYL-N-(5-METHYLPYRIDIN-2-YL)PIPERIDINE- 4-CARBOXAMIDE4bdiAV234 A247 L354
RQQN-[(4-METHOXYPHENYL)METHYL]QUINOXALINE-6- CARBOXAMIDE4bdkAV234 A247 L354
NXPN-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE2ycsAV234 E308 L354
A9T2-(4-{[1-(4-CHLOROBENZYL)PIPERIDIN-4-YL] METHOXY}PHENYL)-1H-BENZIMIDAZOLE-5- CARBOXAMIDE4a9tAV234 E308 L354
A9U2-{4-[(1-BENZYLPIPERIDIN-4-YL)METHOXY]PHENYL} -1H-BENZIMIDAZOLE-6-CARBOXAMIDE4a9uAV234 E308 L354 Q358
YITN-{4-[(1E)-N-CARBAMIMIDOYLBUTANEHYDRAZONOYL]PHENYL}-5-METHOXY-1H-INDOLE-2-CARBOXAMIDE2yitAV234 L277 L354
D1AN-[(1Z,4E)-4-{1-[(E)-CARBAMIMIDOYLDIAZENYL]ETHYLIDENE}CYCLOHEXA-2,5-DIEN-1-YLIDENE]-7-NITRO-1H-INDOLE-2-CARBOXAMIDE2w7xAV234 L354
XK9N-{4-[(1E)-N-(N-HYDROXYCARBAMIMIDOYL)ETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE2xk9AV234 L354
YCF(2E)-N-HYDROXY-2-[1-(4-{[(4-{(1E)-1-[2-(N'-HYDROXYCARBAMIMIDOYL)HYDRAZINYLIDENE]ETHYL}PHENYL)CARBAMOYL]AMINO}PHENYL)ETHYLIDENE]HYDRAZINECARBOXIMIDAMIDE2ycfAV234 L354
UPXN-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE2ycqAV234 L354
HCW1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA2ycrAV234 L354
YIQ(E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE2yiqAV234 L354
RU52-[4-(4-CHLOROPHENOXY)PHENYL]-1H- BENZIMIDAZOLE-6-CARBOXAMIDE4a9rAV234 L354
IIIPeptide ligand (HIS,PHE,ASP,THR,TYR,LEU,ILE,ARG)1gxcAY136 T138 N166
IIIPeptide ligand (HIS,PHE,ASP,THR,TYR,LEU,ILE,ARG)1gxcDY136 T138 N166
IIIPeptide ligand (HIS,PHE,ASP,THR,TYR,LEU,ILE,ARG)1gxcJY136 T138 N166


Top
Conservation information for LBS of CHEK2
Multiple alignments for O96017 in multiple species
LBSAA sequence# speciesSpecies
A230TLGSGACGEVK2Homo sapiens, Mus musculus
A230VVGQGAFATVK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A230SLGKGGFGKVL1Caenorhabditis elegans
A230KLGSGAYGLVR1Drosophila melanogaster
A247TCKKVAIKIIS1Homo sapiens
A247TGKTFAVKIIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A247DRSVVAIKQLN1Caenorhabditis elegans
A247TCQQFAMKIVK1Drosophila melanogaster
A247TCQKVAIKIIS1Mus musculus
C231LGSGACGEVKL1Homo sapiens
C231VGQGAFATVKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C231LGKGGFGKVLL1Caenorhabditis elegans
C231LGSGAYGLVRL1Drosophila melanogaster
C231LGSGACGEVKM1Mus musculus
D118GR---DKSCEY2Homo sapiens, Mus musculus
D118GR---NPACDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D118GRGSDDAPTNF1Caenorhabditis elegans
D118GR---GEANDL1Drosophila melanogaster
D347GIIHRDLKPEN2Homo sapiens, Mus musculus
D347GISHRDLKPDN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D347GICHRDIKPEN1Caenorhabditis elegans
D347GITHRDLKPDN1Drosophila melanogaster
D368LIKITDFGHSK1Homo sapiens
D368LVKITDFGLAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D368ILKLTDFGMAK1Caenorhabditis elegans
D368LLKVSDFGLSK1Drosophila melanogaster
D368LIKITDFGQSK1Mus musculus
E273LNVETEIEILK1Homo sapiens
E273-GVTRELEVLQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E273RDIRNEVEVMK1Caenorhabditis elegans
E273-RVLNEAKIMK1Drosophila melanogaster
E273PSVETEIEILK1Mus musculus
E302-YIVLELMEGG2Homo sapiens, Mus musculus
E302YYMVMEFVSGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E302SYMVIEYVGGG1Caenorhabditis elegans
E302VYMVLEFMRGG1Drosophila melanogaster
E305VLELMEGGELF2Homo sapiens, Mus musculus
E305VMEFVSGGDLM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E305VIEYVGGGEFF1Caenorhabditis elegans
E305VLEFMRGGDLL1Drosophila melanogaster
E308LMEGGELFDKV1Homo sapiens
E308FVSGGDLMDFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E308YVGGGEFFSKV1Caenorhabditis elegans
E308FMRGGDLLNRI1Drosophila melanogaster
E308LMEGGELFDRV1Mus musculus
E351RDLKPENVLLS2Homo sapiens, Mus musculus
E351RDLKPDNILIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E351RDIKPENILCS1Caenorhabditis elegans
E351RDLKPDNVLLE1Drosophila melanogaster
G227MSKTLGSGACG2Homo sapiens, Mus musculus
G227IDEVVGQGAFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G227TSHSLGKGGFG1Caenorhabditis elegans
G227VNRKLGSGAYG1Drosophila melanogaster
G229KTLGSGACGEV2Homo sapiens, Mus musculus
G229EVVGQGAFATV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G229HSLGKGGFGKV1Caenorhabditis elegans
G229RKLGSGAYGLV1Drosophila melanogaster
G232GSGACGEVKLA1Homo sapiens
G232GQGAFATVKKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G232GKGGFGKVLLG1Caenorhabditis elegans
G232GSGAYGLVRLV1Drosophila melanogaster
G232GSGACGEVKMA1Mus musculus
G306LELMEGGELFD2Homo sapiens, Mus musculus
G306MEFVSGGDLMD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G306IEYVGGGEFFS1Caenorhabditis elegans
G306LEFMRGGDLLN1Drosophila melanogaster
G307ELMEGGELFDK1Homo sapiens
G307EFVSGGDLMDF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G307EYVGGGEFFSK1Caenorhabditis elegans
G307EFMRGGDLLNR1Drosophila melanogaster
G307ELMEGGELFDR1Mus musculus
G370KITDFGHSKIL1Homo sapiens
G370KITDFGLAKVQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G370KLTDFGMAK--1Caenorhabditis elegans
G370KVSDFGLSKFV1Drosophila melanogaster
G370KITDFGQSKIL1Mus musculus
H371ITDFGHSKILG1Homo sapiens
H371ITDFGLAKVQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H371LTDFGMAK--N1Caenorhabditis elegans
H371VSDFGLSKFVQ1Drosophila melanogaster
H371ITDFGQSKILG1Mus musculus
I286NHPCIIKIKNF1Homo sapiens
I286NHPRIVRLKGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I286SHPNIVAIYDW1Caenorhabditis elegans
I286SHPCVVRMHDI1Drosophila melanogaster
I286NHPCIIKIKDV1Mus musculus
I288PCIIKIKNFFD1Homo sapiens
I288PRIVRLKGFYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I288PNIVAIYDWIT1Caenorhabditis elegans
I288PCVVRMHDIVD1Drosophila melanogaster
I288PCIIKIKDVFD1Mus musculus
K119R---DKSCEYC2Homo sapiens, Mus musculus
K119R---NPACDYH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K119RGSDDAPTNFN1Caenorhabditis elegans
K119R---GEANDLI1Drosophila melanogaster
K141YRTYSKKHFRI2Homo sapiens, Mus musculus
K141SRL-SNKHFQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K141YRFISKIQFSI1Caenorhabditis elegans
K141TRI-SKVHFII1Drosophila melanogaster
K224Y-IMSKTLGSG2Homo sapiens, Mus musculus
K224FSIIDEVVGQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K224YHVTSHSLGKG1Caenorhabditis elegans
K224Y-YVNRKLGSG1Drosophila melanogaster
K245RKTCKKVAIKI1Homo sapiens
K245RTTGKTFAVKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K245KSDRSVVAIKQ1Caenorhabditis elegans
K245TRTCQQFAMKI1Drosophila melanogaster
K245RKTCQKVAIKI1Mus musculus
K249KKVAIKIISKR1Homo sapiens
K249KTFAVKIISKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K249SVVAIKQLNTQ1Caenorhabditis elegans
K249QQFAMKIVKKN1Drosophila melanogaster
K249QKVAIKIISKR1Mus musculus
L226IMSKTLGSGAC2Homo sapiens, Mus musculus
L226IIDEVVGQGAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L226VTSHSLGKGGF1Caenorhabditis elegans
L226YVNRKLGSGAY1Drosophila melanogaster
L277TEIEILKKLNH2Homo sapiens, Mus musculus
L277RELEVLQKLNH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L277NEVEVMKKLSH1Caenorhabditis elegans
L277NEAKIMKNLSH1Drosophila melanogaster
L301Y-YIVLELMEG2Homo sapiens, Mus musculus
L301SYYMVMEFVSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L301YSYMVIEYVGG1Caenorhabditis elegans
L301SVYMVLEFMRG1Drosophila melanogaster
L303YIVLELMEGGE2Homo sapiens, Mus musculus
L303YMVMEFVSGGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L303YMVIEYVGGGE1Caenorhabditis elegans
L303YMVLEFMRGGD1Drosophila melanogaster
L354KPENVLLSSQE2Homo sapiens, Mus musculus
L354KPDNILIE-QD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L354KPENILCSDKA1Caenorhabditis elegans
L354KPDNVLLETND1Drosophila melanogaster
M304IVLELMEGGEL2Homo sapiens, Mus musculus
M304MVMEFVSGGDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M304MVIEYVGGGEF1Caenorhabditis elegans
M304MVLEFMRGGDL1Drosophila melanogaster
N166EDHSGNGTFVN2Homo sapiens, Mus musculus
N166NDISTNGTWLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N166HDHSRNGTLVN1Caenorhabditis elegans
N166QDLSRNGTFVN1Drosophila melanogaster
N352DLKPENVLLSS2Homo sapiens, Mus musculus
N352DLKPDNILIE-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N352DIKPENILCSD1Caenorhabditis elegans
N352DLKPDNVLLET1Drosophila melanogaster
Q358VLLSSQEEDCL2Homo sapiens, Mus musculus
Q358ILIE-QDDPVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q358ILCSDKAERCI1Caenorhabditis elegans
Q358VLLETNDEETL1Drosophila melanogaster
R117NYWFGR---DK2Homo sapiens, Mus musculus
R117-WTFGR---NP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R117HFVCGRGSDDA1Caenorhabditis elegans
R117EFTAGR---GE1Drosophila melanogaster
R137RTDKYRTYSKK2Homo sapiens, Mus musculus
R137--NISRL-SNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R137DVGLYRFISKI1Caenorhabditis elegans
R137EKILTRI-SKV1Drosophila melanogaster
S140KYRTYSKKHFR2Homo sapiens, Mus musculus
S140ISRL-SNKHFQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S140LYRFISKIQFS1Caenorhabditis elegans
S140LTRI-SKVHFI1Drosophila melanogaster
S192SEIALSLS---1Homo sapiens
S192DEITVGVGVES1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S192DLISIGIP---1Caenorhabditis elegans
S192DVISLSHP---1Drosophila melanogaster
S192SEIALSLC---1Mus musculus
S228SKTLGSGACGE2Homo sapiens, Mus musculus
S228DEVVGQGAFAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S228SHSLGKGGFGK1Caenorhabditis elegans
S228NRKLGSGAYGL1Drosophila melanogaster
T138TDKYRTYSKKH2Homo sapiens, Mus musculus
T138-NISRL-SNKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T138VGLYRFISKIQ1Caenorhabditis elegans
T138KILTRI-SKVH1Drosophila melanogaster
T367CLIKITDFGHS1Homo sapiens
T367VLVKITDFGLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T367CILKLTDFGMA1Caenorhabditis elegans
T367TLLKVSDFGLS1Drosophila melanogaster
T367CLIKITDFGQS1Mus musculus
V234GACGEVKLAFE1Homo sapiens
V234GAFATVKKAIE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V234GGFGKVLLGYK1Caenorhabditis elegans
V234GAYGLVRLVYD1Drosophila melanogaster
V234GACGEVKMAFE1Mus musculus
Y136KRTDKYRTYSK1Homo sapiens
Y136---NISRL-SN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y136KDVGLYRFISK1Caenorhabditis elegans
Y136PEKILTRI-SK1Drosophila melanogaster
Y136RRTDKYRTYSK1Mus musculus
Y139DKYRTYSKKHF2Homo sapiens, Mus musculus
Y139NISRL-SNKHF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y139GLYRFISKIQF1Caenorhabditis elegans
Y139ILTRI-SKVHF1Drosophila melanogaster


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas