|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for DDX19B |
 Gene summary |
| Basic gene Info. | Gene symbol | DDX19B |
| Gene name | DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B | |
| Synonyms | DBP5|DDX19|RNAh | |
| Cytomap | UCSC genome browser: 16q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001014449.2, NM_001014451.2,NM_001257172.1,NM_001257173.1,NM_001257174.1, NM_001257175.1,NM_007242.5, | |
| Description | ATP-dependent RNA helicase DDX19ATP-dependent RNA helicase DDX19BDEAD (Asp-Glu-Ala-As) box polypeptide 19BDEAD box RNA helicase DEAD5DEAD box protein 19BDEAD-box RNA helicase DEAD5DEAD-box protein 5DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (D | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605812 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157349 | ||
| HPRD : 05781 | ||
| Vega : OTTHUMG00000137577 | ||
| Protein | UniProt: Q9UMR2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DDX19B | |
| BioGPS: 11269 | ||
| Pathway | NCI Pathway Interaction Database: DDX19B | |
| KEGG: DDX19B | ||
| REACTOME: DDX19B | ||
| Pathway Commons: DDX19B | ||
| Context | iHOP: DDX19B | |
| ligand binding site mutation search in PubMed: DDX19B | ||
| UCL Cancer Institute: DDX19B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for DDX19B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R114 | R114C | STAD | 1 | T171 | T171M | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for DDX19B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T171 | T171M | -0.82534257 | R114 | R114C | -0.62850848 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DDX19B from PDB |
| Top |
| Differential gene expression and gene-gene network for DDX19B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for DDX19B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for DDX19B |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of DDX19B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 3ews | A | R114 | ADP | ADP | 3ews | B | R114 | ANP | AMP-PNP | 3fht | A | R114 | ANP | AMP-PNP | 3fht | B | R114 | ADP | ADP | 3fmo | B | R114 | ADP | ADP | 3fmp | B | R114 | ADP | ADP | 3fmp | D | R114 | ANP | AMP-PNP | 3g0h | A | R114 | NUC | Nucleic Acids | 3fht | A | T171 | NUC | Nucleic Acids | 3fht | B | T171 | NUC | Nucleic Acids | 3g0h | A | T171 |
| Top |
| Conservation information for LBS of DDX19B |
| Multiple alignments for Q9UMR2 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |