mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for U2AF2
Gene summary
Basic gene Info.Gene symbolU2AF2
Gene nameU2 small nuclear RNA auxiliary factor 2
CytomapUCSC genome browser: 19q13.42
Type of geneprotein-coding
DescriptionU2 (RNU2) small nuclear RNA auxiliary factor 2U2 auxiliary factor 65 kDa subunitU2 small nuclear ribonucleoprotein auxiliary factor (65kD)U2 snRNP auxiliary factor large subunithU2AF65splicing factor U2AF 65 kDa subunit
Modification date20141207
dbXrefs MIM : 191318
Ensembl : ENSG00000063244
HPRD : 01872
Vega : OTTHUMG00000180908
ProteinUniProt: P26368
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_U2AF2
BioGPS: 11338
PathwayNCI Pathway Interaction Database: U2AF2
Pathway Commons: U2AF2
ContextiHOP: U2AF2
ligand binding site mutation search in PubMed: U2AF2
UCL Cancer Institute: U2AF2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0033120positive regulation of RNA splicing21536736
GO:0048025negative regulation of mRNA splicing, via spliceosome15009664

Ligand binding site mutations for U2AF2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for U2AF2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for U2AF2 from PDB

Differential gene expression and gene-gene network for U2AF2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of U2AF2 and the right PPI network was created from samples without mutations in the LBS of U2AF2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for U2AF2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for U2AF2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of U2AF2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3vagBK300 Y302
NUCNucleic Acids3vahBK300 Y302
NUCNucleic Acids3valIK300 Y302
NUCNucleic Acids2g4bAR150 R227
NUCNucleic Acids3vafAR150 R227
NUCNucleic Acids3vafBR150 R227
NUCNucleic Acids3vagAR150 R227
NUCNucleic Acids3vagBR150 R227
NUCNucleic Acids3vahAR150 R227
NUCNucleic Acids3vahBR150 R227
NUCNucleic Acids3vaiAR150 R227
NUCNucleic Acids3vaiBR150 R227
NUCNucleic Acids3vajAR150 R227
NUCNucleic Acids3vajBR150 R227
NUCNucleic Acids3vakAR150 R227
NUCNucleic Acids3valAR150 R227
NUCNucleic Acids3valIR150 R227
NUCNucleic Acids3vamAR150 R227
NUCNucleic Acids3vamBR150 R227
NUCNucleic Acids4tu7AR150 R227
NUCNucleic Acids4tu7BR150 R227
NUCNucleic Acids4tu8AR150 R227
NUCNucleic Acids4tu8BR150 R227
NUCNucleic Acids4tu9AR150 R227
NUCNucleic Acids2yh1AR150 R227 V291 K300 Y302
NUCNucleic Acids4tu9BR227
NUCNucleic Acids3vafBV291 K300 Y302
NUCNucleic Acids3vaiBV291 K300 Y302
NUCNucleic Acids3vajBV291 K300 Y302
NUCNucleic Acids3vakBV291 K300 Y302
NUCNucleic Acids3valAV291 K300 Y302
NUCNucleic Acids3valBV291 K300 Y302
NUCNucleic Acids3valDV291 K300 Y302
NUCNucleic Acids3vamBV291 K300 Y302
NUCNucleic Acids4tu7BV291 K300 Y302
NUCNucleic Acids4tu8BV291 K300 Y302
NUCNucleic Acids4tu9BV291 K300 Y302

Conservation information for LBS of U2AF2
Multiple alignments for P26368 in multiple species
LBSAA sequence# speciesSpecies
A335LLVQRASVGAK1Homo sapiens
A335LHAQFACVGLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A335LTVRRAIQGAI1Arabidopsis thaliana
A335LTVRRANQGAS1Oryza sativa subsp. japonica
A335LTVRRANQGAA1Oryza sativa subsp. japonica
A335LVVQLACANQQ1Caenorhabditis elegans
A335LIVQRASVGAK1Drosophila melanogaster
A54-DQRSASRDRR1Homo sapiens
A54LRYSSVGRSRS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A54HHRRSRDRDRR1Arabidopsis thaliana
A54DRRRGHDSERR1Oryza sativa subsp. japonica
A54DRHRSRDSERR1Oryza sativa subsp. japonica
A54DRDRSRSRERR1Caenorhabditis elegans
A54-RHRSRSRDRH1Drosophila melanogaster
D167EEAMMDFFNAQ1Homo sapiens
D167EDAFVSFIEDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D167EQSVSTFFSQV1Arabidopsis thaliana
D167EHTVAVYFNQV1Oryza sativa subsp. japonica
D167EQSVAIYFNQV1Oryza sativa subsp. japonica
D167EEAMLDFFNQQ1Caenorhabditis elegans
D167EEEMMEFFNQQ1Drosophila melanogaster
D194VYINHDKKFAF2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
D194CQINLDKNFAF2Caenorhabditis elegans, Drosophila melanogaster
D194VQINQDKNFAF1Homo sapiens
D194VNVCKEENFAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D194VYINHEKKFAF1Arabidopsis thaliana
D231VRRPTDYNPSL3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
D231IRRPHDYQPLP1Homo sapiens
D231FQRIQNYIVPQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D231VRRPRDYQPSQ1Caenorhabditis elegans
D231IRRPHDYQPMP1Drosophila melanogaster
D401EEIVEDVRDEC1Homo sapiens
D401EDIYESVKTQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D401AEIMEDMRQEG1Arabidopsis thaliana
D401EDIVQDMREEG1Oryza sativa subsp. japonica
D401EDIMEDMRLEA1Oryza sativa subsp. japonica
D401EEILEDVRDEC1Caenorhabditis elegans
D401EDILEDIKEEC1Drosophila melanogaster
D404VEDVRDECSKY1Homo sapiens
D404YESVKTQFSNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D404MEDMRQEGGKF1Arabidopsis thaliana
D404VQDMREEGCRY1Oryza sativa subsp. japonica
D404MEDMRLEAGKY1Oryza sativa subsp. japonica
D404LEDVRDECSKY1Caenorhabditis elegans
D404LEDIKEECTKY1Drosophila melanogaster
E163FGITEEAMMDF1Homo sapiens
E163NEFVEDAFVSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E163PTANEQSVSTF1Arabidopsis thaliana
E163PTANEHTVAVY1Oryza sativa subsp. japonica
E163PTANEQSVAIY1Oryza sativa subsp. japonica
E163FGCNEEAMLDF1Caenorhabditis elegans
E163FGVTEEEMMEF1Drosophila melanogaster
E201KFAFVEMRSVE3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E201NFAFLEFRSVD1Homo sapiens
E201NFAILEVATPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E201NFAFIEFRSID1Caenorhabditis elegans
E201NFAFLEFRSID1Drosophila melanogaster
E277EAQVRELLESF2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
E277DDQVKELLTSF1Homo sapiens
E277EDQVVELLKPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E277EVQIRELLESF1Arabidopsis thaliana
E277EDQVKELLCSF1Caenorhabditis elegans
E277DDQVKELLLSF1Drosophila melanogaster
E393ELLDDEEYEEI1Homo sapiens
E393EIMDVQEYEDI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E393DLRDDEEYAEI1Arabidopsis thaliana
E393ELRDDEEYEDI1Oryza sativa subsp. japonica
E393ELKDDEEYEDI1Oryza sativa subsp. japonica
E393ELKADDEYEEI1Caenorhabditis elegans
E393ELRDEEEYEDI1Drosophila melanogaster
E394LLDDEEYEEIV1Homo sapiens
E394IMDVQEYEDIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E394LRDDEEYAEIM1Arabidopsis thaliana
E394LRDDEEYEDIV1Oryza sativa subsp. japonica
E394LKDDEEYEDIM1Oryza sativa subsp. japonica
E394LKADDEYEEIL1Caenorhabditis elegans
E394LRDEEEYEDIL1Drosophila melanogaster
E396DDEEYEEIVED1Homo sapiens
E396DVQEYEDIYES1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E396DDEEYAEIMED1Arabidopsis thaliana
E396DDEEYEDIVQD1Oryza sativa subsp. japonica
E396DDEEYEDIMED1Oryza sativa subsp. japonica
E396ADDEYEEILED1Caenorhabditis elegans
E396DEEEYEDILED1Drosophila melanogaster
E397DEEYEEIVEDV1Homo sapiens
E397VQEYEDIYESV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E397DEEYAEIMEDM1Arabidopsis thaliana
E397DEEYEDIVQDM1Oryza sativa subsp. japonica
E397DEEYEDIMEDM1Oryza sativa subsp. japonica
E397DDEYEEILEDV1Caenorhabditis elegans
E397EEEYEDILEDI1Drosophila melanogaster
E400YEEIVEDVRDE1Homo sapiens
E400YEDIYESVKTQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E400YAEIMEDMRQE1Arabidopsis thaliana
E400YEDIVQDMREE1Oryza sativa subsp. japonica
E400YEDIMEDMRLE1Oryza sativa subsp. japonica
E400YEEILEDVRDE1Caenorhabditis elegans
E400YEDILEDIKEE1Drosophila melanogaster
E405EDVRDECSKYG2Homo sapiens, Caenorhabditis elegans
E405ESVKTQFSNYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E405EDMRQEGGKFG1Arabidopsis thaliana
E405QDMREEGCRYG1Oryza sativa subsp. japonica
E405EDMRLEAGKYG1Oryza sativa subsp. japonica
E405EDIKEECTKYG1Drosophila melanogaster
F197NHDKKFAFVEM2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F197NQDKNFAFLEF1Homo sapiens
F197CKEENFAILEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F197NHEKKFAFVEM1Arabidopsis thaliana
F197NLDKNFAFIEF1Caenorhabditis elegans
F197NLDKNFAFLEF1Drosophila melanogaster
F199DKNFAFLEFRS2Homo sapiens, Drosophila melanogaster
F199DKKFAFVEMRS2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F199EENFAILEVAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F199EKKFAFVEMRS1Arabidopsis thaliana
F199DKNFAFIEFRS1Caenorhabditis elegans
F262GPDRIFVGGLP3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F262SAHKLFIGGLP1Homo sapiens
F262SKDKIYISNLP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F262SANKIFIGGLP1Caenorhabditis elegans
F262SPHKIFIGGLP1Drosophila melanogaster
F304SKGYAFCVYQD3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
F304SKGYAFCEYVD2Homo sapiens, Drosophila melanogaster
F304SKGFCFCEFKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F304SKGYAFAEYLD1Caenorhabditis elegans
F454LTGRKFANRVV1Homo sapiens
F454MKGCKFNDRTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F454MNGRKFGGNQV1Arabidopsis thaliana
F454MHGRKFANNQV1Oryza sativa subsp. japonica
F454MHGRKFGGNPV1Oryza sativa subsp. japonica
F454LTGRKFANRTV1Caenorhabditis elegans
F454LTGRKFSDRVV1Drosophila melanogaster
G264DRIFVGGLPYY3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G264HKLFIGGLPNY1Homo sapiens
G264DKIYISNLPLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G264NKIFIGGLPNY1Caenorhabditis elegans
G264HKIFIGGLPNY1Drosophila melanogaster
G265RIFVGGLPYYF3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G265KIFIGGLPNYL2Caenorhabditis elegans, Drosophila melanogaster
G265KLFIGGLPNYL1Homo sapiens
G265KIYISNLPLNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G326NGIKMGDKTLT3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
G326NGMQLGDKKLL1Homo sapiens
G326DGKDTYGNKLH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G326NGMQLGDKQLV1Caenorhabditis elegans
G326NGMQLGDKKLI1Drosophila melanogaster
G451MQGLTGRKFAN1Homo sapiens
G451MEEMKGCKFND1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G451RSGMNGRKFGG1Arabidopsis thaliana
G451KNGMHGRKFAN1Oryza sativa subsp. japonica
G451KTAMHGRKFGG1Oryza sativa subsp. japonica
G451QAALTGRKFAN1Caenorhabditis elegans
G451QQALTGRKFSD1Drosophila melanogaster
H230KVRRPTDYNPS3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
H230KIRRPHDYQPL1Homo sapiens
H230KFQRIQNYIVP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H230KVRRPRDYQPS1Caenorhabditis elegans
H230KIRRPHDYQPM1Drosophila melanogaster
I191L-NVYINHDKK2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
I191L-AVQINQDKN1Homo sapiens
I191FSSVNVCKEEN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I191V-NVYINHEKK1Arabidopsis thaliana
I191L-LCQINLDKN1Caenorhabditis elegans
I191L-ACQINLDKN1Drosophila melanogaster
I398EEYEEIVEDVR1Homo sapiens
I398QEYEDIYESVK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I398EEYAEIMEDMR1Arabidopsis thaliana
I398EEYEDIVQDMR1Oryza sativa subsp. japonica
I398EEYEDIMEDMR1Oryza sativa subsp. japonica
I398DEYEEILEDVR1Caenorhabditis elegans
I398EEYEDILEDIK1Drosophila melanogaster
K195YINHDKKFAFV2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K195QINQDKNFAFL1Homo sapiens
K195NVCKEENFAIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K195YINHEKKFAFV1Arabidopsis thaliana
K195QINLDKNFAFI1Caenorhabditis elegans
K195QINLDKNFAFL1Drosophila melanogaster
K225GQS-LKIRRPH2Homo sapiens, Drosophila melanogaster
K225GAP-VKVRRPT2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K225NDVFLKFQRIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K225GVP-VKVRRPT1Arabidopsis thaliana
K225GQQ-LKVRRPR1Caenorhabditis elegans
K260LEGPDRIFVGG3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K260PDSAHKLFIGG1Homo sapiens
K260LDSKDKIYISN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K260VDSANKIFIGG1Caenorhabditis elegans
K260PDSPHKIFIGG1Drosophila melanogaster
K300ETGNSKGYAFC3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K300ATGLSKGYAFC2Homo sapiens, Drosophila melanogaster
K300ADGSSKGFCFC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K300Q-GNSKGYAFA1Caenorhabditis elegans
K328IKMGDKTLTVR3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K328MQLGDKKLLVQ1Homo sapiens
K328KDTYGNKLHAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K328MQLGDKQLVVQ1Caenorhabditis elegans
K328MQLGDKKLIVQ1Drosophila melanogaster
K329KMGDKTLTVRR3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
K329QLGDKKLLVQR1Homo sapiens
K329DTYGNKLHAQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K329QLGDKQLVVQL1Caenorhabditis elegans
K329QLGDKKLIVQR1Drosophila melanogaster
K453GLTGRKFANRV1Homo sapiens
K453EMKGCKFNDRT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K453GMNGRKFGGNQ1Arabidopsis thaliana
K453GMHGRKFANNQ1Oryza sativa subsp. japonica
K453AMHGRKFGGNP1Oryza sativa subsp. japonica
K453ALTGRKFANRT1Caenorhabditis elegans
K453ALTGRKFSDRV1Drosophila melanogaster
L270GLPNYLNDDQV2Homo sapiens, Drosophila melanogaster
L270GLPYYFTEAQV2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L270NLPLNLGEDQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L270GLPYYFTEVQI1Arabidopsis thaliana
L270GLPNYLTEDQV1Caenorhabditis elegans
L325LNGIKMGDKTL3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L325LNGMQLGDKKL2Homo sapiens, Drosophila melanogaster
L325LDGKDTYGNKL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L325LNGMQLGDKQL1Caenorhabditis elegans
L331GDKTLTVRRAN2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
L331GDKKLLVQRAS1Homo sapiens
L331YGNKLHAQFAC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L331GDKTLTVRRAI1Arabidopsis thaliana
L331GDKQLVVQLAC1Caenorhabditis elegans
L331GDKKLIVQRAS1Drosophila melanogaster
L449KAMQGLTGRKF1Homo sapiens
L449VAMEEMKGCKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L449KARSGMNGRKF1Arabidopsis thaliana
L449KAKNGMHGRKF1Oryza sativa subsp. japonica
L449KAKTAMHGRKF1Oryza sativa subsp. japonica
L449RAQAALTGRKF1Caenorhabditis elegans
L449KAQQALTGRKF1Drosophila melanogaster
M383LCLMNMVLPEE1Homo sapiens
M383LQLHNLITGDE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M383VCLTQVVTADD1Arabidopsis thaliana
M383VCLTQVVSPDE1Oryza sativa subsp. japonica
M383VCLTQVVSADE1Oryza sativa subsp. japonica
M383LCLMNMVTEDE1Caenorhabditis elegans
M383LCLLNMVTPDE1Drosophila melanogaster
N155RVYVGGLPPTA3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
N155RLYVGNIPFGI1Homo sapiens
N155RLVVTGIPNEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N155RLYVGNIPFGC1Caenorhabditis elegans
N155RLYVGNIPFGV1Drosophila melanogaster
N192-NVYINHDKKF2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
N192-AVQINQDKNF1Homo sapiens
N192SSVNVCKEENF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N192-NVYINHEKKF1Arabidopsis thaliana
N192-LCQINLDKNF1Caenorhabditis elegans
N192-ACQINLDKNF1Drosophila melanogaster
N196INHDKKFAFVE2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
N196INQDKNFAFLE1Homo sapiens
N196VCKEENFAILE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N196INHEKKFAFVE1Arabidopsis thaliana
N196INLDKNFAFIE1Caenorhabditis elegans
N196INLDKNFAFLE1Drosophila melanogaster
N289PLRGFDLVKDR2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
N289PLKAFNLVKDS1Homo sapiens
N289DLLSFQLIKNI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N289PLRGFNLVKDR1Arabidopsis thaliana
N289PLKAFSLNVDS1Caenorhabditis elegans
N289KLRAFNLVKDA1Drosophila melanogaster
P229VKVRRPTDYNP3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
P229LKIRRPHDYQP2Homo sapiens, Drosophila melanogaster
P229LKFQRIQNYIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P229LKVRRPRDYQP1Caenorhabditis elegans
Q190VL-NVYINHDK2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Q190VL-AVQINQDK1Homo sapiens
Q190HFSSVNVCKEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q190VV-NVYINHEK1Arabidopsis thaliana
Q190IL-LCQINLDK1Caenorhabditis elegans
Q190VL-ACQINLDK1Drosophila melanogaster
Q274YLNDDQVKELL2Homo sapiens, Drosophila melanogaster
Q274YFTEAQVRELL2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Q274NLGEDQVVELL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q274YFTEVQIRELL1Arabidopsis thaliana
Q274YLTEDQVKELL1Caenorhabditis elegans
Q333KTLTVRRANQG2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Q333KKLLVQRASVG1Homo sapiens
Q333NKLHAQFACVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q333KTLTVRRAIQG1Arabidopsis thaliana
Q333KQLVVQLACAN1Caenorhabditis elegans
Q333KKLIVQRASVG1Drosophila melanogaster
R150TRHARRVYVGG3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R150TRQARRLYVGN2Homo sapiens, Drosophila melanogaster
R150SRQARRLVVTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R150TCQSRRLYVGN1Caenorhabditis elegans
R227P-VKVRRPTDY3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R227S-LKIRRPHDY2Homo sapiens, Drosophila melanogaster
R227VFLKFQRIQNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R227Q-LKVRRPRDY1Caenorhabditis elegans
R228-VKVRRPTDYN3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R228-LKIRRPHDYQ2Homo sapiens, Drosophila melanogaster
R228FLKFQRIQNYI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R228-LKVRRPRDYQ1Caenorhabditis elegans
R334TLTVRRANQGA2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
R334KLLVQRASVGA1Homo sapiens
R334KLHAQFACVGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R334TLTVRRAIQGA1Arabidopsis thaliana
R334QLVVQLACANQ1Caenorhabditis elegans
R334KLIVQRASVGA1Drosophila melanogaster
R452QGLTGRKFANR1Homo sapiens
R452EEMKGCKFNDR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R452SGMNGRKFGGN1Arabidopsis thaliana
R452NGMHGRKFANN1Oryza sativa subsp. japonica
R452TAMHGRKFGGN1Oryza sativa subsp. japonica
R452AALTGRKFANR1Caenorhabditis elegans
R452QALTGRKFSDR1Drosophila melanogaster
S294DLVKDRETGNS2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
S294NLVKDSATGLS1Homo sapiens
S294QLIKNIADGSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S294NLVKDRETGNS1Arabidopsis thaliana
S294SLNVDSQ-GNS1Caenorhabditis elegans
S294NLVKDAATGLS1Drosophila melanogaster
T296VKDRETGNSKG3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
T296VKDSATGLSKG1Homo sapiens
T296IKNIADGSSKG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T296NVDSQ-GNSKG1Caenorhabditis elegans
T296VKDAATGLSKG1Drosophila melanogaster
V291RGFDLVKDRET2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
V291KAFNLVKDSAT1Homo sapiens
V291LSFQLIKNIAD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V291RGFNLVKDRET1Arabidopsis thaliana
V291KAFSLNVDSQ-1Caenorhabditis elegans
V291RAFNLVKDAAT1Drosophila melanogaster
V459FANRVVVTKYC1Homo sapiens
V459FNDRTIVIAFY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V459FGGNQVVAVYY1Arabidopsis thaliana
V459FANNQVVAVFY1Oryza sativa subsp. japonica
V459FGGNPVVAVFY1Oryza sativa subsp. japonica
V459FANRTVVTSYY1Caenorhabditis elegans
V459FSDRVVVTSYF1Drosophila melanogaster
Y152HARRVYVGGLP3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Y152QARRLYVGNIP2Homo sapiens, Drosophila melanogaster
Y152QARRLVVTGIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y152QSRRLYVGNIP1Caenorhabditis elegans
Y269GGLPNYLNDDQ2Homo sapiens, Drosophila melanogaster
Y269GGLPYYFTEAQ2Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Y269SNLPLNLGEDQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y269GGLPYYFTEVQ1Arabidopsis thaliana
Y269GGLPNYLTEDQ1Caenorhabditis elegans
Y302GNSKGYAFCVY3Arabidopsis thaliana, Oryza sativa subsp. japonica, Oryza sativa subsp. japonica
Y302GLSKGYAFCEY2Homo sapiens, Drosophila melanogaster
Y302GSSKGFCFCEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y302GNSKGYAFAEY1Caenorhabditis elegans

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