mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CHN1
Gene summary
Basic gene Info.Gene symbolCHN1
Gene namechimerin 1
SynonymsARHGAP2|CHN|DURS2|NC|RHOGAP2
CytomapUCSC genome browser: 2q31.1
Type of geneprotein-coding
RefGenesNM_001025201.3,
NM_001206602.1,NM_001822.5,NR_038133.1,
DescriptionA-chimaerinN-chimaerinRho GTPase-activating protein 2a2-chimaerinalpha-chimerinchimaerin 1chimerin (chimaerin) 1n-chimerin
Modification date20141219
dbXrefs MIM : 118423
HGNC : HGNC
Ensembl : ENSG00000128656
HPRD : 00319
Vega : OTTHUMG00000154225
ProteinUniProt: P15882
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CHN1
BioGPS: 1123
PathwayNCI Pathway Interaction Database: CHN1
KEGG: CHN1
REACTOME: CHN1
Pathway Commons: CHN1
ContextiHOP: CHN1
ligand binding site mutation search in PubMed: CHN1
UCL Cancer Institute: CHN1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for CHN1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C255D254NLUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CHN1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C255D254N-1.2422274
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CHN1 from PDB

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Differential gene expression and gene-gene network for CHN1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CHN1 and the right PPI network was created from samples without mutations in the LBS of CHN1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CHN1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0013261Duane Retraction Syndrome8Biomarker, GeneticVariation
umls:C0751083DUANE RETRACTION SYNDROME 21GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CHN1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CHN1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)3cxlAC255


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Conservation information for LBS of CHN1
Multiple alignments for P15882 in multiple species
LBSAA sequence# speciesSpecies


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