|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for CBX3 |
 Gene summary |
| Basic gene Info. | Gene symbol | CBX3 |
| Gene name | chromobox homolog 3 | |
| Synonyms | HECH|HP1-GAMMA|HP1Hs-gamma | |
| Cytomap | UCSC genome browser: 7p15.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007276.4, NM_016587.3, | |
| Description | HP1 gamma homologchromobox homolog 3 (HP1 gamma homolog, Drosophila)chromobox protein homolog 3heterochromatin protein 1 homolog gammaheterochromatin protein HP1 gammaheterochromatin-like protein 1modifier 2 protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604477 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000122565 | ||
| HPRD : 05130 | ||
| Vega : OTTHUMG00000022911 | ||
| Protein | UniProt: Q13185 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CBX3 | |
| BioGPS: 11335 | ||
| Pathway | NCI Pathway Interaction Database: CBX3 | |
| KEGG: CBX3 | ||
| REACTOME: CBX3 | ||
| Pathway Commons: CBX3 | ||
| Context | iHOP: CBX3 | |
| ligand binding site mutation search in PubMed: CBX3 | ||
| UCL Cancer Institute: CBX3 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0045892 | negative regulation of transcription, DNA-templated | 9636147 |
| Top |
| Ligand binding site mutations for CBX3 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | C69 | C69R | COAD | 1 | W51 | W51C | COAD | 1 | L72 | I73N | UCEC | 1 | V32 | V32M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for CBX3 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W51 | W51C | -1.3706523 | C69 | C69R | -1.0330694 | L72 | I73N | -0.98964119 | V32 | V32M | -0.57793771 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CBX3 from PDB |
| Top |
| Differential gene expression and gene-gene network for CBX3 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for CBX3 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for CBX3 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of CBX3 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (VAL,HIS,ARG,ALA,ARG,LYS,THR,MET,SER,LYS) | 3dm1 | C | V32 W51 | III | Peptide ligand (LYS,VAL,HIS,ARG,ALA,ARG,LYS) | 3dm1 | G | V32 W51 | III | Peptide ligand (LYS,VAL,HIS,ARG,ALA,ARG,LYS,THR) | 3dm1 | A | V32 W51 C69 | III | Peptide ligand (LYS,VAL,HIS,ARG,ALA,ARG,LYS,THR,MET) | 3dm1 | E | V32 W51 C69 | III | Peptide ligand (TYR,PRO,VAL,LYS,LYS,LYS,ALA,ARG,LYS,SER,ALA,GLY) | 3tzd | A | V32 W51 L72 |
| Top |
| Conservation information for LBS of CBX3 |
| Multiple alignments for Q13185 in multiple species |
| LBS | AA sequence | # species | Species |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |