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mutLBSgeneDB |
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| Gene summary for CLC |
 Gene summary |
| Basic gene Info. | Gene symbol | CLC |
| Gene name | Charcot-Leyden crystal galectin | |
| Synonyms | GAL10|Gal-10|LGALS10|LGALS10A|LPPL_HUMAN | |
| Cytomap | UCSC genome browser: 19q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001828.5, | |
| Description | Charcot-Leyden crystal proteineosinophil lysophospholipasegalectin 10galectin-10lectin, galactoside-binding, soluble, 10lysolecithin acylhydrolase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 153310 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105205 | ||
| HPRD : 08351 | ||
| Vega : OTTHUMG00000183144 | ||
| Protein | UniProt: Q05315 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLC | |
| BioGPS: 1178 | ||
| Pathway | NCI Pathway Interaction Database: CLC | |
| KEGG: CLC | ||
| REACTOME: CLC | ||
| Pathway Commons: CLC | ||
| Context | iHOP: CLC | |
| ligand binding site mutation search in PubMed: CLC | ||
| UCL Cancer Institute: CLC | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0070231 | T cell apoptotic process | 17502455 |
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| Ligand binding site mutations for CLC |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V63 | V63L | BRCA | 1 | D85 | G86D | COAD | 1 | D85 | G86D | LUAD | 1 | V63 | R61S | SKCM | 1 | V63 | V63I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CLC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V63 | V63I | -0.95119627 | V63 | R61S | -0.77709452 | V63 | V63L | -0.73447482 | D85 | G86D | -0.45317977 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLC from PDB |
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| Differential gene expression and gene-gene network for CLC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CLC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CLC |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB02967 | N-Ethylmaleimide | Small molecule |  |
| Experimental | DB02983 | Para-Mercury-Benzenesulfonic Acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CLC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NEQ | N-ETHYLMALEIMIDE | 1g86 | A | D85 | NEQ | N-ETHYLMALEIMIDE | 1g86 | A | V63 | MAN | ALPHA-D-MANNOSE | 1qkq | A | V63 |
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| Conservation information for LBS of CLC |
| Multiple alignments for Q05315 in multiple species |
| LBS | AA sequence | # species | Species |
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